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Stiff-person Syndrome: more detail

The Official Patient's Sourcebook on Stiff-Person Syndrome: A Revised and Updated Directory for the Internet Age by Icon Health Publications, 2002-10-10
Stiff Person Syndrome
Stiff person syndrome: An entry from Thomson Gale's <i>Gale Encyclopedia of Neurological Disorders</i> by Bruno Azevedo, Iuri, MD, PhD Louro, 2005
Rare disease may offer clues to MS. (Moersch-Woltman syndrome): An article from: Inside MS by Phyllis Shaw, 1989-06-22

lists with details

SearchBug Directory: Health: Conditions_and_Diseases: Neurological_Disorders: Mu
Search the Web Web. Open Directory. Search stiffperson syndrome,
http://www.searchbug.com/directory.aspx/Health/Conditions_and_Diseases/Neurologi

Extractions: Web Pages - ranked by popularity Stiff-Person Syndrome http://www.ninds.nih.gov/health_and_medical/disorders/stiffperson_doc.htm Information sheet compiled by National Institute of Neurological Disorders and Stroke. MCW HealthLink http://healthlink.mcw.edu/article/921988627.html An article about Stiff-person syndrome, a rare progressive neurological disorder. NORD: Stiff Person Syndrome http://www.rarediseases.org/search/rdbdetail_abstract.html?disname=Stiff%20Person%20Syndrome Offers synonyms, a general discussion and further resources.
SearchBug Directory: Health: Conditions_and_Diseases: Neurological_Disorders: Mu
Myotonic Dystrophy (3) Post Polio Syndrome (20) Reflex Sympathetic Dystrophy (35), Refsum s (5) Spinal Muscular Atrophy (11) stiffperson syndrome (3) Tangier (2
http://www.searchbug.com/directory.aspx/Health/Conditions_and_Diseases/Neurologi
Baylor Neurology Case Of The Month
Diagnosis stiffperson syndrome The clinical presentation of this patient is a relatively typical case of stiff-person syndrome.
http://www.bcm.tmc.edu/neurol/challeng/pat40/summary.html

Extractions: Diagnosis: Stiff-person Syndrome Summary and Differential Diagnosis The clinical presentation of this patient is a relatively typical case of stiff-person syndrome . The patient had stiffness and rigidity of muscles, predominantly in the lower limbs, which resulted in slowly progressive impairment of her ability to ambulate. She had frequent superimposed episodes of spasms, precipitated by emotional stress and by sudden movements. Her intellectual functions were normal. She had increased muscle tone and hyperreflexia on examination, consistent with her stated complaints, and occurring in the absence of sensory findings. The electromyographic study showed continuous muscle activity despite relaxation, suggesting excessive activity of otherwise normal motor units. A test for serum antibodies glutamic acid decarboxylase (GAD) was positive, providing additional support for the diagnosis of stiff-person syndrome. Several of the respondents suggested the possibility of a paraneoplastic association for this patient's diagnosis of stiff-person syndrome, which is occasionally reported (e.g., Folli et al., 1993). Although the patient did have a small (
Patient 40 Selftest
Patient 40 stiffperson syndrome. 1. Which of the following is a diagnostic feature of the classical stiff-person syndrome? A. rigidity
http://www.bcm.tmc.edu/neurol/challeng/pat40/selftest.html

Extractions: 3. Which of the following electromyographic findings stongly suggests a diagnosis of stiff-person syndrome? A. increased motor unit activity on exercise B. decreased muscle activity or electromyographic silence C. signficant decrement or repetitive nerve stimulation D. increased spontaneous motor unit activity which cannot be abolished on relaxation
Beth Murinson, MD, PhD
Her clinical and research interests are in neuromuscular diseases with special emphasis on peripheral neuropathies, neuropathic pain and stiffperson syndrome.
http://www.neuro.jhmi.edu/profiles/murinson.html

Extractions: Dr. Beth B. Murinson is an Assistant Professor of Neurology and has been a faculty member in the Department of Neurology since 2002. Her clinical and research interests are in neuromuscular diseases with special emphasis on peripheral neuropathies, neuropathic pain and Stiff-person syndrome. Dr. Murinson has participated in a wide range of research investigations including nerve structure and function, immune-mediated neurological disorders such as Stiff-person syndrome and multi-disciplinary studies of pain originating from nerve injury and dysfunction. She has recently served as a Visiting Lecturer at King's College, University of London. Current research includes the characterization of complex assemblies of small nerve fibers important in the sensation of pain. Major alterations in small fibers following painful nerve injuries have been identified at Hopkins and it is anticipated that these findings will expand treatment strategies for painful peripheral neuropathies. Planned research includes developing methods to rapidly evaluate sensory dysfunction and advancing the understanding of Stiff-person syndrome.
NEJM -- Sign In
HighDose Intravenous Immune Globulin for stiff-person syndrome. report the efficacy of intravenous immune globulin for treating stiff-person syndrome.
http://content.nejm.org/cgi/content/full/346/22/1747

Extractions: SIGN IN User Name Password Forgot your Password? Click here and we'll e-mail it to you. If you do not use cookies, sign in here. Remember my User Name and Password. PURCHASE THIS ARTICLE Purchase a single article and get immediate online access for just $10. If you're a subscriber but have not yet activated your full online access ACTIVATE YOUR SUBSCRIPTION Subscribers to NEJM are entitled to full access to all online content and features, including 20 FREE online CME exams. OR Receive full access to ALL current content and online features including Personal Archives, PDF article downloads, PDA access, E-mail alerts and 20 FREE online CME exams. OR Receive FREE online access to NEJM Original and Special Articles 6 months after publication and choose to receive the Table of Contents and notification of early release articles via e-mail.
NEJM -- High-Dose Intravenous Immune Globulin For Stiff-Person Syndrome
PreviousPrevious, Volume 34617471748, May 30, 2002, Number 22. Next Next. High-Dose Intravenous Immune Globulin for stiff-person syndrome.
http://content.nejm.org/cgi/content/short/346/22/1747

Extractions: Add to Personal Archive ... PubMed Citation To the Editor: Dalakas et al. (Dec. 27 issue) report the efficacy of high-dose intravenous immune globulin for the treatment of stiff-person syndrome. Stiff-person syndrome is a devastating disorder, and evidence of the associated immunologic impairment began to emerge in the 1980s. Over the next decade, it was confirmed that stiff-person syndrome was caused, in particular, by damage by an autoimmune mechanism. Intravenous immune globulin is extraordinarily costly; thus, the current focus of interest among clinicians is not on the efficacy of this approach but, rather, on the timing of the treatment and its long-term outcome, including the Full Text of this Article References
Health Library -
Stiff Person Syndrome. Synonyms Disorder Subdivisions General Discussion Resources The exact cause of stiffperson syndrome is not known.. Resources.
http://www.wellspan.org/library/healthguide/IllnessConditions/topic.asp?hwid=nor
NodeWorks - Muscle Diseases: Stiff-Person Syndrome
thumbnail, 1. MCW HealthLink An article about stiff-person syndrome, a rare progressive neurological disorder. 2. NORD Stiff
http://dir.nodeworks.com/Health/Conditions_and_Diseases/Neurological_Disorders/M

Extractions: in entire NodeWorks Directory in Health in Neurological Disorders in Muscle Diseases in ++ Stiff-Person Syndrome Top Health Neurological Disorders Muscle Diseases Stiff-Person Syndrome A condition characterized by persistent spasms involving multiple muscles, primarily in the lower limbs and trunk. The illness tends to occur in the fourth to sixth decade of life, presenting with intermittent spasms that become continuous. Minor sensory stimuli, such as noise and light touch, precipitate severe spasms. Spasms do not occur during sleep and only rarely involve cranial muscles. MCW HealthLink An article about Stiff-person syndrome, a rare progressive neurological disorder. NORD: Stiff Person Syndrome Offers synonyms, a general discussion and further resources. Stiff-Person Syndrome Information sheet compiled by National Institute of Neurological Disorders and Stroke.
Cleveland Clinic Health System - Health Information
Search Results The following information is available for the topic stiffperson syndrome. Please select one. , stiff-person syndrome. New Search.
http://www.cchs.net/health/getcontents.asp?DocID=do-query&TopicId=1361
The Infography About Stiff-Man Syndrome
Floeter MK, VallsSole J, Toro C, Jacobowitz D, Hallett M. Physiologic studies of spinal inhibitory circuits in patients with stiff-person syndrome.
http://www.infography.com/content/865274012491.html

Extractions: Search The Infography: Lorish TR, Thorsteinsson G, Howard FM Jr. Stiff-man syndrome updated. Mayo Clin Proc. 1989 Jun;64(6):629-36. Review. Solimena M, Folli F, Aparisi R, Pozza G, De Camilli P. Autoantibodies to GABA-ergic neurons and pancreatic beta cells in stiff-man syndrome. N Engl J Med. 1990 May 31;322(22):1555-60. Solimena M, De Camilli P. Autoimmunity to glutamic acid decarboxylase (GAD) in Stiff-Man syndrome and insulin-dependent diabetes mellitus. Trends Neurosci. 1991 Oct;14(10):452-7. Review. Stayer C, Meinck HM. Stiff-man syndrome: an overview. Neurologia. 1998 Feb;13(2):83-8. Review. Folli F, Solimena M, Cofiell R, Austoni M, Tallini G, Fassetta G, Bates D, Cartlidge N, Bottazzo GF, Piccolo G, et al. Autoantibodies to a 128-kd synaptic protein in three women with the stiff-man syndrome and breast cancer. N Engl J Med. 1993 Feb 25;328(8):546-51. Butler MH, Hayashi A, Ohkoshi N, Villmann C, Becker CM, Feng G, De Camilli P, Solimena M. Autoimmunity to gephyrin in Stiff-Man syndrome. Neuron. 2000 May;26(2):307-12.
Entrez PubMed
Rhabdomyolysis/drug therapy; Rhabdomyolysis/immunology*; Spinal Cord/pathology; stiffperson syndrome/complications; stiff-person syndrome
http://www.biomedcentral.com/pubmed/14755734

Extractions: Summary Brief Abstract Citation ASN.1 MEDLINE XML UI List LinkOut Related Articles Cited in Books CancerChrom Links Domain Links 3D Domain Links GEO DataSet Links Gene Links Genome Links GEO Links HomoloGene Links Nucleotide Links OMIM Links PMC Links Cited in PMC PopSet Links Protein Links SNP Links Structure Links UniSTS Links Show: Sort Author Journal Pub Date Text File Clipboard E-mail Order
Paraneoplastic Cerebellar Degeneration
Antibody name, Associations, Reacts with, Neurological symptoms. GAD, Diabetes, stiffperson syndrome, Glutamine dehydrogenase, Various, including cerebellar.
http://www.dizziness-and-balance.com/disorders/central/pcd.htm

Extractions: Last edited: 11/22/2001 by Timothy C. Hain, MD , Chicago IL. Click here to return to index . Please read our Paraneoplastic cerebellar degenerations are disorders of the cerebellum, the part of the brain responsible for coordination, which are associated with tumors (neoplasms). They arise when tumors express proteins that are normally found only in neurons, and it is believed that the immune system, in its attempt to kill the tumor, also damages the cerebellum. Although antibodies occasionally useful for diagnosis, they do not appear to be the cause of the cerebellar damage. Rather, current thought is that "killer T-cells", or cytotoxic CD8+ T lymphocytes, are the most likely mediator of neuronal injury. Treatments to reduce the antibodies are ineffective, and attempts to reproduce disease by transfer of antibodies into animals have been unsuccessful Certain tumors are more common than others. These include cancer of the ovary, uterus or adnexa, cancer of the breast, and especially small cell carcinoma of the lung. The condition frequently begins before the tumor is diagnosed. Examination of patients with anti-Purkinje cell antibodies, especially anti-Yo, is usually dominated by a rapidly progressive unsteadiness, and downbeating nystagmus. Pathological examination often reveals profound loss of Purkinje cells, which are the output cells for the cerebellum. The MRI scan of the brain may be normal. The single most useful clinical test is usually a chest X-ray. In situations where a paraneoplastic syndrome is suspected, but antibodies have not yet been done, a chest-X ray is also generally the most useful clinical test.
Mother Manages Pain, Stiffness
As if that weren t enough, the young mother of two has been diagnosed with a rare nerve disorder called stiffperson syndrome. The
http://www.mult-sclerosis.org/news/Jan2004/WomanwMSandStiffPersonSyndrome.html

Extractions: The Ledger On a good day, Kimber Bias copes with debilitating pain to keep up with her rambunctious toddler, Kaitlyn, and 5year-old Jocelyn. On those bad days when the pain flares out of control, the Lakeland woman can barely get out of bed, leaving her mother or husband to watch the kids. At 28, Bias is learning to manage life with the knowledge that her muscles and some body functions are slowly wasting to one of the milder forms of multiple sclerosis. As if that weren't enough, the young mother of two has been diagnosed with a rare nerve disorder called stiff-person syndrome. The disorder, more common among women, stiffens muscles primarily from the chest down. Bias said she will eventually require a wheelchair, but for now she endures the pain with the help of medications and exercise, so that she can keep up with her girls. "The only good thing about it is I get to be with them," said Bias, who recently quit her job as head receptionist at Lakeland Veterinary Hospital for health reasons.
Neuromuscular Diseases
stiffperson syndrome. About stiff-person syndrome - NINDS (US). Stiffman Syndrome Foundation Geilman family - (US). stiff-person syndrome GF Zeolla.
http://www.mic.ki.se/Diseases/C10.668.html

Extractions: Diseases and Disorders Links pertaining to Neuromuscular Diseases Alert! Patients and laypersons looking for guidance among the target sources of this collection of links are strongly advised to review the information retrieved with their professional health care provider. Start Page Contents: Amyotrophic Lateral Sclerosis Brachial Plexus Neuritis Brachial Plexus Neuritis Brachial Plexus Neuropathies ... Ulnar Nerve Compression Syndromes Neuromuscular Diseases Motor Cortex illustration [Earles et al.] - Furman Univ. (US) EMG and Nerve Conductions Homepage [JF Jabre] The Neuromuscular Disease Information Center - REHABinfo Network/UC-Davis (US) Neuromuscular Diseases - MDA (US) Neuromuscular Disorders [Nadeau and Valenstein] - Univ of Florida (US) About some Neuromuscular Diseases - Wake Forest Univ. Neuromuscular Disorders Information - Musc Dystrophy Group of (UK)+ N. Ireland Neuromuscular Disease Center , and a collection of one-page summaries of Differential Diagnoses of Neuromuscular Syndromes - School of Medicine/Washington Univ., St Louis (US)
HONselect - Neuromuscular Diseases
stiffperson syndrome. Accepted term(s) -Amyotonia Congenita -Oppenheim Disease -Cramp-Fasciculation Syndrome -Fasciculation-Cramp Syndrome, Benign.
http://www.hon.ch/HONselect/Selection/C10.668.html
Wauu.DE: Health: Conditions And Diseases: Neurological Disorders: Muscle Disease
Links URL hinzufügen. MCW HealthLink An article about stiffperson syndrome, a rare progressive neurological disorder. http//healthlink
http://www.wauu.de/Health/Conditions_and_Diseases/Neurological_Disorders/Muscle_

Extractions: © 1998- 2002 Ein Service von Wauu.de UserNet.DE Linktip: MnogoSearch.ORG Map TopTen TopTen eng Aktuelle Linktips Mozilla 1.7 RC 1 Basteln 0190 Warner Free Rund ums Rad ... Fantasy - Shop Webmaster-Links Webspace Free Subdomain Service Merchandise Fun SUMA - Forum ... Abmahnungen ber Wauu Regeln Webmasterservice Impressum b
Stiff-man Syndrome
NLM Medline definition of stiffperson syndrome A condition characterized by persistent spasms (SPASM) involving multiple muscles, primarily in the lower
http://www.ion.ucl.ac.uk/library/patient/stiff.htm

Extractions: Stiff-Man Syndrome NLM Medline definition of stiff-person syndrome: A condition characterized by persistent spasms (SPASM) involving multiple muscles, primarily in the lower limbs and trunk. The illness tends to occur in the fourth to sixth decade of life, presenting with intermittent spasms that become continuous. Minor sensory stimuli, such as noise and light touch, precipitate severe spasms. Spasms do not occur during sleep and only rarely involve cranial muscles. Respiration may become impaired in advance cases. Pubmed Medline search on stiff-man syndrome
February 2, 2002 - Our FM/CFS World
STIFF PERSON SYNDROME *****. What is stiffperson syndrome? Is there any treatment?
http://www.ourfm-cfidsworld.org/html/february_2__2002.html

Extractions: our site WELCOME TO OUR FM/CFS WORLD, INC. NEWSLETTER OUR MISSION Our FM/CFS World Inc. is a non-profit organization maintained by sufferers of Fibromyalgia and Chronic Fatigue Syndrome. Our mission is to improve the quality of life for fellow sufferers, while increasing public, governmental and medical awareness of these diseases, through education. *************************************************************** A CHAT WITH THE EDITOR: We are not permitted to choose the frame of our destiny. But what we put into it is ours." Dag Hammarskjold This quote caught my eye. I hadnt really thought about the picture I was painting in my life. But now that I have given my masterpiece some consideration, I realize that I want it to portray happiness and contentment. I want it to depict the joy I experience sharing things with my family and friends. I want it to show that I am not a quitter. I want it to be vibrant and alive. As you can see, there is no room for Fibromyalgia in my picture. Im sure if you look hard enough, you can see a trace of it someplace, but there are too many other good things in my world to cover up those dark spots. There are too many opportunities to paint in color and to take pride in the things I accomplish.
Www.nlm.nih.gov/cgi/mesh/2K/MB_cgi?term=Stiff-Person+Syndrome
On Target Weekly Journal, Issue January 13, 2002 HISTORY OF MEDICINE The Hospital Ship III. IMMUNOLOGY Stiff Person Syndrome (SPS) IV. III. IMMUNOLOGY back to top. Stiff Person Syndrome (SPS).
http://www.nlm.nih.gov/cgi/mesh/2K/MB_cgi?term=Stiff-Person Syndrome

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