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Adiposis Dolorosa:     more detail

Adiposis Dolorosa, 300 B.C. by LeRoy Crummer, 1924 Conditions of the Subcutaneous Fat: Adiposis Dolorosa, Erythema Nodosum, Tumor Lysis Syndrome, Barraquer-simons Syndrome, Lipodermatosclerosis Three cases of a hitherto unclassified affection resembling in its grosser aspects obesity, but associated with special nervous symptoms -adiposis dolorosa by Francis X Dercum, 1892

lists with details

1. EMedicine - Adiposis Dolorosa : Article By Nada Macaron, MD
   adiposis dolorosa First described in 1892 by the American neurologist Francis Xavier Dercum at Jefferson Medical College in Philadelphia, Pa, Dercum disease  
   http://www.emedicine.com/derm/topic839.htm
   
   Extractions: (advertisement) Home Specialties CME PDA ... Patient Education Articles Images CME Patient Education Advanced Search Link to this site Back to: eMedicine Specialties Dermatology Diseases Of The Subcutaneous Tissue Last Updated: March 27, 2003 Rate this Article Email to a Colleague Synonyms and related keywords: Dercum’s disease, Dercum disease, painful lipoma, fatty tissue rheumatism, juxta-articular adiposis dolorosa (occurs around the knees) AUTHOR INFORMATION Section 1 of 9 Author Information Introduction Clinical Differentials ... Bibliography Author: Nada Macaron, MD , Staff Physician, Department of Pathology, Emory University School of Medicine Coauthor(s): Jack Arbiser, MD, PhD , Assistant Professor, Department of Dermatology, Emory University School of Medicine Nada Macaron, MD, is a member of the following medical societies: College of American Pathologists , and United States and Canadian Academy of Pathology Editor(s): C Lisa Kauffman, MD , Chief of Dermatology, Associate Professor, Departments of Internal Medicine and Pathology, Georgetown University Medical Center; David F Butler, MD

2. Dercum's Syndrome,Lipomatosis Dolorosa-Adiposis Dolorosa And Morbus Dercum
   Relatively unknown disease like Lipomatosis Dolorosa also know as adiposis dolorosa or Morbus Dercum and Dercum s Syndrome May Respond to Special Diet.  
   http://www.dstressdoc.com/dercum's.htm
   
   Extractions: Pain, definite or indefinite swellings or lipomas, weight gain of maybe 50%, fatigue, difficulty in walking. The disease occurs mainly among women and increases with age. In spite of the fact that the disease has been known and described for more than 100 years. http://www.algon.dk/dercum/dercumeng2.php paints a pretty bleak picture with little know about treatment and the disease eventually attacking internal organs. Some believe that Dercum's Syndrome is an umbrella term for a whole host of health problems with unknown cause/cure. My first awareness of this syndrome came from a woman in Alabama who related to symptoms I experienced for many years related in a page on my website. I was lucky in that I had identified the source of my infection and I also lucked out in discovering the value of high dosages of garlic and a diet to control my symptoms. Otherwise, I certainly may have developed the lipomas or "cushion"-like fatty swellings, chronic pain, described as burning or smarting. The pain can be found in all of the subcutaneous fat, but also in the skeleton and joints. The pain can vary regarding strength and localization, but is almost always symmetrical. In almost all cases the patients will become heavy overweight, about 50% above their normal weight. Fatigue is a very important symptom which can arise very suddenly in connection with even slight physical strain and put a stop to any kind of activity. The disease makes it difficult for the patient to walk or stand up for long periods, and can in the long run develop into a real handicap.

3. Redirect
   This OMIM (Online Mendelian Inheritance in Man) site uses some very limited research (2 papers dealing with 3 families) to conclude that this may be an inherited illness.  
   http://www.ncbi.nlm.nih.gov/htbin-post/Omim/dispmim?103200

4. Brorson/Fagher Article On Dercum's Disease Or Adiposis Dolorosa
   This is an excellent overview article on the disease characterized by painful lipomas (benign fatty tumors). Note that the first part of the article is a biography of Dr. Dercum.  
   http://dercums_data.tripod.com/brorson.html
   
   Extractions: to get to the description of the disease, click here! This article is © 1996 by LÄKARTIDENINGEN - The Journal of the Swedish Medical Association Translation courtesy of Ruth Weaver (many thanks for an excellent job!) DERCUM'S DISEASE Fatty tissue rheumatism caused by immune defense reaction? Authors: Håkan Brorson, M.D., Ph.D.

5. HONselect - Adiposis Dolorosa
   Language MeSH term Accepted terms English adiposis dolorosa Dercum's Disease - Dercum Disease - Dercums Disease - Disease, Dercum - Disease, Dercum's. Français ADIPOSE DOULOUREUSE - DERCUM, MALADIE - Dercum-Krankheit. Español adiposis dolorosa - ENFERMEDAD DE DERCUM  
   http://www.hon.ch/HONselect/RareDiseases/C17.800.849.077.html

6. Article: Corticosteroid-Induced Juxta-articular Adiposis Dolorosa (Dercum's Dise
   This article discusses a case of Dercum's Disease in the knee that was apparently caused by corticosteroid usage.  
   http://dercums_data.tripod.com/greenbaum.html
   
   Extractions: Adiposis dolorosa is an uncommon disorder of subcutaneous tissue that was first described by Dercum in 1892 at Jefferson Medical College, Philadelphia, Pa. The understanding of this disease has not progressed very much in the past 98 years. It remains better understood as a clinical entity than as a physiologic or metabolic process.

7. Dercum's Disease - Aka Adiposis Dolorosa
   This site discusses the symptoms, personal stories and research that has been done in the study of Dercum s Disease (adiposis dolorosa).  
   http://www.dercum.org/
   
   Extractions: (or 10 p.m. EDST) on AOL at Dercum Chat on Homestead "Evidently the disease is not simple obesity. If so, how are we to dispose of the nervous elements present? Equally plain is it there we have not myxoedema to deal with. ... It would seem, then, that we have here to deal with a connective-tissue dystrophy, a fatty metamorphosis of various stages of completeness, occurring in separate regions, or at best unevenly distributed and associated with symptoms suggestive of an irregular and fugitive irritation of the nerve-trunks – possibly a neuritis … Inasmuch as fatty swelling and pain are the most prominent features of the disease, I propose for it the name Adiposis Dolorosa." [ From: Dercum FX.

8. Emerging Worlds Chronic Illness And Viral Infections
   Dercums Disease/adiposis dolorosa First identified by Francis X. Dercum, in 1892, Dercums Disease (also Dercum Disease or Adiposis  
   http://www.emergingworlds.com/ch_conditions_detail.cfm?vPageid=157

9. LIPOMAS, LIPOMATOSIS, AND CERTAIN CLINICAL TYPES OF ABNORMAL FAT DEPOSIT
   This is an older article (1974) that has a section describing the adiposis dolorosa (Dercum's Disease or Dercum Syndrome), as well as other diseases affecting the fatty deposits.  
   http://www.jeghers.com/annts/lipomas.htm
   
   Extractions: LIPOMAS, LIPOMATOSIS, AND CERTAIN CLINICAL TYPES OF ABNORMAL FAT DEPOSIT (Annotations and Bibliographies of Selected References) Prepared for: Medical Grand Rounds St. Vincent Hospital Worcester, Mass. Date: June 14, 1974 Prepared by: Harold J. Jeghers, M.D. and Solomon O. Oyesola, M.S.L.S., A.L.A. (On study leave from Medical Library, College of Medicine, University of Lagos, Nigeria. Presently at Case Western Reserve University, School of Library Science) Does not include data on ordinary obesity, obesity related to endocrine disorders, atrophy or necrosis of subcutaneous fat tissue, etc. **Read First *Read Next ADIPOSE TISSUE (General Information) There is an enormous literature on the type of obesity related to imbalance of caloric intake and energy output and abnormalities of body fat distribution related to certain endocrine disorders. It is well known that the amount and distribution of body fat varies with age, sex and race. By contrast, less attention has been paid to certain disorders characterized by abnormal localized forms of excess adipose tissue. Reading a few selected articles related to basic science concepts and general orientation to the subject of adipose tissue will be helpful. **Wells: Adipose tissue, a neglected subject. JAMA 114: 2177-2183; 2284-2289, 1940 (a scholarly and classic paper; literature; several helpful illustrations)

10. EMedicine - Lipomas : Article By Robert A Moraru, MD
    Synonyms and related keywords lipomatosis, Madelung disease, Madelung s disease, Dercum disease, Dercum s disease, adiposis dolorosa, angiolipoma, hibernoma.  
    http://www.emedicine.com/derm/topic242.htm
    
    Extractions: (advertisement) Home Specialties Resource Centers CME ... Patient Education Articles Images CME Patient Education Advanced Search Consumer Health Link to this site Back to: eMedicine Specialties Dermatology Benign Neoplasms Last Updated: November 7, 2001 Rate this Article Email to a Colleague Synonyms and related keywords: lipomatosis, Madelung disease, Madelung's disease, Dercum disease, Dercum's disease, adiposis dolorosa, angiolipoma, hibernoma AUTHOR INFORMATION Section 1 of 9 Author Information Introduction Clinical Differentials ... Bibliography Author: Robert A Moraru, MD Robert A Moraru, MD, is a member of the following medical societies: American Academy of Dermatology Editor(s): Janet Fairley, MD , Professor, Program Director, Section Chief, Department of Dermatology, Medical College of Wisconsin; Michael J Wells, MD , Staff Physician, Department of Dermatology, Texas Tech University Health Sciences Center; Rosalie Elenitsas, MD , Director of Dermatopathology, Associate Professor, Department of Dermatology, University of Pennsylvania; Catherine Quirk, MD

11. HONcode: Principles - Quality And Trustworthy Health Information
    Dercum s Disease, also known as adiposis dolorosa is in compliance with the HONcode. Title of the site Dercum s Disease, also known as adiposis dolorosa.  
    http://www.hon.ch/HONcode/Conduct.html?HONConduct619568

12. CANCER: CAUSES AND EFFECTS
    Chapter from Dr. Ed Friedlander's online textbook. adiposis dolorosa (Dercum's Disease) is mentioned (search for adiposis ). Even though the lipomas (tumors) are benign, they can cause problems just by being, and he lists a number of examples.  
    http://www.pathguy.com/lectures/neo-2-3.htm
    
    Extractions: scalpel_blade@yahoo.com Cyberfriends: The help you're looking for is probably here. Welcome to Ed's Pathology Notes, placed here originally for the convenience of medical students at my school. You need to check the accuracy of any information, from any source, against other credible sources. I cannot diagnose or treat over the web, I cannot comment on the health care you have already received, and these notes cannot substitute for your own doctor's care. I am good at helping people find resources and answers. If you need me, send me an E-mail at scalpel_blade@yahoo.com Your confidentiality is completely respected. Allan N. Spreen MD also handles internet questions at no charge, with a primary focus on nutrition. Dr. Spreen is also my former student and my close friend. DoctorGeorge.com is a larger, full-time service. There is also a fee site at myphysicians.com , and another at www.afraidtoask.com Translate this page automatically With one of four large boxes of "Pathguy" replies. I'm still doing my best to answer everybody. Sometimes I get backlogged, sometimes my E-mail crashes, and sometimes my literature search software crashes. If you've not heard from me in a week, post me again. I send my most challenging questions to the medical student pathology interest group, minus the name, but with your E-mail where you can receive a reply.

13. Dercum's Disease - Aka Adiposis Dolorosa
    This site discusses the symptoms, personal stories and research that has been done in the study of Dercum's Disease (adiposis dolorosa). Contains much reference material. also known as. Adiposis  
    http://members.tripod.com/~Dercums_Data
    
    Extractions: (or 10 p.m. EDST) on AOL at Dercum Chat on Homestead "Evidently the disease is not simple obesity. If so, how are we to dispose of the nervous elements present? Equally plain is it there we have not myxoedema to deal with. ... It would seem, then, that we have here to deal with a connective-tissue dystrophy, a fatty metamorphosis of various stages of completeness, occurring in separate regions, or at best unevenly distributed and associated with symptoms suggestive of an irregular and fugitive irritation of the nerve-trunks – possibly a neuritis … Inasmuch as fatty swelling and pain are the most prominent features of the disease, I propose for it the name Adiposis Dolorosa." [ From: Dercum FX.

14. Dercum Disease - Information / Diagnosis / Treatment / Prevention
    Brorson/Fagher Article on Dercum s Disease or adiposis dolorosa This is an adiposis dolorosa (Dercum s Disease) is mentioned (search for adiposis ).  
    http://www.healthcyclopedia.com/skin-disorders/dercum-disease.html
    
    Extractions: Web Directory: Bones and Soft Tissue Section of an online medical/pathology text book by Dr. Ed Friedlander. Buried in here are some comments on Dercum's Disease (search for "dercum" to find them). Brorson/Fagher Article on Dercum's Disease or Adiposis Dolorosa This is an excellent overview article on the disease characterized by painful lipomas (benign fatty tumors). Note that the first part of the article is a biography of Dr. Dercum.

15. Dercum Disease
    this report. Synonyms adiposis dolorosa; JuxtaArticular adiposis dolorosa. Disorder Subdivisions None. General Discussion Dercum Disease  
    http://my.webmd.com/hw/health_guide_atoz/nord490.asp
    
    Extractions: This disorder usually occurs in obese females between the ages of 45 and 60. Various areas of the body may swell for no apparent reason. The swelling may disappear without treatment, leaving hardened tissue or pendulous skin folds. In some cases, affected individuals may also experience depression, lethargy, and/or confusion.

16. Dercum's Disease (Adiposis Dolorosa) - PubMed MedLine References
    This is a listing of the references to Dercum's Disease culled from Medline, the National Library of Medicine data base.  (aka Dercum Syndrome, adiposis dolorosa)  
    http://Dercums_Data.tripod.com/ref-list.html
    
    Extractions: var cm_role = "live" var cm_host = "tripod.lycos.com" var cm_taxid = "/memberembedded" Check out the NEW Hotbot Tell me when this page is updated Dercum's Disease PubMed MedLine References This is a listing of the all the references I've found (so far) that discuss Dercum's disease or Adiposis Dolorosa or some aspect that might be of interest. Sometimes there is only the title (typically of foreign language articles) because no abstract is available. The Pub Med document number is included for reference. Web author comments are in blue (like this statement). A few of the articles have links that allow you access the actual article. Dr. Dercum's article (#64) and some other older ones have been recently added and can be found at the bottom of the list. Humangenetik 1973 Mar 23;18(1):89-91 PMID: 4721343, UI: 73226373 Am Fam Physician 1981 Nov;24(5):155-7 Dercum's disease: adiposis dolorosa.

17. Dercum's Disease (Adiposis Dolorosa) - PubMed MedLine References
    This site discusses the symptoms, personal stories and research that has been done in the study of Dercum's Disease (adiposis dolorosa). This page has medical references. so far) that discuss Dercum's disease or adiposis dolorosa or some aspect that might be of adiposis dolorosa is a disease characterized by painful, subcutaneous fatty tumors  
    http://dercum.tripod.com/ref-list.html
    
    Extractions: var cm_role = "live" var cm_host = "tripod.lycos.com" var cm_taxid = "/memberembedded" Dercum's Disease PubMed MedLine References This is a listing of the all the references I've found (so far) that discuss Dercum's disease or Adiposis Dolorosa or some aspect that might be of interest. Sometimes there is only the title (typically of foreign language articles) because no abstract is available. The Pub Med document number is included for reference. Web author comments are in blue (like this statement). A few of the articles have links that allow you access the actual article. Dr. Dercum's article (#64) and some other older ones have been recently added and can be found at the bottom of the list. Humangenetik 1973 Mar 23;18(1):89-91 PMID: 4721343, UI: 73226373 Am Fam Physician 1981 Nov;24(5):155-7 PMID: 7293909, UI: 82043245 Vestn Khir 1969 Jun;102(6):123-4

18. Dercum's Disease / Adiposis Dolorosa
    Dercum s Disease. Dercum s Disease / adiposis dolorosa Dercum s Disease Online. Founded 1998. Support for persons with Dercum s disease  
    http://my.webmd.com/hw/health_guide_atoz/shc29der.asp
    
    Extractions: Support for persons with Dercum's disease (aka adiposis dolorosa), characterized by fatty lipomas under the skin that cause pain. Aim is to eradicate the pain and suffering of Dercum's Disease through finding the cause and cure. Forum for personal stories, links to support groups, and medical articles. The above information is based upon information available through the "verified" date at the end of each listing. Since American Self-Help Group Clearinghouse's resources are limited; it is not possible to keep every entry in American Self-Help Group Clearinghouse database completely current and accurate. Please check with the organizations listed for the most current information. For additional information and assistance about self-help groups, please contact the American Self-Help Group Clearinghouse in Cedar Knolls, New Jersey, by email at: info@selfhelpgroups.org

19. NORD - National Organization For Rare Disorders, Inc.
    A short discussion about this rare disorder (aka Dercum's Disease, adiposis dolorosa), characterized by pressure of fatty deposits on nerves, resulting in weakness and pain. Some resources are listed for further study. This entry is provided by NORD (National Organization for Rare Disorders).  
    http://www.rarediseases.org/search/rdbdetail_abstract.html?disname=Dercum Diseas

20. Article: Fat-cell Heat Production ... In Adiposis Dolorosa
    This site discusses the symptoms, personal stories and research that has been done in the study of Dercum's Disease (adiposis dolorosa). This is a article discusses the difference between Dercum  
    http://dercum.tripod.com/fat_heat.html
    
    Extractions: al Science SUMMARY 1. Gluteal adipose tissue was examined in 13 patients with generalized adiposis dolorosa, a clinical condition characterized by painful adiposity with a chronic intractable course. The total metabolic activity of fat cells, isolated by collagenase and suspended in Krebs-Ringer bicarbonate buffer with glucose and insulin, was assessed by the measurement of heat production at 37°C using microcalorimetry. 2. Fat cells were markedly enlarged; their metabolic activity expressed in terms of/~W/g, but not in pW/cell, was significantly decreased when compared with both lean and weight-matched non-painful subjects. Both mean values were, however, significantly higher than in grossly obese subjects with similar mean cell size. Heat production as expressed per g of tissue, but not per cell, was inversely correlated with body mass index. One additional patient had unilateral disease, and fat cells from the painful side had a lower heat production than cells from the unaffected side. 3. The fatty acid composition of adipose tissue, as determined by g.c., revealed a significantly increased proportion of monounsaturated (18:1 and 16:1) at the expense of saturated (14:0 and 18:0) fatty acids compared with healthy control subjects. The activity of adipose tissue lipoprotein lipase was slightly, but not significantly, decreased.

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