1. NORD - National Organization For Rare Disorders, Inc. Offers the synonyms, a general discussion and further resources. http://www.rarediseases.org/search/rdbdetail_abstract.html?disname=Subacute Scle

2. MedlinePlus Medical Encyclopedia: Subacute Sclerosing Panencephalitis subacute sclerosing panencephalitis, a definition and a look at the causes, incidence and risk factors. http://www.nlm.nih.gov/medlineplus/ency/article/001419.htm

@import url(http://www.nlm.nih.gov/medlineplus/images/advanced.css); Skip navigation Medical Encyclopedia Other encyclopedia topics: A-Ag Ah-Ap Aq-Az B-Bk ... Z Subacute sclerosing panencephalitis Contents of this page: Illustrations Alternative names Definition Causes, incidence, and risk factors ... Prevention Illustrations Central nervous system Alternative names Return to top SSPE; Subacute sclerosing leukoencephalitis; Dawson´s encephalitis Definition Return to top SSPE is a progressive, debilitating, and fatal brain disorder caused by infection with a mutant measles rubeola ) virus (a measles virus that has undergone certain genetic changes or mutations). Causes, incidence, and risk factors Return to top Measles virus usually doesn't cause brain damage, but certain mutant forms can invade the brain, causing severe illness and death. SSPE has been reported in all parts of the world, but in western countries it is considered a rare disease. Fewer than 10 cases per year are reported in the United States, decreasing the frequency of this disease dramatically, following the nationwide measles immunization program. However, in some countries like India, over 20 cases of SSPE per million people are annually reported.

3. Subacute Sclerosing Panencephalitis - Online Neuropathology Atlas subacute sclerosing panencephalitis Panencephalitis subacuta sclerotisans. Subacute sclerosing encephalitis, SSPE, gross image, Subacute http://www.neuropat.dote.hu/panenc.htm

Subacute sclerosing panencephalitis Panencephalitis subacuta sclerotisans Macroscopic Appearance Perivascular Infiltration Mononuclear Infiltration ... Nuclear Inclusion Click on any image for larger view. Relevant Web Sites: Baylor Neurology Case of the Month Subacute Sclerosing Pancephalitis - Kansas University Infection Internet Handbook of Neurology var site="sm5hegeduskdote" Last modified: February 17, 2001 If you have any comments, please, contact Neuroanatomy Structures Online Neuropathology Atlas Internet Handbook of Neurology

4. Subacute Sclerosing Panencephalitis (SSPE) & Vaccines subacute sclerosing panencephalitis (SSPE) Vaccines RB, et al (1997). Measles, mumps, rubella vaccine induced subacute sclerosing panencephalitis. J Indian Med Assoc http://www.whale.to/vaccines/sspe1.html

Diseases linked to vaccines "Stacey Berry, of Atherton, Manchester was 13 when she had a booster jab in November 1994. Days later she started having fits, "stopped smiling, and stared into space." She was diagnosed with the brain disease SSPE and given two years to live. She died in November 2000, aged 19. A post mortem examination concluded the disease was a "rare complication" of the vaccine"." Media "It is believe that the administration of Salk vaccine in N Zealand was related to the appearance of SSPE in the community. The idea that an unusual reaction to measles infection is the sole cause of SSPE is not consistent with the observations in N Zealand." SSPE AND SALK VACCINE Belgamwar RB, et al (1997). Measles, mumps, rubella vaccine induced subacute sclerosing panencephalitis. J Indian Med Assoc. 1997 Nov;95(11):594. No abstract available. PMID: 9567594; UI: 98229001. Halsey N. Risk of subacute sclerosing panencephalitis from measles vaccination. Pediatr Infect Dis J. 1990 Nov;9(11):857-8. No abstract available.PMID: 2263442; UI: 91088240. "Polymerase chain reaction detection of the hemagglutinin gene from an attenuated measles vaccine strain in the peripheral mononuclear cells of children with autoimmune hepatitis," Archives of Virology volume 141, 1996, pages 877-884: "The measles virus is known to be persistent in patients with subacute sclerosing panencephalitis (SSPE) and measles inclusion body encephalitis (MIBE). Since the introduction of measles vaccines, vaccine-associated SSPE has increased in the USA. Therefore, we should pay attention to SSPE after inoculation with measles vaccine, despite the decrease in the incidence of [wild] measles."

5. Subacute Sclerosing Panencephalitis Surveillance -- United States subacute sclerosing panencephalitis (SSPE) is a slowvirus infection of the central nervous system associated with prior measles infection. http://www.cdc.gov/mmwr/preview/mmwrhtml/00001185.htm

Subacute Sclerosing Panencephalitis Surveillance United States Subacute sclerosing panencephalitis (SSPE) is a slow-virus infection of the central nervous system associated with prior measles infection. Onset generally occurs in late childhood or adolescence and is usually characterized by the insidious onset of mental deterioration and myoclonia. Although spontaneous improvement or stabilization can occur, the vast majority of patients proceed over a period of months to years to generalized convulsions, dementia, coma, and death. To collect demographic and clinical information on SSPE cases, a national SSPE registry was initiated in 1969 at the University of Tennesee. Since October 1980, responsibility for the registry has resided with the Medical College of Georgia.* The registry is supported by the Office of Biologics, Food and Drug Administration, and maintained in collaboration with CDC. *Inquiries and suspected case reports can be directed to Dr. Paul R. Dyken, Professor and Chief, Section of Pediatric Neurology, Medical College of Georgia, 1459 Laney-Walker Boulevard, Augusta GA 30912. A case of SSPE is defined by CDC as an illness with a compatible clinical course plus one of the following items of supporting laboratory evidence: 1) measles antibody detected in the cerebrospinal fluid (CSF), 2) a characteristic pattern on electroencephalography, or 3) typical histologic findings in brain biopsy material or tissue obtained on postmortem examination.

6. Subacute Sclerosing Panencephalitis Information Diseases Database subacute sclerosing panencephalitis van Bogaert's sclerosing leukoencephalitis Measles inclusion body encephalitis SSPE, Disease Database Information Sponsors Contact Previous Page. Subacute http://www.diseasesdatabase.com/sieve/item1.asp?glngUserChoice=12597

7. NINDS Subacute Sclerosing Panencephalitis Information Page subacute sclerosing panencephalitis information sheet compiled by NINDS, the National Institute of Neurological Disorders and Stroke. http://www.ninds.nih.gov/health_and_medical/disorders/subacute_panencephalitis.h

National Institute of Neurological Disorders and Stroke Accessible version Science for the Brain The nation's leading supporter of biomedical research on disorders of the brain and nervous system Browse all disorders Browse all health organizations More about Subacute Sclerosing Panencephalitis Studies with patients Research literature Press releases Search NINDS... (help) Contact us My privacy NINDS is part of the National Institutes of Health NINDS Subacute Sclerosing Panencephalitis Information Page Synonym(s): Dawson Disease Reviewed 11-01-2002 Get Web page suited for printing Email this to a friend or colleague Table of Contents (click to jump to sections) What is Subacute Sclerosing Panencephalitis? Is there any treatment? What is the prognosis? What research is being done? ... Related NINDS Publications and Information What is Subacute Sclerosing Panencephalitis? Is there any treatment? For several decades, the palliative treatment for SSPE has included anticonvulsant therapy and supportive measures (tube feedings and good nursing care especially in patients with advanced disease). Medical literature during the last decade, however, has shown stabilization of disease and delay in clinical progression after therapy with inosine pranobex (oral Isoprinosine); oral isoprinosine combined with intrathecal or intraventricular interferon alpha (up to 50% rate of remission or improvement); oral isoprinosine combined with interferon beta; and intrathecal interferon alpha combined with I.V. ribavirin. However, no controlled studies have been performed. The Food and Drug Administration has added inosine pranobex (Isoprinosine) to its List of Orphan Products Designations and Approvals (1988) for the treatment of SSPE.

8. Virtual Hospital: Infectious Diseases Of The Central Nervous System: Parenchymal An article about subacute sclerosing panencephalitis written by Gary Baumbach, M.D. http://www.vh.org/Providers/TeachingFiles/CNSInfDisR2/Text/PInf.VSSP.html

For Providers Infectious Diseases of the Central Nervous System Parenchymal Infections: Subacute Sclerosing Panencephalitis Gary Baumbach, M.D., Department of Pathology, University of Iowa College of Medicine Peer Review Status: Internally Peer Reviewed Subacute sclerosing panencephalitis (SSPE) is one of three types of encephalitis that may occur secondary to measles virus. The other two types are 1) an acute encephalitis characterized by lymphocytic infiltrates in meninges and around vessels associated with the acute rash of measles, and 2) a post-measles demyelinating process which is probably an autoimmune hyperallergenic phenomenon. In this tutorial only subacute sclerosing panencephalitis will be discussed. Subacute sclerosing panencephalitis develops following the reactivation of the latent measles virus. Clinically, it is insidious in its onset, and is characterized by progressive motor and mental deterioration with myoclonus. The course usually runs from 1 to 3 years. The frequency of SSPE is about 1 in 1 million, there is a male-to-female ratio of 4:1, and 85% of the cases arise in a rural environment. The gross pathology of subacute sclerosing panencephalitis, which is shown on this slide

9. Virtual Hospital: Infectious Diseases Of The Central Nervous System: Parenchymal Parenchymal Infections subacute sclerosing panencephalitis. In this tutorial only subacute sclerosing panencephalitis will be discussed. http://www.vh.org/adult/provider/pathology/CNSInfDisR2/Text/PInf.VSSP.html

For Providers Infectious Diseases of the Central Nervous System Parenchymal Infections: Subacute Sclerosing Panencephalitis Gary Baumbach, M.D., Department of Pathology, University of Iowa College of Medicine Peer Review Status: Internally Peer Reviewed Subacute sclerosing panencephalitis (SSPE) is one of three types of encephalitis that may occur secondary to measles virus. The other two types are 1) an acute encephalitis characterized by lymphocytic infiltrates in meninges and around vessels associated with the acute rash of measles, and 2) a post-measles demyelinating process which is probably an autoimmune hyperallergenic phenomenon. In this tutorial only subacute sclerosing panencephalitis will be discussed. Subacute sclerosing panencephalitis develops following the reactivation of the latent measles virus. Clinically, it is insidious in its onset, and is characterized by progressive motor and mental deterioration with myoclonus. The course usually runs from 1 to 3 years. The frequency of SSPE is about 1 in 1 million, there is a male-to-female ratio of 4:1, and 85% of the cases arise in a rural environment. The gross pathology of subacute sclerosing panencephalitis, which is shown on this slide

10. Virtual Hospital: Infectious Diseases Of The Central Nervous System: Subacute Sc For Providers. Infectious Diseases of the Central Nervous System. subacute sclerosing panencephalitis. Gary Baumbach, MD, Department http://www.vh.org/adult/provider/pathology/CNSInfDisR2/Text/228.html

For Providers Infectious Diseases of the Central Nervous System Subacute Sclerosing Panencephalitis Gary Baumbach, M.D., Department of Pathology, University of Iowa College of Medicine Peer Review Status: Internally Peer Reviewed The gross pathology of subacute sclerosing panencephalitis, which is shown on this slide, consists of profound atrophy of the cortex, loss of white matter and ventricular enlargement. Section Top Title Page See related Provider Textbooks about Neurology or Pathology See related Provider Topics Abscesses Bacterial Infections Brain and Nervous System Brain Diseases ... Pathology or Viral Infections See related Patient Textbooks about Neurology or Pathology See related Patient Topics Bacterial Infections Brain and Nervous System Brain Diseases Creutzfeldt-Jakob Disease ... Pathology or Viral Infections Virtual Hospital Home Virtual Children's Hospital Home Site Map ... UI Health Care Home http://www.vh.org/adult/provider/pathology/CNSInfDisR2/Text/228.html

11. L'Oiseau Bleu A French association for parents and other carers of children struck by subacute sclerosing panencephalitis (SSPE). http://www.oiseaubleu.org/

12. THE MERCK MANUALSECOND HOME EDITION, Subacute Sclerosing subacute sclerosing panencephalitis. subacute sclerosing panencephalitis results from a longterm brain infection with the measles virus. http://www.merck.com/mrkshared/mmanual_home2/sec23/ch273/ch273l.jsp

13. NeuroGate.com Search results for "subacute sclerosing panencephalitis" Cardioguide Matches 1 2 of 2 Search AltaVista for more on 'subacute sclerosing panencephalitis' http://www.neurogate.com/neuro/result.php3?search=Subacute Sclerosing Panencepha

14. THE MERCK MANUAL, Sec. 19, Ch. 265, Childhood Infections subacute sclerosing panencephalitis (SSPE) is also associated with measles virus and is discussed below. Diagnosis. subacute sclerosing panencephalitis. http://www.merck.com/mrkshared/mmanual/section19/chapter265/265b.jsp

15. Introduction: Subacute Sclerosing Panencephalitis - WrongDiagnosis.com Introduction to subacute sclerosing panencephalitis as a medical condition including symptoms, diagnosis, misdiagnosis, treatment, prevention, and prognosis. http://www.wrongdiagnosis.com/s/subacute_sclerosing_panencephalitis/intro.htm

Diseases IMPORTANT! Use of this site is subject to our and Home Symptoms Diseases Risks Search: We show you all these ads in order to provide this free site; give your feedback WrongDiagnosis TM Premium Report: Diabetes Diagnosis and Misdiagnosis Available Now! Condition Lists By Organ By Symptom By Class By Prevalence ... List A-Z Current chapter: Subacute Sclerosing Panencephalitis Next sections Basic Summary for Subacute Sclerosing Panencephalitis Prevalence and Incidence of Subacute Sclerosing Panencephalitis Prognosis of Subacute Sclerosing Panencephalitis Causes of Subacute Sclerosing Panencephalitis ... Symptoms of Subacute Sclerosing Panencephalitis Next chapters: Syncope Syringomyelia Tardive Dyskinesia Tethered Spinal Cord Syndrome ... Feedback Introduction: Subacute Sclerosing Panencephalitis Subacute Sclerosing Panencephalitis: Rare brain condition arising years after measles infection. Subacute Sclerosing Panencephalitis: Subacute sclerosing panencephalitis (SSPE) is caused by a reaction to the measles virus. It can occur anywhere from 2 to 10 years after the original measles illness, and generally results in progressive neurological deterioration due to brain inflammation. Contents for Subacute Sclerosing Panencephalitis: Basic Summary for Subacute Sclerosing Panencephalitis Prevalence and Incidence of Subacute Sclerosing Panencephalitis Prognosis of Subacute Sclerosing Panencephalitis Causes of Subacute Sclerosing Panencephalitis ... Statistics about Subacute Sclerosing Panencephalitis Footnotes:

16. THE MERCK MANUAL, Sec. 19, Ch. 265, Childhood Infections subacute sclerosing panencephalitis ( SSPE) is also associated with measles virus and is subacute sclerosing panencephalitis (SSPE) is thought to represent a persistent measles virus http://www.merck.com/pubs/mmanual/section19/chapter265/265b.htm

This Publication Is Searchable The Merck Manual of Diagnosis and Therapy Section 19. Pediatrics Chapter 265. Childhood Infections Topics Bacterial Infections Viral Infections Miscellaneous Infections Viral Infections (For a summary of differential diagnosis of the more common exanthems, see Table 265-8. MEASLES (Rubeola; Morbilli; Nine-Day Measles) A highly contagious, acute viral infection characterized by fever, cough, coryza, conjunctivitis, enanthem (Koplik's spots) on the buccal or labial mucosa, and a spreading maculopapular cutaneous rash. Etiology and Pathogenesis Measles is caused by a paramyxovirus. Measles (like chickenpox) is extremely communicable and is spread mainly by small droplets from the nose, throat, and mouth of a person in the prodromal or an early eruptive stage of the disease or by airborne droplet nuclei. Indirect spread by uninfected persons or by objects is unusual. The communicable period of the disease begins 2 to 4 days before the rash appears until 2 to 5 days after onset. The virus disappears from nose and throat secretions by the time the rash clears. Persons who develop mild desquamation after the rash are no longer infectious. Atypical measles syndrome usually occurs in persons previously immunized with the original killed virus measles vaccines, which are no longer available. Presumably, inactivated measles virus vaccines do not prevent wild virus infection and can sensitize patients so that disease expression is altered significantly. However, atypical measles syndrome may also follow immunization with live, attenuated measles vaccine, perhaps resulting from inadvertent inactivation due to improper storage.

17. Subacute Sclerosing Panencephalitis - Information / Diagnosis / Treatment / Prev home neurological disorders infections subacute sclerosing panencephalitis subacute sclerosing panencephalitis. Information http://www.healthcyclopedia.com/neurological-disorders/infections/subacute-scler

Home Health cyclopedia All Topics by Category The Good Health Search Engine Health Conditions A-Z Gurus ... infections > subacute sclerosing panencephalitis Subacute Sclerosing Panencephalitis Information / Diagnosis / Treatment / Prevention External links (marked with an arrow ) open in a new window. This site is a web directory and does not offer medical advice. We cannot take responsibility for information found on listed sites. This Page Related Topics Medical Definition Health News Web Directory: Related Topics: Rare Disorders Medical Definition: University of Newcastle-upon-Tyne Medical Dictionary: "subacute sclerosing panencephalitis" Health News: Search millions of published articles for news on Subacute Sclerosing Panencephalitis Modern Medicine Aging The Ardell Wellness Report HealthFacts Medical Post Medical Update Men's Health and the National Women's Health Report Note: Subscription required to access the full text of articles. Web Directory: Adam - An Overview Subacute sclerosing panencephalitis, a definition and a look at the causes, incidence and risk factors. L'Oiseau Bleu A French association for parents and other carers of children struck by Subacute Sclerosing Panencephalitis (SSPE).

18. Subacute Sclerosing Panencephalitis subacute sclerosing panencephalitis (SSPE) is a progressive neurological disorder characterized by inflammation of the brain (encephalitis). The disease may develop due to reactivation of the National subacute sclerosing panencephalitis Registry. PO Box 70191 http://www.peacehealth.org/kbase/nord/nord185.htm

var hwPrint=1;var hwDocHWID="nord185";var hwDocTitle="Subacute Sclerosing Panencephalitis";var hwRank="1";var hwSectionHWID="nord185-Header";var hwSource="en-us6.1";var hwDocType="Nord"; National Organization for Rare Disorders, Inc. Subacute Sclerosing Panencephalitis Important It is possible that the main title of the report Subacute Sclerosing Panencephalitis is not the name you expected. Please check the synonyms listing to find the alternate name(s) and disorder subdivision(s) covered by this report. Synonyms Panencephalitis, Subacute Sclerosing SSPE Dawson's Disease Dawson's Encephalitis Disorder Subdivisions None General Discussion Subacute sclerosing panencephalitis (SSPE) is a progressive neurological disorder characterized by inflammation of the brain (encephalitis). The disease may develop due to reactivation of the measles virus or an inappropriate immune response to the measles virus. SSPE usually develops 2 to 10 years after the original viral attack. Initial symptoms may include memory loss, irritability, seizures, involuntary muscle movements, and/or behavioral changes, leading to neurological deterioration. Resources National Subacute Sclerosing Panencephalitis Registry PO Box 70191 Mobile, AL 36670-0191

19. Subacute Sclerosing Panencephalitis MAIN SEARCH INDEX. subacute sclerosing panencephalitis. http://www.ehendrick.org/healthy/001311.htm

MAIN SEARCH INDEX Subacute sclerosing panencephalitis Definition Description Causes and symptoms Diagnosis ... Resources Definition Subacute sclerosing panencephalitis is a rare, progressive brain disorder caused by an abnormal immune response to the measles virus. Description This fatal condition is a complication of measles, and affects children and young adults before the age of 20. It usually occurs in boys more often than in girls, but is extremely rare, appearing in only one out of a million cases of measles. Causes and symptoms Experts believe this condition is a form of measles encephalitis (swelling of the brain), caused by an improper response by the immune system to the measles virus. The condition begins with behavioral changes, memory loss, irritability, and problems with school work. As the neurological damage increases, the child experiences seizures, involuntary movements, and further neurological deterioration. Eventually, the child starts suffering from progressive dementia . The optic nerve begins to shrink and weaken (atrophy) and subsequently the child becomes blind. Diagnosis Blood tests and spinal fluid reveal high levels of antibodies to measles virus, and there is a characteristically abnormal electroencephalogram (EEG), or brain wave test. Typically, there is a history of measles infection two to ten years before symptoms begin.

20. Subacute Sclerosing Panencephalitis, A Measles Complication, In An International Dispatch subacute sclerosing panencephalitis, a Measles Complication, in an Internationally Adopted Child. Gascon GG. subacute sclerosing panencephalitis. http://www.cdc.gov/ncidod/eid/vol6no4/bonthius.htm

Past Issue Vol. 6, No. 4 Jul–Aug 2000 Download Article PDF Help Feedback Dispatch Subacute Sclerosing Panencephalitis, a Measles Complication, in an Internationally Adopted Child Daniel J. Bonthius,* Nicholas Stanek,† and Charles Grose* *Department of Pediatrics, University of Iowa, Iowa City, Iowa, USA; †Department of Neurology, Medical Associates Clinic, Dubuque, Iowa, USA A healthy 13-year-old boy who had spent the first 4.5 years of his life in an orphanage in Thailand before adoption by an American couple became ill with subacute sclerosing panencephalitis and died several months later. The boy had most likely contracted wild-type measles in Thailand. Measles complications are a risk in international adoptions. Undiagnosed infections in internationally adopted children have been receiving increasing attention throughout the past decade. HIV, hepatitis viruses, Treponema pallidum Mycobacterium tuberculosis , and intestinal parasites frequently complicate such adoptions ( ). Subacute sclerosing panencephalitis (SSPE), a postinfectious neurologic complication of measles, can also occur. We describe a fatal case of SSPE in an internationally adopted child 9 years after he arrived in the United States. Case Report A 13-year-old boy of Thai descent was referred to the pediatric neurology clinic at the University of Iowa Hospital with cognitive difficulties and a progressive movement disorder. The boy was born in 1984 and spent the first 4 ½ years of his life in an orphanage in Thailand before being adopted by an American couple from Dubuque, Iowa. His adoptive parents were told by the adoption agency that the boy's medical history was unremarkable. No history of measles was reported. At adoption, the child appeared healthy and well nourished, and at no time afterwards did he have an illness suggestive of measles. Shortly after arrival, he displayed a short attention span and easy distractibility, for which he was eventually diagnosed with attention deficit hyperactivity disorder. He was treated with low-dose methylphenidate for several years with good results.

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