1. Tangier Disease tangier disease (TD) is a genetic disorder of cholesterol transport named for the secluded island of Tangier, located off the coast of Virginia. http://www.ncbi.nlm.nih.gov/disease/tangier.html

This Genes and Disease page has been moved to: Please update your bookmarks. If you are not automatically transported to the new page after 15 seconds, click on this link Genome View on chromosome 9 Databases PubMed the literature Key Papers Recent literature LocusLink collection of gene-related information OMIM catalog of human genes and disorders Information American Heart Association fighting heart disease and stroke National Heart, Lung and Blood Institute, NIH cardiovascular information TANGIER DISEASE (TD) is a genetic disorder of cholesterol transport named for the secluded island of Tangier, located off the coast of Virginia. TD was first identified in a five-year-old inhabitant of the island who had characteristic orange tonsils, very low levels of high density lipoprotein (HDL) or 'good cholesterol', and an enlarged liver and spleen. TD is caused by mutations in the (ATP-binding cassette) gene on chromosome 9q31. codes for a protein that helps rid cells of excess cholesterol. This cholesterol is then picked up by HDL particles in the blood and carried to the liver, which processes the cholesterol to be reused in cells throughout the body. Individuals with TD are unable to eliminate cholesterol from cells, leading to its buildup in the tonsils and other organs. The discovery of this important cholesterol transport gene may lead to a better understanding of the inverse relationship between HDL levels and coronary artery disease, an important killer in the US. New drugs that regulate HDL levels may be developed and such drugs would not only help individuals with TD, but also people with more common disorders such as familial HDL deficiency. This is a good illustration of how research into rare diseases can sometimes help more common disorders.

2. Tangier Disease By Jackie Newman An article about this rare disease, its history, characteristics of the disease and the treatments. http://www-personal.umd.umich.edu/~jcthomas/JCTHOMAS/1997 Case Studies/J. Newman

Tangier Disease by Jackie Newman Tangier Disease is an extremely rare autosomal recessive metabolic disorder. Documentation shows that as of 1988, 27 cases of Tangier Disease had been reported (Makrides pg.465) and in 1992 the reported cases were still fewer than 50 persons worldwide (Thoene pg.265). The majority of the cases tend to localize in one single area of the U.S., Tangier Island, Virginia. The fact that most of the people that are affected by Tangier disease all live in close proximity to one another could be due to Founder's effect. The original settlers to the island came in 1686 and it is possible that one or two of them were carriers of the disease or actually had the symptoms and passed it down through the blood line. Characteristics of Tangier Disease include increased levels or even a complete absence of high-density lipoproteins (HDL) concentrations in one's plasma, low cholesterol levels in the plasma, increased cholesteryl esters in the tonsils, spleen, liver, skin and lymph nodes. One easily visual characteristic usually found in children with Tangier disease is the presence of enlarged, yellow-orange tonsils. Initial research of Tangier disease showed a marked decrease in the HDL concentrations when compared to normal controls. In some cases the reduction was as great as 50% (Schmitz pg.6306). Scientists studied the HDL concentrations and looked for any possible links in its involvement with the disease. They specifically looked at the apo A-I (apolipoprotein) concentrations, which is a major protein component of HDL.

3. Tangier Disease tangier disease is an inherited blood disorder involving decreased concentrations of fat compounds in the blood called high density lipoproteins. Large amounts of these compounds may accumulate in http://www.bchealthguide.org/kbase/nord/nord385.htm

document.write(''); var hwPrint=1; var hwDocHWID="nord385"; var hwDocTitle="Tangier Disease"; var hwRank="1"; var hwSectionHWID="nord385"; var hwSectionTitle=""; var hwSource="cn6.0"; var hwProdCfgSerNo="wsh_html_031_s"; var hwDocType="NORD"; National Organization for Rare Disorders, Inc. Tangier Disease Important It is possible that the main title of the report is not the name you expected. Please check the synonyms listing to find the alternate name(s) and disorder subdivision(s) covered by this report. Synonyms Alpha High-Density Lipoprotein Deficieny Alphalipoproteinemia Analphalipoproteinemia Familial Alpha-Lipoprotein Deficiency Familial High-Density Lipoprotein Deficiency Disorder Subdivisions None Related Disorders List Information on the following diseases can be found in the Related Disorders section of this report: Acanthocytosis General Discussion Tangier Disease is an inherited blood disorder involving decreased concentrations of fat compounds in the blood called high density lipoproteins. Large amounts of these compounds may accumulate in certain organs of the body causing tissue discoloration. In later stages, these accumulations may cause organ enlargement and/or blood circulation problems. Symptoms Tangier Disease is a slowly progressive disorder initially characterized by enlarged orange or yellowish-gray tonsils. This same discoloration may be found in other parts of the throat and/or rectum. In time, the liver, spleen and lymph nodes may become enlarged. Brain dysfunction, loss of tendon reflexes and coronary artery disease may also occur. In some cases, small solid elevated skin lesions (papules) may appear.

4. Tangier Disease tangier disease. Pathology. In tangier disease exact link between the underlying cause, and the observed symptoms and physiological effects remain unknown. http://www.diseasedir.org.uk/genetic/gene0901.htm

Tangier Disease Disease Type: Genetic Disease Sub-Type: Chromosome 9 Pathology In Tangier disease exact link between the underlying cause, and the observed symptoms and physiological effects remain unknown. Tangiers disease is characterised by a defect in the efflux (flowing out of the cell) of cholesterol and its associated esters. This is detected in a large reduction in high-density lipoprotein (HDL) HDL is important because it redistributes fat around the body. On consumption of a meal, fat is first patched into 'chylomicrons' in the intestine. The Chylomicrons are absorbed into the liver, which processes them and releases them as VLDL, and LDL lipoproteins. The VLDL and LDL are distributed throughout the body, and absorbed by a variety of tissues. These tissues and organs then re-emit the particles as HDL lipoportiens to recycle unused cholesterol back to the liver. It is this final step which is in some way defective in Tangiers disease, surprisingly however, it leads to large deposits of cholesterol in the tonsils, and not the more common HDL emmiter tissues, for example muscles. It is thought that the repackaging into HDL requires either a Apolipoprotein mediated mechanism, or a aqueos method. In Tangiers disease it is thought that only the apolipoprotein mediated mechanism is at fault as this method is known to be used by Macrophage cells, which are present in the tonsils.

5. The Scientist - The Race To Find The Tangier Disease Gene Oct. 1, 2001 Rare disorder sheds some light on a common killer coronary artery disease binding cassette transporter 1 is mutated in tangier disease " Nature Genetics, 22; 347-351, August 1999 http://www.the-scientist.com/yr2001/oct/hot_011001.html

The Scientist 15[19]:21, Oct. 1, 2001 HOT PAPER The Race to Find the Tangier Disease Gene Rare disorder sheds some light on a common killer: coronary artery disease E-mail article By Brendan A. Maher For this article, Brendan A. Maher interviewed Michael R. Hayden , director and senior scientist, Centre for Molecular Medicine and Therapeutics, University of British Columbia, Canada; Stephan Rust Gerd Schmitz , a physician and director of the Institut for Clinical Chemistry and Laboratory Medicine, University Hospital, Regensburg. Data from the Web of Science (ISI, Philadelphia,) show that Hot Papers are cited 50 to 100 times more often than the average paper of the same type and age. Nature Genetics , 22; 347-351, August 1999. (Cited in 198 papers) Nature Genetics , 22; 352-355, August 1999. (Cited in 193 papers) A. Brooks-Wilson, M. Marcil, S. M. Clee, L. Zhang, K. Roomp, M. van Dam, L. Yu, C. Brewer, J. A. Collins, H.O.F. Molhuizen, O. Loubser, B.F. F. Ouelette, K. Fichter, K.J.D. Ashbourne-Excoffon, C.W. Sensen, S. Scherer, S. Mott, M. Denis, D. Martindale, J. Frolich, K. Morgan, B. Koop, S. Pimstone, J.J.P. Kastelein, J. Genest Jr., M. R. Hayden, "Mutations in in Tangier disease and familial high-density lipoprotein deficiency,"

6. CELLULAR CHOLESTEROL EFFLUX IN HETEROZYGOTES FOR TANGIER DISEASE IS MARKEDLY RED CELLULAR CHOLESTEROL EFFLUX IN HETEROZYGOTES FOR tangier disease IS MARKEDLY REDUCED AND CORRELATES WITH HIGH DENSITY LIPOPROTEIN CHOLESTEROL AND SIZE. Author(s) BROUSSEAU MARGARET E. EBERHART GRETCHEN P. DUPUIS JOSEE. ASZTALOS BELA looking for the cause of tangier disease (TD), a very rare genetic http://www.nal.usda.gov/ttic/tektran/data/000011/16/0000111687.html

TEKTRAN CELLULAR CHOLESTEROL EFFLUX IN HETEROZYGOTES FOR TANGIER DISEASE IS MARKEDLY REDUCED AND CORRELATES WITH HIGH DENSITY LIPOPROTEIN CHOLESTEROL AND SIZE Author(s): BROUSSEAU MARGARET E EBERHART GRETCHEN P DUPUIS JOSEE ASZTALOS BELA GOLDKAMP ALLISON L SCHAEFER ERNST J FREEMAN MASON W Interpretive Summary: Keywords: lipoproteins nutrition aging coronary heart disease genetics regulation atherosclerosis Contact: JEAN MAYER HUMAN NUTR. RE 711 WASHINGTON ST., TUFTS BOSTON MA 02111 FAX: (617)556-3103 Email: mbrousseau@hnrc.tufts.edu Approved Date: TEKTRAN United States Department of Agriculture Agricultural Research Service Updated:

7. NORD - National Organization For Rare Disorders, Inc. General Discussion. tangier disease is an inherited blood disorder involving decreased Organizations related to tangier disease. NIH/NINDS Brain Resources and Information http://www.rarediseases.org/search/rdbdetail_abstract.html?disname=Tangier Disea

8. OMIM - TANGIER DISEASE; TGD http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=205400

9. Tangier Disease - Information / Diagnosis / Treatment / Prevention Web Directory ? tangier disease An explanation of this disease and its name, its causes and treatment. ? tangier disease by http://www.healthcyclopedia.com/nutrition-and-metabolism-disorders/cholesterol-a

Home Health cyclopedia All Topics by Category The Good Health Search Engine Health Conditions A-Z Gurus ... cholesterol and other fats > tangier Tangier Disease Information / Diagnosis / Treatment / Prevention External links (marked with an arrow ) open in a new window. This site is a web directory and does not offer medical advice. We cannot take responsibility for information found on listed sites. This Page Related Topics Medical Definition Health News Web Directory: Related Topics: Neurological Disorders/Muscle Diseases Rare Disorders Medical Definition: University of Newcastle-upon-Tyne Medical Dictionary: "tangier disease" Health News: Search millions of published articles for news on Tangier Disease Modern Medicine Aging The Ardell Wellness Report HealthFacts Medical Post Medical Update Men's Health and the National Women's Health Report Note: Subscription required to access the full text of articles. Web Directory: Tangier Disease An explanation of this disease and its name, its causes and treatment. Tangier Disease by Jackie Newman An article about this rare disease, its history, characteristics of the disease and the treatments. Notes: Healthcyclopedia presents health information in the form of websites and articles that encompass conventional medicine and alternative treatments Under no circumstances can it recommend or endorse a specific drug or therapy or treatment.

10. Tangier Disease - Information / Diagnosis / Treatment / Prevention tangier disease An explanation of this disease and its name, its causes and treatment. . tangier disease by Jackie Newman An article about this rare disease, its history http://www.healthcyclopedia.com/tangier_disease.html

Home Health cyclopedia All Topics by Category The Good Health Search Engine Health Conditions A-Z Gurus ... cholesterol and other fats > tangier Tangier Disease Information / Diagnosis / Treatment / Prevention External links (marked with an arrow ) open in a new window. This site is a web directory and does not offer medical advice. We cannot take responsibility for information found on listed sites. This Page Related Topics Medical Definition Health News Web Directory: Related Topics: Neurological Disorders/Muscle Diseases Rare Disorders Medical Definition: University of Newcastle-upon-Tyne Medical Dictionary: "tangier disease" Health News: Search millions of published articles for news on Tangier Disease Modern Medicine Aging The Ardell Wellness Report HealthFacts Medical Post Medical Update Men's Health and the National Women's Health Report Note: Subscription required to access the full text of articles. Web Directory: Tangier Disease An explanation of this disease and its name, its causes and treatment. Tangier Disease by Jackie Newman An article about this rare disease, its history, characteristics of the disease and the treatments. Notes: Healthcyclopedia presents health information in the form of websites and articles that encompass conventional medicine and alternative treatments Under no circumstances can it recommend or endorse a specific drug or therapy or treatment.

11. Proximal Sensory Brachial plexopathy. Rule out Myelopathy. Ana-lipoproteinemia (tangier disease) l ATP binding cassette transporter (ABC1) ; Chromosome 9q31; Codominant http://www.neuro.wustl.edu/neuromuscular/nanatomy/proxsens.html

Front Search Index Links ... Patient Info Sensory involvement: Proximal Neuronopathies Paraneoplastic (anti-Hu) Autoimmune: Sjogren's Hereditary Toxic Pyridoxine intoxication cis-platinum Hereditary neuropathy Acute Intermittent Porphyria Small fiber neuropathies : Proximal pain Local neuropathy Thoracic neuropathies Diabetic Herpes Zoster Other proximal nerves Meralgia paresthetica: Lateral cutaneous nerve of thigh Brachial plexopathy Rule out: Myelopathy l ATP binding cassette transporter (ABC1) ; Chromosome 9q31; Codominant Genetic Same locus as Familial HDL deficiency ABC1 Protein Energy dependent transport of substrates across membranes Intracellular cholesterol transport Other ABC defects Systemic: Cystic fibrosis; Familial intrahepatic cholestasis Neural: Adrenoleukodystrophy ; Zellweger Eye: Stargardt; Retinitis pigmentosa; Cone-Rod dystrophy Neurologic features Onset 1st to 7th decade Neuropathy presenting feature in 30% Sensory Neuropathy: "Pseudosyringomyelic" Course: Slowly progressive Facial diplegia Hand muscle wasting Mononeuropathies Isolated or multiple Oculomotor; Long thoracic; Limb

12. Cholesterol Efflux Regulatory Protein, Tangier Disease And Familial Cholesterol efflux regulatory protein, tangier disease and familialhighdensity lipoprotein deficiencyMichael R. Haydena, Susanne M. Cleea, Angela Brooks-Wilsona e, Jacques Genest Jrb, Alan Attiecand http://www.sci.sdsu.edu/classes/biology/bio575/Week12.ABCA1.PDF

13. Tangier Disease tangier disease Important It is possible that the main title of the report tangier disease is not the name you expected. Please http://my.webmd.com/hw/health_guide_atoz/nord385.asp

var guid_source = ""; var guid_source_id = ""; //unused var encodedurl = ""; WebMD Today Home WebMD News Center Member Services WebMD University My WebMD Find a Physician Medical Info Check Symptoms Medical Library Quizzes, Calculators Clinical Trials ... Women, Men, Lifestyle Who We Are About WebMD Site Map You are in Medical Library Choose a Topic Our Content Sources Ask A Question Clinical Trials Health Guide A-Z Health Topics Symptoms Medical Tests Medications ... For a Complete Report Tangier Disease Important It is possible that the main title of the report Tangier Disease is not the name you expected. Please check the synonyms listing to find the alternate name(s) and disorder subdivision(s) covered by this report. Synonyms Alpha High-Density Lipoprotein Deficieny Alphalipoproteinemia Analphalipoproteinemia Familial Alpha-Lipoprotein Deficiency Familial High-Density Lipoprotein Deficiency Disorder Subdivisions None General Discussion Tangier Disease is an inherited blood disorder involving decreased concentrations of fat compounds in the blood called high density lipoproteins. Large amounts of these compounds may accumulate in certain organs of the body causing tissue discoloration. In later stages, these accumulations may cause organ enlargement and/or blood circulation problems. Resources National Tay-Sachs and Allied Diseases Association, Inc.

14. LookSmart - Directory - Tangier Disease Metabolic tangier disease. tangier disease General information, overviews, organizations, and support groups for tangier disease. http://search.looksmart.com/p/browse/us1/us317837/us317920/us53948/us330917/us10

@import url(/css/us/style.css); @import url(/css/us/searchResult1.css); Home IN the directory this category YOU ARE HERE Home Personal Health Tangier Disease - General information, overviews, organizations, and support groups for Tangier Disease. Directory Listings About NCBI Genes and Disease - Tangier Disease Presents a discussion about this disorder of cholesterol transport. Relays the first case identified, the causes, and the discovery of a cholesterol transport gene. Tangier Disease Jackie Newman authored an article about this very rare autosomal recessive metabolic disorder. Offered are the statistics, the characteristics, and gene therapy. We're always looking for ways to improve your search experience. Tell us how we're doing. Join the Zeal community and help build the "Tangier Disease" Directory Category IN the directory this category About Us Advertise with Us Advertiser Log-in Terms of Service

15. Tangier Disease tangier disease. tangier disease Genes and disease provides short descriptions of inherited disorders. It is hosted by the HONselect - tangier disease. http://www.health-nexus.com/tangier_disease.htm

Health-Nexus.Net Health-Nexus.Org The #1 Health information site Home ... Up Search Health-Nexus for: Match ALL words Match ANY word Email this page to a friend ! Post a question or comment on our Message Board Home Page Health Specialties Health News ... Alternative Health Options Substance Abuse Animal Health Search: Books Magazines Video Keywords: Find it Here Tangier Disease Tangier Disease Genes and disease provides short descriptions of inherited disorders. It is hosted by the ... Lung and Blood Institute, NIH cardiovascular information TANGIER DISEASE (TD) is a genetic disorder of ... Tangier Disease Tangier Disease Disease Type: Genetic Disease Sub-Type: Chromosome 9 Pathology In Tangier disease exact link between the underlying cause ... the genetic defect in the original Tangier disease kindred. Proc. Nat. Acad. Sci. USA ... Tangier Disease Jackie Newman authored an article about this very rare autosomal recessive metabolic disorder. Offered are the statistics, the characteristics, and gene therapy. HONselect - Tangier Disease Tangier Disease ... Organization for Rare Disorders, Inc. Tangier Disease Important It is possible that ... Acanthocytosis General Discussion Tangier Disease is an inherited blood disorder ... circulation problems.Symptoms Tangier Disease is a slowly progressive disorder ...

16. HONselect - Tangier Disease Translate this page English tangier disease, - A-alphalipoprotein Neuropathy - Analphalipoproteinemia - Familial High-Density Lipoprotein Deficiency Disease http://www.hon.ch/HONselect/RareDiseases/C10.668.829.800.875.html

List of rare diseases: English Deutsch Language: MeSH term: Accepted terms: English: Tangier Disease - A-alphalipoprotein Neuropathy - Analphalipoproteinemia - Familial High-Density Lipoprotein Deficiency Disease - Hypoalphalipoproteinemia, Familial - Lipoprotein Deficiency Disease, HDL, Familial - Tangier Disease Neuropathy Français: TANGIER, MALADIE - HYPOALPHALIPOPROTEINEMIE Deutsch: Tangier-Krankheit - Lipoproteine, HDL- - Retinitis pigmentosa - A-Alphalipoprotein-Neuropathie - Alpha-Lipoprotein-Mangelkrankheit, familiäre - Analphaliproteinämie - Familiäre HDL-Mangelkrankheit Español: ENFERMEDAD DE TANGIER - NEUROPATIA POR A-ALFALIPOPROTEINA - ENFERMEDAD POR DEFICIENCIA DE LIPOPROTEINA ALFA FAMILIAR - ANALFALIPOPROTEINEMIA - ENFERMEDAD POR DEFICIENCIA DE LIPOPROTEINA DE ALTA DENSIDAD FAMILIAR - HIPOALFALIPOPROTEINEMIA FAMILIAR - ENFERMEDAD POR DEFICIENCIA DE LIPOPROTEINA HDL FAMILIAR Português: DOENCA DE TANGIER - NEUROPATIA ALFALIPOPROTEINA-A - DOENCA DA DEFICIENCIA DE ALFA-LIPOPROTEINA FAMILIAR - ANALFALIPOPROTEINEMIA - DOENCA DA DEFICIENCIA DE LIPOPROTEINAS DE ALTA DENSIDADE FAMILIAR - HIPOALFALIPOPROTEINEMIA FAMILIAR - DOENCA DA DEFICIENCIA DE LIPOPROTEINA HDL FAMILIAR HONselect ressources Definition: Yes Articles: Yes Images: Yes News: No Conferences: No Clinical trials: No Web sites: English Yes Français Yes Deutsch No Español No Português No Home About us Site map Feedback ... HONewsletter http://www.hon.ch/HONselect/RareDiseases/C10.668.829.800.875.html

17. HON - List Of Rare Diseases Sweet s Syndrome. Takayasu s Arteritis, tangier disease. TaySachs Disease, Thromboangiitis Obliterans. Thyroiditis, Autoimmune, Tietze s Syndrome. http://www.hon.ch/HONselect/RareDiseases/

List of rare diseases: English Deutsch Acrocephalosyndactylia Acrodermatitis ... HONewsletter http://www.hon.ch/HONselect/RareDiseases/index.html Last modified: Wed Apr 28 2004

18. Tangier Disease :: Med Family :: Medicine For The Family RELATED LINKS. tangier disease tangier disease (TD) is a tangier disease Login/Create an account 0 Comments. Threshold 1 http://www.medfamily.org/medArticle165.html

@import url("themes/medFlash/style/style.css"); Site Search: Help Main Menu Home med Books Women's health Breast Examination Colposcopy Endometrial Pelvic Examination ... Examination of Vaginal Secretions Children's health Common illnesses Diagnosis and treatment Medication and Prevention Allergy and Asthma Medical Conditions Cardiology (Heart) Respiratory (Lung) Hemotology (Blood) Oncology (Cancer) ... General Medicine Medical Genetics Genetics Rare Diseases Partners var site="sm4dicmedfamily" CONTACT US to partner with medFamily med Resources med Syndrome med Links med Students med Abbreviations ... Diagnosis Diagnosis contains upto 10000 diseases and terms for you to find easily and quickly. Just search for the disease and find differential diagnosis, treatment, images and more. Learn More Dictionary Find all medical related terms and definition here. You can chat or discuss about each term. Learn More Wednesday, June 02, 2004 [ 11:25 PM ]

19. Tangier Disease | Med Family | Print Page tangier disease. Medical Family medicine for the family. Rare Diseases / Genetic and Evolution . tangier disease. tangier disease http://www.medfamily.org/Print_medArticle165.html

Tangier disease Medical Family - medicine for the family [ Rare Diseases / Genetic and Evolution ] Tangier disease Tangier disease Tangier disease (TD) is a genetic disorder of cholesterol transport named for the secluded island of Tangier, located off the coast of Virginia. TD was first identified in a five-year-old inhabitant of the island who had characteristic orange tonsils, very low levels of high density lipoprotein (HDL) or 'good cholesterol', and an enlarged liver and spleen. TD is caused by mutations in the ABC1 (ATP-binding cassette) gene on chromosome 9q31. ABC1 codes for a protein that helps rid cells of excess cholesterol. This cholesterol is then picked up by HDL particles in the blood and carried to the liver, which processes the cholesterol to be reused in cells throughout the body. Individuals with TD are unable to eliminate cholesterol from cells, leading to its buildup in the tonsils and other organs. The discovery of this important cholesterol transport gene may lead to a better understanding of the inverse relationship between HDL levels and coronary artery disease, an important killer in the US. New drugs that regulate HDL levels may be developed and such drugs would not only help individuals with TD, but also people with more common disorders such as familial HDL deficiency. This is a good illustration of how research into rare diseases can sometimes help more common disorders.

20. Tangier Disease,Alpha High-Density Lipoprotein Deficieny,Alphalipoproteinemia,An tangier disease,Alpha HighDensity Lipoprotein Deficieny,Alphalipoproteinemia,Analphalipoproteinemia,Familial Alpha-Lipoprotein Deficiency,Familial High http://www.icomm.ca/geneinfo/tangier.htm

Tangier Disease,Alpha High-Density Lipoprotein Deficieny,Alphalipoproteinemia,Analphalipoproteinemia,Familial Alpha-Lipoprotein Deficiency,Familial High-Density Lipoprotein Deficiency,Tangier Disease,Alpha High-Density Lipoprotein Deficieny,Alphalipoproteinemia,Analphalipoproteinemia,Familial Alpha-Lipoprotein Deficiency,Familial High-Density Lipoprotein Deficiency For Information on Workshops and Seminars for Special Needs Children click here The GAPS INDEX to Information on the Internet about Genetic Disorders and Birth Defects Genetic Information and Patient Services, Inc. (GAPS) HOME DISORDERS GLOSSARY Alphaliproteinemia also known as: Tangier's Disease Alphalipoprotein Deficiency Analphalipoproteinemia Alpha High-Density Lipoprotein Deficieny Familial Alpha-Lipoprotein Deficiency Familial High-Density Lipoprotein Deficiency (as defined by the National Organization for Rare Disorders Tangier Disease is an inherited blood disorder involving decreased concentrations of fat compounds in the blood called high density lipoproteins. Large amounts of these compounds may accumulate in certain organs of the body causing tissue discoloration.

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