NINDS Miller Fisher Syndrome Information Page miller fisher syndrome information sheet compiled by the National Institute of Neurological Disorders and Stroke (NINDS). What is miller fisher syndrome? http://accessible.ninds.nih.gov/health_and_medical/disorders/miller_fisher.htm
Extractions: Disorders - National Institute of Neurological Disorders and Stroke (NINDS) Skip menus Home About NINDS Disorders-you are in this section ... Find People The nation's leading supporter of biomedical research on disorders of the brain and nervous system. Select Topic Disorder Quick Links Alzheimer's Autism Cerebral Palsy Chronic Pain Epilepsy Headache Multiple Sclerosis Parkinson's Stroke Traumatic Brain Injury Studies with patients Research literature Press release NINDS Search (search help) Contact us My privacy NINDS is part of the National Institutes of Health Contact us NINDS Miller Fisher Syndrome Information Page Miller Fisher syndrome is a rare, acquired nerve disease that is considered to be a variant of Guillain-Barré syndrome. It is characterized by abnormal muscle coordination, paralysis of the eye muscles, and absence of the tendon reflexes. Like Guillain-Barré syndrome, symptoms may be preceded by a viral illness. Additional symptoms include generalized muscle weakness and respiratory failure. The majority of individuals with Miller Fisher syndrome have a unique antibody that characterizes the disorder.
Miller Fisher Syndrome Google, WWW Medical.WebEnds.com. miller fisher syndrome. Fisher Syndrome; Guillain Barre Syndrome, Miller Fisher Variant; Ophthalmoplegia http://medical.webends.com/kw/Miller Fisher Syndrome
Extractions: WWW Medical.WebEnds.com Fisher Syndrome; Guillain Barre Syndrome, Miller Fisher Variant; Ophthalmoplegia, Ataxia and Areflexia Syndrome; Guillain-Barre Syndrome, Miller Fisher Variant; Miller Fisher Variant of Guillain Barre Syndrome; Miller-Fisher Syndrome A variant of the GUILLAIN-BARRE SYNDROME characterized by the acute onset of oculomotor dysfunction, ataxia , and loss of deep tendon reflexes with relative sparing of strength in the extremities and trunk. The ataxia is produced by peripheral sensory nerve dysfunction and not by cerebellar injury. Facial weakness and sensory loss may also occur. The process is mediated by autoantibodies directed against a component of myelin found in peripheral nerves . (Adams et al., Principles of Neurology , 6th ed, p1313; Neurology 1987 Sep;37(9):1493-8)
MILLER FISHER SYNDROME Definition Home/M/MI/miller fisher syndrome. Medical Dictionary Search Engine. Advertise on this site! A service of healthlink-net.com. Browse Dictionary Alphabetically. http://www.books.md/M/dic/millerfishersyndrome.php
GUILLAIN BARRE SYNDROME (GBS) Cranial nerve involvement (unilateral or bifacial weakness 50%, oculomotor paralysis 5%, characteristic in miller fisher syndrome). http://www.uwo.ca/clinns/resident/pocketbook/disorders/neuromuscular/gbs.htm
Extractions: Guillain Barre Syndrome (GBS) Epidemiology - Most common cause of acute flaccid paralysis in Western countries - Overall incidence 1-2/100,000; up to 8.6/100,000 in elderly population - All age groups can be affected, however, more common in elderly - Bimodal peak, small peak in young adults and larger peak in elderly; rare in infancy - 75% have an antecedent event 1-4 weeks before onset of weakness: respiratory (68%), GI (22%), resp and GI (10%), surgery (2%), vaccination or pregnancy - Associated organisms: CMV, EBV, VZV, HIV, C. jejuni , M. pneumoniae , Shigella Clinical course - Initial paresthesias in fingers / toes followed by weakness - Weakness rapidly worsens, sensory loss usually minimal - Usually symmetric, though can be asymetric initially - Classically distal weakness ascending up legs and arms, but proximal weakness not uncommon at onset - Cranial nerve involvement (unilateral or bifacial weakness 50%, oculomotor paralysis 5%, characteristic in Miller Fisher Syndrome) - 66% reach nadir in 2 weeks, 92% in 3 weeks; by definition MUST peak at 4 weeks - Brief plateau phase then improvement and gradual resolution over weeks to months Complications Respiratory weakness / failure 20-30% will need intubation at some point during admission Autonomic dysfunction (in up to 65%) including: Arrythmias (sinus tachycardia, brady and tachy arrythmias)
ORPHANET - Rare Diseases - Orphan Drugs Site map, Contact, Order the Orphanet book, Printing version, DISEASE miller fisher syndrome, No description is available, Other website(s)(2), Support group(s) (1). http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=GB&Expert=2559
Guillain-Barré Syndrome forms are Acute Motor Axonal Neuropathy (AMAN), Acute Motor and Sensory Axonal Neuropathy (AMSAN) and the cranial nerve variant miller fisher syndrome (MFS). http://www.orpha.net/data/patho/GB/uk-Guillain.html
Extractions: Other diseases that may give rise to rapid progressive weakness have to be excluded or made unlikely. The main disorders that may give rapid progressive weakness are electrolyte disturbances (hypophosphatemia, hyperkalemia), porphyria, polymyositis or necrotising myopathies, Lyme borreliosis, myasthenia gravis and poliomyelitis. Diagnosis criteria / definition GBS is a neuropathy characterized by a rapidly progressive weakness (and mostly also sensory disturbances) in at least 2 legs, and low or absent tendon reflexes. Cranial nerves may be affected. The maximal level of weakness is reached within 4 weeks, meaning that the duration of progression is at most 4 weeks. Cerebrospinal fluid (CSF) examination mostly shows an increased protein level, but no increased number of cells. Other causes of rapid progressive weakness need to be excluded or must be unlikely. Differential diagnosis
Entrez PubMed The miller fisher syndrome. Review of the literature. Berlit Since then, 223 cases of miller fisher syndrome have been published. The http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstra
Entrez PubMed Click here to read miller fisher syndrome in the course of an acute pneumonia by Mycoplasma pneumoniae Article in Spanish Bernal SanchezArjona M, Franco http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1
FORMULAIRE INSCRIPTION RECHERCHE WWW.LACHAINETTE.COM Translate this page Contacts Maladie sélectionnée miller fisher syndrome Id, Prenom, Pays, Web. 1707, ALAIN, FRANCE, http://www.lachainette.com/ContactsPathologie.php?Action=contacter&Id=596
Campylobacter Symptoms, Risks And Treatment As many as 40% of GuillainBarré syndrome cases in this country occur following campylobacteriosis.2 miller fisher syndrome is another, related neurological http://www.foodborneillness.com/ecoli1/campylobacter-symptoms.htm
Extractions: Diarrhea is the most consistent and prominent manifestation of campylobacteriosis. It is often bloody.1 Typical symptoms of C. jejuni infection also include fever, nausea, vomiting, abdominal pain, headache, and muscle pain. A majority of cases are mild and do not require hospitalization and may be self-limited. However, C. jejuni infection can be severe and life threatening. Death is more common when other diseases (e.g., cancer, liver disease, and immuno-deficiency diseases) are present. Children under the age of five and young adults aged 15-29 are the age groups most frequently affected. The incubation period (the time between exposure and onset of the first symptom) is typically two to five days, but onset may occur in as few as 2 days or as long as 10 days after ingestion.1 The illness usually lasts no more than one week; however, severe cases may persist for up to three weeks. Are there long term consequences of Campylobacter?
Autoantibody Testing In Neuropathy Suspected miller fisher syndrome or other forms of acute ophthalmoplegia believed to be neuropathic in origin Order antiGQ1b antibodies. http://neuroland.com/nm/autoab_neuro.htm
Extractions: Neuro Med Autoantibody testing in Neuropathy Initial evaluation of Neuropathy: history, examination and electrodiagnostic studies to define the neuropathy symmetric vs. asymmetric sensory vs. motor axonal or demyelinating and if conduction block is present If the etiology for the PN is not apparent, check a serum SPEP and IFE for monoclonal protein Urine testing for a paraprotein is done in some cases, particularly patients with primarily small-fiber sensory or autonomic involvement. Sensory or sensorimotor PN Demyelinating neuropathy with IgM gammopathy: particularly if there is prolonged distal latencies, anti-MAG testing is performed. Early in the course, these patients have sensory greater than motor deficits that are primarily distal. Most patients with positive anti-MAG will have an IgM monoclonal protein. Pure sensory syndromes (Ganglionopathy): Especially if asymmetric, rapidly progressive, sensory loss involving proprioception.
Dictionary Definition Of MILLER FISHER SYNDROME www.nlm.nih.gov/cgi/mesh/2K/MB_cgi?term=Miller+Fisher+Syndrome GlycoWord / GlycopathologyA03 are present in sera from patients with immune-mediated neuropathies such as Guillain-Barré syndrome, miller fisher syndrome, IgM paraproteinemic neuropathy http://www.dictionarybarn.com/MILLER-FISHER-SYNDROME.php
Medicdirect - Comprehensive UK Health Information The miller fisher syndrome, a variant of Guillain Barre syndrome, is associated with antibodies to GQ1b gangliosides. Clinical Features. http://www.medicdirect.co.uk/clinics/default.ihtml?step=4&pid=2316
Neuromuscular Diseases miller fisher syndrome. About miller fisher syndrome Guillain-Barré Syndrome Support G. (UK). A 42 year old female miller fisher syndrome. http://www.mic.ki.se/Diseases/C10.668.html
Extractions: Diseases and Disorders Links pertaining to Neuromuscular Diseases Alert! Patients and laypersons looking for guidance among the target sources of this collection of links are strongly advised to review the information retrieved with their professional health care provider. Start Page Contents: Amyotrophic Lateral Sclerosis Brachial Plexus Neuritis Brachial Plexus Neuritis Brachial Plexus Neuropathies ... Ulnar Nerve Compression Syndromes Neuromuscular Diseases Motor Cortex illustration [Earles et al.] - Furman Univ. (US) EMG and Nerve Conductions Homepage [JF Jabre] The Neuromuscular Disease Information Center - REHABinfo Network/UC-Davis (US) Neuromuscular Diseases - MDA (US) Neuromuscular Disorders [Nadeau and Valenstein] - Univ of Florida (US) About some Neuromuscular Diseases - Wake Forest Univ. Neuromuscular Disorders Information - Musc Dystrophy Group of (UK)+ N. Ireland Neuromuscular Disease Center , and a collection of one-page summaries of Differential Diagnoses of Neuromuscular Syndromes - School of Medicine/Washington Univ., St Louis (US)
NORD - National Organization For Rare Disorders, Inc. variants of GBS (acute inflammatory neuropathy or acute inflammatory demyelinating polyradiculoneuropathy) are recognized miller fisher syndrome, acute motor http://www.rarediseases.org/search/rdbdetail_abstract.html?disname=Guillain Barr
Neuroimmunology Group ganglioside antibodies in the postinfectious paralytic neuropathy termed Guillain Barré syndrome (GBS) and the GBS variant termed miller fisher syndrome (MFS http://www.gla.ac.uk/clinicalneuroscience/neuroimgroup.html
Extractions: 1. Identifying and characterising carbohydrate autoantigens 2. Understanding Campylobacter jejuni LPS structure and immunogenicity 4. Modelling disease in a wide range of genetically modified mice with particular emphasis on the motor nerve terminal 5. Developing therapeutic strategies from animal models 6. Clinical research on serotype/phenotype associations 7. Participation in clinical trials of neuropathy patients In addition, the Group provides diagnostic services for measurement of anti-ganglioside antibodies in autoimmune neuropathy through the NHS Neuroimmunology Laboratory. Ang CW, Laman JD, Willison HJ, Wagner ER, Endtz HP, De Klerk MA, Tio-Gillen AP, Van Den Braak N, Jacobs BC, Doorn PA.Structure of Campylobacter jejuni lipopolysaccharides determines antiganglioside specificity and clinical features of Guillain-Barre and Miller Fisher patients. Infect Immun 2002; 70:1202-8.
