41. AHVH - Vereniging Van Hemofilie En Von Willebrand-patiënten Journée internationale de l’Hémophilie 2004 Le 17 avril est laJournée internationale de l’Hémophilie. Le thème choisi http://www.ahvh.be/

42. Ziekte Van Von Willebrand MEDICI, — Beginpagina — Ziekten en aandoeningen — Ziekte van VonWillebrand Ziekte van von willebrand Synoniem Pseudohemofilie. http://www.erfocentrum.nl/zena/wille.php

erfelijkheid.nl winkel mail ons nieuwsbrief ... sitemap ZIEKTEN EN AANDOENINGEN ERFELIJKHEID LITERATUUR (PARA)MEDICI Beginpagina ... Ziekten en aandoeningen Ziekte van Von Willebrand Ziekte van Von Willebrand Synoniem Pseudo-hemofilie Korte beschrijving Bij de ziekte van von Willebrand is er sprake van een verhoogde bloedingneiging door een gestoorde functie van zowel de bloedplaatjes als van een bepaalde stollingseiwit in het bloed (de Von-Willebrandfactor). Meestal gaat het om een erfelijke aandoening, in enkele gevallen ontstaat een niet-erfelijke vorm als gevolg van een bepaalde auto-immuunziekte. Diagnose De diagnose wordt gesteld door middel van bloedonderzoek waarbij men kijkt naar een verlengde bloedingstijd en de activiteit van de stollingsfactoren. Symptomen Doorgaans zijn de verschijnselen vrij mild zoals het gemakkelijk oplopen van blauwe plekken en eventueel lichte bloedingen van vooral slijmvliezen en maag-darmstelsel. In zeldzame gevallen kunnen wel ernstige bloedingen voorkomen. Er is vaak een voorgeschiedenis van veel neusbloedingen in de jeugd, nabloeden uit kleine snijwonden, overvloedig bloedverlies bij menstruatie, door blijven sijpelen na mond- of kleine gynaecologische operaties en het gemakkelijk oplopen van blauwe plekken. Behandeling Bij ernstige bloedingen kan de patiënt worden behandeld met DDAVP, een analoog van vasopressine (een vaatvernauwer), dat een tijdelijke stijging van de concentratie van de von Willebrandfactor teweegbrengt.

43. Von Willebrand Disease Excessive or prolonged bleeding could be a sign of a genetic disorderknown as von willebrand disease. What Is von willebrand Disease? http://kidshealth.org/teen/diseases_conditions/blood/vwd.html

KidsHealth Teens Blood Disorders Everyone has to deal with bruises and bloody noses from time to time. But some kids and teens seem to have constant nosebleeds, unexplained bruising, or prolonged bleeding after a tooth is pulled. Excessive or prolonged bleeding could be a sign of a genetic disorder known as von Willebrand disease. For many people, the symptoms are so mild that they never even know they have the disorder. For those with more severe forms of the disease, getting the proper diagnosis and treatment usually makes them less likely to have problems from the condition. What Is von Willebrand Disease? Von Willebrand disease, or vWD, is an inherited disorder - meaning it's passed from parent to child through genes - that affects the blood's ability to clot properly. It takes its name from Dr. Erik von Willebrand, who first described the condition in 1926. As a group, bleeding disorders (including hemophilia ) are rare. Von Willebrand disease is the most common inherited bleeding disorder, affecting about 1% of people. In most cases, bleeding occurs when a blood vessel is cut or torn.

44. How Von Willebrand Is Inherited How von willebrand Disease.. is Inherited.. Unlike haemophilia, vonWillebrand disease is not genderrelated. So the effect is http://www.haemophilia.org.za/Vonherit.htm

How von Willebrand Disease is Inherited Unlike haemophilia, von Willebrand disease is not gender-related. So the effect is the same regardless of whether the defective von Willebrand factor (vWF) is passed down from the mother or father. It also makes no difference whether the child is a boy or girl; the disease shows up in the same way. If one parent has a defective gene: Each parent contributes one of his/her genes for vWF to his/her child. As shown, there are four possible genetic combinations than can result from this union If both parents have a defective gene: Again, there are four possible genetic combinations. Odds: 2 out of 4 children (50%) will be genetically normal. 2 out of 4 children (50%) will have the defective vWF gene Odds: 1 out of 4 children (25%) will be genetically normal. 2 out of 4 children (50%) will have one defective vWF gene 1 out of 4 children (25%) will have two defective vWF genes, which will result in severe von Willebrand disease. Von Willebrand types I and II have a "dominant" inheritance pattern. That means that in a child with one normal gene and one gene for either of these von Willebrand types, the defective gene in "stronger. So the child will actually have the disease.

45. Introduction To Von Willibrands Disease Introduction to.. von willebrand Disease.. and Other Coagulation Disorders ..The bleeding disorder von willebrand Disease. It may surprise http://www.haemophilia.org.za/Vonwil1.htm

Introduction to von Willebrand Disease and Other Coagulation Disorders The bleeding disorder now called haemophilia A or factor VIII deficiency has been known since biblical times. Physicians referred to it in medical literature in 1793. Haemophilia B or factor IX deficiency, on the other hand, was not recognized as a distinct entity until 1952. It is now known account for 20% of all cases of haemophilia. At least eight other coagulation disorders have been identified, most of them in the 20th century and some only within the past 25 years. Von Willebrand Disease Mission Statement National News Regional News Medical News ... Children's Page

46. October 1994 - Von Willebrand Disease October, 1994. von willebrand DISEASE. Margaret V. Ragni, MD, MPH,Medical Director,. Coagulation Defects in von willebrand Disease. http://www.itxm.org/Archive/tmu10-94.htm

October, 1994 VON WILLEBRAND DISEASE Margaret V. Ragni, M.D., M.P.H., Medical Director, Hemophilia Center of Western Pennsylvania INTRODUCTION Von Willebrand disease (VWD) is the most common congenital bleeding disorder. It is estimated to occur at a frequency of one in 100 individuals, but is symptomatic in only about one in 10,000. Von Willebrand disease is caused by mutations in von Willebrand factor (VWF). The gene for von Willebrand Factor is located on chromosome 12, and the disease is inherited in an autosomal manner, affecting both males and females. Von Willebrand factor is a glycoprotein consisting of disulfide-linked high molecular weight multimeric FVIII proteins (multimers), and is synthesized in megakaryocytes and endothelial cells, and stored in platelets and endothelial cells. Von Willebrand factor serves as a carrier protein for FVIII and promotes platelet aggregation after vessel injury. Von Willebrand disease is a clinically heterogeneous disease with a number of disease variants, each characterized by different quantitative and/or qualitative defects in von Willebrand factor. It is import to determine the specific von Willebrand disease variant in order to establish the best and safest treatment for each patient. Recently a revised simplified classification system for von Willebrand disease was proposed by the international Society of Thrombosis and Hemostasis (ISTH) (Sadler JE.

47. Canine Von Willebrand's Disease Canine von willebrand s disease. Your are here Pagewise Home Home Garden PetsDogsHealth/Care Canine von willebrand s disease. http://coco.essortment.com/vonwillebrands_rlig.htm

Canine Von Willebrand's disease Von Willebrands Disease is the most common of bleeding disorders in dogs and humans. Symptoms diagnosis and general information of the condition Von Willebrands isnt so much a disease as a condition. Of all the inherited bleeding disorders in animals (and humans) it is the most common. The defect isnt autosomal (sex linked) so both males and females can suffer from the disease. It must be remembered that just because a dog doesnt show symptoms of von Willebrands, it doesnt mean it cant be a carrier. Von Willebrands was discovered in humans and called a disease in the 1920s by a Finnish doctor coincidentally named, von Willebrand. After further research, he was able to figure out the illness was actually linked to a missing factor in the bloods clotting ability. bodyOffer(32256) Modern research has found von Willebrands doesnt lower the number of platelets (the factor in the blood that causes clotting) but changes the platelets actual make up. Researchers have discovered there are twelve factors that go into the platelets make up and allows them to work properly. They have set up a Cascading Clotting Tree to mark and show the different factors. Von Willebrands affects Factor 8 on this tree. There is a large, multimeric glycoprotein that is labeled as vWF. This glycoprotein circulates in the plasma and is required for platelet adhesion. When there is a defect in the vWF gene, there is an insufficient synthesis of the vWF glycoprotein. This insufficiency causes the platelets to fail in their adhesion or sticking together. Like water coming through a damn with a hole in it, the platelet leaks and bleeding continues.

48. Nvhp, Nederlandse Vereniging Van Hemofilie-Patiënten WAT IS DE ZIEKTE VAN von willebrand. De ziekte van von willebrand is een erfelijkeafwijking in de bloedstolling die zowel bij mannen als bij vrouwen voorkomt. http://www.nvhp.nl/nvhp-willebrand.htm

WAT IS DE ZIEKTE VAN VON WILLEBRAND De ziekte van Von Willebrand is een erfelijke afwijking in de bloedstolling die zowel bij mannen als bij vrouwen voorkomt. De ziekte van Von Willebrand komt voornamelijk tot uiting via slijmvliesbloedingen (neus- en tandvleesbloedingen). Bij het trekken van kiezen, operaties en ongelukken bestaat er een ver­hoogd risico op nabloedingen. Bij vrouwelijke patiënten kan het leiden tot hevige bloedingen tijdens de menstruatie of na een bevalling. DE BLOEDSTOLLING Een goed verloop van de bloedstolling in het menselijk lichaam is van zeer veel factoren afhankelijk. Een van deze factoren is het voldoende aanwezig zijn van de Von Willebrand factor. De Von Willebrand factor is een speciaal eiwit dat tijdens het stollingsproces een lijmfunctie vervult. Het eiwit is nodig om de hechting van bloedplaatjes aan de vaatwand mogelijk te maken. De Von Willebrand factor zorgt verder voor het transport van factor VIII, een ander stollingseiwit. Bij mensen met een ver­laagd gehalte aan de Von Willebrand factor, zal ook het factor VIII gehalte verlaagd zijn. Naarmate het gehalte aan de Von Willebrand factor of factor VIII lager is, zal de ziekte ernstiger zijn. Bij ernstige vormen van de ziekte van Von Willebrand kunnen zich ook bloedingen voordoen in gewrichten, spieren en zacht weefsel. Daarmee vertoont de ziekte van Von Willebrand verwantschap met een andere afwijking in de bloedstolling, namelijk hemofilie.

49. Von Willebrand's Disease von willebrand s Disease. by Jennie Bullock. von willebrand s disease is ableeding disorder found in many breeds of dog as well as other animals. http://www.barkbytes.com/medical/med0036.htm

von Willebrand's Disease by Jennie Bullock von Willebrand's disease is a bleeding disorder found in many breeds of dog as well as other animals. It is characterized by hematomas, nosebleeds, and intermittent limping (due to bleeding into the joints). Similarly to hemophilia A, dogs with this disorder are deficient in clotting factor VIII activity. One of the primary distinctions of von Willebrand's disease however, is that this disorder is not sex-linked. von Willebrand's disease appears in two variations: inherited and acquired. In its acquired presentation von Willebrand's is a complication of thyroid deficiency. With proper treatment and stabilization of the dog's thyroid levels the von Willebrand's is negated. Hereditary von Willebrand's disease is far more complex. Each breed of dog will have a different set of "typical symptoms" of the disease. Symptoms can range from abnormally long bleeding time due to a cut toenail, to hemorrhaging during minor surgery, to spontaneous nosebleeds, with a wide assortment of presentations between. Injuries that are followed by bleeding may or may not require a transfusion. Even a small wound may necessitate veterinary treatment. Carriers of this disorder can live their entire lives with no outward indications of this disease. von Willebrand's disease can be fatal. There is no cure and no effective treatment. It appears that DNA screening is the most accurate means of testing currently.

50. Von Willebrand's Disease What is von willebrand s Disease? There are three main variations of von willebrand sdisease. Each variation varies by the severity of symptoms. http://www.mamashealth.com/blood/vonw.asp

Mamashealth.com Home Blood Diseases Agnogenic Metaplasia Amyloidosis Diabetes Hematuria ... Von Willebrand's Disease Links Crystal Products Email Mama What is Von Willebrand's Disease? Von Willebrand's disease is a chronic bleeding disorder where both platelet aggregation and clot formation do not occur properly. It is the most common hereditary bleeding disorder. There are three main variations of Von Willebrand's disease. Each variation varies by the severity of symptoms. Type 1 is a mild disorder. It is the majority of cases. Type 2 is a mild to moderate disorder. It mas moderate symptoms. Type 3 is the most severe form of the disorder. It rarely occurs. Von Willebrand's disease is also called pseudohemophilia and vascular hemophilia. It affects women and men equally. Symptoms? The most common symptoms include: bleeding gums bood in the urine nose bleeds urinary tract bleeding blood in the stool easy bruising heavy menstral flow What causes Von Willebrand's Disease? It is caused by a defect in a clotting factor called Von Willebrand's factor. In many cases, there is also a deficiency of clotting factor VIII.

51. Von Willebrand Disease - Information / Diagnosis / Treatment / Prevention home blood disorders von willebrand von willebrand Disease. CanadianHemophilia Society Offers information about von willebrand disease. http://www.healthcyclopedia.com/blood-disorders/von-willebrand.html

Home Health cyclopedia All Topics by Category The Good Health Search Engine Health Conditions A-Z Gurus ... blood disorders > von willebrand von Willebrand Disease Information / Diagnosis / Treatment / Prevention External links (marked with an arrow ) open in a new window. This site is a web directory and does not offer medical advice. We cannot take responsibility for information found on listed sites. This Page Medical Definition Health News Web Directory: Medical Definition: University of Newcastle-upon-Tyne Medical Dictionary: "Von Willebrand disease" Health News: Search millions of published articles for news on von Willebrand Disease Modern Medicine Aging The Ardell Wellness Report HealthFacts Medical Post Medical Update Men's Health and the National Women's Health Report Note: Subscription required to access the full text of articles. Web Directory: All About Bleeding A resource for education, guidance and support for people who have or suspect they have von Willebrand disease. Offers personalized tools, information resources, and community support. Canadian Hemophilia Society Offers information about Von Willebrand disease. Includes the types, the symptoms, treatment, and heredity.

52. Von Willebrand Disease HOME. (Von) Willebrand Disease. Sage has von willebrand Disease; von willebrandDisease A new attempt at classification of a complex disorder; http://www.bdid.com/vwd.htm

HOME (Von) Willebrand Disease Sage has von Willebrand Disease von Willebrand Disease: A new attempt at classification of a complex disorder vWF Database Willebrand disease ... HOME

53. Von Willebrand Disease - Mesa Veterinary Hospital von willebrand Disease by Dr. Lisa Croteau, DVM. Diagnosis of von willebranddisease is accomplished by a test to measure vWF levels in the blood. http://www.mesavet.com/library/vonwillebranddisease.htm

von Willebrand Disease by Dr. Lisa Croteau, DVM It is the most common bleeding disorder in dogs and is especially common in Dobermans, but also seen in Scottish terriers, Shetland sheepdogs, German shepherds, golden retrievers, and other breeds. Clinical signs vary from case to case. Signs may include bleeding from the nose, excess bleeding in intact females in heat, excess bleeding after having puppies, blood in the urine or stool, bleeding from the gums, lameness, or excess bleeding after surgical procedures or if nails are trimmed too short. Diagnosis of von Willebrand disease is accomplished by a test to measure vWF levels in the blood. Genetic tests also exist for Dobermans, Scottish terriers, Shetland sheepdogs, Manchester terriers, poodles, and Pembroke Welsh corgis which can identify them as being affected by the disease, carriers of the condition, or free of the gene. DNA for these tests is obtained from a swab of the inside of the cheek. Treatment of von Willebrand disease is blood or plasma transfusions to supply vWF during episodes of bleeding.

54. CANINE Von WILLEBRAND's DISEASE CANINE von willebrand s DISEASE What is von willebrand s disease? Thedeficient protein is called von willebrand factor antigen. http://www.pethealthcare.net/html/body_canine_von_willebrand_s_diseas.html

CANINE von WILLEBRAND's DISEASE What is von Willebrand's disease? Von Willebrand's disease (VWD) is the most common inherited bleeding disorder of both man and animals. It is caused by a deficiency in the amount of a protein needed to help platelets (a blood cell used in clotting) seal broken blood vessels. The deficient protein is called von Willebrand factor antigen. Which breeds are most commonly affected by VWD? About 30 different breeds are known to be affected but the Doberman Pinscher is the breed most commonly associated with this disease. Of 15,000 Dobermans screened, more than 70% were found to be carriers of the disease. Fortunately, most of these are not clinically affected (i.e., we see no evidence of bleeding). However, the number of Dobermans with a history of bleeding appears to be on the rise. Although Dobermans are commonly affected, they usually have the mildest form of the disease. The average at diagnosis for this breed is about four years of age. One study showed that 30% of Scotties and 28% of Shelties had abnormally low concentrations of von Willebrand factor. Chesapeake Bay Retrievers and Scotties are affected with the most severe form of the disease. What are some of the signs of VWD?

55. Menorrhagia & Easy Bruising - Von Willebrand's Disease - Q Fever! - Medical Stud What s going on? Answer von willebrand s Disease. This woman, who presentedwith menorrhagia and easy bruising, has von willebrand s Disease. http://www.qfever.com/20010627/medstud.html

June 27, 2001 [BACK ISSUE - Click Here For Current Issue!] Medical Student Corner You are asked to evaluate a 19-year old white female who presents to your office with the chief complaint of menorrhagia and easy bruising. Other than these issues, she has no medical problems, and has never had major surgery. She takes no medications and has no known drug allergies; she does not smoke or drink alcohol, and is a sophomore in college, where she lives with a roomate. Her family history is significant in that her mother also had multiple bleeding problems, and suffered from severe menorrhagia throughout adolescence as well. In addition, a maternal great aunt died of post-operative bleeding in the 1940's. On physical exam, the patient is in no apparent distress, and is very pleasant. Temperature is 97.7F, pulse is 80, blood pressure is 120/70, and respirations are 12. There is a 3 cm ecchymosis on her left upper arm, as well as a smaller one on her right shin. Head and neck, lung, heart, and abdominal exams are normal, as is a pelvic exam.

56. Von Willebrand's Disease Most people, however, are not as familiar with von willebrand s disease and hearof it for the first time when they ask questions about breeding their dog. http://www.marvistavet.com/html/body_von_willebrand_s_disease.html

Most people are familiar with hemophilia A, an inherited blood clotting defect in human beings affecting only male children. Most people, however, are not as familiar with von Willebrand's disease and hear of it for the first time when they ask questions about breeding their dog. Von Willebrand's disease is also an inherited blood clotting defect and breeds at high risk should be screened before being allowed to breed. WHAT IS VON WILLEBRAND'S FACTOR? When there is something wrong with one's von Willebrand's factor, platelets to do not stick together properly and inappropriate prolonged wound bleeding occurs. TYPES OF VON WILLEBRAND'S DISEASE Unlike the genetics of Hemophilia A in humans, which is reviewed in detail in virtually every high schoole biology class as a sex linked recessive trait, von Willebrand's disease is not as simple. Males and females are equally affected and the inheritance seems to be recessive but complicated. DIAGNOSIS OF VON WILLEBRAND'S DISEASE: BLOOD TESTING AND DNA TESTING Classically, testing for von Willebrand's disease is accomplished by measuring von Willebrand's factor in a blood sample. The amount of factor in the patient's serum is compared to that found in "normal" dogs. The patient's results are compared to the normal and expressed in a percentage (thus it is possible for a patient to have >100% as their result).

57. Erik Adolf Von Willebrand (www.whonamedit.com) Erik Adolf von willebrand Finnish internist, born February 1, 1870, Vasa;died 1949. Associated with von willebrand factor,Willebrand s http://www.whonamedit.com/doctor.cfm/2690.html

Home List categories Eponyms A-Z Biographies by country ... Contact Whonamedit.com does not give medical advice. This survey of medical eponyms and the persons behind them is meant as a general interest site only. No information found here must under any circumstances be used for medical purposes, diagnostically, therapeutically or otherwise. If you, or anybody close to you, is affected, or believe to be affected, by any condition mentioned here: see a doctor. Erik Adolf von Willebrand Finnish internist, born February 1, 1870, Vasa; died 1949. Associated eponyms: Von Willebrand factor A factor lacking or defective in patients with von Willebrand's disease I. Willebrand's disease I A familial congenital bleeding disorder characterized by prolonged bleeding time. Willebrand's disease II This disorder resembles a type of von Willebrand’s disease, but the defects appear to be in the platelets, rather than the von Willebrand factor. Biography: Erik Adolf von Willebrand was born in the port city Vaasa, the son of the district engineer Fredrik Magnus von Willebrand and his wife Signe Estlander. After passing the baccalaureate in Vasa in 1888 he entered medical studies at the University of Helsingfors. During the summers of 1894 and 1895 he worked as a physician in Mariehamn, the capital of the Åland islands, partly as a cholera doctor and partly as a subordinate physician to the Mariehamn spa. Here he learned about “Ålandic haemorrhagic disease”. He qualified as a doctor in 1896, and in 1899 he defended a doctoral thesis that dealt with his investigations into the changes in blood after a serious loss of blood, Zur Kenntnis der Blutveränderungen nach Aderlassen. For the rest of his life von Willebrand remained interested in blood and especially in its coagulation properties.

58. Bbc.co.uk - Health - Ask The Doctor Von Willebrand Disease Ask the Doctor. Q. von willebrand s disease. What is von willebrand sdisease and how is it treated? Naomi. Dr Trisha Macnair responds. http://www.bbc.co.uk/health/ask_doctor/vonwillebrand.shtml

@import url('/includes/tbenh.css') ; Home TV Radio Talk ... A-Z Index THURSDAY 3rd June 2004 Text only BBC Homepage Health Home Lifestyle Home ... Help Like this page? Send it to a friend! Ask the Doctor Q. Von Willebrand's disease What is Von Willebrand's disease and how is it treated? Naomi Dr Trisha Macnair responds Von Willebrand disease is an inherited disorder of the blood which leads to abnormal bleeding. Unlike other bleeding disorders such as haemophilia, Von Willebrand disease can affect both men and women - in fact it is the commonest bleeding disorder and about 1 in 100 women have it. It's not actually one condition but a group of similar diseases all caused by a problem with one particular protein in the blood (known as Von Willebrand factor or VWF) which plays an essential part in clotting by helping tiny cells called platelets to stick to the walls of a damaged blood vessel. VWF also has another important job, carrying another clotting chemical called Factor VIII around in the blood. So if levels of VWF are low or it doesn't work properly there is abnormal bleeding. Three types Symptoms of Von Willebrand Disease Easy bruising Frequent nose bleeds.

59. Von Willebrand's Disease - VeterinaryPartner.com - A VIN Company! von willebrand s Disease. Most people are familiar with hemophilia screenedbefore being allowed to breed. What Is von willebrand s Factor? http://www.veterinarypartner.com/Content.plx?P=A&A=1637&S=1&SourceID=42

60. Www.cma.ca/cmaj/vol-153/0019e.htm . The Finnish physicianErik von willebrand was the first to describe von willebrand disease (VWD)....... von willebrand diseaseMAIN SEARCH INDEX. von willebrand disease. http://www.cma.ca/cmaj/vol-153/0019e.htm

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