Dummies::Identifying Variations On The Migraine Theme hemiplegic migraines. hemiplegic migraines are often caused by an inherited gene, but they occur in people with no family history of migraines. http://www.dummies.com/WileyCDA/DummiesArticle/id-1758.html
Extractions: Adapted From: Migraines For Dummies As if migraines aren't big enough mischief-makers as it is, they also like to sing show tunes and take on different personas. So here we turn to migraine variants Abdominal migraines, which are sometimes diagnosed in children, are unusual because they cause pain in the stomach and lead to nausea and vomiting (sometimes without a headache). A child who complains of recurrent pain in his stomach may be experiencing abdominal migraines. Children who suffer from abdominal migraines are likely to have migraine headaches in adulthood. Abdominal migraines are usually treated with anticonvulsant drugs. The basilar migraine was once known as the basilar artery migraine, or BAM. It was considered a problem that was found primarily in young women and adolescent girls, but it occurs in both sexes and all ages. Basilar migraines are extremely rare, but they have the potential to be a serious health hazard in that they can lead to a transient ischemic attack (TIA) or stroke. Symptoms to watch for are double vision, partial vision loss, terrible vomiting, dizziness, loss of balance, slurred speech, lack of coordination, numbness (on one or both sides of the body), weakness, and confusion. These symptoms typically go away at the onset of the actual headache, although they may last for days after the pain disappears.
Arch Neurol -- Topic Collections : Migraine Abstract Full text. Editorials Familial hemiplegic migraine Arnulf H. Koeppen Arch Neurol 2003; 60 663664. Full text. Original http://archneur.ama-assn.org/cgi/collection/migraine
Extractions: Select Journal or Resource JAMA Archives of Dermatology Facial Plastic Surgery Family Medicine (1992-2000) General Psychiatry Internal Medicine Neurology Ophthalmology Surgery Student JAMA For The Media Classified Ads Meetings Peer Review Congress Citations 1-10 of 24 total displayed. Most recent content (1 May 2004): History of Neurology
Arch Neurol -- Topic Collections : Migraine Observations Mutation Analysis of the CACNA1A Calcium Channel Subunit Gene in 27 Patients With Sporadic hemiplegic migraine Gisela Terwindt, Esther Kors, Joost http://archneur.ama-assn.org/cgi/collection/migraine?page=2
Imigrainet.net B. Todd Troost, M. D. 9799. hemiplegic migraine occurs both sporadically and as a familial syndrome. This entity is defined as vascular headache featured http://imigraine.net/migraine/prolonged.html
Extractions: In the new classification of migraine, Subtype 1.6 indicates complications of migraine. This would include all of the permanent defects discussed in this section. Focal symptoms and signs of the aura may persist beyond a headache phase. In the previous classification, this was termed complicated migraine. It is now defined by the IHS classification with two labels with increased specificity. If the aura lasts for longer than one hour but less than one week, the term migraine with prolonged aura is applied. If the signs persist for more than one week or a neuroimaging procedure demonstrates a stroke, a migrainous infarction has occurred. As pointed out previously, mid or later life the aura may not be followed by headache and has been termed migraine accompagnée or migraine associée . Migraine with aura (classic) in early reports was sometimes referred to as ophthalmic migraine (to be differentiated from ophthalmoplegic migraine, a subtype of migraine with aura). Migraine with aura is further reviewed under the headings: Cerebral, Ophthalmoplegic, Retinal, Basilar, and Other Varieties Cerebral A variety of cerebral symptoms may occur in migraine with aura, including motor, visual, and other sensory defects. As pointed out previously, if the aura lasts for more than one hour , but less than one week, the term migraine with prolonged aura is applied. However, if the signs persist for more than one week, or a neuroimaging procedure shows a stroke the term used is
Imigrainet.net B. Todd Troost, M. D. 17 Specific gene abnormalities have been found in patients with familial hemiplegic migraine, that is a missense mutation in the Alpha I subunit of the voltage http://imigraine.net/migraine/path.html
Extractions: Although there is some understanding of the mechanism of migraine, its precise underlying causes are unknown. Extensive reviews and volumes have been published on the pathophysiology of headache and, in particular, migraine. According to Goadsby et. al. , migraine is best understood as a primary disorder of the brain. Migraine is a polygenetic disorder believed to have a primary problem in the abnormal function of an ion channel in the brain-stem nuclei that modulates sensory input. Specific gene abnormalities have been found in patients with familial hemiplegic migraine, that is a mis-sense mutation in the Alpha I subunit of the voltage-gated P/Q-type calcium channels. As pointed out by Goadsby , it is likely that the aura of migraine is separate from the headache as cases of migraine with aura have been linked to the familial-hemiplegic-migraine locus.
Prepagina It is involved in the characterization of new mutations associated with Familial hemiplegic migraine with or without Progressive Cerebellar Ataxia (FHM and FHM http://www.unisi.it/ricerca/ist/cmn/migraine/prepagina.html
Extractions: The Laboratory of Clinical Molecular Biology, I.R.C.C.S. H San Raffaele, Milano, coordinated by Dr. Paola Carrera. It is involved in the characterization of new mutations associated with Familial Hemiplegic Migraine with or without Progressive Cerebellar Ataxia (FHM and FHM/PCA) and in studying the genetics of more common types of Migraine (MO and MA). In addition, the cloning of full-length cDNAs from CACNA1A human gene is being performed. Exchanges with other teams of the Neuronal Calcium Channel in Disease Research Training Network (link) are planned in order to maximize the sensitivity of mutation detection and to functionally characterize new mutations associated with different phenotypes. The Clinical Molecular Biology Laboratory has a decades worth of experience in mutation detection technology, with a group of fourteen people involved in either molecular genetics research or diagnostics. It is located in the
Æ°«Ðá«ÐªÉiFHMj (Familial hemiplegic migraine ,FHM). A new locus for hemiplegic migraine maps to chromosome 1q31. http://neurol.med.tottori-u.ac.jp/takeshima/ha/HA_MB2.htm
Extractions: Familial hemiplegic migraine (FHM): Mutational analysis of the FHM2 gene ATP1A2 in German families Freilinger T Herzog J Jurkat-Rott K Lehmann-Horn F Gasser T Dichgans M Background: Familial hemiplegic migraine (FHM), a rare autosomal dominant subtype of migraine with aura, is genetically heterogeneous: FHM1 is associated with missense mutations of the CACNA1A gene on chromosome 19p13. The gene for FHM2, ATP1A2 on chromosome 1q23, has recently been cloned, with only two different mutations described so far (De Fusco et al. 2003). Objective: To screen for mutations within the ATP1A2 gene in German FHM families. Methods: Results: Genetic analysis confirmed the known genetic heterogeneity of FHM. All families compatible with linkage to chromosome 1q23 were included in a mutational analysis of the ATP1A2 gene. We identified a novel mutation in the ATP1A2 gene which cosegregates with the disease status and was not detected on 100 control chromosomes. The mutation is located in a highly conserved region of the ATP1A2 gene in close proximity to one of the two previously reported mutations. Conclusions: Our results confirm ATP1A2 as a second gene for FHM by expanding the spectrum of mutations. Mutational screening of ATP1A2 in additional FHM families is underway. Functional analysis of cells expressing the mutant gene product may contribute to a better understanding of the pathophysiological mechanisms underlying FHM and thus to targeted treatment.
Psychiatric Times This presentation, with paranoid delusions, hallucinations and anxiety, has been described in families with hemiplegic migraine (Spranger et al., 1999). http://www.psychiatrictimes.com/p020848.html
WHAT CAUSES MIGRAINE HEADACHES? Researchers have located a single genetic mutation responsible for the very rare familial hemiplegic migraine, but a number of genes are likely to be involved http://www.ucdmc.ucdavis.edu/ucdhs/health/a-z/97migraine/doc97causes.html
Extractions: Until recently, the general theory on the migraine process rested solely on the idea that abnormalities of blood vessel (vascular) systems in the head were responsible for migraines. Now, however, experts tend to believe that migraine starts with an underlying central nervous system disorder, which, when triggered by various stimuli, sets off a chain of neurologic and biochemical events, some of which subsequently affect the brain's vascular system. No experimental model fully explains the migraine process. There is certainly a strong genetic component in migraine with or without auras. Researchers have located a single genetic mutation responsible for the very rare familial hemiplegic migraine, but a number of genes are likely to be involved in the great majority of migraine cases. A number of chemicals, structures, nerve pathways, and other players involved in the process are under investigation. Central Nervous Disorder.
On Target - Weekly Journal, Issue July 15, 2001 5. GENETICS back to top. Familial hemiplegic migraine. Familial hemiplegic migraine is an autosomal dominant disorder characterized http://www.targethealth.com/ontarget/2001/07152001.htm
Extractions: TARGET HEALTH I. WHAT'S NEW back to top New Addition To Our Staff TARGET HEALTH is pleased to announce the appointment of Mr. Joonhyuk Choi as Data Analyst/Programmer to our growing Target e*CRF development team. Mr. Choi holds a degree in Electrical and Computer Engineering and will answer directly to our Chief Technology Officer, Joon You. Other members of the Target e*CRF team include Yong Joong Kim, Laura Suciu, and Kevin Kim. We know that we have the best and most user-friendly Internet-based data collection, retrieval and project management system in the Industry. For more information contact julesmitchel@targethealth.com
SAPO - Portugal Online! Missense mutations in this gene are responsible for familial hemiplegic migraine (FHM), a subtype of migraine inherited as an autosomal dominant, and http://lusomed.sapo.pt/Xn310/367172.html
Extractions: Mensageiro Páginas Amarelas Acesso Mail ... Apresentação Corpos Científicos Conselho Científico Conselho Editorial Áreas Profissionais Medicina Enfermagem Guidelines Internacionais Nacionais Ferramentas Livros Revistas Médicas Med. Genéricos Legislação Pesquisa DCI Acerca de... Quem somos... Como publicar Contactos Press Release ... Homepage Favoritos Recomendar Webmail Ajuda / FAQ's Agenda Fórum Lusomed Áreas Profissionais Artigos CALCIUM AND NEUROLOGICAL DISEASE: from migraine to hemiparesis and ataxia! Alonso I.,Silveira I. and Sequeiros J. Calcium plays several essential roles in human biology, since fetal development up to the end of our lives. In neurons, calcium acts either directly by neurotransmitter release in the pre-synaptic terminal or producing changes in gene expression and protein synthesis, and influencing other second messengers in the post-synaptic neuron. Voltage-gated calcium channels are one of the major entry gates of calcium into the cell. The CACNA1A gene encodes a subunit of a brain calcium channel, which regulates calcium influx in cerebellum Purkinje cells. This subunit is composed by four homologous domains (I-IV), each containing six putative transmembrane segments (S1-S6) and a pore-forming segment between S5-S6. Mutations in the CACNA1A gene cause at least three hereditary neurological diseases. Missense mutations in this gene are responsible for familial hemiplegic migraine (FHM), a subtype of migraine inherited as an autosomal dominant, and characterized by attacks of hemiparesis (often after minor head trauma, like those occurring during a football match!). Nonsense and splice-site mutations are present in patients with an episodic type of ataxia (EA2), characterized by episodes of gait imbalance, with associated symptoms, such as nausea, vertigo and headache. A polyglutamine expansion in the same gene causes a slowly progressive form of spinocerebellar ataxia, named SCA6.
Health Report - 12/1/1997: Genes And Migraines We call it familial hemiplegic migraine. So like all other migraines you have the headache but on top of that you have the onesided paresis. http://www.abc.net.au/rn/talks/8.30/helthrpt/stories/s360.htm
Extractions: Ann Blair-Gould: Between 10% and 12% of the population of most countries suffers from migraines, and the statistics show that it tends to occur in families although migraines are not inherited in the simple predictable manner; and that it occurs much more often in women, about 2-and-a-half-times more often than in men. So when I recently read that scientists at Leiden University here in The Netherlands had come up with a new model of how we think migraines come about, I went off to see what I could find out. I spoke there to Professor Rune Frants, who is originally from Finland, and who is head of the Department of Human Genetics at Leiden. I asked him first what we've known about what causes migraines up till now.
Migraine family history. Identification of a chromosomal abnormality has been confirmed in familial hemiplegic migraine. Incidence/Prevalence http://www.5mcc.com/Assets/SUMMARY/TP0588.html
Extractions: DESCRIPTION: Paroxysmal headache lasting 4-72 hours. Episodes vary in frequency from more than once a week to less than one per year with symptoms abating completely between attacks. Premonitory symptoms consisting of non-specific symptoms occur frequently hours to days before headache. Most frequent sub-types are: Without aura - (common migraine) defining over 80% of attacks With aura - (classic migraine) characterized by focal disruption of neurological function begins and ends prior to headache onset Variants of migraine include: Transformed migraine - chronic headache pattern evolving from episodic migraine. Migraine-like attacks are superimposed on a daily or near-daily headache pattern, e.g., tension headache. Basilar migraine - occipital headache, with aura symptoms of dysarthria, vertigo, tinnitus, ataxia, and bilateral paresis or bilateral paresthesias Hemiplegic migraine - aura consisting of hemiplegia and/or hemiparesis Ophthalmoplegic - palsy of the ipsilateral third cranial nerve during the headache phase Retinal - symptoms of retinal vascular involvement during headache Childhood periodic syndromes - (migraine equivalents) recurrent often cyclic episodes of symptoms Status migrainous - persistent migraine which does not resolve spontaneously Migrainous stroke - persistent or permanent neurologic deficits persisting beyond migraine attack usually with neuro-imaging changes Chronic migraine - migraine-like headaches greater than 15 days a month for greater than 6 months
Migraine Diagnosis 1.1 Migraine without aura 1.2 Migraine with aura 1.2.1 Migraine with typical aura 1.2.2 Migraine with prolonged aura 1.2.3 Familial hemiplegic migraine 1.2.4 http://www.upstate.edu/neurology/haas/hpmidx.htm
Extractions: Homepage Most migraines seen in physicians' offices are migraine without aura (formerly called "common migraine") and migraine with aura (formerly called "classic migraine" by some). Migraine aura without headache is also quite common, and is seen often by ophthalmologists. Neurologists and headache specialists often treat status migrainosus, characterized by a headache phase of over 72 hours. The other migraine types are listed in the left side bar and are fully described in the Headache Classification Committee's classification (1988).
Migraine Associated Vertigo (Baloh et al, 1996). Familial hemiplegic migraine has been linked to mutations in the calcium channel gene (Ophoff et al, 1996). http://www.tchain.com/otoneurology/disorders/central/migraine/mav.html
Extractions: Adapted from lecture handout given for the seminar "Recent advances in the treatment of Dizziness", American Academy of Neurology, 1997 and "Migraine Vs Meniere's", at the American Academy of Otolaryngology meeting, 1999-2001. Last edited: 2/2003 Please read our Education Index Search this site Timothy C. Hain, MD , Chicago IL. Dizziness and headache are individually very common human conditions and their combination is also a common symptom complex. Diagnostically, one must determine whether the dizziness and headaches are independent or related to each other, and in particular, whether they are a manifestation of migraine. Here we will review the association between vertigo and migraine. This subject has also been recently reviewed by Reploeg and Goebel (2002) as well as Radke et al (2002). Epidemiology Nearly 13% of the adult population of the United States has migraine. There is a male-female distribution difference. At all ages, about 5% of men have migraine (Stewart, 1994; Lipton et al, 2002). Women of childbearing age have a much higher prevalence, jumping up to roughly 10% at the onset of menstruation, and increasing to nearly 30% at the peak age of 35 years. At menopause, rates of migraine abruptly decline in women back to roughly 10%. The prevalence of Migraine is far higher than that of Meniere's disease , which occurs in only 0.2% of the US population (Wladislavosky-Waserman et al, 1984). In a small study of persons with Menieres disease, the prevalence of Migraine was about 50%, compared with a figure of about 25% in the non-Meniere's population (Radke et al, 2002). Other studies have shown different results however. There have also been recent studies showing that there is a higher frequency of
HEMIPLEGIC A novel missense ATP1A2 mutation in a Finnish family with familial hemiplegic migraine type 2. link Familial hemiplegic migraine (FHM), a rare autosomal http://mind-brain.com/abstracts.php?qa=hemiplegic
