NINDS Mobius Syndrome Information Page Also known as congenital facial diplegia, an information sheet compiled by NINDS. http://www.ninds.nih.gov/health_and_medical/disorders/mobius.htm
Extractions: Mobius syndrome is a rare birth defect caused by the absence or underdevelopment of the 6th and 7th cranial nerves, which control eye movements and facial expression. The first symptom, present at birth, is an inability to suck. Other symptoms can include: feeding, swallowing, and choking problems; excessive drooling; crossed eyes; lack of facial expression; inability to smile; eye sensitivity; motor delays; high or cleft palate; hearing problems; and speech difficulties. Small or absent brain stem nuclei that control the cranial nerves, as well as decreased numbers of muscle fibers, have been reported. Deformities of the tongue, jaw, and limbs, such as clubfoot and missing or webbed fingers, may also occur. As children get older, lack of facial expression and inability to smile become the dominant visible symptoms. The prognosis for otherwise normal development is excellent in most cases.
Extractions: It is possible that the main title of the report is not the name you expected. Please check the synonyms listing to find the alternate name(s) and disorder subdivision(s) covered by this report. Moebius syndrome is a rare developmental disorder that may have a number of different causes and is characterized by facial paralysis present at birth (congenital). Facial nerve development is absent or diminished causing abnormalities of the facial muscles and jaw. The sixth (abducens) and seventh (facialis) cranial nerves are most often affected. Additional symptoms may include numerous abnormalities of the mouth and face (orofacial region) and malformations of limbs. Mental retardation occurs in approximately 10 percent of cases. Most cases of Moebius syndrome occur randomly, for no apparent reason (sporadic cases). Children's Craniofacial Association
MedlinePlus: Facial Injuries And Disorders Know the Score on Facial Sports Injuries ( American Academy of OtolaryngologyHead and Mobius Syndrome (congenital facial diplegia) ( National Institute of Neurological Disorders and http://www.nlm.nih.gov/medlineplus/facialinjuriesanddisorders.html
Extractions: General/Overviews Facial Injuries (American Association of Oral and Maxillofacial Surgeons) - Links to PDF File Anatomy/Physiology Atlas of the Body: The Skull (American Medical Association) Clinical Trials ClinicalTrials.gov: Craniofacial Abnormalities (National Institutes of Health) Specific Conditions/Aspects Coffin Lowry Syndrome (National Institute of Neurological Disorders and Stroke) - Short Summary Craniofacial Syndrome Descriptions (Children's Craniofacial Association) Craniosynostosis and Craniofacial Disorders (American Association of Neurological Surgeons) Crouzon Syndrome (Craniofacial Dysostosis) (Cleft Palate Foundation) Hemifacial Spasm (National Institute of Neurological Disorders and Stroke) - Short Summary Holoprosencephaly (National Institute of Neurological Disorders and Stroke) - Short Summary Information About Pierre Robin Sequence/Complex (Cleft Palate Foundation) Know the Score on Facial Sports Injuries (American Academy of OtolaryngologyHead and Neck Surgery) Melkersson-Rosenthal Syndrome (National Institute of Neurological Disorders and Stroke) - Short Summary
Extractions: This survey of medical eponyms and the persons behind them is meant as a general interest site only. No information found here must under any circumstances be used for medical purposes, diagnostically, therapeutically or otherwise. If you, or anybody close to you, is affected, or believe to be affected, by any condition mentioned here: see a doctor. Akinesia algera; arthrogryposis; congenital abducens-facial paralysis; congenital bulbar paralysis; congenital facial diplegia; congenital facial paralysis; congenital nuclear agenesis; congenital nuclear aplasia; congenital occulofacial paralysis; congenital paralysis of the sixth and seventh nerves; infantile nuclear aplasia; nuclear agenesis syndrome; oculofacial paralysis syndrome; In this very rare syndrome, the abducens and facial nerves, which originate in the brain stem, may not develop from birth. It is characterized by congenital palsy of the external rectus and facial muscles, usually bilateral, associated with paralysis of the sixth and seventh nerves. The patient has a masklike expression and is unable to abduct the eyes beyond midpoint. Involvement of the jaw may cause feeding problems.
NINDS - Health And Medical Type II Coffin Lowry Syndrome Coma, including Persistent Vegetative State ComplexRegional Pain Syndrome congenital facial diplegia Congenital Myasthenia http://www.ninds.nih.gov/health_and_medical/research.htm
Extractions: Web Directory: About.com with Laura L. Jelliffe, Ph.D. Symptoms, diagnosis, and treatment of mobius syndrome. Information on research, community outreach and support. MCW Healthlink: Mobius Syndrome Details about this disease, including what it is, the causes, symptoms and treatment options. Mobius Syndrome Also known as congenital facial diplegia, an information sheet compiled by NINDS.
EMedicine - Möbius Syndrome : Article By Cheryl Ann Palmer, MD Möbius Syndrome Möbius syndrome is due, in part, to loss of function of motor cranial nerves. Although von Graefe described a case of congenital facial diplegia in 1880, the syndrome was only http://www.emedicine.com/neuro/topic612.htm
Extractions: (advertisement) Home Specialties Resource Centers CME ... Patient Education Articles Images CME Patient Education Advanced Search Consumer Health Link to this site Back to: eMedicine Specialties Neurology Pediatric Neurology Last Updated: November 28, 2001 Rate this Article Email to a Colleague Synonyms and related keywords: congenital facial diplegia, congenital nuclear agenesis, congenital nuclear hypoplasia, congenital oculofacial paralysis AUTHOR INFORMATION Section 1 of 11 Author Information Introduction Clinical Differentials ... Bibliography Author: Cheryl Ann Palmer, MD , Fellowship Director, Associate Professor, Departments of Pathology and Neurology, University of Alabama at Birmingham Cheryl Ann Palmer, MD, is a member of the following medical societies: American Academy of Neurology American Association of Neuropathologists College of American Pathologists , and Medical Association of the State of Alabama Editor(s): Robert Baumann, MD , Program Director, Professor, Departments of Neurology and Pediatrics, University of Kentucky;
Extractions: Moebius syndrome is a rare developmental disorder that may have a number of different causes and is characterized by facial paralysis present at birth (congenital). Facial nerve development is absent or diminished causing abnormalities of the facial muscles and jaw. The sixth (abducens) and seventh (facialis) cranial nerves are most often affected. Additional symptoms may include numerous abnormalities of the mouth and face (orofacial region) and malformations of limbs. Mental retardation occurs in approximately 10 percent of cases. Most cases of Moebius syndrome occur randomly, for no apparent reason (sporadic cases).
Extractions: (advertisement) Synonyms, Key Words, and Related Terms: congenital facial diplegia, congenital nuclear agenesis, congenital nuclear hypoplasia, congenital oculofacial paralysis Background: Möbius syndrome is due, in part, to loss of function of motor cranial nerves. Although von Graefe described a case of congenital facial diplegia in 1880, the syndrome was reviewed and defined further by Möbius in 1888 and 1892. Because of these contributions, Möbius is now the eponym used to describe the syndrome. The definition and diagnostic criteria for Möbius syndrome vary among authors. Both von Graefe and Möbius accepted only cases with both congenital facial diplegia and bilateral abducens nerve palsies as constituting Möbius syndrome. In 1939, Henderson broadened the definition and included cases with congenital unilateral facial palsy. Other authors are more restrictive in attempts to eliminate conditions of a different pathogenesis being labeled as Möbius syndrome. These investigators require the presence of a congenital musculoskeletal anomaly in order to make the diagnosis. Pathophysiology: The complete pathophysiological description of Möbius syndrome remains elusive. Whether nerve, brainstem, or muscle aplasia is the primary event has not been established. Nerves that may be involved include cranial nerves (CN) VI through XII, with general sparing of CN VIII. CN III and CN IV can be involved, but rarely are. The facial nerves (CN VII) are involved in all cases, the abducens nerves (CN VI) in a high percentage of cases (75%), and the hypoglossal nerves (CN XII) in only a minority of cases.
:: Ez2Find :: Mobius Syndrome html; Mobius Syndrome Site Info - Translate - Open New Window Also knownas congenital facial diplegia, an information sheet compiled by NINDS. http://ez2find.com/cgi-bin/directory/meta/search.pl/Health/Conditions_and_Diseas
Extractions: Any Language English Afrikaans Arabic Bahasa Melayu Belarusian Bulgarian Catala Chinese Simplified Chinese Traditional Cymraeg Czech Dansk Deutsch Eesti Espanol Euskara Faroese Francais Frysk Galego Greek Hebrew Hrvatski Indonesia Islenska Italiano Japanese Korean Latvian Lietuviu Lingua Latina Magyar Netherlands Norsk Polska Portugues Romana Russian Shqip Slovensko Slovensky Srpski Suomi Svenska Thai Turkce Ukrainian Vietnamese Mode Guides Mobius Syndrome Web Sites About.com with Laura L. Jelliffe, Ph.D. [Site Info] [Translate] [Open New Window] MCW Healthlink: Mobius Syndrome [Site Info] [Translate] [Open New Window] Details about this disease, including what it is, the causes, symptoms and treatment options. URL: http://healthlink.mcw.edu/article/921441372.html
Extractions: Any Language English Afrikaans Arabic Bahasa Melayu Belarusian Bulgarian Catala Chinese Simplified Chinese Traditional Cymraeg Czech Dansk Deutsch Eesti Espanol Euskara Faroese Francais Frysk Galego Greek Hebrew Hrvatski Indonesia Islenska Italiano Japanese Korean Latvian Lietuviu Lingua Latina Magyar Netherlands Norsk Polska Portugues Romana Russian Shqip Slovensko Slovensky Srpski Suomi Svenska Thai Turkce Ukrainian Vietnamese Mode
Moebius Syndrome Northern California Moebius Syndrome Support Group Homepage. MOEBIUS SYNDROMESUPPORT NETWORK HOMEPAGE. Moebius Syndrome (congenital facial diplegia) http://www.health-nexus.com/moebius_syndrome.htm
Extractions: Health-Nexus.Net Health-Nexus.Org The #1 Health information site Search Health-Nexus for: Match ALL words Match ANY word Email this page to a friend ! Post a question or comment on our Message Board Home Page Health Specialties Health News ... Alternative Health Options Substance Abuse Animal Health Search: Books Magazines Video Keywords: Find it Here Moebius Syndrome Moebius Syndrome Foundation of Canada The Moebius Syndrome Foundation of Australia is gathering speed. Moebius Syndrome Foundation of Australia
Neuroguide.com - Human Neurological Diseases Web sites providing information on human neurological diseases can be accessed viathis section. congenital facial diplegia. Mobius Syndrome Information (NINDS). http://www.neuroguide.com/cgi-bin/pdistoc.pl?file=CongenitalFacialDiplegia
Síndrome De Mobius Unilateral Translate this page Mobius syndrome The congenital facial diplegia syndrome. Arch Dis Childh. The congenitalFacial diplegia syndrome clinical features, pathology and ethiology. http://www.encolombia.com/otorrino28200-sindrome.htm
Extractions: María Fernanda Aragón****, MD. Profesor Asociado Universidad Militar Nueva Granada. Servicio de Otorrinolaringología, Grupo de Otología-Neurotología. Hospital Militar Central. Santafé de Bogotá, Colombia. Profesor Universidad Militar Nueva Granada. Jefe del Servicio de Otorrinolaringología, Grupo de Otología-Neurotología. Hospital Militar Central. Santafé de Bogotá, Colombia. Residente Tercer Nivel Universidad Militar Nueva Granada. Servicio de Otorrinolaringología. Hospital Militar Central. Santafé de Bogotá, Colombia. Residente Segundo Nivel Universidad Militar Nueva Granada. Servicio de Otorrinolaringología. Hospital Militar Central. Santafé de Bogotá, Colombia. RESUMEN El síndrome de Mobius es una entidad caracterizada por parálisis del VI y VII par, pudiendo existir compromiso de otros pares craneanos o asociación a alteraciones de la pared torácica, retardo mental y alteraciones de las extremidades. Normalmente es de presentación bilateral, pero puede presentarse en forma unilateral. El presente reporte muestra el caso de una paciente de 15 años de edad quién consulta por presentar parálisis facial congénita unilateral y VI par ipsilateral; siendo estas sus únicas manifestaciones clínicas.
Extractions: I CONG - CRAM http://dermatlas.med.jhmi.edu/derm/ Congenital (Infantile) Glaucoma (Glaucoma) Congenital Abnormalities http://cpmcnet.columbia.edu/texts/guide/toc/toc09.html Congenital Abnormalities http://www.hc-sc.gc.ca/hpb/lcdc/search_e.html Congenital abnormalities and disorders http://www.intelihealth.com/IH/ihtIH/WSIHW000/9339/9339.html?k=menux408x9939xALZ Congenital Absence of the Abdominal Muscles http://my.webmd.com/content/healthwise/30/7398 Congenital Absence of the Rods and Cones http://my.webmd.com/content/healthwise/30/7398 Congenital Absence of the Thymus and Parathyroids http://my.webmd.com/content/healthwise/30/7398 Congenital Achromia http://my.webmd.com/content/healthwise/30/7398 Congenital adrenal hyperplasia http://health.yahoo.com/encyclopedia/a.html Congenital Adrenal Hyperplasia Congenital Adrenal Hyperplasia http://www.healthcentral.com/library/library.cfm Congenital Adrenal Hyperplasia http://content.health.msn.com/content/healthwise/106/26476 Congenital Adrenal Hyperplasia http://www.ahealthyme.com/primerindex/a
Moebius Syndrome And Possible Causes Ziter et al. (1977) observed congenital facial diplegia and flexionfinger contractures in 7 members of 3 generations of a family. http://neuro-www.mgh.harvard.edu/forum/MoebiusSyndromeF/3.21.982.19AMMoebiussynd
Extractions: Harbord et al. (1989) described a child with Moebius syndrome associated with unilateral cerebellar hypoplasia. Journel et al. (1989) described Moebius syndrome in 2 brothers and a male first cousin who were sons of sisters, thus suggesting X-linked recessive inheritance. The 2 brothers also had hypoplasia of the thumbs and absence of the big toes. Kawai et al. (1990) described the fourth case of Moebius syndrome (which they referred to as Moebius sequence) associated with peripheral neuropathy and hypogonadotropic hypogonadism. Pulsatile administration of gonadotropin-releasing hormone for 3 months was effective therapy. Kumar (1990) provided a review, which was critiqued by Lipson et al. (1990). MacDermot et al. (1991) urged that the term Moebius syndrome be restricted to cases with congenital sixth and seventh nerve paralysis with skeletal defects; according to their analysis, the recurrence risk is low (about 2%) in these cases. In their review, no recurrence was noted in 31 cases with cranial nerve palsies associated with oral abnormalities and limb defects. The features in an index case that may indicate a higher risk of recurrence are the absence of skeletal defects, isolated facial palsy, deafness, ophthalmoplegia, and digital contractures. As an example of the latter category, MacDermot et al. (1991) described mother and son with fifth, sixth, seventh, and bulbar cranial nerve paralysis who had 2 similarly affected relatives: the mother's maternal aunt and her son.
Leslie of two cases. med8589 327 The spectrum of congenital facial diplegia(Moebius syndrome). med75-79 327 Moebius syndrome. med93-95 http://neuro-www.mgh.harvard.edu/neurowebforum/ChildNeurologyArticles/Leslie.htm
Extractions: Although previuosly it was thought that there was an agenesis ( failure to develop )of the control centers for the cranial nerves ( especially cranial nerve VI and VII) some of the recent research seems to call this into question. If there is complete agenesis this means that there is no possibility of the facial paralysis improving or worsening. One recent report describes muscle recruitment measured by EMG studies in two Moebius patients following treatment with simple physical therapy. In another report there is described improvement in facial paralysis using biofeedback techniques (the patients were both children). The Miami Project in FL seems to be the center that is doing the most research with biofeedback training in muscle paralysis. There is also a research center in England who claims to have gotten improvement in muscle hypotonia and facial paralysis using a type of tactile kinesthetic stimulation using "brushing technique" wirth a number of Moebius patients (mostly children). As of yet their research is unpublished. There are likewise reports of a Moebius patient's paralysis worsening and thought to be caused by a superimposed Bell's Palsy. When I was younger I recieved treatment at the Michigan State University
