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Hyperhomocysteinemia: more detail

Hyperhomocysteinemia: Webster's Timeline History, 1992 - 2007 by Icon Group International, 2009-02-20
Hyperhomocysteinemia as a result of the methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism causes an increased risk of cerebrovascular disease: ... An article from: Original Internist by Robert A., Jr. Duca, 2010-09-01
Hyperhomocysteinemia in end stage renal disease: is treatment necessary? (Continuing Education).: An article from: Nephrology Nursing Journal by Jennifer Snavely, 2002-04-01

lists with details

Hyperhomocysteinemia
Elevation of the plasma homocysteine concentration (hyperhomocysteinemia) is a common and important risk factor for atherosclerotic arterial disease (Boushey
http://www.tigc.org/eguidelines/hyperhomocysteinemia02.htm

Extractions: November 2002 Background Elevation of the plasma homocysteine concentration (hyperhomocysteinemia) is a common and important risk factor for atherosclerotic arterial disease (Boushey CJ et al., JAMA 274:1049-1057, 1995) and for venous thromboembolism (Ray JG, Arch. Intern. Med. 158:2101-2106, 1998). The risk conferred by homocysteine adds to or even multiplies the risk conferred by factors such as smoking, hypertension, diabetes, and lipid disorders (for arterial disease) and Factor V Leiden (for venous thromboembolism). Even mild elevations of plasma homocysteine confer risk. Homocysteine levels are influenced by diet, as homocysteine is produced from metabolism of methionine, and cleared by metabolic pathways that require folic acid, vitamin B , and vitamin B as cofactors. Low levels of these vitamins are therefore associated with hyperhomocysteinemia. Congenital deficiencies of enzymes in these metabolic pathways, and renal failure, also are important causes of hyperhomocysteinemia. Screening Fasting plasma or serum homocysteine concentrations should be measured as a part of the investigation of selected patients with venous thromboembolism, particularly those with idiopathic thrombosis, recurrent thrombosis, and thrombosis at a young age or at an unusual site (see guideline on Investigation of Suspected Hypercoagulable States). Measurement of a homocysteine level should be considered in patients with arterial disease.
High Homocysteine, Hyperhomocysteinemia
Also indexed as hyperhomocysteinemia. hyperhomocysteinemia increases risk of death, especially in type 2 diabetes 5year follow-up of the Hoorn Study.
http://www.truestarhealth.com/Notes/1029002.html

Extractions: Gift of Health Hi ! Welcome to Truestar Health. Log In Welcome to the Truestar Health Encyclopedia Welcome to the Truestar Health Encyclopedia the most comprehensive information database available on health, wellness, food, nutrition, vitamins and supplements. Use of our encyclopedia will enable you to make well-informed, responsible decisions for the promotion of your own health and wellness. Enter search items High Homocysteine Truestar Vitamin and Supplement Plans Heart Health Plan Highly Recommended: TrueBASICS for Men - Optimal Wellness Pack / TrueBASICS for Women - Optimal Wellness Pack TrueCARDIO Support - Heart Health Pack Optional: Greens + - Healthy Immune and Colon Cleansing System Also indexed as: Hyperhomocysteinemia Homocysteine, a normal breakdown product of the essential amino acid methionine , is believed to exert several toxic effects. A growing body of evidence suggests that an elevated homocysteine level is a risk factor for heart disease , independent of other known risk factors, such as elevated serum cholesterol and hypertension The evidence is not all one-sided, however. In some research the link has appeared only in women
NEJM -- Hyperhomocysteinemia As A Risk Factor For Deep-Vein Thrombosis
Original Article from The New England Journal of Medicine hyperhomocysteinemia as a Risk Factor for DeepVein Thrombosis.
http://content.nejm.org/cgi/content/short/334/12/759

Extractions: Add to Personal Archive ... Chapters at Harrison's ABSTRACT Background Previous studies have suggested that hyperhomocysteinemia may be a risk factor for venous thrombosis. To assess the risk of venous thrombosis associated with hyperhomocysteinemia, we studied plasma homocysteine levels in patients with a first episode of deep-vein thrombosis and in normal control subjects. Methods We measured plasma homocysteine levels in 269 patients with a first, objectively diagnosed episode of deep-vein thrombosis and in 269 healthy controls matched to the patients according to age and sex. Hyperhomocysteinemia was defined as a plasma homocysteine level above the 95th percentile in the control Results Of the 269 patients, 28 (10 percent) had plasma homocysteine levels above the 95th percentile for the controls, as compared with 13 of the controls (matched odds ratio, 2.5; 95 percent
NEJM -- Hyperhomocysteinemia As A Risk Factor For Deep-Vein Thrombosis
Correspondence from The New England Journal of Medicine hyperhomocysteinemia as a Risk Factor for DeepVein Thrombosis.
http://content.nejm.org/cgi/content/short/335/13/974

Extractions: Add to Personal Archive Add to Citation Manager E-mail When Cited ... PubMed Citation To the Editor: The article by den Heijer et al. (March 21 issue) supports our finding that hyperhomocysteinemia is a risk factor for deep-vein thrombosis that is independent of coexisting abnormalities of naturally occurring anticoagulants. This important confirmation challenges the suggestion by Mandel et al., in their article in the same issue, that hyperhomocysteinemia increases the risk of thrombosis only if the elevation in homocysteinemia is associated with the presence of factor V Leiden. Unlike our study of patients with early-onset deep-vein thrombosis and their previous study of patients with recurrent deep-vein thrombosis
Hyperhomocysteinemia: A Nutritional Component Of Heart Disease
hyperhomocysteinemia. What You Are Not Eating Could Hurt You. The important role of folaterich foods in the prevention of arteriosclerosis.
http://www.pea-lentil.com/homocysteine.html

Extractions: Heart disease is the number one killer in this country, claiming 500,000 lives every year. Factors such as cigarette smoking, high blood pressure and cholesterol, physical inactivity, age, stress, hereditary factors, diabetes, and being a male all contribute to an increased risk of heart disease. However, many heart attacks occur in people without any of these risk factors. Recently studies point to a new risk factor. Homocysteine, an amino acid and a basic unit of protein, appears to be implicated in 10-15 percent of vascular (heart) disease cases. A 1992 study of over 14,000 male physicians found that those with the highest levels of homocysteine had more than three times the risk of heart disease. Foods rich in B vitamins - folate, B12 and B6 - help keep homocysteine at safe levels. In other words, when B-vitamins are provided, the homocysteine levels may decrease. Conversely, low levels of blood folate are consistently related to high levels of homocysteine. Folate (also known as folic acid) seems to have a greater clearing effect on homocysteine levels that B6, B12, or both vitamins combined. Some people may be more prone to homocysteine buildup and may consequently need more B-vitamins.
Preventive Health Care, 2000 Update: Screening And Management Of Hyperhomocystei
GUIDELINE TITLE. Preventive health care, 2000 update screening and management of hyperhomocysteinemia for the prevention of coronary artery disease events.
http://www.guideline.gov/summary/summary.aspx?ss=15&doc_id=2702&nbr=1928
THE MERCK MANUAL, Sec. 11, Ch. 132, Thrombotic Disorders
hyperhomocysteinemia. hyperhomocysteinemia is also strongly correlated with atherosclerotic thrombosis (including coronary artery diseasesee Ch. 201).
http://www.merck.com/mrkshared/mmanual/section11/chapter132/132a.jsp
HYPERHOMOCYSTEINEMIA
hyperhomocysteinemia Chapter 3 Hypercoagulable States in Venous proteins. Elevated homocysteine levels (hyperhomocysteinemia) have been found to increase the risk of venous thrombosis up to fourfold.
http://www.websters-online-dictionary.org/definition/english/Hy/Hyperhomocystein

Extractions: Philip M. Parker, INSEAD. HYPERHOMOCYSTEINEMIA Specialty Definition: HYPERHOMOCYSTEINEMIA Domain Definition An inborn error of methionone metabolism which produces an excess of homocysteine in the blood. It is often caused by a deficiency of cystathionine beta-synthase and is a risk factor for coronary vascular disease. ( references Source: compiled by the editor from various references ; see credits. Top Specialty definitions using "HYPERHOMOCYSTEINEMIA" Cystathionine beta-Synthase references Top Frequency of Internet Keywords: HYPERHOMOCYSTEINEMIA The following statistics estimate the number of searches per day across the major English-language search engines as identified by various trade publications. Hyperlinks lead to commercial use of the expression at Amazon.com
Homocysteine
a startling 100% of French elderly hospitalized patients showed higher than desired homocysteine levels, with 45% suffering from severe hyperhomocysteinemia
http://qualitycounts.com/fphomocysteine.html

Extractions: Comprehensive Anti-aging Research Click here for (r)HGH buyers co-op: www.somatropinonline.com Home iHerb Vitacost ... Drug Databases Longevity Affiliates: Complete Shopping Directory Life Extension Buyers Club Life Extension Magazine iHerb(5% discount code "qc") ... Gerovital-GH3 -see procaine Nutri/System eDiets.com WebMD Weight Loss Clinic ... Health Conditions Homocysteine Related Topics: Popular Supplements: Alternative News: Homocysteine - Life Extension Foundation High Homocysteine - Healthwell.com Vitamins May Lower Osteoporosis Fractures - Intelihealth, 5/13/04 - "B vitamins are known to reduce levels of homocysteine ... high levels of homocysteine at least double the risk of osteoporosis-related fractures" 48,000 Lives Saved by Vitamin Additive
HONselect
hyperhomocysteinemiahyperhomocysteinemia An inherited or acquired independent risk factor for atherothrombotic vascular disease hyperhomocysteinemia
http://129.195.254.70/cgi-bin/HONselect?browse C18.452.648.066.480
Homocysteine
Homocysteine hyperhomocysteinemia. Book, Home homocysteine levels; Dose response curve lowest Folate, Highest risk. Causes of hyperhomocysteinemia
http://www.fpnotebook.com/CV247.htm

Extractions: Home About Links Index ... Editor's Choice document.write(code); Advertisement Cardiovascular Medicine Prevention Coronary Artery Disease ... Alcohol Related Cardiac Effects Homocysteine Hypertension Hypertension General Measures Coronary Artery Disease Cardiac Risk Factor ... Low Fat Diet Homocysteine Hyperhomocysteinemia Book Home Page Cardiovascular Medicine Dentistry Dermatology Emergency Medicine Endocrinology Gastroenterology General Medicine Geriatric Medicine Gynecology Hematology and Oncology HIV Infectious Disease Jokes Laboratory Neonatology Nephrology Neurology Obstetrics Ophthalmology Orthopedics Otolaryngology Pediatrics Pharmacology Prevention Psychiatry Pulmonology Radiology Rheumatology Sports Medicine Surgery Urology Chapter Cardiovascular Medicine Index Arrhythmia Coronary Artery Disease Congestive Heart Failure EKG Endocrinology Examination Ophthalmology Hypertension Infectious Disease Laboratory General Hyperlipidemia Pulmonology Myocardium Neurology Neonatology Obstetrics Pediatrics Pericardium Pharmacology Prevention Procedure Radiology Sports Medicine Surgery Symptom Evaluation Valvular Disease Vessel Page Prevention Index CAD Alcohol CAD Homocysteine Htn See Also Homocystinuria Hypercoagulable State Epidemiology Elevated in 15-30% of patients with premature CAD Pathophysiology Folate needed to convert homocysteine to methionine May reduce CAD risk by lowering homocysteine levels Dose response curve: lowest Folate, Highest risk
Hyperhomocysteinemia, Testing At Millenova Immunology Laboratories
hyperhomocysteinemia has been identified as a major risk factor for both arterial and venous thrombosis disease.
http://millenova.com/tests/hyperhom.asp

Extractions: Hyperhomocysteinemia has been identified as a major risk factor for both arterial and venous thrombosis disease. Individuals homozygous for the thermolabile variant of the methylene tetrahydrofolate reductase gene (MTHFR) have significantly elevated plasma homocysteine levels. Homozygous thermolabile MTHFR has been described in 5% of normal Caucasians, 19% of patients with arterial disease, 11% of patients with venous thrombosis and 2% of women with recurrent pregnancy loss. Indications for Testing
Hyperhomocysteinemia
Videos hyperhomocysteinemia. Printable version. Etiology. methionine synthase deficiency by mutations of gene MTR (1p43). Mutations
http://www.humpath.com/article.php3?id_article=1714
News Bureau MDNews - Hyperhomocysteinemia Linked To Diabetes
10/26/2000 hyperhomocysteinemia linked to diabetesrelated retinopathy Print Email NEW YORK, Oct 26 (Praxis Press) hyperhomocysteinemia may be a risk factor
http://praxis.md/index.asp?page=newsarchive&news_id=390&news=MD
News Bureau HEALTHNews - Hyperhomocysteinemia Linked To Diabetes
10/26/2000 hyperhomocysteinemia linked to diabetesrelated retinopathy Print Email NEW YORK, Oct 25 (Praxis Press) One of the long-term effects of having type
http://praxis.md/index.asp?page=newsarchive&news_id=2628&news=health
ARS | Publication Request: Hyperhomocysteinemia In Renal Transplant Patients
Title hyperhomocysteinemia in Renal Transplant Patients. Authors, Friedman, Allon HNRCA. Rosenberg, Irwin - HNRCA. Selhub, Jacob - HNRCA. Levey, Andrew - NEMC.
http://www.ars.usda.gov/research/publications/Publications.htm?seq_no_115=153461
ARS | Publication Request: Hyperhomocysteinemia Associated With Poor Recall In A
Title hyperhomocysteinemia Associated with Poor Recall in a Nationally Representative Sample of US Seniors. Authors, Morris, Martha HNRCA-TUFTS.
http://www.ars.usda.gov/research/publications/Publications.htm?seq_no_115=113242
PharmGKB: Hyperhomocysteinemia
hyperhomocysteinemia. Alternate Names hyperhomocysteinemias. PharmGKB Primary Data. Phenotype Data Sets None. Literature Annotations, Legend.
http://www.pharmgkb.org/do/serve?objId=PA446892&objCls=Disease
Hyperhomocysteinemia May Accelerate The Development Of Atherosclerotic Lesions D
hyperhomocysteinemia May Accelerate the Development of Atherosclerotic Lesions Despite Significantly Lowering Plasma Cholesterol Levels in LDL Receptor
http://depts.washington.edu/nutr/Hyperhomocysteinemia.html

Extractions: Hyperhomocysteinemia May Accelerate the Development of Atherosclerotic Lesions Despite Significantly Lowering Plasma Cholesterol Levels in LDL Receptor Knockout Mice. Rebecca L. Eastgard, Elizabeth A. Kirk, Renee C LeBoeuf, Michael E. Rosenfeld. Department of Pathobiology and Program in Nutritional Sciences, University of Washington, Seattle WA. Hyperhomocysteinemia is an independent risk factor for vascular diseases but the mechanisms by which homocysteine contributes to the disease process are not known. To address this question, we have developed a dietary protocol for induction of homocysteinemia involving stepwise increases in methionine intake from 2% to 4% over 16 and 24 week periods in the LDL receptor knockout mouse (LDLR-/-). This protocol results in a range of plasma homocysteine levels between 14 and 47 umol/l (n=58). Surprisingly, the elevation of plasma homocysteine was highly correlated with a significant reduction in total plasma cholesterol levels at all time points between 4 and 24 weeks in the LDLR-/-mice (r = -0.43) (average 223 +/- 37mg/dl [n=57] in the methionine fed LDLR-/- mice versus m m [n=19] for the chow fed mice vs. 13,721 +/- 6011
German Journal Of Psychiatry Bleich Hyperhomocysteinemia Manganese Induced Parki
Home. German Journal of Psychiatry. ISSN 14331055. Moderate hyperhomocysteinemia and neuropsychiatric symptoms in manganese-induced parkinsonism.
http://www.gjpsy.uni-goettingen.de/gjp-article-bleich.htm

Extractions: Home German Journal of Psychiatry ISSN 1433-1055 Moderate hyperhomocysteinemia and neuropsychiatric symptoms in manganese-induced parkinsonism Stefan Bleich, Detlef Degner, Borwin Bandelow, Antje Riegel , Juan M. Maler, Eckart Rüther, and Johannes Kornhuber Department of Psychiatry Department of Neuroradiology Georg-August University of Göttingen, Germany Corresponding author: Stefan Bleich, M.D, Department of Psychiatry, Georg-August University of Göttingen, von-Siebold-Str. 5, D-37075 Göttingen, Germany; e-mail stefan.bleich@t-online.de Abstract Manganese intoxication is a well-known cause of parkinsonism and dementia. Here we present the case of an 80-year-old patient with proven manganese poisoning. We observed no long-term progression of the manganese-induced parkinsonian syndrome. The blood manganese concentration is now reduced to below the normal range (4.8 m g/l), but the manganese concentration in scalp hair (2.79 m g/g) has kept on increasing. Strikingly, even though we found normal cobalamin and even elevated serum folate levels, we observed a moderate hyperhomocysteinemia in two independent samples. We did not find any common known risk factors for this moderate hyperhomocysteinemia The possible role of hyperhomocysteinemia in manganese-induced parkinsonism is discussed (German J Psychiatry 2000;3:14-20) Key words: manganese, homocysteine, parkinsonism

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