41. Toxic Epidermal Necrolysis About YMG. Search YMG. toxic epidermal necrolysis. What is toxic epidermal necrolysis? What are the symptoms of toxic epidermal necrolysis? http://ymghealthinfo.org/content.asp?pageid=P00321

42. Dermatlas: Online Dermatology Image Library Dermatology Image,drug Reaction,toxi Dermatlas Dermatology Images toxic epidermal necrolysis,drug reaction,dermatology image,Stevens-Johnson syndrome images. Match ALL words Match ANY word. http://dermatlas.med.jhmi.edu/derm/result.cfm?Diagnosis=1081703912

43. NEJM -- Sign In Correspondence from The New England Journal of Medicine toxic epidermal necrolysis. Number 14. Next Next. toxic epidermal necrolysis. http://content.nejm.org/cgi/content/full/334/14/922

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44. NEJM -- Sign In Correspondence from The New England Journal of Medicine LifeThreatening toxic epidermal necrolysis with Thalidomide Therapy for Myeloma. http://content.nejm.org/cgi/content/full/343/13/972

HOME SEARCH CURRENT ISSUE PAST ISSUES ... HELP Access to this article requires sign-in. Subscribers have access to all content. Other registered users have access to research articles six months old and older. If you're a registered user or an activated subscriber SIGN IN User Name Password Forgot your Password? Click here and we'll e-mail it to you. If you do not use cookies, sign in here. Remember my User Name and Password. PURCHASE THIS ARTICLE Purchase a single article and get immediate online access for just $10. If you're a subscriber but have not yet activated your full online access If you'd like to purchase a subscription to NEJM If you're not a subscriber and want FREE limited access... ACTIVATE YOUR SUBSCRIPTION Subscribers to NEJM are entitled to full access to all online content and features, including 20 FREE online CME exams. OR Receive full access to ALL current content and online features including Personal Archives, PDF article downloads, PDA access, E-mail alerts and 20 FREE online CME exams. OR Receive FREE online access to NEJM Original and Special Articles 6 months after publication and choose to receive the Table of Contents and notification of early release articles via e-mail.

45. Erythema Multiforme - Information / Diagnosis / Treatment / Prevention Nonprofit organization dedicated to providing information and support to persons afflicted with Stevens Johnson Syndrome and toxic epidermal necrolysis. http://www.healthcyclopedia.com/skin-disorders/erythema-multiforme.html

Home Health cyclopedia All Topics by Category The Good Health Search Engine Health Conditions A-Z Gurus ... skin disorders > erythema multiforme Erythema Multiforme Information / Diagnosis / Treatment / Prevention External links (marked with an arrow ) open in a new window. This site is a web directory and does not offer medical advice. We cannot take responsibility for information found on listed sites. This Page Medical Definition Health News Web Directory: Medical Definition: University of Newcastle-upon-Tyne Medical Dictionary: "erythema multiforme" Health News: Search millions of published articles for news on Erythema Multiforme Modern Medicine Aging The Ardell Wellness Report HealthFacts Medical Post Medical Update Men's Health and the National Women's Health Report Note: Subscription required to access the full text of articles. Web Directory: Erythema A consumer website for information about this disorder of the skin. Erythema Toxicum Read about a benign condition that is sometimes confused with more a more serious newborn illness. From Dr Greene. Stevens Johnson Syndrome Foundation Non-profit organization dedicated to providing information and support to persons afflicted with Stevens Johnson Syndrome and Toxic Epidermal Necrolysis.

46. Medications That May Cause Toxic Epidermal Necrolysis (TEN) Medications that may cause toxic epidermal necrolysis (TEN). toxic epidermal necrolysis (TEN) is a skin disorder that causes severe http://www.meritcare.com/hwdb/_followLink.asp?sgml_id=th1304

47. Toxic Epidermal Necrolysis Cochrane Skin Group. Interventions for toxic epidermal necrolysis. toxic epidermal necrolysis (TEN or Lyell s disease) is a rare lifethreatening skin condition. http://www.nottingham.ac.uk/~muzd/reviews/rev07TEN.dwt

Cochrane Skin Group Interventions for toxic epidermal necrolysis Majumdar S, Mockenhaupt M, Roujeau J-C, Townshend A CSG Home Page Synopsis Go to an image of this disease Thalidomide is not safe or effective for the skin condition toxic epidermal necrolysis, but there is not enough evidence to show which treatments are effective. Toxic epidermal necrolysis (TEN or Lyell's disease) is a rare life-threatening skin condition. It is probably an immune response triggered by some drugs or infection, which is more likely to happen in people with suppressed immunity. TEN causes extensive blistering and shedding of skin, similar to burns. Drugs used include oral steroids, thalidomide, immunosuppressants and immunoglobulins. This review of trials did not find any reliable evidence for the treatment of TEN. The only trial available used thalidomide, but this trial did not show any benefit from treatment compared against placebo but highlighted increased chances of dying from the treatment. Abstract Background Toxic epidermal necrolysis is a rare condition where a drug reaction induces skin loss, similar to that seen in extensive burns. It is associated with high morbidity and mortality and there is no clear agreement on effective treatment.

48. TREATMENT OF TOXIC EPIDERMAL NECROLYSIS (TEN) TREATMENT OF toxic epidermal necrolysis (TEN). Brambilla G. 1 , Brucato F. 1 , Angrisano A. 2 , Palmieri G. 1. Becker DS toxic epidermal necrolysis. http://www.medbc.com/annals/review/vol_15/num_1/text/vol15n1p17.asp

Annals of Burns and Fire Disasters - vol. XV - n. 1 - March 2002 TREATMENT OF TOXIC EPIDERMAL NECROLYSIS (TEN) Brambilla G. , Brucato F. , Angrisano A. , Palmieri G. Divisione di Medicina Interna II, Ospedale Niguarda Ca’ Granda, Milan, Italy Divisione di Pediatria, Ospedale “Caduti Bollatesi”, Bollate, Milan SUMMARY. Toxic epidermal necrolysis (ten) is a common and potentially dangerous mucocutaneous disease characterized by rash, bullae, and diffuse exfoliation of wide cutaneous surface areas. A description is given of the disease, also known as Lyell’s syndrome, and it is distinguished from similar conditions. Information is provided regarding the epidemiology, aetiology, and pathogenesis of TEN, as well as its clinical features. Diagnosis and therapy are also considered. Pharmacological therapy is required, particularly with cyclosporin. Definition Toxic epidermal necrolysis (TEN), also known as Lyell’s syndrome, is a widespread life-threatening mucocutaneous disease that is particularly observed secondary to drug-taking. It characterized by rash, bullae, and diffuse exfoliation of wide cutaneous surface areas, as in second-degree burns. Separation of the dermal-epidermal junction causes Nikolsky’s sign and gives the skin the typical “wet dressing” appearance. Classification In 1956 Lyell distinguished two entities in the description of toxic epidermal necrolysis: the Staphylococcal Scalded Skin Syndrome (SSSS) and what is now known as TEN.1

49. TOPICAL TREATMENT OF TOXIC EPIDERMAL NECROLYSIS USING OMIDERM® AND GLYCEROL-PRE TOPICAL TREATMENT OF toxic epidermal necrolysis USING OMIDERM® AND GLYCEROLPRESERVED HUMAN CADAVER SKIN*. Acikel C., Eren F., Ergun O., Celikoz B. http://www.medbc.com/annals/review/vol_15/num_2/text/vol15n2p75.asp

Annals of Burns and Fire Disasters - vol. XV - n. 2 - June 2002 TOPICAL TREATMENT OF TOXIC EPIDERMAL NECROLYSIS USING OMIDERM® AND GLYCEROL-PRESERVED HUMAN CADAVER SKIN* Acikel C., Eren F., Ergun O., Celikoz B. Gulhane Military Medical Academy Haydarpasa Training Hospital, Department of Plastic and Reconstructive Surgery and Burns Unit,Uskudar, Istanbul, Turkey SUMMARY. The extensive epidermal slough seen in toxic epidermal necrolysis resembles that of partial-thickness burns. Temporary coverage of denuded skin with biological or synthetic dressing materials minimizes heat and fluid loss from the wound, prevents wound infection, reduces pain, and promotes re-epithelialization. A 36-year-old female with epidermal sloughing in 90% total body surface area was successfully treated in this way. All detached epidermis was removed and the denuded skin was temporarily covered with Omiderm® and glycerol-preserved human cadaver allografts. We observed that these synthetic and biological materials were equally effective as regards healing time and quality. Introduction Toxic epidermal necrolysis (TEN) or Lyell’s syndrome is an idiosyncratic severe systemic disease characterized by extensive full-thickness epidermal sloughing (30-100% total body surface area) associated with mucous membrane and corneal involvement, fever, and severe pain. TEN is most often related to adverse drug reaction and has a significant morbidity and high mortality (mean, 30%) with an average incidence in Western countries of about 1 per million.1

50. Toxic Epidermal Necrolysis toxic epidermal necrolysis. toxic epidermal necrolysis is a lifethreatening skin disease in which the epidermis peels off in sheets http://www.tpmm.com/health/bacterial/epidermal.htm

Toxic Epidermal Necrolysis Toxic epidermal necrolysis is a life-threatening skin disease in which the epidermis peels off in sheets, leaving widespread denuded areas. This disorder can be caused by a drug reaction, most often penicillin, or by staphylococcal infections. About one-third of all diagnosed are a result of unknown causes. The symptoms of toxic epidermal necrolysis are: a painful, red area that spreads quickly, the top layer of skin may peel without blistering, scalded-looking raw areas of flesh, discomfort and fever. The condition may spread to eyes, mouth, and genitals. Medical University of South Carolina Tai Skin Clinic Lists Drugs that can cause this reaction. Find Articles.Com Medscape Merck Is your favorite site missing from this list? Tell our webmaster the address and we'll post it! Can patients find you online? GET LISTED! is quick, easy, and FREE! Advertise Contact Us FAQ ... Home

51. Toxic Epidermal Necrolysis toxic epidermal necrolysis. toxic epidermal necrolysis, Skin biopsy ; albumin, electrolytes. Drug induced eg, Sulphonamides, Allopurinol, http://www.rcpa.edu.au/pathman/toxic_ep.htm

This site has been updated. Please go to www.rcpamanual.edu.au This page will be permanently removed on 30th September 2004. Please update your links. Toxic epidermal necrolysis Toxic epidermal necrolysis Skin biopsy ; albumin, electrolytes. Drug induced eg Sulphonamides Allopurinol

52. Scott White - Toxic Epidermal Necrolysis toxic epidermal necrolysis is a lifethreatening skin disorder characterized by a blistering and peeling of the skin. Dermatology toxic epidermal necrolysis. http://www.sw.org/sw/portal/.cmd/SWActionDispatcher/_pagr/107/_pa.107/116/.swact

53. Dermatology Health Content Home Page Dermatology toxic epidermal necrolysis. What is toxic epidermal necrolysis? What are the symptoms of toxic epidermal necrolysis? http://uuhsc.utah.edu/healthinfo/adult/derm/toxic.htm

Call 581.2897 (SLC Metro) or toll-free 1.866.850.UUMD (8863) to make an appointment or consult with a University physician. Call Center Let us help make an appointment or arrange for a consultation... Dermatology Physicians Review our Dermatologists credentials and subspecialty interests... Dermatology Facilities Locations where our Dermatology physicians practice... Dermatology: Toxic Epidermal Necrolysis What is toxic epidermal necrolysis? Toxic epidermal necrolysis is a life-threatening skin disorder characterized by a blistering and peeling of the skin. This disorder can be caused by a drug reaction - frequently antibiotics or anticonvulsives. About one-third of all diagnosed cases of toxic epidermal necrolysis do not have an identifiable cause. What are the symptoms of toxic epidermal necrolysis? Toxic epidermal necrolysis causes the skin to peel in sheets, leaving large, raw areas exposed. The loss of skin allows fluids and salts to ooze from the raw, damaged areas and can easily become infected. The following are the other most common symptoms of toxic epidermal necrolysis. However, each individual may experience symptoms differently. Symptoms may include: a painful, red area that spreads quickly

54. Discover: Fire In The Flesh - Toxic Epidermal Necrolysis Print friendly Tell a friend Find subscription deals Fire in the Flesh toxic epidermal necrolysis Discover, Feb, 1999 by Robert A. Norman. http://articles.findarticles.com/p/articles/mi_m1511/is_2_20/ai_53631764

@import url(/css/us/style.css); @import url(/css/us/searchResult1.css); @import url(/css/us/articles.css); Advanced Search Home Help IN all publications this publication Reference Automotive Business Computing Entertainment Health News Reference Sports YOU ARE HERE Articles Discover Feb, 1999 Content provided in partnership with Print friendly Tell a friend Find subscription deals Fire in the Flesh - toxic epidermal necrolysis Discover Feb, 1999 by Robert A. Norman Mary Grove was suddenly shedding skin in large red patches. The loss was a threat to her life. My Friend Bill Cook, a primary care physician, called me one morning. "I've admitted a patient, a 28-year-old woman," he said. "She's losing her skin. Can you come and take a look at her?" He explained that the patient, Mary Grove, had come to his office the day before, complaining that her skin had suddenly begun to peel. She felt strangeweak and tenderand her eyes and mouth felt irritated. I am a dermatologist, and from Bill's description I had a good idea of what was wrong with Mary. Before going in to see her, I reviewed her chart. Mary worked as a receptionist and had a husband and two small children. She had felt fine until the day she was hospitalized. The hospital staff performed routine tests, including a chest X-ray and blood tests. They also put Mary on intravenous fluid replacement therapy and pain medications.

55. Pediatrics: Treatment Of Extensive Toxic Epidermal Necrolysis In Children Print friendly Tell a friend Find subscription deals Treatment of extensive toxic epidermal necrolysis in children Pediatrics, Nov, 2001 by Marcus Spies http://articles.findarticles.com/p/articles/mi_m0950/is_5_108/ai_80221919

@import url(/css/us/style.css); @import url(/css/us/searchResult1.css); @import url(/css/us/articles.css); Advanced Search Home Help IN all publications this publication Health Automotive Business Computing Entertainment Health News Reference Sports YOU ARE HERE Articles Pediatrics Nov, 2001 Content provided in partnership with Print friendly Tell a friend Find subscription deals Treatment of extensive toxic epidermal necrolysis in children Pediatrics Nov, 2001 by Marcus Spies Arthur P. Sanford J.F. Aili Low Steven E. Wolf ... David N. Herndon ABBREVIATIONS. TEN, toxic epidermal necrolysis; EM, erythema multiforme minor; SJS, Stevens-Johnson syndrome; TBSA, total body surface area; ADEN, acute disseminated epidermal necrosis. Toxic epidermal necrolysis (TEN) is a rare but life-threatening exfoliating disease of the skin and mucous membranes. The disease manifests itself by extensive blistering of the skin with full-thickness necrosis of the epidermis and involvement of mucosal surfaces (Fig 1). (1-3) The skin separation occurs at the dermoepidermal junction, and, even in unblistered areas, the epidermis can be removed easily by light tangential pressure (Nikolski's sign). [FIGURE 1 OMITTED] TEN and SJS both seem to be caused by immunologic reactions to foreign antigens. Drugs are implicated in 77% to 94% of cases. (8-11) Antibacterials and antifungals (36%), anticonvulsants (24%), analgesics, nonsteroidal anti-inflammatory agents (38%), and even corticosteroids (14%) have been suspected of causing the disease process. (11-13) The underlying pathophysiologic mechanism is unclear. The histologic characteristics of TEN include dermoepidermal separation resembling a blistering scald burn, followed by necrosis and shedding of the epidermis. (14) Because of histologic similarities with graft-versus-host reaction, specifically infiltration by cytotoxic T-lymphocytes, an autoimmune reaction to keratinocytes has been postulated. (1,15)

56. Revista Médica De Chile - Translate this page caso. toxic epidermal necrolysis. A toxic epidermal necrolysis was diagnosed and therapy with iv immunoglobulins was started. After http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872000001200006&l

57. SkinDrug DermAtlas 1 2 3 1. EXANTHEMATOUS DRUG REACTION 2. HALOGENODERMA 3. URTICARIA DermAtlas 4. PHOTOSENSITIVE REACTION 5. toxic epidermal necrolysis 6. LICHENOID http://www.geocities.com/sampyroy2000/SkinDrug.html

DRUG RELATED CUTANEOUS LESIONS Soft Tissue Tumour Onlne - India GI Path Online- India Link Dr. Sampurna Roy M.D. E-Mail Inflammatory Skin Disease CLICK ... Folliculitis Drug reaction is defined as undesirable response caused by medicinal substance. DRUG RLATED CLINICOPATHOLOGICAL PATTERNS DermAtlas 1. EXANTHEMATOUS DRUG REACTION 2. HALOGENODERMA 3. URTICARIA DermAtlas 4. PHOTOSENSITIVE REACTION 5. TOXIC EPIDERMAL NECROLYSIS 6. LICHENOID / INTERPHASE PATTERNS - LICHENOID DRUG REACTION DermAtlas - FIXED DRUG REACTION DermAtlas - ERYTHEMA MULTIFORME DermAtlas - LUPUS ERYTHEMATOUS- LIKE REACTION 7. VESICULOBULLOUS AND PUSTULAR REACTION 8. SPONGIFORM REACTION 9. GRANULOMAS 10. VASCULITIS 11. PSORIASIFORM DRUG REACTIONS 12. ACNE DermAtlas 13. PANNICULITIS 14. ERYTHEMA NODOSUM 15. EXFOLIATIVE DERMATITIS (ERYTHRODERMA) 16. HYPERSENSTIVITY SYNDROME 17. PIGMENTATION DermAtlas 18. PSEUDOLYMPHOMA 19. LIPODYSTROPHY 20. ELASTOSIS PERFORANS SERPINGINOSA Histological features indicative of drug reaction 1. Presence of eosinophils

58. Toxic Epidermal Necrolysis And Stevens Johnson Syndrome Facts StevensJohnson Syndrome SJS, and toxic epidermal necrolysis TENS another more serious form of SJS are severe adverse reactions to medications. http://www.kaitlynlangstaff.org/SJS_Facts/sjs_facts.html

SJS: What is It? Stevens-Johnson Syndrome (SJS), and Toxic Epidermal Necrolysis (TENS) - another more serious form of SJS - are severe adverse reactions to medications. Adverse drug reactions account for approximately 150,000 deaths per yet in the U.S. alone, making drug reactions the fourth leading cause of death in the United States. SJS is one of the most debilitating adverse drug reaction recognized. It was first discovered in 1922 by pediatricians A.M. Stevens and S.C. Johnson after diagnosing a child with severe ocular and oral involvement to a drug reaction. What Causes SJS? Almost any medication including over-the-counter drugs, such as Ibuprofen, can cause SJS. Most commonly implicated drugs are anti-convulsants, antibiotics (such as sulfa, penicillin and cephalosporin) and anti-inflammatory medications. Who Can Get SJS or TENS? Although SJS afflicts people of all ages a large amount of its victims are children. More female cases have been reported than male, however it does not discriminate against anyone. The SJS Foundation hears from people around the world who suffer from SJS and TENS. SJS: Know the Signs!

59. Toxic Epidermal Necrolysis And Stevens Johnson Syndrome - In The News Kaitlyn Langstaff is a nine year old girl who suffers from toxic epidermal necrolysis, a severe form of stevens johnson syndrome. http://www.kaitlynlangstaff.org/About_Kaitlyn/In_the_News/in_the_news.html

Links to newspaper articles about Kaitlyn Langstaff and her battle with Toxic Epidermal Necrolysis, a severe form of Stevens Johnson Syndrome. San Jose Mercury News - January 18, 2004 “Memorial for girl felled by illness” Saratoga News - Jan. 14, 2004 “Memorial service will be a celebration of Kaitlyn” San Jose Mercury News - Jan. 11, 2004 Memorial celebration planned in S.J. Saturday for Saratoga girl” Campbell Times - Jan. 10, 2004 “Kaitlyn’s Legacy” San Jose Mercury News - Dec. 22 “Pets Help Us Hold on for Dear Life” San Jose Mercury News - Dec. 19, 2003 “Disease Claims Inspiring Girl” San Jose Mercury News - Nov. 5, 2003 Talent scouts should check out local artists on charity CD” Metroactive Silicon Valley - April 10, 2003 Without Warning - A rare but debilitating and potentially deadly allergic reaction to some drugs, including Children's Motrin, may be on the rise. But you won't read about it on drug labels” Saratoga News - April 9, 2003 Winning a state championship... just imagine!” San Jose Mercury News - March 20, 2003 Parents of Stricken Girl Sue Makers of Children’s Motrin” Saratoga News - March 19, 2003

60. NewYork-Presbyterian Hospital: Health A To Z: Toxic Epidermal Necrolysis Health information about toxic epidermal necrolysis from NewYorkPresbyterian. The University Hospitals of Columbia and Cornell. http://wo-pub2.med.cornell.edu/cgi-bin/WebObjects/PublicA.woa/1/wa/viewHContent?

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