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Short Bowel Syndrome:     more detail

The Official Patient's Sourcebook on Short Bowel Syndrome: A Revised and Updated Directory for the Internet Age by Icon Health Publications, 2002-08 Diarrhea: Defecation, Lactose intolerance, Short bowel syndrome, Hyperthyroidism, Coeliac disease Short bowel syndrome: New therapeutic approaches (Current problems in surgery) by Douglas W Wilmore, 1997 Mrs. Smith: the boarding school enemas (Stories of J. G. Knox) by J. G. Knox, 2008-10-20

lists with details

61. Short Bowel Syndrome
    short bowel syndrome. short bowel syndrome (SBS) occurs whenever the functions of the small bowel have been removed from the body by disease or surgery.  
    http://www.julies-story.org/ibd/sbs.htm
    
    Extractions: The Digestive Tract Short bowel syndrome Short bowel syndrome (SBS) occurs whenever the functions of the small bowel have been removed from the body by disease or surgery. The normal small bowel varies in length between 10 and 28 feet and is divided into three sections. The first section is the duodenum and is located just after the stomach. The duodenum is relatively short, measuring only about 10-12 inches. The next section is the jejunum, which is the largest but not the longest section. The jejunum comprises only 2/5 of the rest of the small intestine but is the largest section because its many folds give it an increased diameter. The final 3/5 of the small bowel is the ileum. The level of difficulty experienced by a patient with SBS is often determined by which sections are affected. One half of the small bowel can be removed without significant disability resulting, especially if the ileum is not involved. However, the more intestine removed, the greater the disability a patient will experience. The entire jejunum can be removed without much disability except for lactose intolerance. The ileum can compensate for all the losses of the jejunum except the lactose deficiency. Removal of the ileum accounts for most of the problems seen in short bowel syndrome since it is responsible for the absorption of fats, bile salts, and B12.

62. Re: Short Bowel Syndrome/
    Subject Re short bowel syndrome/ Forum The Gastroenterology and Liver Diseases Forum Topic Area Malabsorption Posted by HFHSM.D.ym on October 25, 1998 at  
    http://www.medhelp.org/forums/gastro/archive/4321.html
    
    Extractions: : I experienced a traumatic loss of all but 19" of small intestine s/p colectomy for a dysfunctional colon (very complicated medical/surgical hx, born with exstrophy of bladder). I have been on TPN now for 20 months. I have asked what criteria is used to decrease TPN and theres been little discussion about this. I currently cycle TPN 12h/d. Weight stable 118lbs. @ 5"3'.

63. Short Bowel Syndrome/
    Subject short bowel syndrome/ Topic Area Malabsorption Forum The Gastroenterology and Liver Diseases Forum Question Posted By Eydie on Sunday, October 25  
    http://www.medhelp.org/perl6/gastro/archive/4324.html
    
    Extractions: : I experienced a traumatic loss of all but 19" of small intestine s/p colectomy for a dysfunctional colon (very complicated medical/surgical hx, born with exstrophy of bladder). I have been on TPN now for 20 months. I have asked what criteria is used to decrease TPN and theres been little discussion about this. I currently cycle TPN 12h/d. Weight stable 118lbs. @ 5"3'.

64. Short Bowel Syndrome (SBS)
    short bowel syndrome (SBS). The considered. short bowel syndrome Clinic at Mott Children’s Hospital. University of Michigan. Team Members.  
    http://pediatric.um-surgery.org/new_070198/new/Library/Short Bowel Syndrome.htm
    
    Extractions: Short Bowel Syndrome (SBS) The short bowel syndrome occurs from massive small intestinal resection leaving less than 200 cm (6.5 feet) of small bowel. In children, however, a length which is less than 30% of the normal length for age is the generally accepted definition of SBS. Etiologies range from a loss due to congenital anomalies, loss from necrotizing enterocolitis , resections due to strangulation of the intestine (volvulus) or from extensive resections for inflammatory bowel disease . Approximately 10 to 20,000 patients are cared for each year with SBS in the United States. Severity of the loss of intestine has generally been associated with a loss of excess bowel length or loss of the ileocecal valve. Over the past decade, it has been better appreciated that the severity of SBS is most correlated with the absolute function of the intestine. Many individuals with 40 cm of small bowel may eventually adapt and transition off TPN. More important is the need for normal motility of the stomach and small intestine, as well as the overall injury that the remaining intestine incurred. Figure above shows the various etiologies, and approximate frequencies, of SBS in infants and children.

65. Zorbtive (Somatropin), Treatment Of Short Bowel Syndrome, Launched
    Zorbtive (Somatropin), Treatment of short bowel syndrome, Launched in US Use of Recombinant Human Growth Hormone Reduces Patient Dependence on Parenteral  
    http://www.pslgroup.com/dg/244012.htm

66. Short Bowel Syndrome
    short bowel syndrome A brief look at this syndrome and what it is, the symptoms, reasons and treatment. short bowel syndrome Site  
    http://www.thenewhealthfind.com/Health/ConditionsandDiseases/DigestiveDisorders/

67. Short Bowel Syndrome - Digestive Disease Terms And Definitions By Health Diction
    Definition for short bowel syndrome and other Digestive Disease Terms by Health Dictionary. Hospital Directory. Doc Loan s Advice. short bowel syndrome  
    http://www.health-dictionary.com/digestive-term-details/Short-Bowel-Syndrome
    
    Extractions: Information and definitions of the medical conditions and diseases have been taken from various reliable government publications and we have done our best to verify their accuracy. If you feel any of the definitions are incorrect or needs to be updated please contact us and we will look into it. Contact Health Dictionary - Medical and Disease Terms and Definitions

68. SHORT BOWEL SYNDROME
    short bowel syndrome. Specialty Definition short bowel syndrome. Domain, Definition. Health. Top. Commercial Usage short bowel syndrome. Domain, Title. References.  
    http://www.websters-online-dictionary.org/definition/english/Sh/Short_Bowel_Synd
    
    Extractions: Philip M. Parker, INSEAD. SHORT BOWEL SYNDROME Specialty Definition: SHORT BOWEL SYNDROME Domain Definition A malabsorption syndrome resulting from extensive operative resection of small bowel. ( references Source: compiled by the editor from various references ; see credits. Top Commercial Usage: SHORT BOWEL SYNDROME Domain Title Source: compiled by the editor from various references ; see credits. Top Non-Fiction Usage: SHORT BOWEL SYNDROME Subject Topic Quote Diarrhea is the main symptom of short bowel syndrome references Short bowel syndrome is a group of problems affecting people who have had half or more of their small intestine removed. ( references Many people with short bowel syndrome are malnourished because their remaining small intestine is unable to absorb enough water, vitamins, and other nutrients from food. They may also become dehydrated, which can be life threatening. ( references Source: compiled by the editor from ICON Group International, Inc.

69. Short Bowel Syndrome
    short bowel syndrome. These symptoms make up what is called the short bowel syndrome. What are the signs and symptoms of the condition?  
    http://atoz.iqhealth.com/HealthAnswers/encyclopedia/HTMLfiles/2414.html
    
    Extractions: Removal of part of the small bowel decreases the area to absorb these nutrients. Many people can tolerate removal of up to 50% to 60% of the small bowel without having problems. However, when more than this amount or a key part of small bowel is removed, symptoms often occur. These symptoms make up what is called the short bowel syndrome.

70. Healthology Hormonal Therapy For Short Bowel Syndrome
    http://www.advancesinoncology.com/autodetect/autodetect.asp?f=gi&c=gi_shortbowel

71. ScienceDaily -- Browse Topics: Health/Conditions_and_Diseases/Digestive_Disorder
    Click Here. Top Health Conditions and Diseases Digestive Disorders Intestinal short bowel syndrome (24 links). News about short bowel syndrome  
    http://www.sciencedaily.com/directory/Health/Conditions_and_Diseases/Digestive_D
    
    Extractions: Front Page Today's Digest Week in Review Email Updates ... Intestinal Short Bowel Syndrome (24 links) News about Short Bowel Syndrome New Cardiac Arrhythmia Syndrome Identified (June 1, 2004) full story Silence Of The Genes: Researchers Provide Unique View Of Inherited Disorders And Cancer (June 1, 2004) full story Viruses Clear Bacterial Contamination In Chickens (May 28, 2004) full story Shortened Chromosomes Linked To Early Stages Of Cancer Development (May 28, 2004) full story UW-Madison Scientists Find A Key To Cell Division (May 28, 2004) full story [ More news about Short Bowel Syndrome

72. Short Bowel Syndrome - Allnurses.com - Nursing Discussion Board For Nurses
    Age 45. Posts 5,536. short bowel syndrome. We have a young patient who has infarcted most of his bowel there is about 3 ft left.  
    http://allnurses.com/forums/showthread.php?t=57377

73. Short Bowel Syndrome At Bowel Cleanse Forum # 4 [Archive]
    Bowel Cleanse Page Image Gallery Rules Disclaimer.short bowel syndrome Bowel Cleanse Forum 4 Archive FAQ A  
    http://www.curezone.com/forums/m.asp?f=153&i=1052

74. Re: Short Bowel Syndrome At Bowel Cleanse Forum # 4 [Archive]
    Bowel Cleanse Page Image Gallery Rules Disclaimer.Re short bowel syndrome Bowel Cleanse Forum 4 Archive FAQ A  
    http://www.curezone.com/forums/m.asp?f=153&i=1094

75. Ingenta: Article Summary -- Short Bowel Syndrome And Crohn's Disease
    short bowel syndrome and crohn s disease Journal of Gastrointestinal Surgery 1 December 2003, vol. 7, no. 8, pp. 10691072(4) Thompson  
    http://www.ingenta.com/isis/searching/ExpandTOC/ingenta?issue=pubinfobike://els/

76. FDA Advisory Committee
    Serono Serostim Additional Studies For short bowel syndrome Indication Needed, Cmte. Says There are about 10,000 patients in the US with short bowel syndrome.  
    http://www.fdaadvisorycommittee.com/FDC/AdvisoryCommittee/Committees/Gastrointes
    
    Extractions: Serono Serostim requires more study prior to approval for short bowel syndrome, FDA’s Gastrointestinal Drugs Advisory Committee said June 25. "Efficacy has not been shown in a generalizable fashion," Committee Chair Michael Wolfe, MD, Boston University, said. The committee voted six to three that the study submitted by Serono was not sufficient to demonstrate the efficacy of the growth hormone product for short bowel syndrome patients. One of the main concerns of the committee, and FDA, was that in the 41-patient study conducted by Serono, 38 patients were enrolled from one center. The committee voted seven to two that the results were not generalizable to other patients with the condition. The committee did find that the study results, however, were "clinically meaningful" in a six-to-three vote, responding to a question that FDA had posed about study results and primary endpoint.

77. FDA Advisory Committee
    Serono Serostim For short bowel syndrome To Receive Review At June 25 Meeting Serono’s Serostim NDA (21597) (somatotropin) for  
    http://www.fdaadvisorycommittee.com/FDC/AdvisoryCommittee/Committees/Gastrointes
    
    Extractions: Serono’s Serostim NDA (21-597) (somatotropin) for the treatment of short bowel syndrome in patients receiving specialized nutritional support will be reviewed by FDA’s Gastrointestinal Drugs Advisory Committee at its June 25 meeting. Serono reported in July 2002 that a Phase III study demonstrated that Serostim in combination with glutamine reduced the requirements for intravenous parenteral nutrition in patients with short bowel syndrome. Short bowel syndrome is a condition which follows extensive surgical removal of the small intestine as a treatment for various conditions, including severe inflammatory bowel disease, trauma or blockage of a blood vessel supplying the bowel. The committee will meet on June 26 to review Axcan's Photofrin (porfimer sodium) for treatment of dysplasia in Barrett's esophagus.

78. Novel Approaches To Curing Short Bowel Syndrome, Cincinnati Children's Hospital
    Faculty Profiles. Novel Approaches to Curing short bowel syndrome. Faculty Profile Brad Warner and Christopher Erwin, Pediatric Surgery.  
    http://www.cincinnatichildrens.org/research/about/ann-report/profile2003/surgery
    
    Extractions: Home Contact Us Site Map Go to Advanced Search ... Research Horizons What causes intestinal tissue to grow back after part of the bowel has been removed? And how can scientists use that knowledge to give newborns hope for a normal life? Those are the questions being studied by Brad Warner, MD , and his colleague Christopher Erwin, PhD , in the Cincinnati Children's Division of Pediatric General and Thoracic Surgery . Their research focuses on short bowel syndrome, most often the result of a large portion of the intestine being removed to treat necrotizing enterocolitis in preterm infants. The remnant bowel tries to grow back in length and girth to compensate for the missing portion a process known as the intestinal adaptation response. If the intestine grows back fully, the child can tolerate oral feedings completely. However, if the response is incomplete, the child will need nutrition by vein, which eventually can result in chronic liver failure. Since 1994, Drs. Warner and Erwin have researched how various growth factors, particularly epidermal growth factor (EGF), can enhance the intestinal adaptation response. They have established that the EGF receptor in the intestine is critical, through studies in mice that both inhibited and increased the amount of EGF, thus correspondingly suppressing or amplifying the adaptation response. Their laboratory also pioneered small bowel resection procedures in mice.

79. Short Bowel Syndrome - NPS Pharmaceuticals, Inc.
    SBS Overview short bowel syndrome (SBS). When a significant length of the intestinal tract is removed, short bowel syndrome is the result.  
    http://www.shortbowel.com/information/short.bowel.syndrome.asp
    
    Extractions: Short Bowel Syndrome (SBS) When a significant length of the intestinal tract is removed, short bowel syndrome is the result. SBS is characterized by inefficient absorption of nutrients and fluids. The severity of the condition is determined by the amount of bowel removed and the type and length of the remaining bowel, as well as the condition of the remaining bowel and digestive organs, and the presence or absence of the ileocecal valve. The ileum is better able to take over the functions of the jejunum than when the situation is reversed. This is because the important digestive function of absorption of fats, bile salts, and vitamin B12 takes place in the ileum. After bowel surgery, a process called intestinal adaptation occurs in which the remaining bowel improves its ability to absorb nutrients by an increase in its surface area and in the absorptive capacity of individual cells in the intestine and colon. This process begins immediately after intestinal surgery and continues for up to two years. This information is provided as a general educational service

80. BioSpace News: Irritable Bowel Syndrome/Colitis
    (See Story from WebMD) (4/29/04); NPS Pharmaceuticals (NPSP) Begins Pivotal Study With Teduglutide In Patients With short bowel syndrome  
    http://www.biospace.com/news_rxtarget.cfm?RxTargetID=225

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