21. Sheltie Von Willebrand’s Disease Can Now Be Diagnosed By A DNA Test Sheltie von willebrand's Disease. Can Now Be Diagnosed by a DNA Test. by George J. Brewer, Professor, Department of Human Genetics and Internal Medicine, University of Michigan Medical School and Patrick J. von willebrand's disease vWD, an inherited bleeding disorder, usually comes in two major types, type I and type http://www.vetgen.com/sheltvwd.html

Sheltie von Willebrand's Disease Can Now Be Diagnosed by a DNA Test by George J. Brewer, Professor, Department of Human Genetics and Internal Medicine, University of Michigan Medical School and Patrick J. Venta, Assistant Professor, Department of Small Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, Co-Founders of VetGen LLC Von Willebrand's disease vWD, an inherited bleeding disorder, usually comes in two major types, type I and type III. (There is also a rarer Type II, not relevant to Shelties). Type III is a severe bleeding disorder with a high risk of spontaneous bleeding as well as a risk of serious bleeding from trauma and surgery. It is probably best known in Scottish Terriers. Type I is milder, with most of the risk coming from trauma or surgery. It is probably best known in Doberman Pinschers. The Sheltie breed has type III vWD, the severe type. There may also be a second less prevalent defect, causing some Shelties to have the less severe Type I vWD, but this is uncertain at present. Enter the era of DNA testing! DNA tests have now been developed for the type III vWD of Scotties, the type I vWD of Dobermans, and the type III vWD for Shelties. These DNA tests can be done at any age, can be done from mouth swabs collected by the breeder/owner (the swabs pick up cells from inside the mouth which provide the DNA), and unambiguously classify dogs for the rest of their lives into affected, carrier, and clear animals. With this test the breeder can rapidly eliminate the vWD disease gene from the breed. If a particularly valuable dog turns out to be a carrier, it can be bred to a clear animal, and non-carrier puppies saved for the next round of breeding.

22. OBGYN.net - Von Willebrand Q And A von willebrand Disease Information Sheet. A Brief History. We now know that theirplatelets behaved abnormally because their plasma lacked von willebrand factor. http://www.obgyn.net/ENGLISH/PUBS/ANNOUNCEMENTS/VWD_Q_A.HTM

von Willebrand Disease Information Sheet A Brief History von Willebrand disease (vWD) is thought to be the most common hereditary bleeding disorder, affecting up to 3% of the U.S. population. vWD was first recognized in 1925 by Erik von Willebrand, a Finnish physician, who described a new type of bleeding disorder in inhabitants of the C land Islands. Using simple laboratory equipment, von Willebrand observed that his patients had an abnormality in blood platelet function. We now know that their platelets behaved abnormally because their plasma lacked von Willebrand factor. von Willebrand factor helps platelets adhere to damaged blood vessels to form a platelet plug, an integral aspect of hemostasis. von Willebrand factor also serves as a carrier protein for plasma factor VIII. vWD affects men and women in equal numbers, but it does not affect them equally. Because the most common symptoms of vWD in women (heavy and prolonged menstrual periods) are often misunderstood to be a gynecologic rather than a hematologic problem, the risk of misdiagnosis and undertreatment poses a greater health concern for women than it does for men. vWD in its mildest form can cause an inconvenience for women. They may require pre-treatment for certain dental procedures, surgery, or child birth. But for women with moderate to severe vWD, the bleeding disorder can be debilitating and potentially life threatening if undiagnosed and untreated.

23. David Ginsburg David Ginsburg, M.D An article covering von willebrand Factor, coagulation factor V, plasminogen activator inhibitor1, primary pulmonary hypertension and bone marrow transplantation. http://www.hhmi.org/science/genetics/ginsburg.htm

HHMI INVESTIGATORS / David Ginsburg HHMI INVESTIGATORS HHMI INVESTIGATOR ALUMNI INTERNATIONAL RESEARCH SCHOLARS HHMI-NIH RESEARCH SCHOLARS ... HHMI HOME ALSO OF INTEREST Search PubMed Researchers Pinpoint Cause of Deadly Blood-Clotting Disorder The Ginsburg Lab Molecular Genetics of Blood Clotting David Ginsburg, M.D. Investigator, University of Michigan Medical School Biography... A blood clot formed in vitro... Summary: David Ginsburg is interested in understanding the components of the blood-clotting system and how disturbances in their function lead to human bleeding and blood-clotting disorders. Precise control of the blood-clotting system is essential for maintenance of the circulation in all higher animals. Deficient function of this system can lead to fatal bleeding following even a minor injury, whereas overactivity of this system can produce unwanted blood clots, resulting in blockages to critical blood vessels, as occurs in such diseases as heart attack and stroke. von Willebrand Factor The blood-clotting protein von Willebrand factor (VWF) functions as the critical initial bridge connecting blood platelets to the wall of injured blood vessels, thereby helping to control bleeding. VWF also serves as the carrier for factor VIII, the substance missing in patients with hemophilia. Abnormalities in VWF result in von Willebrand disease (VWD), the most common human inherited bleeding disorder.

24. Sheffield University VWF Homepage Genetic mutation and polymorphism database for human von willebrand factor with other useful information for researchers, from the University of Sheffield, UK. http://www.sheffield.ac.uk/vwf/

Maintained at the University of Sheffield, United Kingdom ISTH SSC VWF Information Homepage Supported by Up-to-date databases of point mutations, insertions, deletions, and polymorphisms found in the gene for human von Willebrand Factor. Fast link: Mutations Polymorphisms Nomenclature VWF Sequences VWD Diagrams Useful links Database submission References Downloads Searches Sponsor Patient information Credits Please select one of the following links: Mutations Mutations in the human VWF gene sorted by nucleotide number and by association with type of von Willebrand disease (VWD) Polymorphisms Polymorphisms in the human VWF gene Nomenclature Current nomenclature recommended by the ISTH VWF SSC VWF Sequences Amino acid, cDNA and genomic DNA links with Mancuso genomic and pseudogene sequences. Also links to VWF sequences of other species VWD A brief description of the types of von Willebrand Disease (VWD) Diagrams Figures of the VWF gene, mRNA and protein (including binding domains) and example multimer gels for VWD type 2 defects Links Links to other useful web sites New Mutations/Polymorphisms How to submit a new mutation or polymorphism to the database manager References Alphabetical list of VWF mutation and polymorphism references in the database Downloads Useful VWF downloads, including PDB files containing the structure of VWF A1 and A3 domains to be viewed in Rasmol

25. Von Willebrands Sygdom von willebrands sygdom er den mest almindelige arvelige bl¸dersygdom op til ©n procent af befolkningen (b¥de m¦nd og kvinder) kan have den. At have von willebrands sygdom betyder, at man ikke har nok af det protein, der hedder von willebrandfaktor, eller at proteinet er forkert bygget op. von willebrand-faktoren er med til at s¸rge for, at bl¸dninger kan stoppe. http://www.netdoktor.dk/sygdomme/fakta/vonwillebrand.htm

i NetDoktor i Fagbogen NetDoktor.dk Forside Nyheder Genveje Babyklub Fagbogen Leksikon Sygdomme Medicin Symptomer Sundhed Emner Inkontinens Mave og tarm Psoriasis Rygestop ... Patientforeninger Service Test dig selv Information Kontakt NetDoktor Om NetDoktor ND i andre lande Von Willebrands sygdom Af Hvad er von Willebrands sygdom? De fleste (cirka 80 procent) har sygdommen i mild grad (type 1) med symptomer som kraftige menstruationer Von Willebrands sygdom er arvelig. Sygdommen skyldes en fejl i gener kromosom Kraftig og langvarig menstruation hovedpine , svimmelhed, Hvordan behandles sygdommen P-piller I Danmark er de tre mest brugte midler til von Willebrands sygdom: desmopressin tranexamsyre faktor VIII/von Willebrand-faktor. Gentag proceduren Octostim Cyklokapron Pamol Panodil Pinex Setamol Udsigt for fremtiden Patientforening Medicin som kan anvendes: Sidst opdateret: GENVEJE: Babyklub Fagbogen LEKSIKON: Sygdomme Medicin Symptomer Sundhed EMNER: Inkontinens Mave og tarm Psoriasis Rygestop ... Patientforeninger SERVICE: Test dig selv INFORMATION: Kontakt NetDoktor Om NetDoktor ND i andre lande Brugerbetingelser: Vigtige juridiske informationer ... fortrolighedspolitik The documents contained in this web site are presented for information purposes only. The material is in no way intended to replace professional medical care or attention by a qualified practitioner. The materials in this web site cannot and should not be used as a basis for diagnosis or choice of treatment. Click here - Conditions for use - Important legal information.

26. La Maladie De Von Willebrand http://www.hemophilia.ca/fr/2.2.php

La maladie de Von Willebrand La maladie de Von Willebrand Introduction Les types de maladies Le diagnostic Les traitements ... Les produits sanguins

27. Von Willebrand's Disease Management And Treatment In The Home Setting Patient selfcare helps ward off complications of excessive hemorrhagic episodes in this inherited bleeding disorder. http://www.uspharmacist.com/NewLook/Ce/von/lesson.cfm

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28. MedlinePlus Medical Encyclopedia: Von Willebrand’s Disease von willebrand’s disease. Definition Return to top. von willebrand s disease isa hereditary bleeding disorder caused by a deficiency of von willebrand factor. http://www.nlm.nih.gov/medlineplus/ency/article/000544.htm

@import url(http://www.nlm.nih.gov/medlineplus/images/advanced.css); Skip navigation Medical Encyclopedia Other encyclopedia topics: A-Ag Ah-Ap Aq-Az B-Bk ... Z Von Willebrand’s disease Contents of this page: Illustrations Definition Causes, incidence, and risk factors Symptoms ... Calling your health care provider Illustrations Blood clot formation Blood clots Definition Return to top Von Willebrand's disease is a hereditary bleeding disorder caused by a deficiency of von Willebrand factor. Von Willebrand factor helps platelets to stick to the blood vessel wall and to each other, which is necessary for normal blood clotting. Causes, incidence, and risk factors Return to top Von Willebrand's disease is the most common hereditary bleeding disorder. It affects both sexes approximately equally. Most cases are mild, and bleeding may occur after a surgical procedure or tooth extraction. The condition is worsened by the use of aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs). Bleeding may decrease during pregnancy. The disease is very common, affecting at least 1% of the population. A family history of a bleeding disorder is the primary risk factor. In women with heavy or prolonged menstrual bleeding, Von Willebrand's is more common in Caucasian women than African American women.

29. NVHP Nederlandse Vereniging Van Hemoflie-Patiënten Belangenvereniging voor mensen met hemofilie en aanverwante (erfelijke) afwijkingen in bloedstolling, zoals de ziekte van von willebrand, de ziekte van Glanzmann en Trombocytopenie (ITP of de ziekte van Werlhof). http://www.nvhp.nl/

30. MedlinePlus Enciclopedia Médica: Enfermedad De Von Willebrand Translate this page Enfermedad de von willebrand. Además hay insuficiencia del factor vonWillebrand, que también ayuda a la coagulación sanguínea. http://www.nlm.nih.gov/medlineplus/spanish/ency/article/000544.htm

@import url(http://www.nlm.nih.gov/medlineplus/images/advanced.css); Omita y vaya al Contenido Otros enciclopedia temas: A-Ag Ah-Ap Aq-Az B-Bk ... Z Enfermedad de von Willebrand Contenido: Definici³n Causas, incidencia y factores de riesgo S­ntomas Signos y ex¡menes ... Co¡gulos sangu­neos Definici³n Volver al comienzo Trastorno hemorr¡gico de origen hereditario causado por la deficiencia del factor VIII que puede ser de leve a severa, niveles bajos del ant­geno relacionado con el factor Vlll (sustancias necesarias para la coagulaci³n de la sangre). Adem¡s hay insuficiencia del factor von Willebrand, que tambi©n ayuda a la coagulaci³n sangu­nea . El factor von Willebrand ayuda a que las plaquetas se adhieran a las paredes de los vasos sangu­neos y a que se adhieran unas con otras, lo cual es necesario para lograr la coagulaci³n normal de la sangre. Causas, incidencia y factores de riesgo Volver al comienzo La enfermedad de Von Willebrand es el trastorno hereditario de sangrado m¡s comºn y afecta a ambos sexos m¡s o menos de igual forma. La mayor­a de los casos son leves y el sangrado se puede presentar despu©s de un procedimiento quirºrgico o de una extracci³n dental y puede disminuir durante el embarazo. Esta condici³n empeora con el uso de aspirina y otros medicamentos antiinflamatorios no esteroideos (AINES). Esta enfermedad es muy comºn y afecta al menos al 1% de la poblaci³n. El factor principal de riesgo es un antecedente familiar de trastorno hemorr¡gico. En las mujeres que presentan sangrado menstrual profuso o prolongado, la enfermedad de Von Willebrand es m¡s comºn en las cauc¡sicas que en las afroamericanas.

31. DNA Helps Man's Best Friend Researchers discovered the genetic mutation responsible for canine von willebrand sDisease (vWD), a bleeding disorder similar to hemophilia, after the gene http://www.vetgen.com/bagp1.html

Human DNA Helps Man's Best Friend Cloning of human gene leads to breakthrough genetic discovery (Ann Arbor, Mich.) - VetGen, Inc. has announced a major breakthrough in canine genetic research with the introduction of a new test that could eradicate a potentially fatal disease in dogs. Researchers discovered the genetic mutation responsible for canine von Willebrand's Disease (vWD), a bleeding disorder similar to hemophilia, after the gene was successfully cloned in humans. VetGen, a Michigan-based company specializing in canine disease detection services, has developed the first reliable, non-invasive test for vWD in Scottish Terriers. The research project, headed by University of Michigan geneticist Dr. George Brewer, was a joint effort between VetGen, Michigan State University and the University of Michigan. Researchers focused their initial vWD study on Scottish Terriers, one of the primary breeds affected by the disease, although work is underway to analyze the gene in several other breeds. When used by Scottie breeders, the VetGen vWD test can provide owners with the assurance that their dogs and puppies are free of the disease, Another advantage of VetGen's vWD test is that it can be performed on dogs of any age. In addition, breeders who use VetGen's vWD test can register the results of their dog's test with the Orthopedic Foundation for Animals.

32. Page Not Found Information including Pediatric studies. http://www.beckmancoulter.com/Coulter/Techpubs/Pediatric-Profiles/vWD.asp

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33. WebMD Health - 404 Error Information on definition, causes, incidence and risk factors, symptoms and signs and treatment as well as expectations, prognosis and complications. http://my.webmd.com/content/healthwise/109/27028

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34. The Other Bleeding Disorder Information on the three types of von willebrand Disease as well as treatments. http://www.haemophilia.org.za/Vonwil2.htm

The "Other" Bleeding Disorder W hat is the most common inherited bleeding disorder, the one that affects many millions of people around the world, and up to two million in the United States? You may be surprised to hear that it is not haemophilia. It is von Willebrand disease , a related disorder that few people have heard of, unless they have it or know someone who does. Why is such a common illness such a secret? Perhaps because the disease is usually less severe than haemophilia, it has not generated the kind of publicity, educational efforts and support that other chronic illnesses have. In fact, it is often so mild, it is not diagnosed at all. Some people live with the disease for many years before getting an accurate diagnosis. For more severely affected patients, this lack of knowledge has caused real suffering. Alice Arabshian, a college student was diagnosed with clinically severe von Willebrand disease when she was a year old, says of her early childhood in Cyprus where almost nothing was known about von Willebrand: "There were no facilities for people with this illness. It was virtually impossible to get proper treatment." Fortunately, substantial progress has been made in recent years. The von Willebrand gene has been identified and research is underway to develop gene therapy. As research continues, however, the challenge continues to educate healthcare professionals and the public about this disorder. That is the best way to assure those with von Willebrand that they will receive proper diagnoses and treatment.

35. What Is Von Willebrand Disease? What Is von willebrand Disease? von willebrand disease is an inherited bleedingdisorder. This clotting protein is called von willebrand factor. http://123819272.net/Diseases/vWD/vWD_WhatIs.html

36. Sheffield University VWF Homepage Supported by Aventis. Upto-date databases of point mutations, insertions, deletions,and polymorphisms found in the gene for human von willebrand Factor. http://www.shef.ac.uk/vwf/

Maintained at the University of Sheffield, United Kingdom ISTH SSC VWF Information Homepage Supported by Up-to-date databases of point mutations, insertions, deletions, and polymorphisms found in the gene for human von Willebrand Factor. Fast link: Mutations Polymorphisms Nomenclature VWF Sequences VWD Diagrams Useful links Database submission References Downloads Searches Sponsor Patient information Credits Please select one of the following links: Mutations Mutations in the human VWF gene sorted by nucleotide number and by association with type of von Willebrand disease (VWD) Polymorphisms Polymorphisms in the human VWF gene Nomenclature Current nomenclature recommended by the ISTH VWF SSC VWF Sequences Amino acid, cDNA and genomic DNA links with Mancuso genomic and pseudogene sequences. Also links to VWF sequences of other species VWD A brief description of the types of von Willebrand Disease (VWD) Diagrams Figures of the VWF gene, mRNA and protein (including binding domains) and example multimer gels for VWD type 2 defects Links Links to other useful web sites New Mutations/Polymorphisms How to submit a new mutation or polymorphism to the database manager References Alphabetical list of VWF mutation and polymorphism references in the database Downloads Useful VWF downloads, including PDB files containing the structure of VWF A1 and A3 domains to be viewed in Rasmol

37. Nursing Spectrum- Career Fitness Online von willebrand Disease. The commonly inherited bleeding disorder. Examples and treatments. http://nsweb.nursingspectrum.com/ce/ce222.htm

Susanne J. Pavlovich-Danis, ARNP-C, MSN Describe the diagnostic process for vWD. Identify treatments and the educational needs of patients with vWD. Could these three very different patients have something in common? Are their symptoms being evaluated or treated when a true underlying problem remains unnoticed? von What? Erik von Willebrand, MD, first described vWD in 1925 after studying a family of women from Aland Islands, Finland, who had extreme menstrual bleeding. One member was a 12-year-old girl who died during her first menstrual period. vWD occurs in 1% to 2% of the US population. Unlike hemophilia, it occurs equally among genders, yet women are affected more severely because of menstruation and childbirth. Research has shown that white women (15.9%) are more likely than black women (1.4%) to have vWD. Many with the disorder are unaware of the true cause of their symptoms or that treatment is available. While there is no cure, it can be treated. Without proper diagnosis, people with vWD can die unnecessarily during surgery, trauma, or menses. Hemostasis and the vW Factor Normal blood clotting requires a series of reactions among blood factors, proteins, and platelets to form the platelet plug that ultimately creates a fibrin clot that, in turn, stops blood from leaking from vessels. In vWD, an interruption in the normal clotting process causes bleeding into the skin and from mucous membranes, especially the nose, mouth, gums, gastrointestinal/genitourinary tract linings, and the uterus. von Willebrand factor (vWF) is a glue-like, high-molecular-weight protein necessary for platelet adhesion and formation of the platelet plug. Produced by cells lining vessel walls, it is also a carrier protein for plasma factor VIII (classic hemophilia A factor).

38. EMedicine - Von Willebrand Disease : Article By John D Geil, MD von willebrand Disease Although referred to as a single disease, von willebranddisease (vWD) is in fact a family of bleeding disorders caused by an http://www.emedicine.com/ped/topic2419.htm

(advertisement) Home Specialties CME PDA ... Patient Education Articles Images CME Patient Education Advanced Search Link to this site Back to: eMedicine Specialties Pediatrics Hematology Von Willebrand Disease Last Updated: May 24, 2002 Rate this Article Email to a Colleague Synonyms and related keywords: vWD AUTHOR INFORMATION Section 1 of 10 Author Information Introduction Clinical Differentials ... Bibliography Author: John D Geil, MD , Associate Professor, Department of Pediatrics, University of Kentucky Children's Hospital John D Geil, MD, is a member of the following medical societies: American Academy of Pediatrics , and American Society of Pediatric Hematology/Oncology Editor(s): J Martin Johnston, MD , Consulting Staff, Department of Pediatrics, Division of Hematology-Oncology, Saint Luke's Mountain States Tumor Institute; Robert Konop, PharmD , Clinical Assistant Professor, Department of Pharmacy, Section of Clinical Pharmacology, University of Minnesota; James L Harper, MD , Director of Nebraska Regional Hemophilia Treatment Center, Associate Professor, Department of Pediatrics, University of Nebraska Medical Center;

39. EMedicine - Von Willebrand Disease : Article By Eleanor S Pollak, MD von willebrand Disease In 1926, Erik von willebrand first reported an autosomallyinherited mucocutaneous bleeding disorder in a large family from the Aland http://www.emedicine.com/med/topic2392.htm

(advertisement) Home Specialties CME PDA ... Patient Education Articles Images CME Patient Education Advanced Search Link to this site Back to: eMedicine Specialties Medicine, Ob/Gyn, Psychiatry, and Surgery Hematology von Willebrand Disease Last Updated: September 20, 2002 Rate this Article Email to a Colleague Synonyms and related keywords: von Willebrand disease, von Willebrand’s disease, vWD, VWD, von Willebrand factor, VWF, vWF, mucocutaneous bleeding disorder, primary hemostasis impairment, bleeding disorder, hematological disorder AUTHOR INFORMATION Section 1 of 10 Author Information Introduction Clinical Differentials ... Bibliography Author: Eleanor S Pollak, MD , Associate Director of Special Coagulation, Assistant Professor, Department of Pathology and Laboratory Medicine, Section of Hematology and Coagulation, University of Pennsylvania Coauthor(s): Steven Stein, MD , Assistant Professor, Department of Medicine, Division of Hematology/Oncology, University of Pennsylvania Eleanor S Pollak, MD, is a member of the following medical societies:

40. Von Willebrand's Disease What is von willebrand s disease? The much rarer types II and III vWD causesevere bleeding disorders. How is von willebrand s disease inherited? http://www.upei.ca/~cidd/Diseases/clinical pathology/von Willebrand's disease.ht

What is von Willebrand's disease? Von Willebrand's disease (vWD) is a common, usually mild, inherited bleeding disorder in people and in dogs. It is caused by a lack of von Willebrand factor (vWF), which plays an essential role in the blood clotting process. Normally the body responds to an injury causing bleeding through a complex defence system. This consists of local changes in the damaged blood vessels, activation of blood cells called platelets, and the coagulation process. A reduction in von Willebrand factor leads to abnormal platelet function and prolonged bleeding times. Affected dogs are prone to bleeding episodes such as nose bleeds, and generally experience increased bleeding with trauma or a surgical procedure. Three forms of the disease are distinguished based on vWF concentration and function. Dogs with Type I vWD (by far the most common) have mild to moderate bleeding abnormalities, depending on the level of vWF. The much rarer types II and III vWD cause severe bleeding disorders. How is von Willebrand's disease inherited?

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