Extractions: Letters To the Editor: In the past 15 years, knowledge about the role of Shiga toxin-producing Escherichia coli (STEC) in human disease has expanded rapidly. The most distinctive complication of STEC infection is diarrhea-associated hemolytic uremic syndrome (HUS), a major cause of acute renal failure in U.S. children. Other manifestations of STEC infection can range from mild diarrhea to severe hemorrhagic colitis, thrombotic thrombocytopenic purpura, and death ( ). In the United States, O157 is the most common STEC and causes an estimated 20,000 infections and 250 deaths annually. E. Coli O157 outbreaks associated with beef have caused concern among public health workers, clinicians, and the public, prompting major changes in clinical and laboratory practice, meat production, and food preparation. However, critical questions remain unanswered. Have prevention measures decreased risk? Are new sources of STEC infections emerging? Is the incidence of O157 infection changing? How much illness is due to STEC of serotypes other than O157? Diarrhea-associated HUS is associated with Shiga toxin, which is produced in quantity only by STEC and by
EID V1 N4: Hemolytic Uremic Syndrome hemolytic uremic syndrome. Download Article Community outbreak of hemolytic uremic syndrome attributable to Escherichia coli O111NM South Australia, 1995. http://www.cdc.gov/ncidod/eid/vol1no4/cameron.htm
Extractions: EID Volume 1 * Number 4 October-December 1995 Commentary Download Article Along with a report of the first outbreak of hemolytic uremic syndrome (HUS) caused by Shiga-like toxin (SLT) producing E. coli in Australia , this issue of Emerging Infectious Diseases presents three papers detailing the investigations of pediatric HUS cases linked to Shiga toxin (ST) and SLT producing bacteria. Goldwater and Bettelheim present a case of pediatric HUS associated with SLT producing Escherichia coli (SLTEC) O48:H21 in South Australia; this strain has not previously been recognized as an SLTEC. Saeed et al. report on the increasingly common identification of HUS in Saudi Arabia, its association with multiple-antibiotic-resistant Shigella dysenteriae type 1, and the inherent dangers of treating such patients with ampicillin and nalidixic acid. Al-Qawari et al. report on the results of active surveillance for dysentery and HUS in Saudi Arabia and discuss a possibly elevated risk for HUS in patients with bloody diarrhea who are hospitalized and treated with nalidixic acid during an outbreak of S. dysenteriae type
Extractions: Web Directory: Atypical Hemolytic Uremic Syndrome Atypical HUS, is a rare disease among children causing kidney failure and high blood pressure. Offering support and information including, treatment, symptoms, case studies and research. Emergency Medicine Written by William Shapiro MD., an article about hemolytic uremic syndrome. An introduction, lab studies, treatment and follow up.
UAB Health System | Hemolytic Uremic Syndrome hemolytic uremic syndrome. What is hemolytic uremic syndrome (HUS)? About 2 percent to 7 percent of infections lead to hemolytic uremic syndrome. http://www.health.uab.edu/hospital/show.asp?durki=15578
Hemolytic Uremic Syndrome What is hemolytic uremic syndrome? . Additional Information on hemolytic uremic syndrome. http://www.mamashealth.com/syndrome/hemolytic.asp
Extractions: What is Hemolytic Uremic Syndrome? Hemolytic (HEE-mo-LIT-ik) uremic (yoo-REE-mik) syndrome is a rare condition affecting mostly children under the age of 10. Hemolytic uremic syndrome (HUS) is characterized by destruction of red blood cells, damage to the lining of blood vessel walls, and, in severe cases, kidney failure. Most cases of HUS occur after an infection in the digestive system caused by the Escherichia colibacterium found on contaminated food like meat, dairy products, and juice. The first stages of HUS frequently present with gastrointestinal symptoms such as abdominal pain, vomiting, and bloody diarrhea. This stage lasts from 1 to 15 days. Recovery from this acute colitic phase is the rule. However, more severe problems in the bowel and colon may develop in some cases. (The most vulnerable and severely stricken of children with HUS can die during the first acute stage of the diseasebetween 5 percent and 10 percent.) For most children with HUS, the vomiting and diarrhea stop after 2 or 3 days. Even when the gastroenteritis has stopped, the child does not recover full health, remaining pale, tired, and irritable. The bacteria originally lodged in the digestive system make toxins that enter the bloodstream, and these toxins destroy red blood cells. Small, unexplained bruises or small clot-sized hemorrhages visible in the mucosal lining of the mouth may occur because the toxins also destroy the platelets, cells that normally contribute to the clotting system.
Hemolytic Uremic Syndrome MEDSTUDENTS PEDIATRICS A brief review on HemolyticUremic Syndrome, itÂ’s etiology, epidemiology, pathogenesis, clinical manifestations, diagosis, treatment and prognosis. http://www.medstudents.com.br/pedia/pedia5.htm
Extractions: Medstudents'Homepage The hemolytic uremic syndrome (HUS) is the most common cause of acute renal failure in infants and young children, and an important cause of cronic renal failure and shock during youth. It is estimated that 90% of cases are preceded by a prodrome of bloody diarrhea. The syndrome may also follow the use of some drugs, malignancy, pregnancy, glomerulopathies, or it may be idiopathic. The classic diagnostic criteria are microangiopathic hemolytic anemia, thrombocytopenia and acute renal failure, following an acute episode of bloody diarrhea. There may be incomplete syndromes, when the diagnosis becomes unclear. The differential diagnosis include disseminated intravascular coagulation (DIC), thrombotic thrombocytopenic purpura (TTP), bilateral renal vein thrombosis and lupus. In DIC, partial thromboplastin time and prothrombin time are prolonged, and the patient may be septic. TTP is common in adults, specially young women, with central nervous system involvement, fever and cutaneous manifestations, and tends to occur as a relapsing illness. The enlargement of kidneys and angiography help distinguish bilateral renal vein thrombosis from the hemolytic uremic syndrome. The most common microorganisms associated to the post-diarrhea hemolytic uremic syndrome are Escherichia coli (0157:H7 strain) and type 1 Shigella dysenteriae . The enterohemorrhagic E. coli
Hemolytic-uremic Syndrome Other hemolytic uremic syndromeVideotape. Lois Joy Galler Foundation for hemolytic uremic syndrome, Inc., 1995. Fact Sheet hemolytic uremic syndrome. http://www.healthatoz.com/healthatoz/Atoz/ency/hemolytic-uremic_syndrome.html
Extractions: Definition Hemolytic-uremic syndrome (HUS) is a rare condition that affects mostly children under the age of 10, but also may affect the elderly as well as persons with other illnesses. HUS, which most commonly develops after a severe bowel infection with certain toxic strains of a bacteria, is characterized by destruction of red blood cells, damage to the lining of blood vessel walls, and in severe cases, kidney failure. Description Most cases of HUS occur after an infection in the digestive system that has been caused by toxin-producing strains of the bacterium Escherichia coli . About 75% of HUS cases in the United States are caused by the strain referred to as E. coli O157:H7, which is found in the intestinal tract of cattle, while the remaining cases are caused by non-O157 strains. Some children infected with E. coli O157:H7 will develop HUS. HUS also can follow respiratory infection episodes in young children. In the United States, there are about 20,000 infections and 250 deaths annually that are caused by E. coli
Extractions: The first stage of HUS frequently lasts from 1 to 15 days and may include gastrointestinal symptoms such as: Severe problems in the bowel and colon may develop in some cases. In these cases, even if the gastroenteritis has stopped, a child may still exhibit the following symptoms: irritability fatigue small, unexplained bruises or small clot-sized hemorrhages visible in the mucosal lining of the mouth
Hemolytic-uremic Syndrome MAIN SEARCH INDEX. Hemolyticuremic syndrome. SyndromeVideotape. Lois Joy Galler Foundation for hemolytic uremic syndrome, Inc., 1995. National http://www.ehendrick.org/healthy/002080.htm
Extractions: Resources Hemolytic-uremic syndrome (HUS) is a rare condition that affects mostly children under the age of 10, but also may affect the elderly as well as persons with other illnesses. HUS, which most commonly develops after a severe bowel infection with certain toxic strains of a bacteria, is characterized by destruction of red blood cells, damage to the lining of blood vessel walls, and in severe cases, kidney failure. Most cases of HUS occur after an infection in the digestive system that has been caused by toxin-producing strains of the bacterium Escherichia coli . About 75% of HUS cases in the United States are caused by the strain referred to as E. coli O157:H7, which is found in the intestinal tract of cattle, while the remaining cases are caused by non-O157 strains. Some children infected with E. coli O157:H7 will develop HUS. HUS also can follow respiratory infection episodes in young children. In the United States, there are about 20,000 infections and 250 deaths annually that are caused by E. coli
Hemolytic Uremic Syndrome - Keep Kids Healthy A discussion of hemolytic uremic syndrome, which usually follows diarrhea caused by E coli 0157, causing acute renal failure and anemia. http://www.keepkidshealthy.com/welcome/conditions/hus.html
Extractions: Main Diseases and Conditions Hemolytic uremic syndrome (HUS) is a disorder that usually causes microangiopathic hemolytic anemia (destruction of red blood cells in small and medium sized blood vessels), thrombocytopenia (a low platelet count), and acute renal failure . It is the most common cause of acute renal failure in infants and children and there are about 2-4 cases per 100,000 children in the United States, usually during the summer and early fall. HUS most commonly affects kids between the ages of six months and four years of age, who usually have the classic or epidemic form of HUS, which is preceded by diarrhea for 3-4 days. The diarrhea is usually watery and may be bloody and associated with vomiting and/or abdominal pain. The diarrhea can last up to 12 days and is most commonly caused by eating meat that is contaminated with the
Hemolytic Uremic Syndrome hemolytic uremic syndrome is a rare condition affecting mostly children under the age of 10. Subscribe now . hemolytic uremic syndrome. http://healthlink.mcw.edu/article/943053875.html
Extractions: Subscribe now >> Hemolytic (HEE-mo-LIT-ik) uremic (yoo-REE-mik) syndrome is a rare condition affecting mostly children under the age of 10. Hemolytic uremic syndrome (HUS) is characterized by destruction of red blood cells, damage to the lining of blood vessel walls, and, in severe cases, kidney failure. Most cases of HUS occur after an infection in the digestive system caused by the E. coli bacterium found on contaminated food like meat, dairy products, and juice. The first stages of HUS frequently present with gastrointestinal symptoms such as abdominal pain, vomiting, and bloody diarrhea. This stage lasts from 1 to 15 days. Recovery from this acute colitic phase is the rule. However, more severe problems in the bowel and colon may develop in some cases. (The most vulnerable and severely stricken of children with HUS can die during the first acute stage of the diseasebetween 5 percent and 10 percent.) For most children with HUS, the vomiting and diarrhea stop after 2 or 3 days. Even when the gastroenteritis has stopped, the child does not recover full health, remaining pale, tired, and irritable. The bacteria originally lodged in the digestive system make toxins that enter the bloodstream, and these toxins destroy red blood cells. Small, unexplained bruises or small clot-sized hemorrhages visible in the mucosal lining of the mouth may occur because the toxins also destroy the platelets, cells that normally contribute to the clotting system.
Hemolytic Uremic Syndrome - Causes, Symptoms & Treatment hemolytic uremic syndrome Facts plus the Latest News on hemolytic uremic syndrome Treatments HealthNewsflash. hemolytic uremic syndrome Fact Book. http://www.healthnewsflash.com/conditions/hemolytic_uremic_syndrome.php
Extractions: Browse By Category Browse Alphabetically Search Health Conditions Hemolytic (HEE-mo-LIT-ik) uremic (yoo-REE-mik) syndrome is a rare condition affecting mostly children under the age of 10. Hemolytic uremic syndrome (HUS) is characterized by destruction of red blood cells, damage to the lining of blood vessel walls, and, in severe cases, kidney failure. Most cases of HUS occur after an infection in the digestive system caused by the Escherichia coli bacterium found on contaminated food like meat, dairy products, and juice. The first stages of HUS frequently present with gastrointestinal symptoms such as abdominal pain, vomiting, and bloody diarrhea. This stage lasts from 1 to 15 days. Recovery from this acute colitic phase is the rule. However, more severe problems in the bowel and colon may develop in some cases. (The most vulnerable and severely stricken of children with HUS can die during the first acute stage of the diseasebetween 5 percent and 10 percent.) For most children with HUS, the vomiting and diarrhea stop after 2 or 3 days. Even when the gastroenteritis has stopped, the child does not recover full health, remaining pale, tired, and irritable. The bacteria originally lodged in the digestive system make toxins that enter the bloodstream, and these toxins destroy red blood cells. Small, unexplained bruises or small clot-sized hemorrhages visible in the mucosal lining of the mouth may occur because the toxins also destroy the platelets, cells that normally contribute to the clotting system.
Hemolytic Uremic Syndrome - Lucile Packard Children's Hospital Genitourinary Kidney Disorders. hemolytic uremic syndrome What is hemolytic uremic syndrome (HUS)? What causes hemolytic uremic syndrome? http://www.lpch.org/DiseaseHealthInfo/HealthLibrary/urology/hus.html
Extractions: What is hemolytic uremic syndrome (HUS)? HUS is a rare condition that can lead to kidney failure in children. Kidney failure develops as a result of destruction of the small, functional structures and vessels inside the kidney. HUS is a serious illness and potentially fatal. What causes hemolytic uremic syndrome? HUS is more common during the summer months and may occur in outbreaks. Outbreaks have been reported in daycare centers, water parks, and fast food restaurants as a result of inadequately cooked hamburger meat. HUS is most common in younger children between 6 months and 4 years, but can occur at any age. HUS has several known causes and some unknown causes. Typically in children, HUS develops after an infection with the E. coli bacterium. E. coli may be found in contaminated food such as dairy products and meat. HUS can also develop as a result of taking certain medications, or may result from a cancer present in the body, although these causes are less common. In less than 5 percent of HUS cases, the disorder is inherited by a dominant gene (a gene passed from parent to child with a 50/50 risk) or recessive gene (each parent carries one copy of the gene and the child inherits both copies; the chance is 25 percent with each pregnancy). What are the symptoms of hemolytic uremic syndrome?
Hemolytic Uremic Syndrome hemolytic uremic syndrome. What is hemolytic uremic syndrome (HUS)? HUS is a serious illness and potentially fatal. What causes hemolytic uremic syndrome? http://www.chw.org/display/PPF/DocID/2624/router.asp
Extractions: What causes hemolytic uremic syndrome? HUS is more common during the summer months and may occur in outbreaks. Outbreaks have been reported in daycare centers, water parks, and fast food restaurants as a result of inadequately cooked hamburger meat. HUS is most common in younger children between 6 months and 4 years, but can occur at any age. HUS has several known causes and some unknown causes. Typically in children, HUS develops after an infection with the E. coli bacterium. E. coli may be found in contaminated food such as dairy products and meat. HUS can also develop as a result of taking certain medications, or may result from a cancer present in the body, although these causes are less common. In less than 5 percent of HUS cases, the disorder is inherited by a dominant gene (a gene passed from parent to child with a 50/50 risk) or recessive gene (each parent carries one copy of the gene and the child inherits both copies; the chance is 25 percent with each pregnancy).
Hemolytic Uremic Syndrome hemolytic uremic syndrome Important It is possible that the main title of the report hemolytic uremic syndrome is not the name you expected. http://my.webmd.com/hw/health_guide_atoz/nord745.asp
HEMOLYTIC UREMIC SYNDROME hemolytic uremic syndrome What is hemolytic uremic syndrome? hemolytic uremic syndrome (HUS) is a condition that affects the blood and blood vessels. http://www.kidney.org/general/atoz/content/hemolytic.html
Extractions: Hemolytic uremic syndrome (HUS) is a condition that affects the blood and blood vessels. It results in the destruction of blood platelets (cells involved in clotting), a low red blood cell count (anemia), and kidney failure due to damage in the very small blood vessels of the kidneys. Other organs, such as the brain or heart, may also be affected by damage in very small blood vessels. Are there different types of HUS? Yes. A syndrome, such as HUS, is a combination of findings that may be due to many different reasons. HUS most commonly follows a severe bowel infection with certain toxic strains of the bacteria called E. coli. It may also occur in response to certain medicines, but this is rare. Only very rarely will it occur for an unknown reason. This fact sheet is primarily focused on the HUS that occurs in infants and children as a result of an E. coli infection. What are the symptoms of HUS? HUS in children generally occurs after an illness involving diarrhea (usually bloody). Most children fully recover from their bowel illness and do not develop HUS. However, a small percentage will become pale and have less energy, related to progression to HUS. They may also have decreasing urine output, but a loss of color in the skin is the most striking feature. How does HUS start?
Kidney Learning System - Hemolytic Uremic Syndrome KLS Home Fact Sheets hemolytic uremic syndrome. Printer friendly. hemolytic uremic syndrome. What is hemolytic uremic syndrome? http://www.kidney.org/kls/factsheets/showFS.cfm?id=31&&title=fs_hemolytic.htm
Extractions: DIFFERENTIAL DIAGNOSIS: The differential diagnosis of oliguric renal failure, thrombocytopenia and thrombotic microangiopathic hemolytic anemia (MAHA) (evidenced by the red blood cell fragments, increased LDH and decreased haptoglobin) in a post partum setting includes acute fatty liver of pregnancy (AFLP), HELLP syndrome (hemolysis, elevated liver enzymes and low platelets), thrombotic thrombocytopenic purpura / hemolytic uremic syndrome (TTP/HUS), disseminated intravascular coagulation (DIC) and preeclampsia (table 1). Differentiating among these conditions is critical because they respond to different therapeutic modalities and the laboratory is often critical in making these distinctions. Table 1. Laboratory Differential Diagnosis Abnormality HUS/TTP AFLP HELLP DIC Preeclampsia Abnormal PT/PTT N Y N Y Y or N Hemolysis Y Y Y Y Y Thrombocytopenia Y Y Y Y Y Abnormal liver function tests N Y Y N N Abnormal renal function tests Y N N N N *adapted from Fricke et al HELLP syndrome is seen in 5% of patients with preeclamsia; 70% of cases occur antenatally and 30% occur within the first 48 hours post partum. Thrombocytopenia, microangiopathic hemolytic anemia, moderately abnormal liver function tests (LFT) and usually mildly abnormal renal function tests are characteristically present. Antepartum preeclampsia developes most commonly in nulliparous women and is characterized by proteinuria, edema and hypertension. Hemolysis is rare, and mild thrombocytopenia is present in 10-15% of cases. LFTs are minimally affected, and renal failure is rare. This patient did not have hypertension and LFTs were only transiently abnormal, making HELLP syndrome and preeclampsia less likely.
A To Z Encyclopedia Topic: Hemolytic Uremic Syndrome Clinical Services. hemolytic uremic syndrome. What is hemolytic uremic syndrome (HUS)? HUS What causes hemolytic uremic syndrome? HUS http://web1.tch.harvard.edu/cfapps/A2ZtopicDisplay.cfm?Topic=Hemolytic Uremic Sy