Geometry.Net - Health_Conditions: Hyperhomocysteinemia


Home - Health_Conditions - Hyperhomocysteinemia

e99.com Bookstore

Images

Newsgroups

81-82 of 82 Back | 1 | 2 | 3 | 4 | 5

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Hyperhomocysteinemia: more detail

Hyperhomocysteinemia: Webster's Timeline History, 1992 - 2007 by Icon Group International, 2009-02-20
Hyperhomocysteinemia as a result of the methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism causes an increased risk of cerebrovascular disease: ... An article from: Original Internist by Robert A., Jr. Duca, 2010-09-01
Hyperhomocysteinemia in end stage renal disease: is treatment necessary? (Continuing Education).: An article from: Nephrology Nursing Journal by Jennifer Snavely, 2002-04-01

lists with details

Graham/SJBR
hyperhomocysteinemia. When dietary intake of folate, vitamin B12, and vitamin B6 are low or absent, there is a higher risk for hyperhomocysteinemia.
http://wwwchem.csustan.edu/chem4400/sjbr/Graham01.htm

Extractions: Hyperhomocysteinemia (in blood) and Homocysteinuria (in urine) has been known for approximately 30 years.(1,3) Hyperhomocysteinemia, which will be discussed here extensively, is elevated blood plasma level of total homocysteine (tHcy). The tHcy is considered elevated when levels are >15umol/L in blood serum. Patients with hyperhomocysteinemia commonly have tHcy levels of 250umol/L.(2) Normal levels of tHcy has been determined to range from 6.1-15.0umol/L.(6) Patients with elevated blood levels of tHcy, in several studies, has indicated in having an increased risk in cardiovascular, peripheral vascular and cerebrovascular disease.(1,2,4) Hyperhomocysteinemia has been estimated to be in 5% of the general population, and 13-47% of patients with diagnosed symptomatic atherosclerotic vascular disease, also have hyper- homocysteinemia.(1) The causative agents for hyperhomocysteinemia are deficiencies in folate (folic acid), vitamin B12, vitamin B6, a genetic disposition or even kidney problems.(1) This paper will discuss the metabolism of homocysteine and how hyperhomocysteinemia causes an increased risk in cardiovascular, peripheral vascular and cerebrovascular disease. Homocysteine (Hcy) is a sulphydryl-containing amino acid by-product that comes from the demethylation of methionine. The major source of methionine is from animal protein.(1,3) In the plasma, Hcy is available in four forms. Hcy can circulate as a free thiol, is disulphide-bound to plasma proteins such as albumin, combined with itself to form a dimer, or bound with other thiols such as a cysteine. These four forms of homocysteine will be referred to as total homocysteine (tHcy).(1) tHcy is metabolized by remethylation or trans-sulphuration.(5)
Diabetes Forum : Complication_Causes Of Hyperhomocyst(e)inemia
Basics. Info Centre. Case Studies. Myths and Facts. Other Links. Site Map. Special features. select one.
http://www.diabetesforum.net/eng_comp_causehyper .htm

Extractions: Elevations in homocyst(e)ine are typically caused either by genetic defects in the enzymes involve in homocysteine metabolism or by nutritional deficiencies in vitamin co-factors. Thus, reduction in activity of MS, MTHFR, or CbS, or decreased availability of their co-factors, vitamin B12, folic acid or vitamin B6 respectively, can cause hyperhomocyst(e)inemia. Defects of betaine homocysteine methylene transferase have not been described in literature. Homocyst(e)ine levels are higher in men than in women, both fasting and post methionine loading, and usually higher in postmenopausal rather than premenopausal women. Homocyst(e)ine also rises with age even when allowance is made for age-related increase in creatinine and decreasing vitamin levels. The rise may be related to age induced reduction in the function of MS or CbS. Other conditions that may be associated with hyperhomocyst(e)inemia are hypothyroidism, impaired kidney function, systemic lupus erythematosus and certain medications, e.g., nicotinic acid, nitrous oxide exposure, theophylline, methotrexate, and L-dopa.

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

81-82 of 82 Back | 1 | 2 | 3 | 4 | 5