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Cowden Syndrome:     more detail

Cowden syndrome more common than suspected. (Genetic Cancer Syndrome).: An article from: Skin & Allergy News by Bruce Jancin, 2003-03-01 Cowden Syndrome - A Bibliography and Dictionary for Physicians, Patients, and Genome Researchers by Philip M. Parker, 2007-07-20 Cowden syndrome more common than suspected: linked to breast cancer risk. (Clinical Rounds).: An article from: Internal Medicine News by Bruce Jancin, 2003-04-01 Genetic cancer syndrome more common than suspected. (Cowden Syndrome).: An article from: Family Practice News by Bruce Jancin, 2003-03-01

lists with details

21. Genetics Of PTEN In Cowden Syndrome And Sporadic Breast Cancer - Storming Media
    Germline mutations in PTEN on 10q23.3 cause 80% of classic cowden syndrome (CS)and SO of BannayanRiley-Ruvalcaba syndrome (CS) as well as up to 20% of  
    http://www.stormingmedia.us/30/3038/A303893.html
    
    Extractions: BIOLOGICAL SCIENCES Genetic Engineering and Molecular Biology Authors: Eng, Charis; OHIO STATE UNIV RESEARCH FOUNDATION COLUMBUS Abstract: Limitations: APPROVED FOR PUBLIC RELEASE Description: Final rept. 1 Oct 1998-30 Sep 2001 Pages: Report Date: OCT 2001 Report number: Price: (24% savings) Shipping terms

22. Genetics Of PTEN In Cowden Syndrome And Sporadic Breast Cancer
    3, is associated with 80% of cowden syndrome (CS) probands ascertainedby the strict operational diagnostic criteria of the Intern.  
    http://www.stormingmedia.us/64/6489/A648983.html

23. Cowden Syndrome
    cowden syndrome. (Dec 2002). I. Contracting. 1. Includes cowden syndrome,BannayanRiley-Ruvalcaba, Proteus syndrome, and Proteus-like syndrome.  
    http://www.genesoc.com/counseling/Outlines/Cowden syndrome.htm
    
    Extractions: Resources for Genetic Counselors site updated May 10, 2004 outlines links search Cowden Syndrome (Dec 2002) I. Contracting A. What were you told about why you were referred? B. What would you like to learn today? C. Do you have any questions or concerns that you would like us to address? A. Breast cancer? Endometrial cancer? Benign or malignant tumor of thyroid? B. Renal cell carcinomas, melanoma, glioblastoma? C. Hamartomas of colon, GI tract? D. Macrocephaly? Mental retardation? E. Facial or oral mucocutaneous lesions (trichilimmomas)? F. Fibrocystic breast disease? G. Lipomas or fibromas? H. Lhermitte-Duclos disease (hamartoma of cerebellum) – altered gait or seizures? A. Multiple hamartoma syndrome with high risk for benign and malignant tumors of breast, thyroid, and endometrium B. Part of PTEN hamartoma tumor syndrome (PHTS) Includes Cowden syndrome, Bannayan-Riley-Ruvalcaba, Proteus syndrome, and Proteus-like syndrome Causes hamartomas and cancer due to PTEN mutations C.

24. Cowden Syndrome
    cowden syndrome. The risk for breast of specific noncancerous features.cowden syndrome is associated with the following characteristics  
    http://www.healthsystem.virginia.edu/uvahealth/adult_breast/cowden.cfm
    
    Extractions: @import url(/assets/UVAHealth/ssi/css/greystone_advance.css); Blood Disorders Bone Disorders Breast Health Cardiovascular Disease Dermatology Diabetes Digestive Disorders Endocrinology Environmental Medicine Eye Care Glossary Gynecological Health Infectious Diseases Kidney Disease Men's Health Mental Health Nervous System Disorders Non-Trauma Emergency Oral Health Orthopaedics Otolaryngology Pathology Pediatrics, General Health Prostate Health Radiology Respiratory Disorders Skin Cancer Surgical Care Urology Women's Health FIND A DOCTOR MAKE AN APPOINTMENT CALENDAR OF EVENTS CLINICAL TRIALS ... WHY CHOOSE UVA The risk for breast cancer is increased with Cowden syndrome, a rare autosomal dominant disorder that is also associated with a number of specific noncancerous features. Cowden syndrome is associated with the following characteristics: multiple hamartomatous lesions (benign, or noncancerous,tumors of normal organ tissue) of the skin and other organs, usually present by the late 20s

25. Síndrome De Cowden (Cowden Syndrome)
    Translate this page Topics. Genética del Cáncer del Seno (Genetics of BreastCancer). Síndrome de Cowden (cowden syndrome)  
    http://www.healthsystem.virginia.edu/UVAHealth/adult_breast_sp/cowden.cfm
    
    Extractions: @import url(/assets/UVAHealth/ssi/css/greystone_advance.css); Alergias y Asma Artritis Cáncer de La Piel Cirugía Ortopédica Cirugía Plástica Columna-Hombro-Pelvis Cuidado de Los Ojos Cuidado Quirúrgico Dermatología Diabetes Embarazo y Parto Emerg. No Traumática Endocrinología Enf. Cardiovasculares Enf. Digestivas Enf. Infecciosas Hematología Hígado-Bilis-Páncreas Huesos Med. Medio Ambiente Med. para el Viajero Medicina Alternativa Otorrinolaringología Patología Pediatría Problemas Respiratorios Radiología Rehabilitación Salud de la Próstata Salud de las Mujeres Salud de los Hombres Salud del Seno Salud en el Hogar Salud Ginecológica Salud Mental Salud Oral Sistema Nervioso Urología FIND A DOCTOR MAKE AN APPOINTMENT CALENDAR OF EVENTS CLINICAL TRIALS ... Los Recursos en la Red de La Salud del Seno. Topics Genética del Cáncer del Seno (Genetics of Breast Cancer)

26. Genetic Disorders: Cowden Syndrome
    Genetic Disorders cowden syndrome. cowden syndrome. A CHORUS notecarddocument about this syndrome. Cowdens Syndrome Support Group.  
    http://www.puredirectory.com/Health/Conditions-and-Diseases/Genetic-Disorders/Co
    
    Extractions: Home Health Conditions and Diseases Genetic Disorders : Cowden Syndrome google_ad_client = 'pub-3272565765518472';google_ad_width = 336;google_ad_height = 280;google_ad_format = '336x280_as';google_color_border = 'FFFFFF';google_color_bg = 'FFFFFF';google_ad_channel ='7485447737';google_alternate_color = 'FFFFFF';google_color_link = '0000FF';google_color_url = '008000';google_color_text = '000000';

27. Cowden Syndrome
    Home Health Conditions and Diseases Genetic Disorders cowden syndrome (3)See Also cowden syndrome A CHORUS notecard document about this syndrome.  
    http://www.thenewhealthfind.com/Health/ConditionsandDiseases/GeneticDisorders/Co

28. Genetics Cancer - Cowden Syndrome
    Cancer The Genetics of Breast and Ova / Genetics Cancer - cowden syndrome CowdenSyndrome. cowden syndrome is associated with the following characteristics  
    http://www.readinghospital.org/content/content.asp?pageid=P07171

29. Kprones CowdenID10018
    Bibliography. Cowden s disease a possible new syndrome with multiple system involvement. Thecowden syndrome a clinical and genetic study in 21 patients.  
    http://www.infobiogen.fr/services/chromcancer/Kprones/CowdenID10018.html
    
    Extractions: Home Genes Leukemias Solid Tumours ... NA Identity Other names Multiple hamartoma syndrome Inheritance autosomal dominant; high penetrance (close to 100% by the age of 30 yrs); highly variable expressivity (between and within families) Clinics Phenotype and clinics clinical manifestations usually occur during the 2nd and 3rd decade; they are dystrophic, hamartomatous or tumoral lesions including the following to variable extend: Overlapping syndromes Bannayan-Riley-Ruvalcaba syndrome including precocious stigmata of Cowden disease (macrocephaly, lipomas, genital pigmented macules, hamartomatous intestinal tract polyps) is considered as a pediatric form of Cowden disease Lhermitte Duclos syndrome or dysplastic gangliocytoma of the cerebelum is a rare and complex hamartomatous condition of the cerebellum which can occur alone but also in association with Cowden disease juvenile polyposis and Peutz Jeghers syndrome : Cowden disease, by its intestinal tract lesions can be linked to the scope of hereditary hamartomatous polyposis; molecular diagnosis can be useful in distinguishing juvenile polyposis, Peutz Jeghers syndrome or Cowden disease/Bannayan

30. Health, Conditions And Diseases, Genetic Disorders: Cowden Syndrome
    Cowden disease (CD), also termed cowden syndrome and multiple hamartoma syndrome,is an autosomal dominant condition with variable expression that results from  
    http://www.combose.com/Health/Conditions_and_Diseases/Genetic_Disorders/Cowden_S
    
    Extractions: Related links of interest: Cowden disease (CD), also termed Cowden syndrome and multiple hamartoma syndrome, is an autosomal dominant condition with variable expression that results from a mutation in the PTEN gene on chromosome arm 10q, as reported by Liaw et al. CD causes hamartomatous neoplasms of the skin and mucosa, GI tract, bones, central nervous system (CNS), eyes, and genitourinary tract. Skin is involved in 90-100% of cases; the thyroid in 66%. Help build the largest human-edited directory on the web. Submit a Site Open Directory Project Become an Editor The combose.com directory is based on the Open Directory and has been modified and enhanced using our own technology.

31. OB/GYN News: Cowden Syndrome More Common Than Suspected - Linked To Increased Ri
    Print friendly Tell a friend Find subscription deals cowden syndrome more commonthan suspected Linked to Increased Risk for Breast CA OB/GYN News, March 15  
    http://articles.findarticles.com/p/articles/mi_m0CYD/is_6_38/ai_99376510
    
    Extractions: SAN ANTONIO Cowden syndrome is much more common than traditionally thought, Dr. Charis Eng said at a breast cancer symposium sponsored by the San Antonio Cancer Institute. Since the discovery that germline mutations of the tumor suppressor gene PTEN cause Cowden syndrome, it has become evident that some women who present with breast cancer in the absence of obvious features of Cowden syndrome have unsuspected PTEN mutations. The same is likely to hold true for as yet uncertain numbers of men and women presenting with what appears to be isolated thyroid cancer or a broad range of other disorders, according to Dr. Eng, professor of medicine and director of the clinical cancer genetics program at Ohio State University in Columbus. Cowden syndrome is notoriously difficult to diagnosis. Penetrance of PTEN mutations is variable, the spectrum of associated clinical manifestations is large and diverse, and the hallmark skin lesions are subtle and easily missed.

32. :: Ez2Find :: Cowden Syndrome
    Guide cowden syndrome, Global Metasearch Any Language Guides, cowden syndrome.ez2Find Home Directory Health  
    http://ez2find.com/cgi-bin/directory/meta/search.pl/Health/Conditions_and_Diseas
    
    Extractions: Any Language English Afrikaans Arabic Bahasa Melayu Belarusian Bulgarian Catala Chinese Simplified Chinese Traditional Cymraeg Czech Dansk Deutsch Eesti Espanol Euskara Faroese Francais Frysk Galego Greek Hebrew Hrvatski Indonesia Islenska Italiano Japanese Korean Latvian Lietuviu Lingua Latina Magyar Netherlands Norsk Polska Portugues Romana Russian Shqip Slovensko Slovensky Srpski Suomi Svenska Thai Turkce Ukrainian Vietnamese Mode

33. Genetics & Cancer - Cowden Syndrome
    Search YMG. cowden syndrome. cowden syndrome is a rare autosomal dominant disorderthat is also associated with a number of specific noncancerous features.  
    http://ymghealthinfo.org/content.asp?pageid=P07171

34. Cowden Syndrome
    Search the MerriamWebster Medical Dictionary. About YMG. Search YMG. CowdenSyndrome. cowden syndrome is associated with the following characteristics  
    http://ymghealthinfo.org/content.asp?page=I220

35. Ministry Health Care
    Home Page  Health Information  Breast Health Home Page ÂBreast Health Site Index  cowden syndrome, cowden syndrome.  
    http://www.ministryhealth.org/display/ppf/docid/17745/router.aspx
    
    Extractions: Locations/Maps Print Page Site Map Home Page ... Breast Health Site Index Cowden Syndrome Search Home Page Breast Health Site Index Ataxia Telangiectasia (A-T) Cowden Syndrome Genetics of Breast Cancer Hereditary Breast Ovarian Cancer Syndrome (BRCA1 / BRCA2) Li-Fraumeni Syndrome Peutz-Jeghers Syndrome ... The Ministry Network The risk for breast cancer is increased with Cowden syndrome, a rare autosomal dominant disorder that is also associated with a number of specific noncancerous features. Cowden syndrome is associated with the following characteristics: increased risk of endometrial cancer Additional features can include noncancerous thyroid lesions, hamartomatous intestinal polyps, lipomas (benign fatty tumors), fibromas, uterine fibroids, and fibrocystic disease of the breast. Some individuals who have inherited a germline PTEN mutation never develop cancer because they never get the second mutation necessary to knock out the function of the gene and start the process of tumor formation. This can make the cancer appear to skip generations in a family, when, in reality, the mutation is present. Persons with a mutation, regardless of whether they develop cancer, however, have a 50/50 chance to pass the mutation on to the next generation. It is also important to remember that the PTEN gene is not located on the sex chromosomes. Therefore, mutations can be inherited from the mother or the father's side of the family.

36. EMedicine - Cowden Disease (Multiple Hamartoma Syndrome) : Article By Charles Mi
    Cowden Disease (Multiple Hamartoma Syndrome) Cowden disease (CD), also termedcowden syndrome and multiple hamartoma syndrome, is an autosomal dominant  
    http://www.emedicine.com/DERM/topic86.htm
    
    Extractions: (advertisement) Home Specialties Resource Centers CME ... Patient Education Articles Images CME Patient Education Advanced Search Consumer Health Link to this site Back to: eMedicine Specialties Dermatology Internal Medicine Last Updated: July 10, 2002 Rate this Article Email to a Colleague Synonyms and related keywords: multiple hamartoma syndrome, Cowden syndrome AUTHOR INFORMATION Section 1 of 10 Author Information Introduction Clinical Differentials ... Bibliography Author: Charles Miller, MD , Dermatologist, Department of Dermatology, Southern California Kaiser Permanente Charles Miller, MD, is a member of the following medical societies: American Academy of Dermatology Editor(s): Craig A Elmets, MD , Director of Dermatology, Departments of Dermatology, Professor, Pathology, Environmental Health Sciences, The Kirklin Clinic, University of Alabama at Birmingham; Richard Vinson, MD , Chief, Department of Dermatology, William Beaumont Medical Center; Lester Libow, MD

37. EMedicine - Trichilemmoma : Article Excerpt By: William P Baugh, MD
    cowden syndrome is a rare autosomal dominant condition characterized by the formationof multiple types of hamartomas and neoplastic growths, which may be  
    http://www.emedicine.com/derm/byname/trichilemmoma.htm
    
    Extractions: (advertisement) Synonyms, Key Words, and Related Terms: tricholemmoma, benign neoplasms of the follicular epithelium, Cowden syndrome, Cowden’s syndrome, Cowden disease, Cowden’s disease, multiple hamartomas, multiple hamartoma syndrome, nevus sebaceous of Jadassohn Background: In 1962, Headington and French first described trichilemmoma as a benign neoplasm with differentiation toward pilosebaceous follicular epithelium. Subtle clinical and distinctive histologic features may characterize these superficial cutaneous tumors. Their significance resides in the association with Cowden disease and the need to differentiate trichilemmomas from other more aggressive cutaneous tumors. Clinically, trichilemmomas present as smooth, asymptomatic papules or verrucoid growths. They may occur as a solitary lesion or as multiple lesions, and they are usually found on the face (see Image 1 ). These lesions often mimic a basal cell carcinoma or a wart. Trichilemmoma should be considered in the differential diagnosis of any indistinct facial papule. Differentiation from a basal cell carcinoma or a trichilemmal carcinoma is needed for appropriate patient management. Trichilemmomas are often reported in association with a nevus sebaceous of Jadassohn. When many trichilemmomas are present, Cowden disease (multiple hamartoma syndrome) should be suspected. The diagnosis of trichilemmoma is usually obtained by microscopic examination, revealing distinct histologic features.

38. Anales De Medicina Interna -
    Translate this page Hamartomas m?tiples. Oral. cowden syndrome a clinical case with orallesions. KEY WORDS cowden syndrome. Multiple hamartomas. Oral.  
    http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S0212-7199200100080000

39. An. Med. Interna (Madrid)  Vol.18 no.8; Abstract: S0212-71992001000800006
    cowden syndrome a clinical case with oral lesions . An. Med. Interna (Madrid),Aug. Keywords cowden syndrome; Multiple hamartomas; Oral.  
    http://scielo.isciii.es/scielo.php?script=sci_abstract&pid=S0212-719920010008000

40. Gastric Hamartomatous Polyposis, Cowden Syndrome, And H. Pylori.
    Click here to read Gastric hamartomatous polyposis, cowden syndrome,and H. pylori. Isomoto H, Urata M, Mizuta Y, Kohno S, Sawada  
    http://www.biomedcentral.com/pubmed/15093765

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