61. VetCentric - Canine Von Willebrand’s Disease - Vo Occurring because of abnormalities involving a protein called von willebrand’sfactor, von willebrand’s disease is an inherited bleeding disorder of dogs. http://www.vetcentric.com/reference/encycEntry.cfm?ENTRY=78&COLLECTION=EncycIlln

62. One Percent Of Americans Have Von Willebrand Disease: What Is It? von willebrand Disease (VWD) is a hereditary bleeding disorder that involves a proteinin the blood called von willebrand factor, or VWF, which helps our blood http://healthlink.mcw.edu/article/1030552013.html

Search Articles: search tips Please Take the HealthLink Survey Email this article Print this article Find related articles: By topic: Children's Health Genetics By keywords: Receive Health Link via email! Subscribe now >> One Percent of Americans Have Von Willebrand Disease: What Is It? Most of us have become accustomed to life's bumps and bruises...and scrapes, cuts, sprains and strains. We've all had those clumsy times where life seems like nothing but a series of minor mishaps. We're able to ignore many of these injuries, while others are easily put right with a bandage or a few days' rest. But for children and young adults with abnormal reactions to life's accidents - including heavy bleeding, bleeding that doesn't stop, or very frequent bruising - testing for von Willebrand disease could be in order. Von Willebrand disease (VWD) is a hereditary bleeding disorder, in fact, one of the most common bleeding disorders known: it affects about 1% of all Americans. The illness involves a protein in the blood called von Willebrand factor, or VWF, which helps our blood to clot. People with von Willebrand disease don't have enough of the factor available in their blood, or the VWF that is present doesn't perform effectively. Simple injuries can bring on heavier and longer bleeding episodes than usual or cause frequent bruises to form under the skin. Men and women can both have VWD, but women are usually more symptomatic, with heavy menstrual bleeding (menorrhagia) being a common symptom.

63. Von Willebrand Disease Causes Excessive Bleeding People with von willebrand disease may bleed easily, particularly after surgery,such as a tonsillectomy or oral surgery, that involves the mucous membranes. http://healthlink.mcw.edu/article/1031002252.html

Search Articles: search tips Please Take the HealthLink Survey Email this article Print this article Find related articles: By topic: Blood/Blood Pressure Genetics By keywords: clotting disorders blood diseases von Willebrand disease Receive Health Link via email! Subscribe now >> Von Willebrand Disease Causes Excessive Bleeding Q: When my teenage grand-niece had her tonsils removed, she bled badly. The doctor suggested that her parents be tested for bleeding disorders. It turns out her mother (my brother's daughter) carries the gene for von Willebrand disease. She was told the male carries the disease. Is it possible I am also a carrier? I have had surgery with no problems. A: Whenever our skin or mucus membranes are cut, about a dozen clotting factors work together to make a clot. One clotting factor is von Willebrand factor, and when this factor is mutated, you have von Willebrand disease . People with von Willebrand disease may bleed easily, particularly after surgery on mucus membranes, such as a tonsillectomy or oral surgery. Nearly 1% of all people have von Willebrand disease, but some are only affected mildly and some are never diagnosed. Women with von Willebrand disease are more often diagnosed because they may notice increased menstrual bleeding.

64. Von Willebrand's Disease -- Topic Overview von willebrand s Disease Topic Overview What is von willebrand s disease?von willebrand s disease is a bleeding disorder in which http://my.webmd.com/hw/health_guide_atoz/hw183233.asp

var guid_source = ""; var guid_source_id = ""; //unused var encodedurl = ""; WebMD Today Home WebMD News Center Member Services WebMD University My WebMD Find a Physician Medical Info Check Symptoms Medical Library Quizzes, Calculators Clinical Trials ... Women, Men, Lifestyle Who We Are About WebMD Site Map You are in Medical Library Choose a Topic Our Content Sources Ask A Question Clinical Trials Health Guide A-Z Health Topics Symptoms Medical Tests Medications ... Credits Von Willebrand's Disease Topic Overview What is von Willebrand's disease? Von Willebrand's disease is a bleeding disorder in which the body's blood system has a missing or malfunctioning von Willebrand factor. The von Willebrand factor ordinarily attracts platelets and helps them stick together to form a blood clot, which is necessary to stop bleeding when you are cut or injured. The von Willebrand factor also protects a related blood-clotting component called factor VIII. What causes von Willebrand's disease? Von Willebrand's disease is passed down through families. It is the most common bleeding disorder present at birth (congenital). Approximately 1% of people inherit this disease.

65. CCHS Clinical Digital Library von willebrand Disease Clinical Resources. Chapter 113 Structure,Biology, and Genetics of von willebrand Factor Access document http://cchs-dl.slis.ua.edu/clinical/hematology/bleedingdisorders/coagulation-dis

Clinical Resources by Topic: Hematology Von Willebrand Disease Clinical Resources Emergency Pediatrics Radiology Pathology ... Miscellaneous Resources See also: General Hematology Clinical Resources Von Willebrand Disease Patient/Family Resources Harrison's Principles of Internal Medicine 15th Ed.-2001: Table of contents Health Sciences Library subscription INFO Chapter 62: Bleeding and Thrombosis: Table of contents Introduction: Access document Normal Hemostasis: Access document Clinical Evaluation: Access document Physical Examination: Access document Laboratory Tests: Access document Chapter 116: Disorders of the Platelet and Vessel Wall: Table of contents Introduction: Access document Functional Platelet Disorders: Access document Introduction: Access document Von Willebrand's Disease: Access document Treatment: Access document Acquired vWD: Access document Hoffman: Hematology: Basic Principles and Practice 3rd Ed.-2000 (MD Consult): Table of contents Health Sciences Library subscription INFO Chapter 105 - Clinical Evaluation of Hemorrhagic Disorders: The Bleeding History and Differential Diagnosis of Purpura: Access document Introduction: Access document The Bleeding History: Access document Differential Diagnosis of Hemorrhagic Dermatologic Lesions: Access document Chapter 106 - Laboratory Evaluation of Hemostatic Disorders: Access document Introduction: Access document Screening Tests of Plasma Coagulation Factors: Access document Further Evaluation of Abnormal Screening Tests: Access document Chapter 113 - Structure, Biology, and Genetics of von Willebrand Factor:

66. CCHS Clinical Digital Library von willebrand Disease Patient/Family Resources. Miscellaneous von willebrandDisease Patient/Family Resources Healthfinder (US DHHS) Homepage http://cchs-dl.slis.ua.edu/patientinfo/hematology/bleedingdisorders/coagulation-

Patient/Family Resources by Topic: Hematology Von Willebrand Disease Patient/Family Resources Pediatrics Spanish Miscellaneous See also: General Hematology Patient/Family Resources Von Willebrand Disease Clinical Resources Canadian Hemophilia Society Homepage Von Willebrand Disease: Table of contents Introduction: Access document Types of Von Willebrand Disease: Access document Heredity: Access document Symptoms: Access document Diagnosis: Access document Treatment: Access document Blood Products: Access document Precautions: Access document Summary Chart of Factor Deficiencies: Access document MEDLINE plus Medical Encyclopedia: Table of contents Von Willebrand Disease: English Spanish Bleeding Disorders: English Spanish Merck Manual - Second Home Edition Table of contents Section 14. Blood Disorders: Table of contents Chapter 173. Bleeding and Clotting Disorders: Table of contents Introduction: Access document Von Willebrand's Disease: Access document Pediatrics KidsHealth (Nemours Foundation): Homepage Health Information for Parents: Table of contents Medical Problems: List of documents von Willebrand Disease: Access document Spanish MEDLINE plus Medical Encyclopedia: Table of contents Von Willebrand Disease: English Spanish Bleeding Disorders: English Spanish Miscellaneous Von Willebrand Disease Patient/Family Resources Healthfinder (US DHHS): Homepage Bleeding Disorders: List of documents National Library of Medicine MEDLINE plus Health Topics: Index Bleeding Disorders: List of documents YAHOO - Health:Diseases and Conditions:Blood Disorders Additional Blood Disorders resources (

67. Von Willebrand's Disease von willebrand s Disease, Pathophysiology von willebrand factor mediatesplatelet adhesion; vWF Deficiency results in mucocutaneous bleeding. http://www.fpnotebook.com/HEM17.htm

Home About Links Index ... Editor's Choice document.write(code); Advertisement Hematology and Oncology Coagulopathy Assorted Pages Coagulation Bleeding Disorders Dysfibrinogenemia Hemophilia A Factor IX Deficiency ... Perioperative Anticoagulation Von Willebrand's Disease Book Home Page Cardiovascular Medicine Dentistry Dermatology Emergency Medicine Endocrinology Gastroenterology General Medicine Geriatric Medicine Gynecology Hematology and Oncology HIV Infectious Disease Jokes Laboratory Neonatology Nephrology Neurology Obstetrics Ophthalmology Orthopedics Otolaryngology Pediatrics Pharmacology Prevention Psychiatry Pulmonology Radiology Rheumatology Sports Medicine Surgery Urology Chapter Hematology and Oncology Index Anemia Cancer Coagulopathy Cardiovascular Medicine Dermatology Endocrinology Otolaryngology Examination Gastroenterology Hemoglobin Hemolysis Histiocytosis HIV Infectious Disease Laboratory Leukemia General Pulmonology Lymph Marrow Neurology Obstetrics Orthopedics Pediatrics Pharmacology Platelet Prevention Procedure Psychiatry Rheumatology Sarcoma Surgery Symptom Evaluation Vascular Page Coagulopathy Index Bleeding Bleeding Dysfibrinogenemia Bleeding Hemophilia A Bleeding Hemophilia B Bleeding Von Willebrands Clotting Pathway Background Clotting Pathway Common Clotting Pathway Extrinsic Clotting Pathway Inhibition Clotting Pathway Intrinsic DIC Hypercoagulable Hypercoagulable Antithrombin III Hypercoagulable APC resistance Hypercoagulable Fibrinolysis Hypercoagulable Protein C-S Epidemiology Most common inherited bleeding disorder Mild bleeding disorder (often undiagnosed)

68. Disease Directory : Blood Disorders : Von Willebrand Diseases Blood Disorders von willebrand. All Canadian Hemophilia Society Offers information about von willebrand disease. Includes http://www.diseasedirectory.net/Blood_Disorders/von_Willebrand/default.aspx

Thursday, June 03, 2004 Blood Disorders Anemia Blood Coagulation Eosinophilia ... Blood Disorders : von Willebrand All About Bleeding - A resource for education, guidance and support for people who have or suspect they have von Willebrand disease. Offers personalized tools, information resources, and community support. Canadian Hemophilia Society - Offers information about Von Willebrand disease. Includes the types, the symptoms, treatment, and heredity. Many Faces of von Willebrand's Disease - Information including Pediatric studies. Matt Klimshuk - von Willebrand's Disease - Information on von Willebrand's Disease and links to von Willebrand's and Hemophilia sites. Nursing Spectrum- Career Fitness Online - von Willebrand Disease. The commonly inherited bleeding disorder. Examples and treatments. Obgynnet's von Willebrand Disease Information Sheet - Specific information on how this hereditary disease impacts women. St George's Hospital Haemophilia Centre - Offers a resource for anyone who is interested in the work of the Centre. Also includes a comprehensive library of information leaflets that can be ordered on-line. The Other Bleeding Disorder - Information on the three types of von Willebrand Disease as well as treatments.

69. Von Willebrand Disease - Medical Dictionary Definitions Of Popular Medical Terms MedicineNet Home MedTerms medical dictionary AZ List von willebrand disease. VonWillebrand factor is made by cells lining the wall of blood vessels. http://www.medterms.com/script/main/art.asp?articlekey=31159

70. Von Willebrand's Disease von willebrand s disease. von willebrand s disease is an inheritedbleeding disorder that prevents blood from clotting properly. http://www.meritcare.com/hwdb/_followLink.asp?sgml_id=stv5464

71. Von Willebrand's Disease: Topic Overview von willebrand s Disease. Topic Overview. What is von willebrand sdisease? von willebrand s disease is a bleeding disorder http://www.meritcare.com/hwdb/showTopic.asp?pd_hwid=hw183233

72. Sheffield University VWF Homepage von willebrand Disease (VWD). VWD is a congenital bleeding disorder which resultsfrom quantitative or qualitative defects of von willebrand factor (VWF). http://www.sheffield.ac.uk/vwf/vwd.html

Maintained at the University of Sheffield, United Kingdom ISTH VWF SSC Information Homepage Fast link: Back to index Mutations Polymorphisms Nomenclature VWF Sequences Diagrams Useful links Database submission References Downloads Searches Sponsor Credits von Willebrand Disease (VWD) VWD is a congenital bleeding disorder which results from quantitative or qualitative defects of von Willebrand factor (VWF). It is the most common inherited bleeding disorder in humans with a prevalence ranging from 3-4 per 100,000 to 1.3% of the population (reviewed in Keeney and Cumming, 2001). More than 20 subtypes of VWD have been described, although current classification consists of 6 distinct types (Sadler, 1994). Types 1 and 3 are quantitative VWF defects whilst the four type 2 variants are qualitative VWF defects. For more information, see the review by Keeney and Cumming, 2001. For example multimer diagrams, click here Back to VWF mutations Back to index VWD Classification Description Type 1 Partial quantitative deficiency of VWF. Typically autosomal dominant in inheritance although diagnosis is complicated by reduced penitrance and variable expressivity. Characterised by parallel reductions in VWF:Ag and Factor VIII. Multimer distribution is normal. Type 2A Qualitative VWF defect associated with absence of the largest multimers and low levels of VWF:Ricof activity relative to VWF:Ag. Generally autosomal dominant, caused by missense mutations within the VWF A2 repeat. Group 1 (defect in intracellular transport) or group 2 (increase in proteolysis in plasma after secretion).

73. Von Willebrand Factor - Wikipedia, The Free Encyclopedia von willebrand factor. von willebrand factor (vWF, also called Factor VIIIrelatedantigen ) is a blood protein of the coagulation system. http://en.wikipedia.org/wiki/Von_Willebrand_factor

Von Willebrand factor From Wikipedia, the free encyclopedia. Von Willebrand factor (vWF, also called " Factor VIII -related antigen") is a blood protein of the coagulation system . It is defective in von Willebrand disease and is involved in a large number of other diseases, including thrombotic thrombocytopenic purpura Heyde's syndrome , and possibly hemolytic-uremic syndrome Table of contents 1 Biochemistry 1.1 Synthesis 1.2 Structure 1.3 Function ... edit Biochemistry edit Synthesis vWF is a large multimeric glycoprotein present in blood plasma and produced constitutively in endothelium (in the Weibel-Palade bodies megakaryocytes platelets ), and subendothelial connective tissue edit Structure The basic vWF monomer is a 2050 amino acid protein. Every monomer contains a number of specific domains with a specific function; elements of note are: the D'/D3 domain, which binds to Factor VIII the A1 domain, which binds to: platelet gp1b-receptor heparin possibly collagen the A3 domain, which binds to collagen the C1 domain, in which the R G D domain binds to platelet integrin IIb when this is activated the "cysteine knot" domain (at the C-terminal end of the protein), which vWF shares with

74. THE MERCK MANUALSECOND HOME EDITION, Von Willebrand S Disease In von willebrand s Disease. von willebrand s function. The von willebrand factoris found in plasma, platelets, and the walls of blood vessels. When http://www.merck.com/mrkshared/mmanual_home2/sec14/ch173/ch173e.jsp

75. HONselect - Von Willebrand Disease English von willebrand Disease, Angiohemophilia - Hemophilia, Vascular - von willebrand sDisease - Angiohemophilias - Disease, von willebrand - Disease, von http://www.hon.ch/HONselect/RareDiseases/C15.378.100.141.900.html

List of rare diseases: English Deutsch Language: MeSH term: Accepted terms: English: von Willebrand Disease - Angiohemophilia - Hemophilia, Vascular - von Willebrand's Disease - Angiohemophilias - Disease, von Willebrand - Disease, von Willebrand's Français: VON WILLEBRAND, MALADIE - PSEUDOHEMOPHILIE - THROMBOPATHIE CONSTITUTIONNELLE VON WILLEBRAND - MALADIE VON WILLEBRAND - WILLEBRAND, MALADIE Deutsch: Von-Willebrand-Krankheit - Angiohämophilie - Hämophilie, vaskuläre - Pseudohämophilie, hereditäre - Von-Willebrand-Syndrom Español: ENFERMEDAD DE VON WILLEBRAND - ANGIOHEMOFILIA - HEMOFILIA VASCULAR Português: DOENCA DE VON WILLEBRAND - ANGIOHEMOFILIA - HEMOFILIA VASCULAR HONselect ressources Definition: Yes Articles: Yes Images: Yes News: No Conferences: No Clinical trials: No Web sites: English Yes Français Yes Deutsch No Español Yes Português No Home About us Site map Feedback ... HONewsletter http://www.hon.ch/HONselect/RareDiseases/C15.378.100.141.900.html Last modified: Wed Apr 28 2004

76. Von Willebrand Disease von willebrand Disease is the most common hereditary blood disorder thatis characterized by prolonged bleeding time. von willebrand Disease. http://www.tylermedicalclinic.com/von willebrand disease.htm

The Tyler Medical Clinic Assisted Conception - Affordable Infertility Treatments - List of Diseases - Von Willebrand Disease Von Willebrand Disease is the most common hereditary blood disorder that is characterized by prolonged bleeding time. Approximately 1% of the US population is affected by Von Willebrand Disease. There are different subtypes of Von Willebrand Disease, namely Types 1, 2A, 2B, 2M, 2N, and 3. Type 1 is mildest form as well as the most common. Type 3 on the other hand, is rare and is the most severe form. They are classified according to the genetic mutation present. In response to an injury such as a cut, the body releases platelets to form a plug at the injury site and to prevent further bleeding. Various factors are released by platelets including von Willebrand Factor (vWF) to aid in the clotting process. Reduced levels or reduced functioning of vWF results in prolonged bleeding times in individuals affected with Von Willebrand Disease. Patients with a severe form of Von Willebrand Disease may also suffer from spontaneous nose bleeds and bleeding from mouth, stomach, intestines or urinary system. Increased bleeding time, reduced levels and functioning of vWF and decreased levels of another clotting factor, Factor VIII, must be present for a definitive diagnosis of Von Willebrand Disease. The most common treatment for Von Willebrand Disease is replacement therapy. Factor VIII and vWF replacements are administered to the patients. Other drugs may also be administered to aid in the clotting process of the patient.

77. Von Willebrand's Disease von willebrand s disease. Definition von willebrand s disease is an inheritedblood disorder characterized by prolonged bleeding time. http://www.chclibrary.org/micromed/00070640.html

Main Search Index Definition Description Causes ... Resources Von Willebrand's disease Definition Von Willebrand's disease is an inherited blood disorder characterized by prolonged bleeding time . It is the most common hereditary bleeding disorder in humans. Description The disease was first described by the Finnish physician Erik von Willebrand in 1926, when he noticed that many members of a large family from the Aland Islands in the Gulf of Bothnia had a bleeding disorder with a distinct inherited pattern. Von Willebrand's disease affects about 1-3% of the world's population, including about 1% of people in the United States. Von Willebrand's disease is classified into three basic types. The mildest form, type 1, occurs in approximately 70-80% of patients. The moderate form of von Willebrand's disease is called type 2 and affects about 20-30% of people with the disease. The most severe form is called type 3. Type 3 disease is very rare, occurring in about one person per million. The classification system for von Willebrand's disease was revised in 1994. The three major types were subdivided into types 1, 2A, 2B, 2M, 2N, and 3. This revision was necessary because of the many different genetic mutations that cause the disorder.

78. Von Willebrand's Disease von willebrand s Disease. Introduction. von willebrand s disease (vWD) is acongenital, extrinsic platelet defect resulting in platelet dysfunction. http://www.vet.uga.edu/vpp/clerk/anderson/

Von Willebrand's Disease Julie B. Anderson, BS; Kenneth S. Latimer, DVM, PhD; Perry J. Bain, DVM, PhD; Heather L. Tarpley, DVM Class of 2004 (Anderson), College of Veterinary Medicine, University of Tennessee, Knoxville, TN 37996 and the Department of Pathology (Latimer, Bain, Tarpley), College of Veterinary Medicine, University of Georgia, Athens, GA 30602-7388 Introduction Von Willebrand's disease (vWD) is a congenital, extrinsic platelet defect resulting in platelet dysfunction. It is characterized by a deficiency of von Willebrand factor (vWF), a glycoprotein that is involved in platelet adhesion to the vessel wall during formation of the primary hemostatic plug. Although vWD is most commonly reported in dogs, it also has been observed in swine, horses, cattle, and cats. Disease Mechanism vWD is characterized by a lack of functional vWF, resulting in abnormal primary hemostasis (platelet plug formation) and prolongation of bleeding time in vivo Figure 1. Small, medium, and large multimers of vWF exist. The largest ones (high molecular weight) are most active in hemostasis because they presumably have increased numbers of binding sites per molecule or because their physical characteristics alter under certain conditions of blood flow. vWF circulates bound to factor VIII and appears to prolong the half life of factor VIII. In dogs with vWD, factor VIII concentrations usually remain at 20% or more of normal values. The role of vWF in the release and production of factor VIII has not been clarified.

79. The Diagnosis And Treatment Of Von Willebrand Disease In Children The diagnosis and treatment of von willebrand disease in children. REGISTER NOW! Lediagnostic et le traitement de la maladie de von willebrand chez les enfants. http://www.pulsus.com/Paeds/07_04/klas_ed.htm

forgot your password? ORIGINAL ARTICLES April 2002, Volume 7, Number 4: The diagnosis and treatment of von Willebrand disease in children RJ Klaassen, JM Halton von Willebrand disease is the most common bleeding disorder seen in children and it affects approximately 1% of the population. Because the bleeding symptoms in von Willebrand disease are generally mild, the diagnosis is often delayed. Prompt diagnosis and management can help to avoid potentially life-threatening bleeding events and unnecessary exposure to blood products. In this review, the various types of von Willebrand disease are outlined, the difficulties in diagnosis are discussed and the therapeutic approach to this common disorder is described. Key Words: Child; Factor VIII; von Willebrand disease; von Willebrand factor

80. HealthCentral - General Encyclopedia - Von Willebrand's Disease General Health Encyclopedia, von willebrand s disease. Additionally, thereis insufficient von willebrand factor which also helps blood clot. http://www.healthcentral.com/mhc/top/000544.cfm

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