41. SearchBug Directory: Health: Conditions_and_Diseases: Neurological_Disorders: Mu Search the Web Web. Open Directory. Search stiffperson syndrome, http://www.searchbug.com/directory.aspx/Health/Conditions_and_Diseases/Neurologi

document.write(''); All Searches Auctions CompanyFinder Entertainment ... Travel Search the Web: Web Images Audio Files News Multimedia Shopping Open Directory Search: Featured Websites Official Patients Guide on Stiff Person Syndrome - icongrouponline.com "This book has been created for patients who have decided to make education and research an integral part of the treatment process." Stiff-Person Syndrome Health Conditions and Diseases Neurological Disorders Muscle Diseases ... Go to Directory Home Related Categories: Web Pages - ranked by popularity Stiff-Person Syndrome http://www.ninds.nih.gov/health_and_medical/disorders/stiffperson_doc.htm Information sheet compiled by National Institute of Neurological Disorders and Stroke. MCW HealthLink http://healthlink.mcw.edu/article/921988627.html An article about Stiff-person syndrome, a rare progressive neurological disorder. NORD: Stiff Person Syndrome http://www.rarediseases.org/search/rdbdetail_abstract.html?disname=Stiff%20Person%20Syndrome Offers synonyms, a general discussion and further resources. Help build the largest human-edited directory on the web.

42. SearchBug Directory: Health: Conditions_and_Diseases: Neurological_Disorders: Mu Myotonic Dystrophy (3) Post Polio Syndrome (20) Reflex Sympathetic Dystrophy (35), Refsum s (5) Spinal Muscular Atrophy (11) stiffperson syndrome (3) Tangier (2 http://www.searchbug.com/directory.aspx/Health/Conditions_and_Diseases/Neurologi

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43. Baylor Neurology Case Of The Month Diagnosis stiffperson syndrome The clinical presentation of this patient is a relatively typical case of stiff-person syndrome. http://www.bcm.tmc.edu/neurol/challeng/pat40/summary.html

Patient #40 Summary and Discussion Madhavi Thomas, M.D. Diagnosis: Stiff-person Syndrome Summary and Differential Diagnosis The clinical presentation of this patient is a relatively typical case of stiff-person syndrome . The patient had stiffness and rigidity of muscles, predominantly in the lower limbs, which resulted in slowly progressive impairment of her ability to ambulate. She had frequent superimposed episodes of spasms, precipitated by emotional stress and by sudden movements. Her intellectual functions were normal. She had increased muscle tone and hyperreflexia on examination, consistent with her stated complaints, and occurring in the absence of sensory findings. The electromyographic study showed continuous muscle activity despite relaxation, suggesting excessive activity of otherwise normal motor units. A test for serum antibodies glutamic acid decarboxylase (GAD) was positive, providing additional support for the diagnosis of stiff-person syndrome. Several of the respondents suggested the possibility of a paraneoplastic association for this patient's diagnosis of stiff-person syndrome, which is occasionally reported (e.g., Folli et al., 1993). Although the patient did have a small (

44. Patient 40 Selftest Patient 40 stiffperson syndrome. 1. Which of the following is a diagnostic feature of the classical stiff-person syndrome? A. rigidity http://www.bcm.tmc.edu/neurol/challeng/pat40/selftest.html

Patient #40 Stiff-person Syndrome 1. Which of the following is a diagnostic feature of the classical stiff-person syndrome? A. rigidity with superimposed spasms B. rigidity with myoclonus C. dystonia and intermittent spasms D. depression and spasms 2. Which of the following endocrine abnormalities have been described in patients with stiff-person syndrome? A. insulin-dependent diabetes mellitus B. hypothyroidism C. premature ovarian dysfunction D. all of the above 3. Which of the following electromyographic findings stongly suggests a diagnosis of stiff-person syndrome? A. increased motor unit activity on exercise B. decreased muscle activity or electromyographic silence C. signficant decrement or repetitive nerve stimulation D. increased spontaneous motor unit activity which cannot be abolished on relaxation 4. Which of the following autoantibodies have been associated with the stiff-person syndrome? A. anti-glutamic acid decarboxylase (GAD) B. anti-amphiphysin C. anti-thyroglobluin D. a and b E. all of the above 5. Which of the following treatments would be LEAST useful for patients with the stiff-person syndrome?

45. Beth Murinson, MD, PhD Her clinical and research interests are in neuromuscular diseases with special emphasis on peripheral neuropathies, neuropathic pain and stiffperson syndrome. http://www.neuro.jhmi.edu/profiles/murinson.html

10-Oct-2003 Beth Murinson, M.D., Ph.D. Dr. Beth B. Murinson is an Assistant Professor of Neurology and has been a faculty member in the Department of Neurology since 2002. Her clinical and research interests are in neuromuscular diseases with special emphasis on peripheral neuropathies, neuropathic pain and Stiff-person syndrome. Dr. Murinson has participated in a wide range of research investigations including nerve structure and function, immune-mediated neurological disorders such as Stiff-person syndrome and multi-disciplinary studies of pain originating from nerve injury and dysfunction. She has recently served as a Visiting Lecturer at King's College, University of London. Current research includes the characterization of complex assemblies of small nerve fibers important in the sensation of pain. Major alterations in small fibers following painful nerve injuries have been identified at Hopkins and it is anticipated that these findings will expand treatment strategies for painful peripheral neuropathies. Planned research includes developing methods to rapidly evaluate sensory dysfunction and advancing the understanding of Stiff-person syndrome. Dr. Murinson sees patients by referral at the Johns Hopkins Outpatient Center on Tuesday mornings. Contact Nancy Rosenberg at (410) 955-3730 for appointments.

46. NEJM -- Sign In HighDose Intravenous Immune Globulin for stiff-person syndrome. report the efficacy of intravenous immune globulin for treating stiff-person syndrome. http://content.nejm.org/cgi/content/full/346/22/1747

HOME SEARCH CURRENT ISSUE PAST ISSUES ... HELP Access to this article requires sign-in. Subscribers have access to all content. Other registered users have access to research articles six months old and older. If you're a registered user or an activated subscriber SIGN IN User Name Password Forgot your Password? Click here and we'll e-mail it to you. If you do not use cookies, sign in here. Remember my User Name and Password. PURCHASE THIS ARTICLE Purchase a single article and get immediate online access for just $10. If you're a subscriber but have not yet activated your full online access If you'd like to purchase a subscription to NEJM If you're not a subscriber and want FREE limited access... ACTIVATE YOUR SUBSCRIPTION Subscribers to NEJM are entitled to full access to all online content and features, including 20 FREE online CME exams. OR Receive full access to ALL current content and online features including Personal Archives, PDF article downloads, PDA access, E-mail alerts and 20 FREE online CME exams. OR Receive FREE online access to NEJM Original and Special Articles 6 months after publication and choose to receive the Table of Contents and notification of early release articles via e-mail.

47. NEJM -- High-Dose Intravenous Immune Globulin For Stiff-Person Syndrome PreviousPrevious, Volume 34617471748, May 30, 2002, Number 22. Next Next. High-Dose Intravenous Immune Globulin for stiff-person syndrome. http://content.nejm.org/cgi/content/short/346/22/1747

HOME SEARCH CURRENT ISSUE PAST ISSUES ... HELP Please sign in for full text and personal services Previous Volume 346:1747-1748 May 30, 2002 Number 22 Next High-Dose Intravenous Immune Globulin for Stiff-Person Syndrome Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings. Full Text PDF PDA Full Text Add to Personal Archive ... PubMed Citation To the Editor: Dalakas et al. (Dec. 27 issue) report the efficacy of high-dose intravenous immune globulin for the treatment of stiff-person syndrome. Stiff-person syndrome is a devastating disorder, and evidence of the associated immunologic impairment began to emerge in the 1980s. Over the next decade, it was confirmed that stiff-person syndrome was caused, in particular, by damage by an autoimmune mechanism. Intravenous immune globulin is extraordinarily costly; thus, the current focus of interest among clinicians is not on the efficacy of this approach but, rather, on the timing of the treatment and its long-term outcome, including the Full Text of this Article References HOME SEARCH CURRENT ISSUE PAST ISSUES ... HELP Comments and questions? Please

48. Health Library - Stiff Person Syndrome. Synonyms Disorder Subdivisions General Discussion Resources The exact cause of stiffperson syndrome is not known.. Resources. http://www.wellspan.org/library/healthguide/IllnessConditions/topic.asp?hwid=nor

49. NodeWorks - Muscle Diseases: Stiff-Person Syndrome thumbnail, 1. MCW HealthLink An article about stiff-person syndrome, a rare progressive neurological disorder. 2. NORD Stiff http://dir.nodeworks.com/Health/Conditions_and_Diseases/Neurological_Disorders/M

in entire NodeWorks Directory in Health in Neurological Disorders in Muscle Diseases in ++ Stiff-Person Syndrome Top Health Neurological Disorders Muscle Diseases Stiff-Person Syndrome A condition characterized by persistent spasms involving multiple muscles, primarily in the lower limbs and trunk. The illness tends to occur in the fourth to sixth decade of life, presenting with intermittent spasms that become continuous. Minor sensory stimuli, such as noise and light touch, precipitate severe spasms. Spasms do not occur during sleep and only rarely involve cranial muscles. MCW HealthLink An article about Stiff-person syndrome, a rare progressive neurological disorder. NORD: Stiff Person Syndrome Offers synonyms, a general discussion and further resources. Stiff-Person Syndrome Information sheet compiled by National Institute of Neurological Disorders and Stroke. NodeWorks boosts web surfing! Page Returned in seconds - HTML Compressed Help build the largest human-edited directory on the web. Submit a Site Update a Site Open Directory Project Become an Editor

50. Cleveland Clinic Health System - Health Information Search Results The following information is available for the topic stiffperson syndrome. Please select one. , stiff-person syndrome. New Search. http://www.cchs.net/health/getcontents.asp?DocID=do-query&TopicId=1361

51. The Infography About Stiff-Man Syndrome Floeter MK, VallsSole J, Toro C, Jacobowitz D, Hallett M. Physiologic studies of spinal inhibitory circuits in patients with stiff-person syndrome. http://www.infography.com/content/865274012491.html

Search The Infography: Stiff-Man Syndrome The following sources are recommended by a professor whose research specialty is Stiff-Man Syndrome. Six Superlative Sources Lorish TR, Thorsteinsson G, Howard FM Jr. Stiff-man syndrome updated. Mayo Clin Proc. 1989 Jun;64(6):629-36. Review. Solimena M, Folli F, Aparisi R, Pozza G, De Camilli P. Autoantibodies to GABA-ergic neurons and pancreatic beta cells in stiff-man syndrome. N Engl J Med. 1990 May 31;322(22):1555-60. Solimena M, De Camilli P. Autoimmunity to glutamic acid decarboxylase (GAD) in Stiff-Man syndrome and insulin-dependent diabetes mellitus. Trends Neurosci. 1991 Oct;14(10):452-7. Review. Stayer C, Meinck HM. Stiff-man syndrome: an overview. Neurologia. 1998 Feb;13(2):83-8. Review. Folli F, Solimena M, Cofiell R, Austoni M, Tallini G, Fassetta G, Bates D, Cartlidge N, Bottazzo GF, Piccolo G, et al. Autoantibodies to a 128-kd synaptic protein in three women with the stiff-man syndrome and breast cancer. N Engl J Med. 1993 Feb 25;328(8):546-51. Butler MH, Hayashi A, Ohkoshi N, Villmann C, Becker CM, Feng G, De Camilli P, Solimena M. Autoimmunity to gephyrin in Stiff-Man syndrome. Neuron. 2000 May;26(2):307-12.

52. Entrez PubMed Rhabdomyolysis/drug therapy; Rhabdomyolysis/immunology*; Spinal Cord/pathology; stiffperson syndrome/complications; stiff-person syndrome http://www.biomedcentral.com/pubmed/14755734

Entrez PubMed Nucleotide Protein ... Books Search PubMed Protein Nucleotide Structure Genome Books CancerChromosomes 3D Domains Domains Gene GEO GEO DataSets HomoloGene Journals MeSH NCBI Web Site OMIM PMC PopSet SNP Taxonomy UniGene UniSTS for Limits Preview/Index History Clipboard ... Text Version Entrez PubMed Overview FAQ Tutorial New/Noteworthy ... E-Utilities PubMed Services Journals Database MeSH Database Single Citation Matcher Batch Citation Matcher ... Cubby Related Resources Order Documents NLM Gateway TOXNET Consumer Health ... PubMed Central Summary Brief Abstract Citation ASN.1 MEDLINE XML UI List LinkOut Related Articles Cited in Books CancerChrom Links Domain Links 3D Domain Links GEO DataSet Links Gene Links Genome Links GEO Links HomoloGene Links Nucleotide Links OMIM Links PMC Links Cited in PMC PopSet Links Protein Links SNP Links Structure Links UniSTS Links Show: Sort Author Journal Pub Date Text File Clipboard E-mail Order Ann Neurol. 2004 Feb;55(2):286-90. Related Articles, Links Rhabdomyolysis and paraneoplastic stiff-man syndrome with amphiphysin autoimmunity. Petzold GC, Marcucci M, Butler MH, van Landeghem FK, Einhaupl KM, Solimena M, Valdueza JM, De Camilli P. Department of Neurology, Charite Hospital, Humboldt University, Berlin, Germany.

53. Paraneoplastic Cerebellar Degeneration Antibody name, Associations, Reacts with, Neurological symptoms. GAD, Diabetes, stiffperson syndrome, Glutamine dehydrogenase, Various, including cerebellar. http://www.dizziness-and-balance.com/disorders/central/pcd.htm

Paraneoplastic Cerebellar Degeneration Last edited: 11/22/2001 by Timothy C. Hain, MD , Chicago IL. Click here to return to index . Please read our Paraneoplastic cerebellar degenerations are disorders of the cerebellum, the part of the brain responsible for coordination, which are associated with tumors (neoplasms). They arise when tumors express proteins that are normally found only in neurons, and it is believed that the immune system, in its attempt to kill the tumor, also damages the cerebellum. Although antibodies occasionally useful for diagnosis, they do not appear to be the cause of the cerebellar damage. Rather, current thought is that "killer T-cells", or cytotoxic CD8+ T lymphocytes, are the most likely mediator of neuronal injury. Treatments to reduce the antibodies are ineffective, and attempts to reproduce disease by transfer of antibodies into animals have been unsuccessful Certain tumors are more common than others. These include cancer of the ovary, uterus or adnexa, cancer of the breast, and especially small cell carcinoma of the lung. The condition frequently begins before the tumor is diagnosed. Examination of patients with anti-Purkinje cell antibodies, especially anti-Yo, is usually dominated by a rapidly progressive unsteadiness, and downbeating nystagmus. Pathological examination often reveals profound loss of Purkinje cells, which are the output cells for the cerebellum. The MRI scan of the brain may be normal. The single most useful clinical test is usually a chest X-ray. In situations where a paraneoplastic syndrome is suspected, but antibodies have not yet been done, a chest-X ray is also generally the most useful clinical test.

54. Mother Manages Pain, Stiffness As if that weren t enough, the young mother of two has been diagnosed with a rare nerve disorder called stiffperson syndrome. The http://www.mult-sclerosis.org/news/Jan2004/WomanwMSandStiffPersonSyndrome.html

More MS news articles for January 2004 Mother Manages Pain, Stiffness http://www.theledger.com/apps/pbcs.dll/article?AID=/20040108/NEWS/401080387/1004 Thursday, January 8, 2004 Eric Pera The Ledger On a good day, Kimber Bias copes with debilitating pain to keep up with her rambunctious toddler, Kaitlyn, and 5year-old Jocelyn. On those bad days when the pain flares out of control, the Lakeland woman can barely get out of bed, leaving her mother or husband to watch the kids. At 28, Bias is learning to manage life with the knowledge that her muscles and some body functions are slowly wasting to one of the milder forms of multiple sclerosis. As if that weren't enough, the young mother of two has been diagnosed with a rare nerve disorder called stiff-person syndrome. The disorder, more common among women, stiffens muscles primarily from the chest down. Bias said she will eventually require a wheelchair, but for now she endures the pain with the help of medications and exercise, so that she can keep up with her girls. "The only good thing about it is I get to be with them," said Bias, who recently quit her job as head receptionist at Lakeland Veterinary Hospital for health reasons.

55. Neuromuscular Diseases stiffperson syndrome. About stiff-person syndrome - NINDS (US). Stiffman Syndrome Foundation Geilman family - (US). stiff-person syndrome GF Zeolla. http://www.mic.ki.se/Diseases/C10.668.html

search search staff sitemap ABOUT KAROLINSKA INSTITUTET ... print this page Diseases and Disorders Links pertaining to Neuromuscular Diseases Alert! Patients and laypersons looking for guidance among the target sources of this collection of links are strongly advised to review the information retrieved with their professional health care provider. Start Page Contents: Amyotrophic Lateral Sclerosis Brachial Plexus Neuritis Brachial Plexus Neuritis Brachial Plexus Neuropathies ... Ulnar Nerve Compression Syndromes Neuromuscular Diseases Motor Cortex illustration [Earles et al.] - Furman Univ. (US) EMG and Nerve Conductions Homepage [JF Jabre] The Neuromuscular Disease Information Center - REHABinfo Network/UC-Davis (US) Neuromuscular Diseases - MDA (US) Neuromuscular Disorders [Nadeau and Valenstein] - Univ of Florida (US) About some Neuromuscular Diseases - Wake Forest Univ. Neuromuscular Disorders Information - Musc Dystrophy Group of (UK)+ N. Ireland Neuromuscular Disease Center , and a collection of one-page summaries of Differential Diagnoses of Neuromuscular Syndromes - School of Medicine/Washington Univ., St Louis (US)

56. HONselect - Neuromuscular Diseases stiffperson syndrome. Accepted term(s) -Amyotonia Congenita -Oppenheim Disease -Cramp-Fasciculation Syndrome -Fasciculation-Cramp Syndrome, Benign. http://www.hon.ch/HONselect/Selection/C10.668.html

57. Wauu.DE: Health: Conditions And Diseases: Neurological Disorders: Muscle Disease Links URL hinzufügen. MCW HealthLink An article about stiffperson syndrome, a rare progressive neurological disorder. http//healthlink http://www.wauu.de/Health/Conditions_and_Diseases/Neurological_Disorders/Muscle_

Home Health Conditions and Diseases Neurological Disorders ... Muscle Diseases : Stiff-Person Syndrome Search DMOZ-Verzeichnis: All Categories Categories Onlye Links: MCW HealthLink An article about Stiff-person syndrome, a rare progressive neurological disorder. http://healthlink.mcw.edu/article/921988627.html NORD - Stiff Person Syndrome Offers synonyms, a general discussion and further resources. Stiff-Person Syndrome Information sheet compiled by National Institute of Neurological Disorders and Stroke. http://www.ninds.nih.gov/health_and_medical/disorders/stiffperson_doc.htm WorldMedicus A description of Stiff-Person syndrome, the alternate names and a link to articles. http://www.worldmedicus.com/servlet/Controller/$7006040b416e0000.sj/ © 1998- 2002 Ein Service von Wauu.de UserNet.DE Linktip: MnogoSearch.ORG Map TopTen TopTen eng Aktuelle Linktips Mozilla 1.7 RC 1 Basteln 0190 Warner Free Rund ums Rad ... Fantasy - Shop Webmaster-Links Webspace Free Subdomain Service Merchandise Fun SUMA - Forum ... Abmahnungen œber Wauu Regeln Webmasterservice Impressum b

58. Stiff-man Syndrome NLM Medline definition of stiffperson syndrome A condition characterized by persistent spasms (SPASM) involving multiple muscles, primarily in the lower http://www.ion.ucl.ac.uk/library/patient/stiff.htm

Stiff-Man Syndrome NLM Medline definition of stiff-person syndrome: A condition characterized by persistent spasms (SPASM) involving multiple muscles, primarily in the lower limbs and trunk. The illness tends to occur in the fourth to sixth decade of life, presenting with intermittent spasms that become continuous. Minor sensory stimuli, such as noise and light touch, precipitate severe spasms. Spasms do not occur during sleep and only rarely involve cranial muscles. Respiration may become impaired in advance cases. Pubmed Medline search on stiff-man syndrome Pubmed Medline search on stiff-person syndrome Stiff-person Syndrome factsheet: National Institute for Neurological Disorders and Stroke Support Groups National Organization for Rare Disorders (NORD) P.O. Box 8923, New Fairfield, CT 06812-1783 Tel: (203) 746-6518 or (800) 999-6673

59. February 2, 2002 - Our FM/CFS World STIFF PERSON SYNDROME *****. What is stiffperson syndrome? Is there any treatment? http://www.ourfm-cfidsworld.org/html/february_2__2002.html

Our FM/CFS World, Inc. Register for Our FM/CFS World newsletter and email updates Search our site WELCOME TO OUR FM/CFS WORLD, INC. NEWSLETTER OUR MISSION Our FM/CFS World Inc. is a non-profit organization maintained by sufferers of Fibromyalgia and Chronic Fatigue Syndrome. Our mission is to improve the quality of life for fellow sufferers, while increasing public, governmental and medical awareness of these diseases, through education. *************************************************************** A CHAT WITH THE EDITOR: “We are not permitted to choose the frame of our destiny. But what we put into it is ours." Dag Hammarskjold This quote caught my eye. I hadn’t really thought about the picture I was painting in my life. But now that I have given my masterpiece some consideration, I realize that I want it to portray happiness and contentment. I want it to depict the joy I experience sharing things with my family and friends. I want it to show that I am not a quitter. I want it to be vibrant and alive. As you can see, there is no room for Fibromyalgia in my picture. I’m sure if you look hard enough, you can see a trace of it someplace, but there are too many other good things in my world to cover up those dark spots. There are too many opportunities to paint in color and to take pride in the things I accomplish.

60. Www.nlm.nih.gov/cgi/mesh/2K/MB_cgi?term=Stiff-Person+Syndrome On Target Weekly Journal, Issue January 13, 2002 HISTORY OF MEDICINE The Hospital Ship III. IMMUNOLOGY Stiff Person Syndrome (SPS) IV. III. IMMUNOLOGY back to top. Stiff Person Syndrome (SPS). http://www.nlm.nih.gov/cgi/mesh/2K/MB_cgi?term=Stiff-Person Syndrome

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