Olivopontocerebellar Atrophy - General Practice Notebook olivopontocerebellar atrophy. Olivopontine cerebellar degeneration may occur sporadically or as an autosomal dominant trait. It is http://www.gpnotebook.co.uk/cache/-113967058.htm
Extractions: olivopontocerebellar atrophy Olivopontine cerebellar degeneration may occur sporadically or as an autosomal dominant trait. It is characterised by a general atrophy of the cerebellum spreading in time to involve the pons, medullary olives and other brain stem structures. It can occur at any age but onset in middle life is most common. Presentation is initially with ataxia, dysarthria, and tremor. Parkinsonian features may develop, accompanied by mild dementia, ophthalmoplegia, pyramidal tract signs and autonomic disturbance. Survival ranges from 23 - 30 years from onset.
► Olivopontocerebellar Atrophy Spanish olivopontocerebellar atrophy. earlier. The cause of sporadic olivopontocerebellar atrophy is not known, but the disease is progressive. http://www.umm.edu/ency/article/000758.htm
Extractions: Causes, incidence, and risk factors: This condition can be inherited but it most commonly affects people without a known family history (sporadic form). Sporadic cases tend to affect people in their 50s while familial cases usually start earlier. The cause of sporadic olivopontocerebellar atrophy is not known, but the disease is progressive.
Olivopontocerebellar Atrophy olivopontocerebellar atrophy Medline NLM Definition for Olivopontocerebellar Atrophies A group of inherited and sporadic disorders http://www.ion.ucl.ac.uk/library/patient/olivo.htm
Extractions: Olivopontocerebellar Atrophy Medline NLM Definition for Olivopontocerebellar Atrophies: A group of inherited and sporadic disorders which share progressive ataxia in combination with atrophy of the CEREBELLUM; PONS; and inferior olivary nuclei. Additional clinical features may include MUSCLE RIGIDITY; NYSTAGMUS; RETINAL DEGENERATION; MUSCLE SPASTICITY; DEMENTIA; URINARY INCONTINENCE; and OPHTHALMOPLEGIA. The familial form has an earlier onset (second decade) and may feature spinal cord atrophy. The sporadic form tends to present in the fifth or sixth decade, and is considered a clinical subtype of MULTIPLE SYSTEM ATROPHY. PubMed Medline search on Olivopontocerebellar Atrophies
National Parkinson Foundation, Inc. olivopontocerebellar atrophy adapted from EMedicine April 15, 2002 by Dr Abe Lieberman Author Joseph Quinn, MD, Assistant Professor, Department of Neurology http://www.parkinson.org/newsolivo.htm
Extractions: and the olives Background: In 1900, Dejerine and Thomas first introduced the term olivopontocerebellar atrophy (OPCA). Since then, the classification of idiopathic acquired ataxias has evolved a great deal. The initial cases of Dejerine and Thomas involved 2 middle-aged patients with chronic progressive cerebellar degeneration and autopsy findings of gross atrophy of the pons, cerebellum, middle cerebellar peduncle, and inferior olives. OPCA has not been proven to be a single entity. The nosology of these disorders has been extremely confusing, as the OPCAs overlap with spinocerebellar atrophies (SCAs) and multiple system atrophies (MSAs). Clinical distinction of these entities is based on the dominant feature, which may be cerebellar ataxia (observed in OPCA, SCA, and MSA), parkinsonism (observed in MSA), or autonomic failure (observed in MSA). The term OPCA has been retained to describe a form of progressive ataxia distinguished by pontine flattening and cerebellar atrophy on brain imaging studies and at autopsy. Thus defined, OPCA also may qualify as an SCA or as an MSA. While MSAs are sporadic by definition, the genetic bases of the SCAs are increasingly well defined. Since OPCA may exist as a sporadic or inherited disease, categorizing sporadic OPCA as MSA and inherited OPCA as SCA may be appropriate. Differences between sporadic and inherited OPCA in microscopic pathology support this division. When faced with an adult having progressive ataxia suggestive of OPCA, the role of the clinician includes (1) excluding readily treatable alternative diagnoses, (2) discussing the value of genetic testing with patients in whom such testing is informative, (3) managing symptoms, and (4) advising the patient and family regarding natural history and the need to plan for the future. No definitive therapy for OPCA exists.
N.P.F. / The Parkinson Report When MSA begins with imbalance, incoordination, and difficulties in speaking (dysarthria), it is often called olivopontocerebellar atrophy; as the name suggests http://www.parkinson.org/atrophy.htm
Extractions: VOLUME XIX - ISSUE 2 / Spring 1998 By members of the National Parkinson Foundation Center of Excellence at Vanderbilt University, including David A. Robertson, Director, Nathan S. Blaser Shy-Drager Research Laboratories; Thomas L. Davis, Director, Movement Disorder Clinic; and Ariel Y. Deutch, Director, NPF Center of Excellence A lthough the cause of idiopathic Parkinsons disease is unknown, Parkinsons disease is probably the best characterized of the neurodegenerative disorders. The loss of dopamine in the striatum is the major contributor to the disorder. However, there are several other neurodegenerative disorders involving several different systems in the brain, in which striatal dopamine loss is also found. Among these other neurodegenerative disorders is multiple system atrophy (MSA), in which degeneration in diverse brain regions leads to problems in the control of movement, balance, blood pressure, and sexual and urinary tract function. MSA is often accompanied by some striatal dopamine loss and in certain patients typical parkinsonian symptoms are either the first noted or the most prominent. A number of areas of the brain are involved by MSA. This has led to different varieties of MSA receiving different names, depending on which area of the brain has predominant involvement. When MSA begins with imbalance, incoordination, and difficulties in speaking (dysarthria), it is often called olivopontocerebellar atrophy; as the name suggests, this form of MSA is marked by degeneration in the cerebellum, a structure involved in balance and learned motor tasks. When a patient initially has rigidity (stiffness) and slowness in initiating movements (bradykinesia) that is out of proportion to tremor, this MSA form has been called striatonigral degeneration, involving communication between nerve cells in the striatum and midbrain. In patients in whom changes in autonomic function dominates the initial presentation, particularly changes in blood pressure regulation, the MSA form is often called Shy-Drager syndrome.
Extractions: Related links of interest: Olivopontocerebellar atrophy (OPCA) refers to a group of ataxias characterized by progressive neurological degeneration affecting the cerebellum, the pons and the inferior olives. Help build the largest human-edited directory on the web. Submit a Site Open Directory Project Become an Editor The combose.com directory is based on the Open Directory and has been modified and enhanced using our own technology. About ComboSE Download Combose Toolbar
Extractions: Back Back to main Health Information page Central nervous system Definition: Olivopontocerebellar atrophy is a neurodegenerative illness that causes certain brain areas (which may include the olivary nucleus, the pons, and the cerebellum) to shrink. Alternative Names: OPCA; Olivopontocerebellar degeneration Causes And Risk: This condition can be inherited but it most commonly affects people without a known family history (sporadic form). Sporadic cases tend to affect people in their 50s while familial cases usually start earlier. The cause of sporadic olivopontocerebellar atrophy is not known, but the disease is progressive. Symptoms: Many symptoms are associated with olivopontocerebellar atrophy but the predominant feature is progressive ataxia (clumsiness) and difficulties with balance. There may be slurring of speech and difficulty walking. Other symptoms may include: Signs And Tests: A thorough medical and neurological examination as well as a good history of symptoms and family history are necessary to make the diagnosis. There are no specific tests for this condition.
:: Ez2Find :: Olivopontocerebellar Atrophy Guide olivopontocerebellar atrophy, Global Metasearch Any Language Guides, olivopontocerebellar atrophy. ez2Find Home Directory Health http://ez2find.com/cgi-bin/directory/meta/search.pl/Health/Conditions_and_Diseas
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Neurological Disorders: Brain Diseases: Olivopontocerebellar Atrophy Neurological Disorders Brain Diseases olivopontocerebellar atrophy. NINDS olivopontocerebellar atrophy. A site devoted to olivopontocerebellar atrophy. http://www.puredirectory.com/Health/Conditions-and-Diseases/Neurological-Disorde
Olivopontocerebellar Atrophy - A Medical Reference Article olivopontocerebellar atrophy. A Center. A resource with information on over 10,000 medical topics including olivopontocerebellar atrophy. http://www.marylandinternalmedicine.com/dwp/005225.htm
Header Title. Cerebellar and brainstem hypometabolism in olivopontocerebellar atrophy detected with positron emission tomography. Source. Annals of Neurology. http://pet.radiology.uiowa.edu/webpage/Reference/Pub/files/cerebellar.htm
Extractions: Authors Gilman S. Markel DS. Koeppe RA. Junck L. Kluin KJ. Gebarski SS. Hichwa RD. Institution Department of Neurology, University of Michigan, Ann Arbor 48109-0316. Title Cerebellar and brainstem hypometabolism in olivopontocerebellar atrophy detected with positron emission tomography. Source Annals of Neurology. 23(3):223-30, 1988 Mar. Abstract Back Topics Overview Patient Info Facilities Personnel ... Home
Multiple System Atrophy SND) when Parkinsonism predominates, olivopontocerebellar atrophy (OPCA) when cerebellar signs predominate, and ShyDrager syndrome when autonomic failure is http://www.neuro.nwu.edu/meded/MOVEMENT/msa.html
Extractions: Multiple system atrophy is a rare neurological disorder characterized by a combination of parkinsonism, cerebellar and pyramidal signs, and autonomic dysfunction. The term "Multiple System Atrophy" is synonymous with striatonigral degeneration (SND) when Parkinsonism predominates, olivopontocerebellar atrophy (OPCA) when cerebellar signs predominate, and Shy-Drager syndrome when autonomic failure is dominant. The incidence (new case per 100,000 person years) for ages 50 to 99 years is 3.0 (Bower et al, 1997), or about half as frequent as progressive supranuclear palsy (PSP) . The mean age of onset is 54. The Parkinsonism of MSA is generally an akinetic rigid syndrome, similar to that of PSP . Rest tremor may occur but is not a predominant feature. Postural instability is common. Parkinsonism is generally the most common initial sign and eventually develops in about 90% of all patients. The cerebellar signs inlude finger-to-nose or heel-shin dysmetria, gait ataxia, intention tremor and nystagmus. Cerebellar signs are the first feature on only about 5% of patients. Cerebellar signs are observed in 50% of cases (Ben-Shlomo et al, 1997). Sporadic OPCA evolves into MSA in roughly 25% of cases within 5 years.
Re Olivopontocerebellar Atrophy Re olivopontocerebellar atrophy. This Email Address pbower@inforamp.net What is Sporadic olivopontocerebellar atrophy? Olivopontocerebellar http://neuro-www.mgh.harvard.edu/forum/CerebellarAtaxiaF/Re.Olivopontocerebellar
PD Or Olivopontocerebellar Atrophy? No messages are screened for content. PD or olivopontocerebellar atrophy? Email Address cholmes@mfx.net does olivopontocerebellar atrophy respond to Sinemet? http://neuro-www.mgh.harvard.edu/forum_2/ParkinsonsDiseaseF/7.8.999.23PMPDorOliv
Extractions: This Web Forum is not moderated in any sense. Anyone on the Internet can post articles or reply to previously posted articles, and they may do so anonymously. Therefore, the opinions and statements made in all articles and replies do not represent the official opinions of MGH and MGH Neurology. Neither is MGH or MGH Neurology responsible for the content of any articles or replies. No messages are screened for content. This article submitted by Chris on 7/8/99. does olivopontocerebellar atrophy respond to Sinemet? I have been diagnosed w/PD. I have ataxia of trunk and limbs, dysthria, and intention tremor (more than resting tremor.) What is the difference between PD and olivopontocerebellar atrophy? Also, can the latter be associated with HTLV-II? Next Article
Extractions: There is no specific treatment for OPCA. Physicians may try different medications to treat the ataxia, tremor and rigidity that are associated with the disorder. Other treatments are directed at specific symptoms. Stiffness, spasms, sleep disorders, depression, and tremor may be improved with medication. A physical therapist may be helpful in establishing a routine of exercise and stretching, and in obtaining devices or appliances to assist in walking and other daily activities. What is the prognosis?
Idiopathic Olivopontocerebellar Atrophy : On Medical Dictionary Online Idiopathic olivopontocerebellar atrophy defined on the Free Online Medical Dictionary. Medical Idiopathic olivopontocerebellar atrophy. A http://www.online-medical-dictionary.org/?q=Idiopathic Olivopontocerebellar Atro
Ol : On Medical Dictionary Online Idiopathic Olivopontocerebellar Atrophies, Inherited Olivopontocerebellar Atrophies, Nonfamilial olivopontocerebellar atrophy olivopontocerebellar atrophy http://www.online-medical-dictionary.org/?q=~Ol
Dictionary Definition Of OLIVOPONTOCEREBELLAR ATROPHY Conditions and Diseases Neurological Disorders Brain Diseases Conditions and Diseases Neurological Disorders Brain Diseases olivopontocerebellar atrophy. Health and Home. olivopontocerebellar atrophy. http://www.dictionarybarn.com/OLIVOPONTOCEREBELLAR-ATROPHY.php
