:: Ez2Find :: Ollier Disease Virtual Children s Hospital enchondromatosis Site Info - Translate - Open New Window Clinical presentation, etiology and imaging findings. http://ez2find.com/cgi-bin/directory/meta/search.pl/Health/Conditions_and_Diseas
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Ollier Disease Virtual Children s Hospital A look at enchondromatosis by Michael P. D Alessandro, MD Includes clinical presentation, etiology and imaging findings. http://www.thenewhealthfind.com/Health/ConditionsandDiseases/RareDisorders/Ollie
Enchondromatosis : On Medical Dictionary Online II. Congenital and Hereditary Bone Disorders enchondromatosis is a rare disorder of skeletal development characterized by the presence of multiple circumscribed foci or masses of cartilage in the interior http://www.online-medical-dictionary.org/?q=Enchondromatosis
VII. Bone Tumors H E. The histopathological appearance of solitary enchondroma is similar to that of enchondromatosis, a developmental disorder of cartilage of bone (refer to http://edcenter.med.cornell.edu/CUMC_PathNotes/Skeletal/Bone_07.html
Extractions: Tumor-like Lesions of Bone Focal Lesion Diffuse Lesion Central (Medullary) Eccentric (Cortical/Juxtacortical) Tumorlike Lesions Solitary bone cyst* (metaphysis) Nonossifying fibroma* (metaphysis) Osteoporosis Fibrous dysplasia* (shaft) Aneurysmal bone cyst* (metaphysis) Osteomalacia Eosinophilic granuloma* (shaft) Exuberant fracture callus Hyperparathyroidism Hyperparathyroidism ("brown tumors") Myositis ossificans (juxtacortical) Paget's disease of bone Gaucher's disease Benign Neoplasms Enchondroma (metaphysis) Osteochondroma (metaphysis) Giant cell tumor (also malignant) (metaphysis/epiphysis) Chondroblastoma* (epiphysis) Malignant Neoplasms Central chondrosarcoma (diaphysis) Osteogenic sarcoma* (metaphysis) Osteogenic sarcoma* (osteolytic) Medullary fibrosarcoma Peripheral chondrosarcoma Multiple myeloma (diaphysis) Metastatic carcinoma Ewing's sarcoma* (diaphysis) Metastatic carcinoma * Predilection for children and teenagers T here are, of course, many other features to be considered in the radiological analysis of a bone lesion, among them: the presence or absence of mineralization of the tumor matrix; whether the lesion causes bone destruction (osteolytic lesion) or bone production (osteosclerotic lesion) or has a multiloculated "soap bubble" appearance (Table); presence of reactive periosteal new bone formation; destruction of cortex and extracortical tumor extension.
Penn State Faculty Research Expertise Database (FRED) , Benign growths of cartilage in the metaphyses of several bones. Related Terms,Faculty Research Expertise Database. enchondromatosis. http://fred.hmc.psu.edu/ds/retrieve/fred/meshdescriptor/D004687
Session IV Abstracts Hedgehog and Parathyroid hormone related protein signaling in enchondromatosis, Enchondromas are common benign cartilage tumors of bone. http://www.geocities.com/mhecoalition/Session_IV_Abstracts.html
Extractions: Targets downstream of Gs are still uncertain. One likely target is the cdk inhibitor, p57. Knockout of p57 rescues much of p57 mRNA and protein. Other cell cycle proteins and transcription factors are plausible mediators of PTHrP action, as well. Benjamin Alman, MD, FRCSC, Assistant Professor, Canadian Research Chair, Program in Developmental Biology and Division of Orthopaedic Surgery, University of Toronto, The Hospital for Sick Children Hedgehog and Parathyroid hormone related protein signaling in enchondromatosis Jacqueline Hecht, PhD , Professor of Pediatrics, University of Texas Medical School at Houston, University of Texas Houston Medical Center EXTI and EXT2 Germline Mutations are the Most Common Cause of
Reflections-Alman And Kaplan growth plate. They can occur as solitary lesions or as multiple lesions in enchondromatosis (Ollier and Maffucci diseases). Clinical http://www.geocities.com/mhecoalition/Reflections_Alman_Kaplan.html
Extractions: An integral part of the Conference were speakers on research being done on related disorders, including Ollier and Maffucci (O/M) and Fibrodysplasia Ossificans Progressiva (FOP). By sharing information and ideas, we hope that one day better treatments and ultimately cures can be found for these orphan diseases that affect the lives of so many. Note: Enchondromas, the benign tumors which occur in O/M, are different from the osteochondromas, or exostoses of MHE, as is the research being done on each of these diseases. Enchondromas are common benign cartilage tumours of bone that usually occur next to the growth plate. They can occur as solitary lesions or as multiple lesions in enchondromatosis (Ollier and Maffucci diseases). Clinical problems caused by enchrondromas include skeletal deformity and the potential for malignant change to chondrosarcoma, a form of musculoskeletal cancer.
FORMULAIRE INSCRIPTION RECHERCHE WWW.LACHAINETTE.COM Contacts Rare disease selected enchondromatosis Id, First name, Country, Web. 1194, sandrine, FRANCE, http://www.lachainette.com/US/ContactsPathologie.php?Action=contacter&Id=1815
Search By Specialty Ollier Disease from Linkspider UK Health Directory and resources. Virtual Children s Hospital enchondromatosis Clinical presentation, etiology and imaging findings. NORD Ollier http://www.ramex.com/seek.cgi?1,10,,,enchondromatosis
Connective Tissue Oncology Society - Poster enchondromatosis CAUSED BY A MUTANT TYPE I PTH/PTHRP RECEPTOR Sevan Hopyan 1 , Nalan Gokgoz 1 , Raymond Poon 2 , Robert S. Bell 1 , William G. Cole 2 , Irene L http://www.ctos.org/meeting/2001/posters/poster75.html
Extractions: Musculoskeletal Oncology Unit and Program in Molecular Biology and Cancer, Mount Sinai Hospital, Program in Developmental Biology, The Hospital for Sick Children OBJECTIVE: METHODS: RESULTS: We showed that key IHH-PTHrP pathway members are expressed in enchondromas and chondrosarcomas. The IHH and PTHrP signalling pathways were functional, but the feedback loop regulating IHH was dysregulated in these lesions. We identified a mutant PTHR1 in two patients with enchondromatosis. This mutant lowered baseline cAMP level and abolished IP3 accumulation in vitro. Expression of the mutant, but not WT, PTHR1 in the growth plates of transgenic mice resulted in the appearance of multiple enchondromas. These enchondromas were likely caused by abnormal proliferation and not abnormal resorption, since growth plate zonal architecture was altered, but the number of TRAP positive cells, which resorb the growth plate, were not.
Medical.webends.com/kw/Enchondromatosis Ollier Disease The Family Village / Library / Ollier s Disease Related Disorders Multiple enchondromatosis, Multiple Cartilaginous, Ollier Osteochondromatosis, Unilateral http://medical.webends.com/kw/Enchondromatosis
