Extractions: Bovine Spongiform Encephalopathy (BSE), commonly known as "mad cow disease", is a fatal brain disease that affects cattle. The disease is named after the characteristic sponge-like changes to the brain that it causes. BSE usually has an incubation period of 4-5 years from the time that the animal is exposed. The condition is fatal within weeks or months of its onset. The first signs are weight loss and nervousness. BSE is one type of a group of prion diseases referred to as Transmissible Spongiform Encephalopathies (TSEs). TSEs are fatal diseases that cause spongy degeneration of the brain and severe neurological symptoms. Another example of a TSE is scrapie, a disease found in sheep and goats. TSEs have also been found in other animals including mink, North American mule deer, elk and cats. TSE's found in humans include Creutzfeldt Jakob Disease (CJD) and variant-Creutzfeldt Jakob Disease (vCJD). What causes BSE?
Extractions: Suggested Resources for Further Information Bovine spongiform encephalopathy (BSE) is a disease condition in cattle which is thought to have originated in Great Britain. It occurs in cattle between two and eight years old and is always fatal. The most plausible cause of the disease is a prion, a "self-replicating" protein, rather than a bacterium or virus. BSE causes a portion of the brain to become sponge-like. Brain, central nervous system tissue, and the distal ileum (portion of the small intestine) can carry the infective agent, and measures have been taken to exclude those parts known to carry the infective agent (primarily brain and central nervous system tissue) from the food and feed supply. BSE is often referred to as "mad cow" disease, because animals infected with the disease are often irritable and can react in a somewhat violent or threatening fashion when approached by humans.
Mad Cow Disease And Cjd current news on prions, mad cow disease (bovine spongiform encephalopathy or BSE),scrapie, CreutzfeldtJakob Disease (CJD and nvCJD), kuru,and chronic wasting http://www.purefood.org/madcow.htm
Entrez PubMed bovine spongiform encephalopathy. Holt TA, Phillips J. St James Hospital,London. MeSH Terms Animals; Brain; Brain Diseases/transmission http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=3
Entrez PubMed The risk of bovine spongiform encephalopathy ( mad cow disease )to human health. Brown P. Laboratory of Central Nervous System http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9
Healthfinder® Bovine Spongiform Encephalopathy (BSE) These guidelines are designed to prevent the establishment and spread in the USof bovine spongiform encephalopathy (BSE), the disease commonly known as. http://www.healthfinder.gov/HTMLGen/HFDocs.cfm?DocumentID=3928
CÈó]Ç iBSEj USDA(United States Department of Agriculture)(). BovineSpongiform Encephalopathy ( BSE ). OIE bovine spongiform encephalopathy. http://niah.naro.affrc.go.jp/disease/bse/bse-s.html
USACHPPM - Main bovine spongiform encephalopathy (BSE) (Mad Cow Disease). Bovine SpongiformEncephalopathy (BSE) was first diagnosed in Great Britain in 1986. http://chppm-www.apgea.army.mil/madcowdisease/
Extractions: On 23 December 2003, the US Department of Agriculture (USDA) reported the first suspected case of BSE within the United States in Washington State. This case was from a downer Holstein cow (unable to rise and walk on its own), and samples were collected at slaughter on 9 December 2003 as part of the USDAs routine surveillance program for BSE. Final confirmation is being determined in the United Kingdom and results will be released within 3-5 days. USDA officials are investigating the origin of the animal and how its remains were processed. The farm where the cow first showed clinical signs was identified and has been quarantined.
Extractions: There are also human conditions that are similar to the animal diseases. In most cases the human diseases are not due to transmissible agents. They can be genetic diseases that run in families, a mutation that happens sporadically in individuals and probably animals as well, or they may be transmitted by ingestion of the infectious agent (e.g. kuru of the Fore people was caused by ritualized cannibalism). There is still some controversy regarding the nature of the transmissible agent that causes these fatal conditions, but the most accepted theory is that the agent is a modified form of a normal cell surface component known as a prion (proteinaceous infectious articles and (pronounced preeon) protein) (PrP). This modified version of PrP is disease causing, and is both less soluble and more resistant to enzyme degradation then the normal protein. "Currently there is no known treatment for prion diseases, and the fear that prions passed from cattle to humans may be justified."
Www.foodsafety.gov - Bovine Spongiform Encephalopathy bovine spongiform encephalopathy Mad Cow Disease . Federal Government Web Sites. InternationalWeb Sites. bovine spongiform encephalopathy (BSE) (WHO). http://www.foodsafety.gov/~fsg/bse.html
Extractions: "Mad Cow Disease" Federal Government Web Sites Commonly Asked Questions About BSE in Products Regulated by FDA's Center for Food Safety and Applied Nutrition (CFSAN) January 14, 2004 (FDA) BSE Information and Resources January 2004 (USDA) BSE Update December 31, 2003 (USDA) FDA Statement on New Measures Against BSE December 31, 2003 (FDA) Veneman Announces Additional Portection Measures Against BSE December 30, 2003 (USDA) FDA Statement on Rendered Products Derived From BSE Cow in Washington State December 27, 2003 (FDA) Statement of Probable Case of BSE in Washington State December 24, 2003 (FDA) FDA Bovine Spongiform Encephalopathy Emergency Response Plan Summary December 24, 2003 (FDA) Questions and Answers about BSE March 29, 2001 (FDA) Federal Agencies Take Special Precautions to Keep "Mad Cow Disease" Out of the United States February 5, 2001 (HHS) BSE Documents (APHIS)
Encephalopathy, Bovine Spongiform Inquiry was set up in December 1997 by the government, which aims to investigatethe emergence and identification of bovine spongiform encephalopathy (BSE) and http://omni.ac.uk/browse/mesh/detail/C0085209L0086067.html
Extractions: low graphics Encephalopathy, Bovine Spongiform Encephalopathy, Bovine Spongiform / epidemiology Encephalopathy, Bovine Spongiform / transmission broader: Prion Diseases other: Creutzfeldt-Jakob Syndrome DEFRA BSE information A collection of imformation on BSE in cattle provided by DEFRA (Department for Environment, Food and Rural Affairs), formerly MAFF. Included are press releases and a bibliography of mainly government publications in this area. Encephalopathy, Bovine Spongiform Creutzfeldt-Jakob Syndrome UK Creutzfeldt-Jakob Surveillance Unit The incidence of CJD is monitored in the UK by the CJD Surveillance Unit at the Western General Hospital in Edinburgh. This site summarises the research in progress at the Unit and provides some background information on CJD and other human spongiform encephalopathies, also providing links to other resources. Features include statistics on CJD in the UK and Europe, the Annual Report and list of publications of the Unit. Encephalopathy, Bovine Spongiform
Extractions: Variant Creutzfeldt-Jakob disease and bovine spongiform encephalopathy ("mad cow disease") Variant Creutzfeldt-Jakob disease (CJD) is a degenerative neurologic disease acquired by eating beef from cows with a related illness known as bovine spongiform encephalopathy (BSE) ("mad cow disease"). The disorder was initially described in the United Kingdom. As of February 2003, there were 129 definite or probable cases of variant CJD reported from the United Kingdom, six from France, and two from the Republic of Ireland. "Mad cow disease" has also been identified in Austria, Belgium, Czech Republic, Denmark, Finland, Germany, Greece, Italy, Liechtenstein, Luxembourg, the Netherlands, Portugal, Slovak Republic, Slovenia, Spain, Switzerland, Israel, and Japan, but human cases have not been reported from these countries to date. Bovine spongiform encephalopathy appears to be caused by abnormal proteins called prions, which do not resemble bacteria, viruses, or other conventional causes of human and animal disease. The agent that causes BSE is transmitted when meat and bone meal feed prepared from the carcasses of infected animals is fed back to other cattle. (This practice has been banned within the European Union and many other countries). The infection is not transmitted directly from animal to animal within herds. A new case of BSE arising within a country is therefore much more significant than an imported case, because it implies that recycled ruminant protein is still being used within that country as animal feed, against all current recommendations.
Bovine Spongiform Encephalopathy (BSE) In Sheep? bovine spongiform encephalopathy (BSE) In Sheep? Information about viewingPDF files . New Zealand is free from both BSE and scrapie. http://www.maf.govt.nz/biosecurity/pests-diseases/animals/tse/bse-sheep.htm
Extractions: Biosecurity Home Imports Exports Border Animals Forest Products Plants SPS Animal Welfare About MAF Biosecurity Publications Legislation Information about viewing PDF files New Zealand is free from both BSE and scrapie. MAF risk assessments, reviewed and endorsed by the government's independent BSE Expert Science Panel, concluded that the Scrapie Freedom Assurance Programmes (SFAPs), under which sheep have been imported to New Zealand since the mid-1980s, provide firm guarantees against the introduction of either of the TSEs. The SFAPs involve testing for infection by biosassay, embryos transfers, and prolonged quarantine. The spectre of BSE in sheep is worrying. European sheep were probably exposed to rations containing meat and bone meal(MBM) several years ago. Experimentally it has been shown that sheep can be infected by mouth with BSE. There is no immediately obvious measure that could be taken, such as removal Specified Risk Materials (SRMs), to adequately protect public health should BSE be found to be in the European sheep population. The clinical signs of BSE in the sheep are indistinguishable from those of scrapie. The two diseases can only be distinguished on the basis of bioassay in mice and lesion profiling. The British have been looking for it by taking brains from scrapie cases, inoculating them into mice and then looking for the incubation period and so-called "lesion profile" indicative of BSE. There are, however, two problems with this approach. The first is cost. To profile a single isolate in mice costs around £20,000. They have about 200 isolates underway at present. The second difficulty is time; it takes up to two years to run a single lesion profile study.
Extractions: Some examples: Creutzfeldt-Jakob Disease CJD humans variant Creutzfeldt-Jakob Disease vCJD humans; acquired from cattle with BSE Bovine Spongiform Encephalopathy BSE "mad cow disease" Kuru infectious; in humans who practiced cannibalism in Papua New Guinea GSS inherited disease of humans Fatal Familial Insomnia FFI inherited disease of humans Scrapie infectious disease of sheep and goats other animal TSEs cats, mink, elk, mule deer Before the victim dies of a TSE, the damage to the brain is reflected in such signs as loss of coordination and - in humans - dementia. Injections of ground-up brain tissue from an animal or human patient with a prion disease into another animal (of the appropriate species) transmits the disease. This suggests that the disease is caused by an infectious agent such as a virus. But viruses have a genome and - despite intense efforts - no evidence of a virus has ever been found in these brain extracts. In fact, treating the extracts with agents (e.g., ultraviolet light ) that destroy DNA does not reduce their infectiousness.
Bovine Spongiform Encephalopathy Questions And Answers bovine spongiform encephalopathy Questions and Answers. Disease DiseaseInformation. What is bovine spongiform encephalopathy? Bovine http://www1.agric.gov.ab.ca/$department/deptdocs.nsf/all/cpv6617?opendocument
Bovine Spongiform Encephalopathy (BSE) Iowa State University Extension. bovine spongiform encephalopathy (BSE). AlsoKnown as Mad Cow Disease . Iowa State University Extension Resources. http://www.extension.iastate.edu/emms/bse/homepage.html
Extractions: Also Known as 'Mad Cow Disease' Iowa State University Extension Resources ISU Extension Resources Resources for Beef Producers Resources for Consumers Other Links ... Today's Ag Iowa State University Meat Science Extension, the Iowa Meat Processors Association, and the Meat and Poulty Inspection Bureau of the Iowa Department of Agriculture and Land Stewardship are cosponsoring four meetings for Iowa meat processors to discuss new regtulations that USDA/FSIS has published to further enhance safeguards against BSE. See schedule and locations of the meetings to be held Feb. 10, 11, 12, and 21 in four Iowa cities. A TV broadcast bringing together experts from ISU Extension and the Iowa Beef Center originated Jan. 7 from the Extension 4-H Youth Building on the Iowa State University campus. Streaming audio and video versions of this program also are available from the University of Nebraska for viewing on your computer.
Mad Cow Disease - What You Need To Know Mad Cow Disease. I am your Guide, From Anne Marie Helmenstine, Ph.D., Your Guideto Chemistry. What You Need to Know About bovine spongiform encephalopathy. http://chemistry.about.com/cs/howthingswork/a/aa122703a.htm
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Extractions: (Mad Cow Disease) Centers for Disease Control and Prevention (CDC) Travel Advisory on BSE . In the advisory the CDC notes that the relative risk of becoming infected with vCJD is very small. They estimate that the chances of contracting vCJD is less than one in 10 billion servings, if at all. Additionally, there is a recently announced ban on blood donations from all persons who have lived for six months or longer in the United Kingdom between 1980 and 1996. Some service members and their families may be affected by this ban. This deferral was originally implemented as a precautionary measure to ensure the safety of the blood supply against the risk of contamination by BSE, because there is no known blood-screening test. Even though there is no evidence that vCJD or BSE can be transmitted through blood products, deferral will be continued as a precautionary preventive step. For more information on BSE and vCJD please visit the following sites: ArmyLINK News: Army Surgeon General Bans European Beef Food and Drug Administration Information Page on BSE National Center for Infectious Diseases BSE and CJD Information and Resources National Institute of Health CJD Fact Sheet ... U.S. Department of Agriculture Information Page on BSE