101. Von Willebrand's Disease Health Guide von willebrand s Disease HealthGuidesOnline.com s award-winning consumer Website offering health and medical information, news and self-improvement and http://www.healthguidesonline.com/Von_Willebrand_s_Disease.html

Health Guides - Von Willebrand's Disease Von Willebrand Disease is not a form of hemophilia. Because it is an inherited bleeding disorder people tend to associate it with hemophilia but in fact hemophilia is due to a deficiency of a clotting factor namely Factor VIII or IX. Von Willebrand Disease is due to a deficiency of another blood clotting protein called von Willebrand Factor (von Willebrand's Factor). von Willebrand's Factor is a glue-like protein that helps blood cells called platelets stick to the site of an injury to form a temporary plug known as a platelet plug. If a person has either a low level of von Willebrand's Factor or a defect in the protein then they have von Willebrand's Disease. It is an autosomal dominant disorder meaning it affects males and females equally and you only need inherit one defective gene to have the disorder. It is not uncommon for numerous family members to have von Willebrand's Disease though their symptoms may vary widely. On the other hand, hemophilia is what is known as a sex-linked recessive disorder meaning it affects mainly males and the females are the carriers. Symptoms The main symptoms of von Willebrand's Disease, all related to the body's inability to form a platelet plug include: are easy bruising and mucous membrane bleeding such as prolonged and heavy menstrual bleeding, frequent or prolonged nose bleeds, prolonged oozing after even simple cuts, prolonged bleeding after surgery and dental work and occasionally gastrointestinal bleeding. Unlike von Willebrand's Disease, a person with hemophilia has normal von Willebrand's Factor. The problem is that once the platelet plug is made, they cannot stabilize it with a fibrin blood clot which requires adequate amounts of the other clotting factors especially Factors VIII and IX. Because of this, the platelet plug is pushed out and bleeding resumes.

102. Von Willebrand Hemochromatosis. Thalassemia. Thrombophilia. von willebrand. What is it. Cause. Diagnosis. WhatIs It? Treatments. von willebrand Disease. Cause. Cure. Diagnosis. Reaserch. http://www.liversociety.org/html/von_willebrand_.html

American Liver Society What Is It? Treatments von Willebrand Disease Cause Cure Diagnosis Reaserch Research Symptoms ... Legal

103. Haemophilia Foundation: Knowledge Knowledge Bleeding Disorders von willebrand Disorder. Information.01. What is von willebrand Disorder (vWD)? von willebrand http://www.haemophilia.org.au/knowledge/index.php/cid/9/category/von Willebrand

home about us news Bleeding Disorders ... Bleeding Disorders > von Willebrand Disorder Information 01. What is von Willebrand Disorder (vWD)? von Willebrand Disorder (vWD) is due to a deficiency of von Willebrand Factor (vWF). vWF a plasma factor that circulates in the blood attached to Factor VIII. more .... 02. How is von Willebrand Disorder inherited? Von Willebrand disorder is mostly a genetic disorder. This means it is passed down through the genes from parent to child. The abnormal gene in von Willebrand disorder is on one of the regular chromosomes, not on one of the sex chromosomes (like haemophilia). more .... 03. How is von Willebrand Disorder treated? Most people with mild von Willebrand disorder will only experience a mild form of the condition and no medication will be required except when having surgery, and/or dental extractions. more .... von Willebrand Disorder from my perspective Read a interview with Dianne regarding her personal story with vWD - Leah (interviewer): When did you first find out about von Willebrand disorder in your family? Dianne: From the time I was two, I started having bleeding problems. more ....

104. Von Willebrand Disease: A New Attempt At Classification Of A Complex Disorder 4. von willebrand Disease A new attempt at classification of a complexdisorder. Samuel A. Santoro, MD, Ph.D. References. von willebrand EA. http://medicine.wustl.edu/~labmed/1996vol4no4.html

Laboratory Medicine Newsletter April 1996, Volume 4 No. 4 von Willebrand Disease: A new attempt at classification of a complex disorder Samuel A. Santoro, M.D., Ph.D. V on Willebrand disease (VWD) was first described in 1926 by Erik von Willebrand who reported on a young Finnish girl from the Aland Islands with a bleeding disorder distinguishable from classical hemophilia by its autosomal pattern of inheritance, mucocutaneous hemorrhage rather than joint and soft tissue bleeding, and a prolonged bleeding time. We now know that the disorder arises from the deficiency or abnormal function of von Willebrand factor (VWF) a large, structurally complex platelet adhesive glycoprotein present in plasma, in platelets and in vascular endothelial cells. In fact, VWD is the most common of the hereditary coagulopathies. VWF serves two principal hemostatic functions. It supports adhesion of platelets to damaged vascular walls, and it serves as a carrier for the Factor VIII molecule. Bleeding arises from the loss of one or both of these functions. Laboratory diagnosis is currently established by measurement of the VWF antigen, determination of the ristocetin cofactor activity (a functional measure of the interaction of VWF with its principal platelet receptor), and determination of the level of Factor VIII procoagulant activity. Multimer analysis may be required to establish the presence or absence of the high molecular weight forms of VWF. For more detail on the diagnosis of VWD, the interested reader is referred to a recent review.

105. Gradipore For Biological Separations Technology. von willebrand s Disorder von willebrand Factor (vWF) is an important blood clottingprotein, involved in both assisting platelet adhesion and stabilisation of http://www.gradipore.com/Diagnostics/Default.asp?MenuID=128&RefMenuID=85&Categor

106. Von Willebrand Factor Antigen Test Menu von willebrand Factor Antigen, Primary Name, von willebrand Factor Antigen.Synonym, . Synonym, . Contraction, VWF Ag. Contraction, . Contraction, . http://peir.path.uab.edu/coag/article_143.shtml

Front Page Announcements Contact Us Clinical Conditions ... Test Order Form Search All Categories Front Page Announcements Contact Us Clinical Conditions Guidelines Links Patient Information Test Menu Test Order Form Test Menu Von Willebrand Factor Antigen Email this article Printer friendly page Primary Name Von Willebrand Factor Antigen Synonym Synonym Contraction VWF Ag Contraction Contraction UAB Procedure Number CPT Code Specimen Collect one (1) blue-stopper tube (3.2% sodium citrate), filled to specified volume. Do not underfill or overfill. Specimen Management Centrifuge blue-stopper tube within 1 hour of collection, separate plasma and test or quick-freeze at -70°C. Specimen Accepted Daily including weekends Times Available Test Performed Two days a week Available Stat? Pathologist's approval required. Description The von Willebrand factor antigen assay is used to diagnose von Willebrand disease as it measures plasma von Willebrand factor concentration. When used in combination with the cofactor test, the antigen test helps distinguish von Willebrand disease types 1 and 2. Reference Interval Critical Value Therapeutic Range Follow-up Test *The von Willebrand factor antigen test is usually run together with the ristocetin cofactor test and the factor VIII activity assay, forming the von Willebrand disease profile.

107. Invalid URL! Document not found! I couldn t find the document you requested itmay have moved or been renamed. Try starting at the MM G Home http://mmg2.im.med.umich.edu/vWF/

Document not found! I couldn't find the document you requested - it may have moved or been renamed. Try starting at the to see if you can find what you were looking for. For some of you, your browser will automatically go there after three seconds. Last modified: Mon Apr 28 11:26:20 1997

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