21. Medical Encyclopedia: Subacute Sclerosing Panencephalitis (Print Version) Medical Encyclopedia subacute sclerosing panencephalitis. URL of this page http//www.nlm.nih.gov/medlineplus/ency/article/001419.htm. Alternative names. http://www.nlm.nih.gov/medlineplus/print/ency/article/001419.htm

To print this page, use the print option from your browser. To close this window, click on the "x" in the upper right hand corner of the window. Medical Encyclopedia: Subacute sclerosing panencephalitis URL of this page: http://www.nlm.nih.gov/medlineplus/ency/article/001419.htm Alternative names SSPE; Subacute sclerosing leukoencephalitis; Dawson´s encephalitis Definition SSPE is a progressive, debilitating, and fatal brain disorder caused by infection with a mutant measles (rubeola) virus (a measles virus that has undergone certain genetic changes or mutations). Causes, incidence, and risk factors Measles virus usually doesn't cause brain damage, but certain mutant forms can invade the brain, causing severe illness and death. SSPE has been reported in all parts of the world, but in western countries it is considered a rare disease. Fewer than 10 cases per year are reported in the United States, decreasing the frequency of this disease dramatically, following the nationwide measles immunization program. However, in some countries like India, over 20 cases of SSPE per million people are annually reported. SSPE tends to occur several years after having measles (rubeola), even though recovery from the illness appears to have been normal. More males are affected than females, and the disease generally occurs in children and adolescents.

22. Subacute Sclerosing Pancephalitis I. subacute sclerosing panencephalitis (SSPE) 1. Clinical features a. Onset 520 years of age, predominantly in males. The disease http://kobiljak.msu.edu/CAI/Pathology/CNS_Infections_F/CNS_1i.html

I. SUBACUTE SCLEROSING PANENCEPHALITIS (SSPE) Clinical features a. Onset: 5-20 years of age, predominantly in males. The disease has always been preceded by an attack of measles in the distant past or, occasionally, by measles immunization. b. Clinical presentation: personality changes, intellectual deterioration; periodic involuntary movements; decerebrate rigidity, severe dementia c. Duration: death usually in several years d. CSF changes: elevated gamma globulin; antibody titer elevated to measles Pathological changes a. Gross pathology: Cortical atrophy, demyelination and ventricular dilatation may all be present; changes are mild and are not diagnostic. b. Microscopic pathology: Inclusion bodies in oligodendroglia, neurons and astrocytes; chronic inflammatory reaction (perivascular cuffing by lymphocytes and plasma cells); some neuronal loss, gliosis and demyelination. The entire brain may be involved, but lesions are often more severe in neocortex, white matter, hippocampus, thalamus, ventral brainstem. Ultrastructural changes include paramyxovirus nucleocapsid tubules characteristic of measles virus in the inclusion bodies. This low power microscopic view shows perivascular cuffing in a case of subacute sclerosing panencephalitis, with mononuclear cells clustered around a vessel.

23. Subacute Sclerosing Panencephalitis subacute sclerosing panencephalitis. Definition. subacute sclerosing panencephalitis is a rare, progressive brain disorder caused http://www.healthatoz.com/healthatoz/Atoz/ency/subacute_sclerosing_panencephalit

Encyclopedia Index S Home Encyclopedia Encyclopedia Index S Subacute sclerosing panencephalitis Definition Subacute sclerosing panencephalitis is a rare, progressive brain disorder caused by an abnormal immune response to the measles virus. Description This fatal condition is a complication of measles, and affects children and young adults before the age of 20. It usually occurs in boys more often than in girls, but is extremely rare, appearing in only one out of a million cases of measles. Causes and symptoms Experts believe this condition is a form of measles encephalitis (swelling of the brain), caused by an improper response by the immune system to the measles virus. The condition begins with behavioral changes, memory loss, irritability, and problems with school work. As the neurological damage increases, the child experiences seizures, involuntary movements, and further neurological deterioration. Eventually, the child starts suffering from progressive dementia . The optic nerve begins to shrink and weaken (atrophy) and subsequently the child becomes blind. Diagnosis Blood tests and spinal fluid reveal high levels of antibodies to measles virus, and there is a characteristically abnormal electroencephalogram (EEG), or brain wave test. Typically, there is a history of measles infection two to ten years before symptoms begin.

24. CPS: CPSP Resource Article Subacute Sclerosing Panencephalitis subacute sclerosing panencephalitis in Perspective TI Fulminating subacute sclerosing panencephalitis case report and literature review. http://www.cps.ca/english/CPSP/Resources/Rsspe.htm

Subacute Sclerosing Panencephalitis in Perspective CPSP resource article published September 2000 Principal investigator : W. Walop, PhD Three different forms of infections in the central nervous system have been associated with the measles virus: acute postinfectious encephalitis, acute progressive infectious encephalitis (also known as measles inclusion body encephalitis or MIBE) and subacute sclerosing panencephalitis (SSPE). The postinfectious encephalitis is considered an autoimmune reaction, MIBE appears as a direct attack by the virus on the brain cells, while SSPE is a slow viral infection of the central nervous system, usually resulting in death within months or years. Can measles vaccine cause MIBE? From 1995 to 1998, no definite cases of SSPE were reported through the Canadian Paediatric Surveillance Program (CPSP). In 1999, however, two definite cases, as defined by very high serum and CSF IgG ratios in the presence of typical clinical manifestations, were identified through the CPSP. There also was a Canadian case report on MIBE caused by the vaccine strain of the measles virus, published in 1999.

25. Subacute Sclerosing Panencephalitis Factsheet subacute sclerosing panencephalitis. http://www.ich.ucl.ac.uk/factsheets/diseases_conditions/subacute_sclerosing/

Please use the indexes below to find the factsheet you need. Or search the full alphabetical index: Top Top Top Top ... Top Subacute Sclerosing Panencephalitis Contents Introduction What is the cause? How is it diagnosed? Does it have any alternative name? ... Support Groups Introduction This leaflet explains about Subacute sclerosing panencephalitis (SSPE) which is a rare disease of the brain which results in progressive loss of physical and mental skills. What is the cause? SSPE is caused by an unusual response to the measles virus, which lingers in the brain and then reactivates, often many years after the original infection. The presence of the virus within the brain cells prevents them working properly and passing messages to each other. The brain is the control centre of the whole body so blockages in the messages to other parts of the body will prevent those parts working efficiently even though the parts themselves are quite healthy. How is it diagnosed?

26. Subacute Sclerosing Panencephalitis subacute sclerosing panencephalitis Important report. Synonyms Panencephalitis, Subacute Sclerosing; SSPE; Dawson s Disease; Dawson s Encephalitis. http://my.webmd.com/hw/health_guide_atoz/nord185.asp

var guid_source = ""; var guid_source_id = ""; //unused var encodedurl = ""; WebMD Today Home WebMD News Center Member Services WebMD University My WebMD Find a Physician Medical Info Check Symptoms Medical Library Quizzes, Calculators Clinical Trials ... Women, Men, Lifestyle Who We Are About WebMD Site Map You are in Medical Library Choose a Topic Our Content Sources Ask A Question Clinical Trials Health Guide A-Z Health Topics Symptoms Medical Tests Medications ... For a Complete Report Subacute Sclerosing Panencephalitis Important It is possible that the main title of the report Subacute Sclerosing Panencephalitis is not the name you expected. Please check the synonyms listing to find the alternate name(s) and disorder subdivision(s) covered by this report. Synonyms Panencephalitis, Subacute Sclerosing SSPE Dawson's Disease Dawson's Encephalitis Disorder Subdivisions None General Discussion Subacute sclerosing panencephalitis (SSPE) is a progressive neurological disorder characterized by inflammation of the brain (encephalitis). The disease may develop due to reactivation of the measles virus or an inappropriate immune response to the measles virus. SSPE usually develops 2 to 10 years after the original viral attack. Initial symptoms may include memory loss, irritability, seizures, involuntary muscle movements, and/or behavioral changes, leading to neurological deterioration. Resources National Subacute Sclerosing Panencephalitis Registry PO Box 70191 Mobile, AL 36670-0191

27. AllRefer Health - Subacute Sclerosing Panencephalitis (Dawsons Encephalitis, SSP subacute sclerosing panencephalitis (Dawsons Encephalitis, SSPE, Subacute Sclerosing Leukoencephalitis) information center covers causes, prevention, symptoms http://health.allrefer.com/health/subacute-sclerosing-panencephalitis-info.html

AllRefer Channels :: Yellow Pages Reference Health Home ... Contact Us Quick Jump ADD/ADHD Allergies Alzheimer's Disease Arthritis Asthma Back Pain Breast Cancer Cancer Colon Cancer Depression Diabetes Gallbladder Disease Heart Attack Hepatitis High Cholesterol HIV/AIDS Hypertension Lung Cancer Menopause Migraines/Headaches Osteoporosis Pneumonia Prostate Cancer SARS Stroke Urinary Tract Infection 1600+ More Conditions Alternative Medicine Health News Symptoms Guide Special Topics ... Medical Encyclopedia You are here : AllRefer.com Health Subacute Sclerosing Panencephalitis Subacute Sclerosing Panencephalitis Definition Prevention Treatment Expectations or Prognosis ... Go To Main Page Alternate Names : Dawsons Encephalitis, SSPE, Subacute Sclerosing Leukoencephalitis Definition SSPE is a progressive, debilitating, and fatal brain disorder caused by infection with a mutant measles rubeola ) virus (a measles virus that has undergone certain genetic changes or mutations). Central Nervous System Measles virus usually doesn't cause brain damage, but certain mutant forms can invade the brain, causing severe illness and death. SSPE has been reported in all parts of the world, but in western countries it is considered a rare disease. Fewer than 10 cases per year are reported in the United States, decreasing the frequency of this disease dramatically, following the nationwide

28. AllRefer Health - Subacute Sclerosing Panencephalitis Treatment (Dawsons Encepha subacute sclerosing panencephalitis (Dawsons Encephalitis, SSPE, Subacute Sclerosing Leukoencephalitis) information center covers Treatment. http://health.allrefer.com/health/subacute-sclerosing-panencephalitis-treatment.

AllRefer Channels :: Yellow Pages Reference Health Home ... Contact Us Quick Jump ADD/ADHD Allergies Alzheimer's Disease Arthritis Asthma Back Pain Breast Cancer Cancer Colon Cancer Depression Diabetes Gallbladder Disease Heart Attack Hepatitis High Cholesterol HIV/AIDS Hypertension Lung Cancer Menopause Migraines/Headaches Osteoporosis Pneumonia Prostate Cancer SARS Stroke Urinary Tract Infection 1600+ More Conditions Alternative Medicine Health News Symptoms Guide Special Topics ... Medical Encyclopedia You are here : AllRefer.com Health Subacute Sclerosing Panencephalitis : Treatment of Subacute Sclerosing Panencephalitis Subacute Sclerosing Panencephalitis Definition Prevention Treatment Expectations or Prognosis Complications Calling Your Health Care Provider Go To Main Page Alternate Names : Dawsons Encephalitis, SSPE, Subacute Sclerosing Leukoencephalitis Treatment No cure for SSPE exists. However, certain anti-viral drugs can slow the progression of the disease. A combination of oral isoprinosine and interferon alfa injected directly into the brain ventricles, appears to be the most effective treatment. Ribavirin and Amantadine are other anti-viral medications that have been used with limited success. Patients responding to treatment need to receive it for the rest of their lives. Effective immunization against measles to prevent development of this condition is the only solution presently available.

29. Disease Directory : Neurological Disorders : Infections : Subacute Sclerosing Pa Diseases Neurological Disorders Infections subacute sclerosing panencephalitis. AllRefer Health subacute sclerosing panencephalitis Treatment http://www.diseasedirectory.net/Neurological_Disorders/Infections/Subacute_Scler

Wednesday, June 02, 2004 Neurological Disorders Infections Creutzfeldt Jakob Disease Encephalitis ... Infections : Subacute Sclerosing Panencephalitis Adam - An Overview - Subacute sclerosing panencephalitis, a definition and a look at the causes, incidence and risk factors. AllRefer Health - Subacute Sclerosing Panencephalitis Treatment ... - Subacute Sclerosing Panencephalitis (Dawsons Encephalitis, SSPE, Subacute Sclerosing Leukoencephalitis) information center covers Treatment. - SUBACUTE SCLEROSING PANENCEPHALITIS. CLINICAL ASPECTS AND PROGNOSIS. KEY WORDS: immunization, measles, seizures, subacute sclerosing panencephalitis. CJNS - Subacute Sclerosing Panencephalitis Presenting with ... - Abstract. Close Window Subacute Sclerosing Panencephalitis Presenting with Unilateral Periodic Myoclonic Jerks. Zaitoon M. Shivji, Ibrahim CPS: CPSP Resource Article Subacute Sclerosing Panencephalitis - Subacute Sclerosing Panencephalitis in Perspective TI: Fulminating subacute sclerosing panencephalitis: case report and literature review. Health Library - Subacute Sclerosing Panencephalitis - Subacute Sclerosing Panencephalitis. Synonyms. Panencephalitis, Subacute Sclerosing; SSPE; Dawson's Disease; Dawson's Encephalitis. Disorder Subdivisions. None.

30. Disease Directory : CJNS - Subacute Sclerosing Panencephalitis Presenting With . Diseases Neurological Disorders Infections subacute sclerosing panencephalitis CJNS subacute sclerosing panencephalitis Presenting with http://www.diseasedirectory.net/detailed/19674.aspx

Wednesday, June 02, 2004 Neurological Disorders Infections Creutzfeldt Jakob Disease Encephalitis ... Subacute Sclerosing Panencephalitis : CJNS - Subacute Sclerosing Panencephalitis Presenting with ... Directory Listing Title: CJNS - Subacute Sclerosing Panencephalitis Presenting with ... Description: Abstract. Close Window Subacute Sclerosing Panencephalitis Presenting with Unilateral Periodic Myoclonic Jerks. Zaitoon M. Shivji, Ibrahim Date Added: 2/11/2004 8:55:20 PM URL: http://www.cjns.org/30novtoc/subacute.html

31. Subacute Sclerosing Panencephalitis Information Diseases Database subacute sclerosing panencephalitis,van Bogaert s sclerosing leukoencephalitis,Measles inclusion body encephalitis,SSPE, Disease Database Information. http://www.diseasesdatabase.com/ddb12597.htm

Diseases Database Index Sponsors Contact ... Previous Page Subacute sclerosing panencephalitis Information Search 4 synonyms or equivalents were found. Subacute sclerosing panencephalitis aka/or van Bogaert's sclerosing leukoencephalitis aka/or Measles inclusion body encephalitis aka/or SSPE may be caused by or feature of (Follow link for list) may cause or feature (Follow link for list) belong(s) to the category of (Follow link for list) Subacute sclerosing panencephalitis: Definition(s) via UMLS Code translations and terms via UMLS Subacute sclerosing panencephalitis: specific sites Send Subacute sclerosing panencephalitis to medical search engines (JavaScript enabled browsers only) If your browser has no JavaScript you can still use these: Search using Internet medical databases Search using Internet search engines (non-specialist) We subscribe to the HONcode principles of the Health On the Net Foundation i-medicine.info - the evidence based medicine, informatics and audit portal Valid XHTML 1.0 Served 2004-06-03 04:11:19 Metadata Updated 2004-05-22

32. Subacute Sclerosing Panencephalitis subacute sclerosing panencephalitis (SSPE) is a progressive neurological disorder characterized by inflammation of the brain (encephalitis). http://www.bchealthguide.org/kbase/nord/nord185.htm

document.write(''); var hwPrint=1; var hwDocHWID="nord185"; var hwDocTitle="Subacute Sclerosing Panencephalitis"; var hwRank="1"; var hwSectionHWID="nord185"; var hwSectionTitle=""; var hwSource="cn6.0"; var hwProdCfgSerNo="wsh_html_031_s"; var hwDocType="NORD"; National Organization for Rare Disorders, Inc. Subacute Sclerosing Panencephalitis Important It is possible that the main title of the report is not the name you expected. Please check the synonyms listing to find the alternate name(s) and disorder subdivision(s) covered by this report. Synonyms Panencephalitis, Subacute Sclerosing SSPE Dawson's Disease Dawson's Encephalitis Disorder Subdivisions None Related Disorders List Information on the following diseases can be found in the Related Disorders section of this report: Progressive Rubella Panencephalitis Progressive Multifocal Leukoencephalopathy Inclusion Body Encephalitis General Discussion Subacute sclerosing panencephalitis (SSPE) is a progressive neurological disorder characterized by inflammation of the brain (encephalitis). The disease may develop due to reactivation of the measles virus or an inappropriate immune response to the measles virus. SSPE usually develops 2 to 10 years after the original viral attack. Initial symptoms may include memory loss, irritability, seizures, involuntary muscle movements, and/or behavioral changes, leading to neurological deterioration. Symptoms The complications of subacute sclerosing panencephalitis, such as severe pneumonia or coma, usually become life-threatening within 1 to 3 years. However, there may be improvement in some affected individuals for extended periods of time.

33. Subacute Sclerosing Panencephalitis subacute sclerosing panencephalitis. Definition subacute sclerosing panencephalitis is a rare, progressive brain disorder caused http://www.chclibrary.org/micromed/00066760.html

Main Search Index Definition Description Causes ... Resources Subacute sclerosing panencephalitis Definition Subacute sclerosing panencephalitis is a rare, progressive brain disorder caused by an abnormal immune response to the measles virus. Description This fatal condition is a complication of measles, and affects children and young adults before the age of 20. It usually occurs in boys more often than in girls, but is extremely rare, appearing in only one out of a million cases of measles. Experts believe this condition is a form of measles encephalitis (swelling of the brain), caused by an improper response by the immune system to the measles virus. The condition begins with behavioral changes, memory loss, irritability, and problems with school work. As the neurological damage increases, the child experiences seizures, involuntary movements, and further neurological deterioration. Eventually, the child starts suffering from progressive dementia. The optic nerve begins to shrink and weaken (atrophy) and subsequently the child becomes blind. Diagnosis Blood tests and spinal fluid reveal high levels of antibodies to measles virus, and there is a characteristically abnormal electroencephalogram (EEG), or brain wave test. Typically, there is a history of measles infection two to ten years before symptoms begin.

34. Subacute Sclerosing Panencephalitis subacute sclerosing panencephalitis,. Print this article, (SSPE), a rare, slow, progressive encephalitis resulting from long term http://www.amershamhealth.com/medcyclopaedia/medical/Volume VI 1/SUBACUTE SCLERO

Amershamhealth.com Search for: Type a word or a phrase. All forms of the word are searchable. Browse entry words starting with: A B C D ... Other characters Subacute sclerosing panencephalitis, (SSPE), a rare, slow, progressive encephalitis resulting from long term reactivation of persistent measles virus infection and characterized by a fatal course leading to death over a period of 26 years. Children 5 to 12 years old who showed the exanthematic manifestations of the disease before the age of three years, are the most commonly affected groups. Due to immunization programs the incidence of measles infection is decreasing and consequently that of SSPE, which is currently estimated at around 1/1,000,000 per year. The clinical onset usually consists of mental or behavioural abnormalities. The disease then progresses to myoclonic jerks, tremors and seizures and eventually to final complete loss of cortical function. The diagnosis is confirmed by high titres of measles virus antibodies in the CSF and in the serum. Described pathological changes include demyelination, gliosis and neuronal loss with only mild inflammation.

35. Sclerosing Panencephalitis, Subacute Sclerosing panencephalitis, subacute,. Print this article, see subacute sclerosing panencephalitis. FS. The Encyclopaedia of Medical Imaging Volume VI1. http://www.amershamhealth.com/medcyclopaedia/medical/Volume VI 1/SCLEROSING PANE

Amershamhealth.com Search for: Type a word or a phrase. All forms of the word are searchable. Browse entry words starting with: A B C D ... Other characters Sclerosing panencephalitis, subacute, see subacute sclerosing panencephalitis FS The Encyclopaedia of Medical Imaging Volume VI:1 Contacts GE Healthcare Making Waves

36. Subacute Sclerosing Panencephalitis Definition Of Subacute Sclerosing Panencepha Definition of subacute sclerosing panencephalitis in the Dictionary and Thesaurus. subacute subacute sclerosing panencephalitis. Word http://www.thefreedictionary.com/subacute sclerosing panencephalitis

Dictionaries: General Computing Medical Legal Encyclopedia subacute sclerosing panencephalitis Word: Word Starts with Ends with Definition Noun subacute sclerosing panencephalitis - a rare chronic progressive encephalitis caused by the measles virus and occurring primarily in children and young adults; death usually occurs within three years; characterized by primary measles infection before the age of two years Bosin's disease Dawson's encephalitis inclusion body encephalitis sclerosing leukoencephalitis ... panencephalitis - diffuse inflammation of the entire brain Legend: Synonyms Related Words Antonyms Some words with "subacute sclerosing panencephalitis" in the definition: Bosin's disease cephalitis Dawson's encephalitis encephalitis ... Van Bogaert encephalitis Previous General Dictionary Browser Next Subacetate subacid Subacrid ... Subaid Full Dictionary Browser Sub-provincial City (enc.) sub-rosa sub-Saharan Sub-Saharan Africa Sub-Saharan Africa (enc.) Sub-species (enc.) Sub-system (enc.) Sub-tenant (law) sub-test Sub-tropical (enc.) Subacetate subacid Subacrid Subacromial ... Subahu (enc.)

37. Health Library - subacute sclerosing panencephalitis. Synonyms. Panencephalitis, Subacute Sclerosing; SSPE; Dawson s Disease; Dawson s Encephalitis. Disorder Subdivisions. None. http://yalenewhavenhealth.org/library/healthguide/IllnessConditions/topic.asp?hw

38. Subacute Sclerosing Panencephalitis (SSPE) - Medical Dictionary Definitions Of P MedicineNet Home MedTerms medical dictionary AZ List subacute sclerosing panencephalitis (SSPE). Advanced Search. http://www.medterms.com/script/main/art.asp?articlekey=6341

39. Dictionary Definition Of SUBACUTE SCLEROSING PANENCEPHALITIS Dictionary definition of subacute sclerosing panencephalitis. Medical dictionary. Browse Dictionary by alphabet. 0 1 2 3 4 5 6 7 8 http://www.dictionarybarn.com/SUBACUTE-SCLEROSING-PANENCEPHALITIS.php

Dictionary definition of SUBACUTE SCLEROSING PANENCEPHALITIS Browse Dictionary by alphabet A B C D ... Z Top Words sub- subabdominal subabdominoperitoneal subacetate ... subconscious mind Please select first two letters of word you are looking for SA SB SC SD ... SZ fiSearchFormMaxSetId='AX006027'; Top Words subconsciousness subconstellation subcontrary subcoracoid ... Home Sponsored By: New Hampshire Hotels New Jersey Hotels New Mexico Hotels

40. MMR The Facts some serious illnesses. What are the risks to my child if I go ahead with MMR immunisation? subacute sclerosing panencephalitis. http://www.mmrthefacts.nhs.uk/library/subacute.php

Home Skip navigation Accessiblility Information Thursday June 3 2004 News Basics Library Resources ... The MMR vaccine has been linked to some serious illnesses. What are the risks to my child if I go ahead with MMR immunisation? Subacute sclerosing panencephalitis Subacute sclerosing panencephalitis (SSPE) (A delayed complication of measles that causes brain damage and death.) is a rare condition that can develop some years after natural measles infection and causes brain damage and death. People who were infected at a young age are at most risk from developing SSPE.) The average time between someone having measles to the first symptoms of SSPE is around 8 years, and death invariably follows. Since the introduction of measles vaccine in the 1960s, the numbers of people diagnosed with SSPE has decreased dramatically, and the death rate from SSPE is expected to fall even further. Measles and MMR vaccine directly protects against SSPE. Asthma Autism Crohn's disease Guillain Barre Syndrome ... Back In the MMR library... Glossary MMR and autism MMR and other countries MMR and bowel disease MMR and choice MMR and risk MMR research: overview MMR research timeline MMR video for parents Resources to print Side effects of the MMR vaccine Single vs triple vaccine The diseases Useful websites Vaccine development and testing What the experts say In this section...

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