Medical Encyclopedia: Olivopontocerebellar Atrophy (Print Version) Medical Encyclopedia olivopontocerebellar atrophy. The cause of sporadic olivopontocerebellar atrophy is not known, but the disease is progressive. Symptoms. http://www.nlm.nih.gov/medlineplus/print/ency/article/000758.htm
Extractions: To close this window, click on the "x" in the upper right hand corner of the window. URL of this page: http://www.nlm.nih.gov/medlineplus/ency/article/000758.htm Alternative names OPCA; Olivopontocerebellar degeneration Definition Olivopontocerebellar atrophy is a neurodegenerative illness that causes certain brain areas (which may include the olivary nucleus, the pons, and the cerebellum) to shrink. Causes, incidence, and risk factors This condition can be inherited but it most commonly affects people without a known family history (sporadic form). Sporadic cases tend to affect people in their 50s while familial cases usually start earlier. The cause of sporadic olivopontocerebellar atrophy is not known, but the disease is progressive. Symptoms Many symptoms are associated with olivopontocerebellar atrophy but the predominant feature is progressive ataxia (clumsiness) and difficulties with balance. There may be slurring of speech and difficulty walking. Other symptoms may include: Signs and tests A thorough medical and neurological examination as well as a good history of symptoms and family history are necessary to make the diagnosis. There are no specific tests for this condition.
Olivopontocerebellar Atrophy (OPCA) A description of olivopontocerebellar atrophy (OPCA) including symptoms, treatment and research. What is. olivopontocerebellar atrophy (OPCA)? http://shy-drager-syndrome.org/olivopontocerebellar-atrophy.html
Extractions: What is Olivopontocerebellar Atrophy (OPCA)? Olivopontocerebellar atrophy (OPCA) refers to a group of ataxias characterized by progressive neurological degeneration affecting the cerebellum, the pons and the inferior olives. OPCA may be classified based on clinical, genetic, or neuropathological findings; thus, there are many classifications of the disorder. Among the different classifications there is wide variation in severity and age of onset. What are the symptoms? The symptoms of OPCA differ from person to person. Most patients experience difficulty with balance and coordination of the legs and arms (ataxia) and slurred speech (dysarthria). Other symptoms may include muscle spasms or weakness and stiffness of the muscles; numbness or tingling of the hands or feet; tremor (shaking) of the hand or arm; reduction or slowness of movements; loss of thinking and/or memory skills; difficulty controlling the bladder or bowels; and feeling faint when standing up. Some patients also have fatigue and/or trouble with sleep. Generally symptoms of OPCA begin in mid-adult life and progress slowly over the course of many years. Is there any treatment?
Olivopontocerebellar Atrophy, Hereditary Hereditary olivopontocerebellar atrophy (OPCA) is a rare group of disorders characterized by progressive balance problems (disequilibrium), progressive http://www.bchealthguide.org/kbase/nord/nord495.htm
Extractions: It is possible that the main title of the report is not the name you expected. Please check the synonyms listing to find the alternate name(s) and disorder subdivision(s) covered by this report. Information on the following diseases can be found in the Related Disorders section of this report: Hereditary olivopontocerebellar atrophy (OPCA) is a rare group of disorders characterized by progressive balance problems (disequilibrium), progressive impairment of the ability to coordinate voluntary movements (cerebellar ataxia), and difficulty speaking or slurred speech (dysarthria). There are at least five distinct forms of hereditary OPCA. All forms of hereditary OPCA, except one, are inherited as autosomal dominant traits.
Extractions: Bardet-Biedl Syndrome ... Brain Diseases : Olivopontocerebellar Atrophy Conditions and Diseases - Olivopontocerebellar Atrophy Top Links - Olivopontocerebellar Atrophy Web Site Links. Opca Awareness - A site devoted to Olivopontocerebellar Atrophy. It has links, personal Corticobasal Ganglionic Degeneration (CBGD) - Article by Timothy C. Hain, MD from Northwestern University Medical School. eMedicine - Olivopontocerebellar Atrophy : Article Excerpt by ... - Olivopontocerebellar Atrophy - In 1900, Dejerine and Thomas first introduced the term olivopontocerebellar atrophy (OPCA). Since Geometry.Net - Health_Conditions: Olivopontocerebellar Atrophy - Olivopontocerebellar Atrophy: more detail. MEDLINEplus Medical Encyclopedia: Olivopontocerebellar Atrophy olivopontocerebellar atrophy. Geometry.Net - Health_Conditions: Olivopontocerebellar Atrophy Health Conditions and Diseases Neurological Disorders Brain ... - Top Web Sites: NINDS: Olivopontocerebellar Atrophy - Information sheet compiled by National Institute of Neurological Disorders and Stroke. Health Library - Olivopontocerebellar Atrophy, Hereditary
Olivopontocerebellar Atrophy Other characters, olivopontocerebellar atrophy,. Print this article, see olivopontocerebellar degeneration. FS. The Encyclopaedia of Medical Imaging Volume VI1. http://www.amershamhealth.com/medcyclopaedia/Volume VI 1/OLIVOPONTOCEREBELLAR AT
Health Library - olivopontocerebellar atrophy, Hereditary. Synonyms Disorder Subdivisions General Discussion Resources National Organization for Rare Disorders. http://yalenewhavenhealth.org/library/healthguide/IllnessConditions/topic.asp?hw
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Olivopontocerebellar Atrophy Overview. What Is olivopontocerebellar atrophy? nausea olivopontocerebellar atrophy. olivopontocerebellar atrophy bleeding. diarrhea olivopontocerebellar atrophy. http://www.icongrouponline.com/health/Olivopontocerebellar_Atrophy.html
Extractions: (Atrophy Olivopontocerebellar; Multiple systems atrophy; Olivopontocerebellar degeneration; Spinocerebellar Ataxia Type IV; Spinocerebellar Ataxia Type V; Spinocerebellar Ataxia Type VI; Spinocerebellar Ataxia Type VII; Spinocerebellar Atrophy Type I) Revised and Updated for the Internet Age P A P E R B A C K Paperback Book Paperback Book Order by phone: 800-843-2665 (within USA) 1-201-272-3651 (from outside USA) Paperback Book Shipped in 3 to 5 business days E B O O K Electronic File * E-Book version sent via e-mail in 2 business days Electronic File *E-Book version sent via e-mail in 2 business days Pages Price $28.95(USD) ISBN Published Synopsis A comprehensive manual for anyone interested in self-directed research on Olivopontocerebellar Atrophy. Fully referenced with ample Internet listings and glossary. Related Conditions/Synonyms Atrophy Olivopontocerebellar; Multiple systems atrophy; Olivopontocerebellar degeneration; Spinocerebellar Ataxia Type IV; Spinocerebellar Ataxia Type V; Spinocerebellar Ataxia Type VI; Spinocerebellar Ataxia Type VII; Spinocerebellar Atrophy Type I Description Table of Contents Introduction Overview Organization Scope Moving Forward PART I: THE ESSENTIALS Chapter 1. The Essentials on Olivopontocerebellar Atrophy: Guidelines
Re: Olivopontocerebellar Atrophy Subject Re olivopontocerebellar atrophy Forum The Neurology and Neurosurgery Forum Topic Area Ataxia Posted by CCF Neurology MDNT on January 11, 1999 at 20 http://www.medhelp.org/forums/neuro/archive/15044.html
Extractions: : Hello: : Can you tell me what diagnostic test currently are used to diagnose and confirm OPCA? : Thank you very much!! Dear Dave: Cerebellar degenerations (also called spinocerebellar degenerations) can either be sporadic or heredofamilial. Heredofamilial cerebellar degenerations can be either autosomal dominant (various types termed spinocerebellar ataxia = SCA 1 - 7, DRPLA, Machado-Joseph disease, etc) or autosomal recessive (Friedreich's ataxia, and some other rare types). The syndrome of progressive ataxia (imbalance of gait, incoordination of hands, slurred speech), in association with some other characteristic abnormalities (peripheral neuropathy, optic atrophy, retinitis pigmentosa, dementia, corticospinal dysfunction, oculomotor dysfunction, etc) is seen with heredofamilial forms. Ataxia is associated with autonomic dysfunction and/or parkinsonian features in sporadic cases. Either sporadic or autosomal dominant forms of cerebellar degeneration can be associated with atrophy of the cerebellum, pons and inferior olives, either on MRI, or at autopsy. Hence, OPCA (olivopontocerebellar atrophy) is used as a descriptive term for these disorders.
Olivopontocerebellar Atrophy Subject olivopontocerebellar atrophy Topic Area Neurology General Forum The Neurology and Neurosurgery Forum Question Posted By Sandy Clarke on Monday http://www.medhelp.org/perl6/neuro/archive/15346.html
Extractions: : : Hello: : : Can you tell me what diagnostic test currently are used to diagnose and confirm OPCA? : : Thank you very much!! : Dear Dave: : Cerebellar degenerations (also called spinocerebellar degenerations) can either be sporadic or heredofamilial. Heredofamilial cerebellar degenerations can be either autosomal dominant (various types termed spinocerebellar ataxia = SCA 1 - 7, DRPLA, Machado-Joseph disease, etc) or autosomal recessive (Friedreich's ataxia, and some other rare types). : The syndrome of progressive ataxia (imbalance of gait, incoordination of hands, slurred speech), in association with some other characteristic abnormalities (peripheral neuropathy, optic atrophy, retinitis pigmentosa, dementia, corticospinal dysfunction, oculomotor dysfunction, etc) is seen with heredofamilial forms. Ataxia is associated with autonomic dysfunction and/or parkinsonian features in sporadic cases. Either sporadic or autosomal dominant forms of cerebellar degeneration can be associated with atrophy of the cerebellum, pons and inferior olives, either on MRI, or at autopsy. Hence, OPCA (olivopontocerebellar atrophy) is used as a descriptive term for these disorders.
Neurological Disorders, Brain Diseases, Olivopontocerebellar Atrophy More olivopontocerebellar atrophy Categories » Submit Your Site to the olivopontocerebellar atrophy category. Sponsored olivopontocerebellar atrophy Sites. http://www.iseekhealth.com/olivopontocerebellar_atrophy-1961.php
Extractions: MCW Health Link - An article about olivopontocerebellar atrophy, which involves progressive loss of certain brain structures: the cerebellum, the pons, and the inferior olives. NINDS: Olivopontocerebellar Atrophy - Information sheet compiled by National Institute of Neurological Disorders and Stroke.
Neurological Disorders, Brain Diseases, Olivopontocerebellar Atrophy Home Health Conditions and Diseases Neurological Disorders Brain Diseases olivopontocerebellar atrophy. * Site Title · The name of the site. http://www.iseekhealth.com/directory/index.php?method=show_link_exchange&directo
Olivopontocerebellar Atrophy The New Health Directory, Directory, Home Health Conditions and Diseases Neurological Disorders Brain Diseases olivopontocerebellar atrophy (4) See Also http://www.thenewhealthfind.com/Health/ConditionsandDiseases/NeurologicalDisorde
Extractions: Olivopontocerebellar Atrophy Mark Lamb Abstract Olivopontocerebellar Atrophy(OPCA), is characterized by neuronal degeneration of the cerebellar cortex, the inferior olive, and the pons. The symptoms associated with it are primarily cerebellar ataxia with disturbances in equilibrium and gait. However, broader symptomology is usually seen with OPCA. Current research is focusing on three primary systems thought to be responsible for the etiology of OPCA. They are excitatory amino acid disturbances, oligodendroglial microtubular tangles, and phospholipid metabolism disorders. The only treatment for OPCA is therapy focusing on improving the dysphagia associated with the disorder. Olivopontocerebellar Atrophy Olivopontocerebellar Atrophy (OPCA) is a disease characterized primarily by the degeneration of neurons in the cerebellar cortex, pons, and inferior olive. It is a genetic disease, being either autosomal dominant or autosomal recessive in nature. This disorder, which usually occurs in the middle years of life, presents symptoms of cerebellar ataxia, equilibrium disturbance, nystagmus, dysphasia, dysarthria, and possibly intellectual deficits. According to Merritt, the pathology of OPCA includes loss of Purkinje cells, reduction of the number of neurons in the molecular and granular layers of the cerebellum, degeneration of the folia and white matter of the cerebellum, atrophy of the inferior olives and of the olivo-cerebellar connections, and atrophy of the pontine nuclei, arcuate nuclei, and brachium pontis (15). In addition to this, degeneration of the spinocerebellar tracts, corticospinal tracts, and frontal and temporal lobes has been reported (15).
Opca/ds olivopontocerebellar atrophy. Debra Stenacker. olivopontocerebellar atrophy (OPCA) was first described in 1900 by Dejerine and Thomas. http://www.indstate.edu/thcme/anderson/DS.html
Extractions: OLIVOPONTOCEREBELLAR ATROPHY Debra Stenacker Olivopontocerebellar atrophy (OPCA) was first described in 1900 by Dejerine and Thomas. OPCA is a group of dominant inheritance and sporadic neurological disorders characterized by a chronic, progressive, cerebellar ataxia that begins in middle age. The cerebellum and its connections are the primary sites of the disease in chronic progressive disorders that often occur in familial or hereditary patterns. Postmortem studies indicate an atrophy of the cerebellum, pons, and inferior olives. This neuropathological neuronal cell loss permits classification of OPCA as a non-Alzheimers neurodegenerative illness. Gross postmortem inspection of the brains of patients with OPCA shows marked shrinkage of the ventral half of the pons, and disappearance of the olivary eminence on the ventral surface of the medulla. These brains also exhibit an atrophy of the cerebellum with degeneration of the middle cerebellar peduncles, and to a lesser extent, of the inferior peduncles. Thus, the cerebellum suffers mainly through atrophy of its afferent fibers. The neocerebellum and the olive undergo the primary degeneration. The purkinje cells of the cerebellar cortex are affected secondarily. Histological examination shows severe degeneration of Purkinje cells, reduction in the number of cells in the molecular and granular layers of the cerebellar cortex, severe loss of the number of cells in the pontine nuclei and olives, and demyelination of the middle cerebellar peduncle. The cerebellar nuclei are well preserved. The tegmentum of the pons, the corticospinal tracts, and the restiform body are also usually unaffected. In clinical cases involving extrapyramidal symptoms, degenerative changes in the striatum, especially the putamen, and a loss of pigmented cells in the substantia nigra may be seen. Tubular structures and crystalline inclusions may be found with the electron microscopy. More wide spread degeneration of the central nervous system has been reported in dominant autosomal cases, and may involve the spinocerebellar fibers and the posterior columns.
Olivopontocerebellar Atrophy- Medcohealth.com olivopontocerebellar atrophy is a neurodegenerative illness that causes certain brain areas (which may include the olivary nucleus, the pons, and the cerebellum http://www.medcohealth.com/medco/consumer/ehealth/ehsarticle.jsp?topicID=HE:Dise
