IM Abstract 39-11 Case Reports 11 Slowly Progressive Dystonia Following Central Pontine and ExtrapontineMyelinolysis. A 28year-old woman was hospitalized with dysarthria http://www.naika.or.jp/im/im39/ab3911/c391111.html
Thammasat Medical Journal ? 3 ? Central Pontine and ExtrapontineMyelinolysis A study of 3 cases in Ramathibodi hospital. http://www.med.tu.ac.th/Journal/journal2_2.html
úåãwG@2000N5E59ª5 The summary for this Japanese page contains characters that cannot be correctly displayed in this language/character set. http://www.med.nihon-u.ac.jp/department/NUMA/No59-5/MRI.html
BrainTF19 -Porphyria_Text intermittent porphyria. MRI may show central pontine and extrapontinemyelinolysis and/or cortical laminar necrosis. These are not http://www.mribhatia.com/braintf19/braintf19text.html
Extractions: BrainTF19 -Porphyria Clinical Profile: Patient is a fourteen year old boy who is a known case of porphyria. He presented with weakness of the right upper extremity, seizures and abdominal cramps. Findings: There are hyperintense areas on the Proton, T2W and FLAIR images along the cortex and subcortical white matter in the left fronto-parieto-temporal lobes and in the right centrum semiovale. These are hypointense on the T1W images. Similar signal changes are seen in the lentiform and caudate nuclei, bilaterally, in a symmetric fashion. These changes would be most likely ischemic in etiology. Discussion: Porphyria is a group of at least eight disorders that differ considerably from each other. A common feature in all is the accumulation in the body of "porphyrins" or "porphyrin precursors". Though normal body chemicals, they normally do not accumulate. Which of these chemicals builds up depends upon the type of porphyria. The symptoms arise mostly from effects on the nervous system or the skin. Effects on the nervous system occur in the acute porphyrias. Skin manifestations can include burning, blistering and scarring of sun-exposed areas. The terms "porphyrin" and "porphyria" are derived from the Greek word "porphyrus" meaning purple. Urine from some porphyria patients may be reddish in color due to the presence of excess porphyrins and related substances, and the urine may darken after standing in light. In each type of porphyria there is a deficiency of a specific "enzyme". These enzymes are involved in the synthesis of heme (found in largest amounts in the bone marrow, red blood cells and the liver). Heme exists as hemoglobin in the bone marrow and red blood cells but has other functions in other tissues such as the liver. The type of porphyria present is determined by which enzyme is deficient. These enzyme deficiencies are usually inherited. The different type of porphyrias are as follows:
NEWS Detail The evidence suggests that the neurological complication of pontine and extrapontinemyelinolysis is a consequence of the rapid correction of hyponatraemia http://www.imj.ie/news_detail.php?nNewsId=2899&nVolId=107
David B Methylphenidate Treatment of Neuropsychiatric. Symptoms of Central and ExtrapontineMyelinolysis. Journal of Studies on Alcohol, 61657660, 2000. 12. http://www.uchsc.edu/sm/psych/dept/faculty/arciniegas_d.htm
Extractions: To conact, e-mail: David.Arciniegas@UCHSC.edu RESEARCH AND PROFESSIONAL EXPERIENCE: Experience: 1992 1993 Internship in Community Medicine, University of Colorado Health Sciences Center (UCHSC) 1993 1996 Residency in Adult Psychiatry, UCHSC 1995 1996 Chief Resident in Consultation-Liaison Psychiatry, UCHSC 1996 1998 Instructor/Fellow in Psychiatry, UCHSC 1996 1999 Fellowship in Neuropsychiatry and Clinical Neuroscience Research, UCHSC 1996 1999 Fellowship in Neuroscience Research and Traumatic Brain Injury, Denver VAMC 1996 1998 Associate Director of Medical Student Education, Department of Psychiatry, UCHSC 1997 Director, Neuroscience Course, Adult Psychiatry Residency Training Program, UCHSC 1998 1999 Instructor/Fellow in Psychiatry and Neurology, UCHSC 1998 Member, Behavioral Neurology Section, Department of Neurology, UCHSC 1998 Director of Medical Education, Colorado Mental Health Institute at Pueblo, Pueblo, CO
