41. Dermatlas: Online Dermatology Image Library Dermatology Image,hypopigmentation/d Dermatlas Dermatology Images tuberous sclerosis,macule,macule,hypopigmentation/depigmentation,hypopigmentation,fibrous papule,dermatology image,ash leaf http://dermatlas.med.jhmi.edu/derm/result.cfm?Diagnosis=189

42. Tuberous Sclerosis tuberous sclerosis. Alicia Zukas. According to the Virtual Hospital, other organ systems are usually also affected by tuberous sclerosis. http://serendip.brynmawr.edu/bb/neuro/neuro99/web2/Zukas.html

Biology 202 1999 Second Web Reports On Serendip Tuberous Sclerosis Alicia Zukas Tuberous Sclerosis (TS), or Bourneville disease, covers a broad range of afflictions, but neurologically afflicts 1/6000 newborns in the United States . Its name derives from the "tuber-like growth, on the brain which calcify with age and become hard or sclerotic" . Brain tubers have no distinction between white and gray matter, as indicated by the arrow in the biopsy. TS was first observed by von Recklinshausen in 1862, and was named by Bourneville as tuberous sclerosis in 1880; he described it as a "'tuberous sclerosis of the cerebral circumvolutions' for the unique cerebral pathologic changes he found in the brain of a 15 year-old epileptic and mentally handcapped girl" . The patient's face was also scarred with lesions, now know as facial angiofibroma . By the early 1900's TS was made according to evidence of what is known as the Vogt triad, including seizures, mental retardation, and the facial angiofibroma. It is now known that this triad is not necessarily needed to diagnose TS. The current diagnosis is based upon the following: Multiple ungual fibroma

43. Tuberous Sclerosis Complex tuberous sclerosis Complex. by Cheryl Howell. What is tuberous sclerosis Complex? Physical Symptoms. Genetic Analysis. Current Research. Other TSC Resources. http://biology.kenyon.edu/slonc/bio38/howell/tsc.htm

Tuberous Sclerosis Complex by Cheryl Howell What is Tuberous Sclerosis Complex? Physical Symptoms Genetic Analysis Current Research ... References What is Tuberous Sclerosis Complex? Tuberous Sclerosis Complex (TSC) was discovered in the 1880's by a French physician named Bourneville. TSC, also known as Bourneville's Disease and Epilola, is an incurable multisystem genetic disorder which can have a wide range of effects. Approximately one in 8,000 adults and one in 6,000 newborns are affected by TSC. Although TSC is often inherited, new mutations have been implicated in up to 75% of all cases ( TSA of Greece ). Males and females of equally likely to have Tuberous Sclerosis and the chance of passing it on to offspring is 50%. Physical Symptoms The physical symptoms of TSC which often lead to its diagnosis include hamartomaceous lesions of the brain, heart, kidneys, skin, lungs, and eyes, mental retardation, seizures, autism, fibromas of the finger and toenails, pitted teeth, and dermatological lesions. Three symptoms which constitute a positive diagnosis of TSC are seizures, mental retardation, and adenoma sebaceum, which are known as the clinical triad. People with TSC may exhibit only a few or many of these symptoms. Hamartomaceous lesions, or hamartomas, are tumour-like growths which are referred to as tubers. The most common tuber forms of the internal organs are cerebral hamartias and subependymal giant cell astrocytomas of the brain, rhabdomyomas of the heart, and angiomyolipomas of the kidneys (Kwiatkowski and Short, 1994 cited in Henske

44. Pediatric Oncall-Tuberous Sclerosis Find out all about tuberous sclerosis and its management on www.pediatriconcall.com. DOCTOR CORNER, Search, GO. tuberous sclerosis. UserName. Password. New Register, http://www.pediatriconcall.com/fordoctor/DiseasesandCondition/tuberous_sclerosis

DOCTOR CORNER Search GO Home Back Ask Doctor Post Query Education Teaching Files Question of the day Specialist Answers Latest Updates Conference Journal Search Pharma Updates Search For Pediatricians Hospitals Special Schools Drug Index ... Sign Out TUBEROUS SCLEROSIS UserName Password New Register Dr Ira Shah M.D, DCH(Gold Medalist), FCPS, DNB Q1). What is tuberous sclerosis? EVERY INDIVIDUAL WITH TUBEROUS SCLEROSIS IS AFFECTED DIFFERENTLY. SOME INDIVIDUALS ARE TOTALLY UNAFFECTED WHEREAS SOME PEOPLE ARE MORE SEVERELY AFFECTED. Q2). How common is tuberous sclerosis? A 2). Out of every 6000 newborns, one may have tuberous sclerosis. More than 1 million people around the world are known to have tuberous sclerosis. These may still be many undiagnosed cases and mild forms of the disease. Q3). How does a person with tuberous sclerosis present? A3). The disease spectrum of tuberous sclerosis is very diverse. Some may present with a very severe form whereas some may be totally unaffected.

45. Tuberous Sclerosis -- MGH Molecular Neurogenetics Unit Molecular Neurogenetics Unit. tuberous sclerosis. General Information and Support (The National tuberous sclerosis Association); Cody s Page (Basic Info) http://www.mgh.harvard.edu/depts/diseases/mnu-tsc.htm

Massachusetts General Hospital Molecular Neurogenetics Unit Tuberous Sclerosis General Information and Support (The National Tuberous Sclerosis Association) Cody's Page (Basic Info) Tuberous Sclerosis (TSC) is a genetic disorder that causes benign tumors to form in many different body organs including the brain, skin, heart, kidneys, lungs, and eyes. In any one individual, clinical symptoms will vary depending upon the specific organs affected. While the true prevalence of TSC is not known, it is estimated that TSC occurs in approximately 1 in 10,000 live births. TSC is seen in both sexes and among all racial and ethnic groups. The diagnosis of TSC is made through clinical evaluations of the organ systems involved. A thorough evaluation typically includes careful examinations of the skin, brain, kidneys, heart, and eyes to determine whether any organ involvement has occurred. Additional tests, including ultrasounds, MRI scans, or CT (“cat”) scans may beeeded to confirm a diagnosis. Of the two genes associated with TSC, the TSC2 gene has been located on chromosome 16. Dr. Jonathan Haines is performing mutational analysis of the TSC2 gene and Dr. Vijaya Ramesh has begun characterization of the corresponding protein, tuberin . DNA diagnostic testing for TSC2 mutations is now available for a subset of research families through the clinical laboratory of Dr. Katherine Sims. Dr. Sims also runs the tuberous sclerosis clinic at Massachusetts General Hospital for patients and families affected by this disorder. Dr. Alan Buckler is working on locating the TSC1 gene on chromosome 9 by applying newly developed strategies for physical mapping of human chromosomes and disease gene identification.

46. Tuberous Sclerosis The tuberous sclerosis Comprehensive Clinical Program provides diagnosis and longterm comprehensive care to all children and adults with tuberous sclerosis http://www.mgh.harvard.edu/depts/mghfc/MGHfC_medspec_tuberous-sclerosis.htm

Specialty Profile The Tuberous Sclerosis Comprehensive Clinical Program provides diagnosis and long-term comprehensive care to all children and adults with Tuberous Sclerosis Complex. Cognitive development is monitored closely, with recommendations for optimizing education and development. The Clinical Program also has a group of affiliated specialists who address all aspects of care for TSC. Staff Contact Us About Us Affiliate Hospitals ... MGH Much of the artwork featured on our site is from: "Expressions of Courage - Understanding Epilepsy Through the Art of Children." Photography by Sunny Yellen. Tuberous Sclerosis Comprehensive Clinical Program

47. CNS Pathology This area of firm, whitened gyri that are broader than surrounding normal gyri is typical for tuberous sclerosis. http://medlib.med.utah.edu/WebPath/CNSHTML/CNS080.html

This area of firm, whitened gyri that are broader than surrounding normal gyri is typical for tuberous sclerosis.

48. CNS Pathology Here is another tuber with tuberous sclerosis. The distinction between grey and white matter is lost. These patients can also have http://medlib.med.utah.edu/WebPath/CNSHTML/CNS079.html

Here is another tuber with tuberous sclerosis. The distinction between grey and white matter is lost. These patients can also have cardiac rhabdomyomas, renal angiomyolipomas, adenoma sebaceum of the skin, and pancreatic cysts.

49. Tuberous Sclerosis tuberous sclerosis. Image URL Chronic renal failure, Image URL Tuberose sclerosis, Image URL Tuberose sclerosis, Image URL Tuberose sclerosis, http://www.brisbio.ac.uk/ROADS/subject-listing/tuberoussclerosis.html

A collection of medical, dental and veterinary images for use in teaching. Home About the Archive FAQ Terms and Conditions ... Help Tuberous Sclerosis Chronic renal failure Tuberose sclerosis Tuberose sclerosis Tuberose sclerosis Tuberose sclerosis and lateral ventricle tumour Tuberose sclerosis of frontal cortex Tuberose sclerosis of frontal lobes Tuberose sclerosis of frontal lobes Tuberose sclerosis of parietal cortex Tuberose sclerosis with tumour in caudate nucleus Tuberose sclerosis with tumour in caudate nucleus Tuberose sclerosis

50. Overview, Cincinnati Children's Hospital Medical Center The tuberous sclerosis Clinic at Childrens Hospital Medical Center of Cincinnati assists in the medical care of children/adults with tuberous sclerosis. http://www.cincinnatichildrens.org/svc/prog/tuberous-sclerosis/

Home Contact Us Site Map Go to Advanced Search ... Tuberous Sclerosis Program Overview Patient Referrals Patient Expectations Contact Us Faculty and Staff Tuberous Sclerosis Program Overview The Tuberous Sclerosis Clinic at Children's Hospital Medical Center of Cincinnati, the largest in the United States, was organized in 1993 to assist in the medical care of children and adults who have or are suspected of having Tuberous Sclerosis. The purpose of the Tuberous Sclerosis clinic is not to replace care from the child's pediatrician or family physician, but to assist the primary care doctor in dealing with those aspects of Tuberous Sclerosis that affect the child's health or development. The basis of the Tuberous Sclerosis Clinic is the realization that people with Tuberous Sclerosis are different from other individuals who have epilepsy, learning disabilities, behavior problems, etc. For too long the unique problems found in this disease have been lumped together with similar disorders in children without tuberous sclerosis. Yet, research has increasingly shown that disorders of the brain, learning, heart, kidney, and other organs in Tuberous Sclerosis are different than the same conditions in individuals without Tuberous Sclerosis. The Tuberous Sclerosis Clinic is managed by the Neurology Department at Children's Hospital Medical Center of Cincinnati, and is part of the University of Cincinnati Medical Center.

51. MedlinePlus: Tuberous Sclerosis tuberous sclerosis. Printerfriendly version, E-mail this page to a friend. Search MEDLINE for recent research articles on • tuberous sclerosis. http://www.nlm.nih.gov/medlineplus/tuberoussclerosis.html

@import url(http://www.nlm.nih.gov/medlineplus/images/advanced.css); Skip navigation Other health topics: A B C D ... List of All Topics Tuberous Sclerosis Contents of this page: From the NIH General/Overviews Coping Diagnosis/Symptoms ... Teenagers Search MEDLINE for recent research articles on Tuberous Sclerosis You may also be interested in these MedlinePlus related pages: Brain and Nervous System Genetics/Birth Defects From the National Institutes of Health Tuberous Sclerosis (National Institute of Neurological Disorders and Stroke) Tuberous Sclerosis Information Page (National Institute of Neurological Disorders and Stroke) - Short Summary General/Overviews FAQ's about Tuberous Sclerosis Complex (Tuberous Sclerosis Alliance) Clinical Trials ClinicalTrials.gov: Tuberous Sclerosis (National Institutes of Health) Coping Living with Tuberous Sclerosis Complex (Tuberous Sclerosis Alliance) Diagnosis/Symptoms Diagnostic and Surveillance Screening in TSC (Tuberous Sclerosis Alliance) Neuroimaging in Tuberous Sclerosis Complex (Tuberous Sclerosis Alliance) - Links to PDF File Disease Management Making the Most of Your Doctors Visits (Tuberous Sclerosis Alliance) Research Updates in Tuberous Sclerosis Research (Tuberous Sclerosis Alliance) Specific Conditions/Aspects Brain Involvement (Tuberous Sclerosis Alliance) Epilepsy/Seizure Disorders (Tuberous Sclerosis Alliance) Eye Involvement (Tuberous Sclerosis Alliance) Facts for Teachers (Tuberous Sclerosis Alliance) Heart Involvement (Tuberous Sclerosis Alliance) Independent Living Options (Tuberous Sclerosis Alliance)

52. Tuberous Sclerosis tuberous sclerosis. Findings Discussion The constellation of findings is highly consistent with a diagnosis of tuberous sclerosis. Clinically http://www.med.uc.edu/neurorad/webpage/esa.html

Click on small image to see full size. Tuberous Sclerosis Findings: Axial CT images show chunky calcifications at the gray-white junction, without edema or mass effect. Multiple MR images show enhancement in the region of the right Foramen of Monro, with scattered areas of subcortical T2 signal abnormality. Discussion: The constellation of findings is highly consistent with a diagnosis of tuberous sclerosis. Clinically these patients present with the triad of seizures (90%), mental retardation (50%), and adenoma sebaceum (90%). -autosomal dominant, 1/10,000-1/50,000 -chromosomes: TSC 1 9q, TSC 2 16p- forme fruste 5x more common -criteria (need 1) -facial angiofibromas -ungual fibroma (17%) -retinal hamartoma -cortical tubers (50%) -subependymal nodules -multiple renal AML -presumptive (need 2) -hypomelanotic nodules -shagreen patch -single AML -multicystic kidney -cardiac rhabdomyoma (30-50%) -LAM pattern, honeycomb lung -first degree relative with TS -subependymal giant cell astrocytoma in 15% (WHO grade I) -other findings: retinal benign astrocytic hamartoma, heterotopias, myelination disorder, ventriculomegaly

53. Tuberous Sclerosis Complex; Congressionally Directed Medical Research Programs ( 3 awards in FY02 ~3 awards in FY03. tuberous sclerosis Complex Research Program Fact Sheet. tuberous sclerosis Complex Research Program Integration Panels. http://cdmrp.army.mil/tsrp/

Congressional Appropriations for Peer-reviewed Research $3 million in FY02-FY03 $3 million in FY04 Funding Summary 3 awards in FY02 Tuberous Sclerosis Complex Research Program Fact Sheet Tuberous Sclerosis Complex Research Program Integration Panels Tuberous Sclerosis Complex Research Program Peer Review Participants Tuberous Sclerosis Complex ... Publications Last updated April 28, 2004 (ldm)

54. Funding Opportunities-FY03 TSRP, Congressionally Directed Medical Research Progr tuberous sclerosis Complex Research Program. Synopsis of FY03 TSRP Award Mechanism provides a brief description and key elements of the award mechanism. http://cdmrp.army.mil/funding/03tsrp.htm

Tuberous Sclerosis Complex Research Program Synopsis of FY03 TSRP Award Mechanism - provides a brief description and key elements of the award mechanism. The Department of Defense (DOD) Tuberous Sclerosis Complex Research Program Announcement is provided in electronic format as follows: Idea Development Awards Microsoft Word Adobe PDF Electronic submission of proposals must be accomplished via the CDMRP eReceipt Online Proposal Submission site, and can be accessed at https://cdmrp.org/proposals For PDF file download assistance, click here To determine if your institution is designated as an HBCU/MI for FY03 TSRP, consult the following list: U.S. Department of Education Accredited Postsecondary Minority Institutions List For further information, please send e-mail to: cdmrpmaster@cdmrp.army.mil - for download related questions cdmrp.pa@det.amedd.army.mil - for program related questions CDMRP Home Site Map Search Contact Us ... Publications Last updated March 13, 2003 (ldm)

55. Tuberous Sclerosis Of The Brain tuberous sclerosis of Brain From the Virtual Pathology Museum, Department of Pathology, University of Connecticut Health Center. tuberous sclerosis. http://pathweb.uchc.edu/eAtlas/CNS/672.htm

Search Frames Search No frames PathWeb Home Feed Back ... About Tuberous Sclerosis Click on Image to Enlarge it Tuberous Sclerosis View of the base and frontal lobes of the brain showing tubers or hard, potato like gyri at the arrows. Tubers contain malformed neurons and astrocytes which form the foci for seizures. (Description By:Margaret Grunnet, M.D. ) (Image Contrib. by:Margaret Grunnet, M.D. UCHC ) Tuberous sclerosis Etiology Tuberous sclerosis is a phacomatosis (disease that affects brain, skin and other organs) that an autosomal dominant, inherited with high penetrance. Pathogenesis /see etiology., Epidemiology The prevalance of tuberous sclerosis is 1 in 10,000 children ages 0-5. General Gross Description The brains of most tuberous sclerosis patients show tubers (hard, potato-like nodules in gyri) of the cerebral cortex and candle gutterings (irregular calcified nodules) in the lateral, third and fourth ventricles. The face often shows angiofibromas on the cheeks and forehead, the heart may have rhabdomyomas and the kidneys may show cysts or angiomyolipomas.

56. Tuberous Sclerosis - Information / Diagnosis / Treatment / Prevention home neurological disorders neurodegenerative diseases tuberous sclerosis tuberous sclerosis. Marian s Life with tuberous sclerosis Marian s story. http://www.healthcyclopedia.com/neurological-disorders/neurodegenerative-disease

Home Health cyclopedia All Topics by Category The Good Health Search Engine Health Conditions A-Z Gurus ... neurodegenerative diseases > tuberous sclerosis Tuberous Sclerosis Information / Diagnosis / Treatment / Prevention External links (marked with an arrow ) open in a new window. This site is a web directory and does not offer medical advice. We cannot take responsibility for information found on listed sites. This Page Related Topics Medical Definition Health Portals Health News ... Web Directory: Related Topics: Genetic Disorders Mental Health/Disorders/Child and Adolescent/Mental Retardation/Causes Rare Disorders Medical Definition: University of Newcastle-upon-Tyne Medical Dictionary: "tuberous sclerosis" Health Portals: FamilyDoctor.org Information Sheets : Tuberous Sclerosis and Your Baby Health News: Search millions of published articles for news on Tuberous Sclerosis Modern Medicine Aging The Ardell Wellness Report HealthFacts Medical Post Medical Update Men's Health and the National Women's Health Report Note: Subscription required to access the full text of articles. Web Directory: Children's Hospital Medical Center of Cincinnati Tuberous Sclerosis Program Organized in 1993 to assist in the medical care of children and adults with tuberous sclerosis.

57. Tuberous Sclerosis tuberous sclerosis. What is it? It is sometimes referred to as tuberous sclerosis complex (TSC), Bourneville s disease, or epiloia. http://www.hmc.psu.edu/healthinfo/t/tuberoussclerosis.htm

58. Women With Disabilities - Tuberous Sclerosis tuberous sclerosis. Individuals with tuberous sclerosis may experience none or all of the symptoms with varying degrees of severity. http://www.4woman.gov/wwd/wwd.cfm?page=87

59. Virtual Children's Hospital: Paediapaedia: Tuberous Sclerosis Paediapaedia Neurological Diseases tuberous sclerosis. See related Provider Topics Brain and Nervous System, Genetics/Birth Defects or tuberous sclerosis. http://www.vh.org/pediatric/provider/radiology/PAP/NeuroDiseases/TS.html

Paediapaedia: Neurological Diseases Tuberous Sclerosis Michael P. D'Alessandro, M.D. Peer Review Status: Internally Peer Reviewed Clinical Presentation: Clinical triad is adenoma sebaceum, seizures, and mental retardation. Etiology/Pathophysiology: A hamartomatous proliferation of fibrous and connective tissue in the brain, skin, skeleton, kidneys, and heart. Pathology: The hamartomatous lesions in the brain consist of proliferating glial tissue and ganglion cells. Imaging Findings: The intracranial tubers are usually calcified and usually are in a periventricular / subependymal location but they can occasionally be found in the brain parenchyma. The tubers may undergo malignant degeneration into giant cell astrocytomas. DDX: Not applicable References: See References Chapter. Section Top Title Page See related Provider Topics Brain and Nervous System Genetics/Birth Defects or Tuberous Sclerosis See related Patient Topics Brain and Nervous System or Genetics/Birth Defects Virtual Children's Hospital Home Virtual Hospital Home Site Map ... UI Health Care Home http://www.vh.org/pediatric/provider/radiology/PAP/NeuroDiseases/TS.html

60. Virtual Hospital : Health Topics A-Z : Tuberous Sclerosis Health Topics AZ tuberous sclerosis. Paediapaedia tuberous sclerosis Pediatric Radiology Teaching Files tuberous sclerosis Bourneville s Disease http://www.vh.org/navigation/vh/topics/pediatric_provider_tuberous_sclerosis.htm

Health Topics A-Z Tuberous Sclerosis All Topics Adult Patient Topics Adult Provider Topics Pediatric Patient Topics ... Pediatric Provider Topics For Pediatric Providers Paediapaedia: Tuberous Sclerosis Pediatric Radiology Teaching Files: Tuberous Sclerosis - Bourneville's Disease All Topics Adult Patient Topics ... UI Health Care Home http://www.vh.org/navigation/vh/topics/pediatric_provider_tuberous_sclerosis.html

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