EMedicine - POEMS Syndrome : Article Excerpt By: Wingfield Rehmus, MD, MPH Words, and Related Terms crowfukase syndrome, Takatsuki syndrome, PEP, polyneuropathy endocrinopathy plasma cell The syndrome was termed crow-fukase syndrome (by which it is known http://www.emedicine.com/derm/byname/poems-syndrome.htm
Extractions: (advertisement) Synonyms, Key Words, and Related Terms: Crow-Fukase syndrome, Takatsuki syndrome, PEP, polyneuropathy endocrinopathy plasma cell dyscrasia, polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, skin changes Background: Polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes (POEMS) syndrome is a rare multisystemic disease that occurs in the setting of a plasma cell dyscrasia. The pathophysiologic link between the constellation of symptoms and the underlying disease is not well understood, but the link may be related to changes in the levels of a cytokine or a growth factor. POEMS syndrome first was described by Crow in 1956 and then by Fukase in 1968. The syndrome was termed Crow-Fukase syndrome (by which it is known in Japan) by Nakanishi in a study of 102 cases in Japan. In 1980, the acronym POEMS was coined by Bardwick et al based on the 5 main features of the disease, namely, polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes. No specific case definition for POEMS exists; however, most authors agree that patients with POEMS syndrome should have 3 or more of the 5 features. The pathophysiology of the disease is not known; however, elevated levels of cytokines and growth factors have been implicated. The polyneuropathy associated with POEMS syndrome is a bilateral symmetric disturbance. It involves both motor and sensory nerves, begins distally, and has a progressive proximal spread. Associated cranial or autonomic nerves are not involved. Both demyelination and axonal degeneration are noted.
NORD - National Organization For Rare Disorders, Inc. of POEMS Syndrome. crowfukase syndrome. PEP Syndrome. Polyneuropathy-organomegaly- endocrinopathy organomegaly-endocrinopathy-M protein-skin lesions. Shimpo syndrome. Takatsuki syndrome http://www.rarediseases.org/search/rdbdetail_abstract.html?disname=POEMS Syndrom
ORPHANET - Rare Diseases - Orphan Drugs Printing version, DISEASE POEMS syndrome, Synonym(s) crowfukase syndrome, No description is available, Clinical signs(23), Other website(s)(4), http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=GB&Expert=2905
ORPHANET - Rare Diseases - Orphan Drugs D I S E A S E POEMS syndrome. Synonym(s) crowfukase syndrome http://orphanet.infobiogen.fr/consor/cgi-bin/OC_Exp.php?Lng=GB&Expert=2905
EMedicine - POEM Syndrome : Article Excerpt By: Wingfield Rehmus, MD, MPH and Related Terms crowfukase syndrome, Takatsuki syndrome, PEP, polyneuropathy endocrinopathy plasma then by Fukase in 1968. The syndrome was termed Crow-Fukase (by which it http://www.emedicine.com/derm/byname/poem-syndrome.htm
Extractions: (advertisement) Synonyms, Key Words, and Related Terms: Crow-Fukase syndrome, Takatsuki syndrome, PEP, polyneuropathy endocrinopathy plasma cell dyscrasia, polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, skin changes Background: POEMS (polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, skin changes) syndrome is a rare multisystemic disease that occurs in the setting of a plasma cell dyscrasia. The pathophysiologic link between the constellation of symptoms and the underlying disease is not well understood, but the link may be related to changes in the levels of a cytokine or growth factor. POEMS syndrome first was described by Crow in 1956 and then by Fukase in 1968. The syndrome was termed Crow-Fukase (by which it is known in Japan) syndrome by Nakanishi in a study of 102 cases in Japan. In 1980, the acronym POEMS was coined by Bardwick et al based on the 5 main features of the disease, namely, polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes. No specific case definition for POEMS exists; however, most authors agree that patients with POEMS syndrome should have 3 or more of the 5 systems involved. The pathophysiology of the disease is not known; however, elevated levels of cytokines and growth factors have been implicated. Polyneuropathy: The polyneuropathy associated with POEMS syndrome is a bilateral symmetric disturbance. It involves both motor and sensory nerves, begins distally, and has a progressive proximal spread. Associated cranial or autonomic nerves are not involved. Both demyelination and axonal degeneration are noted.
Untitled JP, Defer GL, Degos JD, Gherardi RK. crowfukase syndrome a case associated with vasospastic angina. A case of crow-fukase syndrome with elevated soluble interleukin-6 receptor http://www.mdinteractive.com/v2/poems.html
Extractions: Polyneuropathy, Organomegaly, Endocrinopathy, Monoclonal gammapathy, Skin changes Syndrome (POEMS) MEDLINE Early weight loss and high serum tumor necrosis factor-alpha levels in polyneuropathy, organomegaly, endocrinopathy, M protein, skin changes syndrome - Ann Neurol 1994 Apr;35(4):501-5, Gherardi RK, et al Castleman's disease in POEMS syndrome with elevated interleukin-6 . - Cancer 1992 Jun 1;69(11):2697-703 Mandler RN, et al Acute arterial obliteration: a new feature of the POEMS syndrome? - Medicine (Baltimore) 1996 Jul;75(4):226-32 Lesprit P, Authier FJ, Gherardi R, Belec L, Paris D, Melliere D, Schaeffer A, Godeau B All-trans-retinoic acid in POEMS syndrome. Therapeutic effect associated with decreased circulating levels of proinflammatory cytokines . - Arthritis Rheum 1996 Aug;39(8):1423-6; Authier FJ, Belec L, Levy Y, Lefaucheur JP, Defer GL, Degos JD, Gherardi RK Crow-Fukase syndrome: a case associated with vasospastic angina. - Acta Neurol (Napoli) 1994 Aug;16(4):170-6; Mochizuki Y, Yoshihashi H, Oishi M, Takasu T, Nozawa K, Uchiyama T, Sawada S The skin changes in the Crow-Fukase (POEMS) syndrome. A case report.
Crow-Fukase Syndrome - General Practice Notebook crowfukase syndrome. POEMS is an acronym for polyneuropathy slow onset of mixed motor and sensory polyneuropathy; peripheral nerve http://www.gpnotebook.co.uk/cache/-1046872034.htm
Alzhheimer JP, Defer GL, Degos JD, Gherardi RK. crowfukase syndrome a case associated with vasospastic angina. A case of crow-fukase syndrome with elevated soluble interleukin-6 receptor http://tuftsneurology.org/webres/poems.htm
Extractions: Polyneuropathy, Organomegaly, Endocrinopathy, Monoclonal gammapathy, Skin changes Syndrome MEDLINE Early weight loss and high serum tumor necrosis factor-alpha levels in polyneuropathy, organomegaly, endocrinopathy, M protein, skin changes syndrome - Ann Neurol 1994 Apr;35(4):501-5, Gherardi RK, et al Castleman's disease in POEMS syndrome with elevated interleukin-6 . - Cancer 1992 Jun 1;69(11):2697-703 Mandler RN, et al Acute arterial obliteration: a new feature of the POEMS syndrome? - Medicine (Baltimore) 1996 Jul;75(4):226-32 Lesprit P, Authier FJ, Gherardi R, Belec L, Paris D, Melliere D, Schaeffer A, Godeau B All-trans-retinoic acid in POEMS syndrome. Therapeutic effect associated with decreased circulating levels of proinflammatory cytokines . - Arthritis Rheum 1996 Aug;39(8):1423-6; Authier FJ, Belec L, Levy Y, Lefaucheur JP, Defer GL, Degos JD, Gherardi RK Crow-Fukase syndrome: a case associated with vasospastic angina. - Acta Neurol (Napoli) 1994 Aug;16(4):170-6; Mochizuki Y, Yoshihashi H, Oishi M, Takasu T, Nozawa K, Uchiyama T, Sawada S The skin changes in the Crow-Fukase (POEMS) syndrome. A case report.
POEMS Syndrome covered by this report. Synonyms crowfukase syndrome; PEP Syndrome; Polyneuropathy-organomegaly-endocrinopathy-M protein-skin lesions; http://my.webmd.com/hw/health_guide_atoz/nord789.asp
Extractions: POEMS syndrome is an extremely rare multisystem disorder. POEMS is an acronym that stands for (P)olyneuropathy, disease affecting many nerves; (O)rganomegaly, abnormal enlargement of an organ; (E)ndocrinoapthy, disease affecting certain hormone-producing glands that help to regulate the rate of growth, sexual development, and certain metabolic functions (endocrine system); (M)onoclonal gammopathy or M proteins; and (S)kin defects. Common symptoms include progressive weakness of the nerves in the arms and legs, an abnormally enlarged liver and/or spleen (hepatosplenomegaly), abnormally darkening of the skin (hyperpigmentation) and excessive hair growth (hypertrichosis). Endocrine abnormalities such as failure of the ovaries and testes (gonads) to function properly (primary gonadal failure) and diabetes mellitus type I may be present. Specific endocrine abnormalities associated with POEMS syndrome vary from case to case.
Blood -- Dispenzieri Et Al. 101 (7): 2496 was shown to be more complex with Crow's1 descriptionof 2 patients with osteosclerotic now call POEMS syndrome, crowfukase syndrome PEP syndrome (plasma cell dyscrasia http://www.bloodjournal.org/cgi/content/full/101/7/2496
Extractions: Clinical Observations, Interventions, and Therapeutic Trials All Versions of this Article: (most recent) Blood, 1 April 2003, Vol. 101, No. 7, pp. 2496-2506 CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS Angela Dispenzieri Robert A. Kyle Martha Q. Lacy S. Vincent Rajkumar Terry M. Therneau Dirk R. Larson Philip R. Greipp Thomas E. Witzig Rita Basu Guillermo A. Suarez Rafael Fonseca John A. Lust and Morie A. Gertz
Extractions: It is possible that the main title of the report is not the name you expected. Please check the synonyms listing to find the alternate name(s) and disorder subdivision(s) covered by this report. Information on the following diseases can be found in the Related Disorders section of this report: POEMS syndrome is an extremely rare multisystem disorder. POEMS is an acronym that stands for (P)olyneuropathy, disease affecting many nerves; (O)rganomegaly, abnormal enlargement of an organ; (E)ndocrinoapthy, disease affecting certain hormone-producing glands that help to regulate the rate of growth, sexual development, and certain metabolic functions (endocrine system); (M)onoclonal gammopathy or M proteins; and (S)kin defects. Common symptoms include progressive weakness of the nerves in the arms and legs, an abnormally enlarged liver and/or spleen (hepatosplenomegaly), abnormally darkening of the skin (hyperpigmentation) and excessive hair growth (hypertrichosis). Endocrine abnormalities such as failure of the ovaries and testes (gonads) to function properly (primary gonadal failure) and diabetes mellitus type I may be present. Specific endocrine abnormalities associated with POEMS syndrome vary from case to case.
POEMS Syndrome - Quest Diagnostics Patient Health Library covered by this report. Synonyms. crowfukase syndrome; PEP Syndrome; Polyneuropathy-organomegaly-endocrinopathy-M protein-skin lesions; http://www.questdiagnostics.com/kbase/nord/nord789.htm
Extractions: It is possible that the main title of the report is not the name you expected. Please check the synonyms listing to find the alternate name(s) and disorder subdivision(s) covered by this report. POEMS syndrome is an extremely rare multisystem disorder. POEMS is an acronym that stands for (P)olyneuropathy, disease affecting many nerves; (O)rganomegaly, abnormal enlargement of an organ; (E)ndocrinoapthy, disease affecting certain hormone-producing glands that help to regulate the rate of growth, sexual development, and certain metabolic functions (endocrine system); (M)onoclonal gammopathy or M proteins; and (S)kin defects. Common symptoms include progressive weakness of the nerves in the arms and legs, an abnormally enlarged liver and/or spleen (hepatosplenomegaly), abnormally darkening of the skin (hyperpigmentation) and excessive hair growth (hypertrichosis). Endocrine abnormalities such as failure of the ovaries and testes (gonads) to function properly (primary gonadal failure) and diabetes mellitus type I may be present. Specific endocrine abnormalities associated with POEMS syndrome vary from case to case.
Entrez PubMed The crowfukase syndrome a study of 102 cases in Japan. Nakanishi T, Sobue I, Toyokura Y, Nishitani H, Kuroiwa Y, Satoyoshi E, Tsubaki http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstra
Entrez PubMed Abstract, Increased vascular endothelial growth factor (VEGF) is causative in crowfukase syndrome Rinsho Shinkeigaku. 1999 Jan;39(1)84-5. Japanese. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Link&db=PubMed&dbFrom=PubMed&f
Blackwell Synergy - Cookie Absent crowfukase syndrome. crow-fukase syndrome was first introduced to Japan at a clinical conference held under the direction of Fukase in 1968. http://www.blackwell-synergy.com/links/doi/10.1046/j.1440-1789.2000.00309.x/abs/
Extractions: Home An Error Occurred Setting Your User Cookie A cookie is a small amount of information that a web site copies onto your hard drive. Synergy uses cookies to improve performance by remembering that you are logged in when you go from page to page. If the cookie cannot be set correctly, then Synergy cannot determine whether you are logged in and a new session will be created for each page you visit. This slows the system down. Therefore, you must accept the Synergy cookie to use the system. What Gets Stored in a Cookie? Synergy only stores a session ID in the cookie, no other information is captured. In general, only the information that you provide, or the choices you make while visiting a web site, can be stored in a cookie. For example, the site cannot determine your email name unless you choose to type it. Allowing a web site to create a cookie does not give that or any other site access to the rest of your computer, and only the site that created the cookie can read it. Please read our for more information about data collected on this site.
Blackwell Synergy - Cookie Absent The crowfukase syndrome a study of 102 cases in Japan. Neurology 1984; 34 712-720. MEDLINE Abstract ISI Abstract. crow-fukase syndrome. diabetic nephropathy. http://www.blackwell-synergy.com/links/doi/10.1111/j.1464-5491.2004.01094.x/enha
Extractions: Home An Error Occurred Setting Your User Cookie A cookie is a small amount of information that a web site copies onto your hard drive. Synergy uses cookies to improve performance by remembering that you are logged in when you go from page to page. If the cookie cannot be set correctly, then Synergy cannot determine whether you are logged in and a new session will be created for each page you visit. This slows the system down. Therefore, you must accept the Synergy cookie to use the system. What Gets Stored in a Cookie? Synergy only stores a session ID in the cookie, no other information is captured. In general, only the information that you provide, or the choices you make while visiting a web site, can be stored in a cookie. For example, the site cannot determine your email name unless you choose to type it. Allowing a web site to create a cookie does not give that or any other site access to the rest of your computer, and only the site that created the cookie can read it. Please read our for more information about data collected on this site.
Crow-Fukase Syndrome : On Medical Dictionary Online Link to the Medical Dictionary Online. crowfukase syndrome. A multisystemic disorder characterized by a sensorimotor polyneuropathy http://www.online-medical-dictionary.org/?q=Crow-Fukase Syndrome
