101. Guideline For The Management Of Acute And Chronic Pain In Sickle-Cell Disease Other sickle cell disease Resources. Easing sickle/. sickle cell disease Association of America http//SickleCellDisease.org/. Back to top. http://www.ampainsoc.org/pub/sc.htm

Give us feedback about our web site Contact the Editor: Michael E. Clark, PhD webeditor@ampainsoc.org Contact APS: American Pain Society 4700 W. Lake Ave. Glenview, IL 60025 fax: 877-734-8758 [Toll Free] info@ampainsoc.org Site Guide American Pain Society announces . . . Order online or call APS at 847/375-4786. Guideline summary is now available online from the National Guidelines Clearinghouse. www.guidelines.gov Press Release Living with Sickle Cell Disease: From Suffering to empowerment Related Resources Guideline for the Management of Acute and Chronic Pain in Sickle-Cell Disease The first publication of the APS Clinical Practice Guidelines program, this guideline is the first comprehensive evidence-based guideline to address treatment of the pain of sickle-cell disease. Contents Overview of Sickle-Cell Disease and Related Pain Types and Characteristics of Pain Associated with Sickle-Cell Disease Pain Assessment Treatment of Pain in Sickle-Cell Disease Pharmacological Management of Sickle Pain Acetaminophen and NSAIDs Opioids: Side Effects, Tolerance, Physical Dependence and Addiction

102. Sickle Cell Disease - Topics In International Health CD-ROM Series aspects of this complicated disease provide an introduction to the biology, epidemiology, diagnosis, treatment, prevention and control of sickle cell disease. http://www.cabi-publishing.org/AllOtherProducts.asp?SubjectArea=&PID=417

103. Sickle Cell Disease, Sickle Cell Anemia sleepless parents, Encyclopedia Index S sickle cell disease, sickle cell anemia, Search. sickle cell disease, sickle cell anemia. This is http://www.sleeptight.com/EncyMaster/S/sickle_cell.html

Help for sleepless parents Encyclopedia Index S sickle cell disease, sickle cell anemia Search sickle cell disease, sickle cell anemia This is a condition of the blood cells that affects mainly persons of African or mediterranean descent (Italian, Spanish, etc.). It is caused by an inherited abnormality of the oxygen carrying protein of the blood (hemoglobin). The abnormality is such that the red blood cells behave normally under normal conditions, but certain factors can cause an abnormal clumping together of the hemoglobin. When this happens the red cells assume a characteristic sickle-like shape - hence the name. These abnormal cells clog up the capillaries (smallest blood vessels) and by obstructing blood flow cause oxygen lack in the body tissues. During such an attack of sickling (called a crisis ), the patient experiences excruciating pain in various areas of the body - for example in the bones, or in the abdomen. This pain is related to poor blood flow and oxygen lack in the tissues. The abnormal red cells break down sooner than normal, causing anemia. Sometimes there is a sudden shutdown of production of the red cells - the aplastic crisis - that can cause critical anemia. The abnormal red cells tend to flow sluggishly through the smallest blood vessels (capillaries) and this may lead to

104. Sickle Cell Disease - Information / Diagnosis / Treatment / Prevention sickle cell disease. Natural History of sickle cell disease in India Lists and describes the contribution of Dr. Bimal Chandra Kar. http://www.healthcyclopedia.com/blood-disorders/sickle-cell.html

Home Health cyclopedia All Topics by Category The Good Health Search Engine Health Conditions A-Z Gurus ... blood disorders > sickle cell Sickle Cell Disease Information / Diagnosis / Treatment / Prevention External links (marked with an arrow ) open in a new window. This site is a web directory and does not offer medical advice. We cannot take responsibility for information found on listed sites. This Page Related Topics Medical Definition Health Portals Health News ... Web Directory: Related Topics: Open Directory: Kids and Teens/Health/Conditions and Diseases/Sickle Cell Anemia Medical Definition: University of Newcastle-upon-Tyne Medical Dictionary: "sickle cell" Health Portals: FamilyDoctor.org Information Sheets : Sickle Cell Disease: Practical Tips for Preventing a Sickle Cell Crisis FamilyDoctor.org Information Sheets : Sickle Cell Disease in Children MayoClinic.com Health News: Search millions of published articles for news on Sickle Cell Disease Modern Medicine Aging The Ardell Wellness Report HealthFacts Medical Post Medical Update Men's Health and the National Women's Health Report Note: Subscription required to access the full text of articles.

105. Sickle Cell Disease sickle cell disease. Sickle cell anemia is the most common type of sickle cell disease and is estimated to affect more than 50,000 AfricanAmericans . History. http://www.pitt.edu/~mahst51/

Sickle Cell Disease Introduction Sickle cell disease refers to a group of genetic disorders characterized by the presence of sickle hemoglobin (HbS), anemia, and acute and chronic tissue injury secondary to the blockage of blood flow by abnormally shaped red blood cells (rbc). Sickle cell anemia is the most common type of sickle cell disease and is estimated to affect more than 50,000 African-Americans History In 1904, a black student from Grenada who was attending the Chicago College of Dental Surgery became ill. His physician, upon examining his blood under a microscope, discovered that some of his rbc were sickle shaped rather than round, as is normal. This was the beginning of the medical profession's recognition of sickle cell anemia, however there is evidence that the disease had been present for many centuries. In several West African ethnic groups, there are indiginous names for the disease that reflect some of its characteristics, and a Ghanaian specialist in sickle cell disease has established, through oral history, that sickle cell anemia has probably been present in nine gernerations of one family dating back to 1670. Then, many years later it was found that the parents of a child with sickle cell anemia also had a few sickled cells in their blood, although both parents could be perfectly healthy. From this it was deduced that the disorder was inherited from the parents and that healthy parents carried the trait, or gene, for sickling. Geneticists state that for a given trait to become common, it must have had some advantage for those individuals that makes them stronger with a better chance of survival than others without the trait. Although, nowadays there is a disadvantage of having the trait, there was a time in which one was very fortunate to have the sickle cell trait. That is, carrying the sickle cell trait protected the individual from a serious case of

106. Overview, Cincinnati Children's Hospital Medical Center These collaborative efforts are now part of a center grant for sickle cell disease supported through the National Institutes of Health. http://www.cincinnatichildrens.org/svc/prog/blood/programs/sickle-cell/

Home Contact Us Site Map Go to Advanced Search ... Sickle Cell Center Overview Newsletter Related Links Faculty Thrombophilia Program ... How to Help Sickle Cell Center Overview The Comprehensive Sickle Cell Center at Cincinnati Children's Hospital Medical Center receives 1,000-plus outpatient visits, with an average of more than 200 admissions and 1,000 inpatient days, per year. The center staff follows approximately 240 patients. Funded by a major grant from the National Institutes of Health , as well as grants from the National Heart Lung and Blood Institute and the Ohio Department of Health , the Sickle Cell Center carries out various education and counseling programs for affected families and the community. Sickle Cell Center Research Interests Stroke as a complication in children with sickle cell disease Pathogenesis of the vaso-occlusive crisis in sickle cell tissues Pathogenesis of thrombotic events Ion transport channels in normal and abnormal red cells Pathogenesis and prevention of acute chest syndrome Use of cord blood banking and blood and marrow transplantation for patients with severe sickle cell disease Psychological coping to determine whether children affected with sickle cell disease relate normally with their peers Improving newborn screening follow-up and services for individuals and families at the community level In collaboration with the University of Cincinnati College of Medicine , the Sickle Cell Center staff is studying the regulation of fetal hemoglobin synthesis and mechanisms regulating red blood cell development and ion transport. These collaborative efforts are now part of a center grant for Sickle Cell Disease supported through the National Institutes of Health.

107. Hemolytic Anemia Looks at the course, management and complications of this disease. http://www.fpnotebook.com/HEM49.htm

Home About Links Index ... Editor's Choice document.write(code); Advertisement Hematology and Oncology Hemolysis Anemia Hemolytic Anemia Hemolytic Anemia Causes G6PD Deficiency Assorted Pages Paroxysmal Cold Hemoglobinuria Blackwater fever March Hemoglobinuria Paroxysmal Nocturnal Hemoglobinuria ... Ham Test Hemolytic Anemia Microangiopathic Anemia Hemolysis Book Home Page Cardiovascular Medicine Dentistry Dermatology Emergency Medicine Endocrinology Gastroenterology General Medicine Geriatric Medicine Gynecology Hematology and Oncology HIV Infectious Disease Jokes Laboratory Neonatology Nephrology Neurology Obstetrics Ophthalmology Orthopedics Otolaryngology Pediatrics Pharmacology Prevention Psychiatry Pulmonology Radiology Rheumatology Sports Medicine Surgery Urology Chapter Hematology and Oncology Index Anemia Cancer Coagulopathy Cardiovascular Medicine Dermatology Endocrinology Otolaryngology Examination Gastroenterology Hemoglobin Hemolysis Histiocytosis HIV Infectious Disease Laboratory Leukemia General Pulmonology Lymph Marrow Neurology Obstetrics Orthopedics Pediatrics Pharmacology Platelet Prevention Procedure Psychiatry Rheumatology Sarcoma Surgery Symptom Evaluation Vascular Page Hemolysis Index Anemia Anemia Causes Anemia G6PD Hemoglobinuria Cold Hemoglobinuria Malaria Hemoglobinuria March Hemoglobinuria Nocturnal Methemoglobinemia See Also Anemia Anemia with Reticulocytosis Causes See Hemolytic Anemia Causes Common Causes Lymphoproliferative Disorders Chronic Lymphocytic Leukemia Non-Hodgkin's Lymphoma Iatrogenic Hemolytic Anemia Medications (Most common cause)

108. My Sickle Cell Homepage Provides a first hand look at sickle cell Anemia, built by a person suffering from the disease. Frequently asked questions and a personal diary of the owner's own battle with this disease. http://www.geocities.com/HotSprings/Spa/3194/

Glad You Stopped By! My initial intention for building this site was in response to the numerous sites that seemed targeted for the medical profession. After viewing several of these sites, I wondered where the Sicklers were and why hadn't they built any sites? Then it dawned on me... I'm a Sickler and I haven't built a site!  Although I'm not a medical professional, I hope this site can shed some light on Sickle Cell Anemia from a personal view. Page descriptions are below and I invite you  to browse the entire site. Hopefully, we'll both learn something in the end! The Sickle Cell Forum Been looking for people, living with Sickle Cell anemia like you? The Sickle Cell Forum is the place to be! The input has been lively and there's a definite community forming. To join our growing family, simply click on the link below. See you there, Charles Click to Join The Sickle Cell Forum For information about me, be sure to read the "About Me" page. The "Sickle Cell Diaries" is my personal account of life with Sickle Cell.

109. Sickle-Cell Disease - UMMC An indepth report on the causes, diagnosis, and treatment of sickle-cell disease. sickle-cell disease. WHAT IS sickle-cell disease? http://www.umm.edu/patiented/articles/what_sickle-cell_disease_000058_1.htm

Home Medical Reference Patient Education Sickle-Cell Disease WHAT IS SICKLE-CELL DISEASE? Hemoglobin and the Sickle-Cell Disease Process Hemoglobin is a complex molecule and the most important component of red blood cells. [For a description of blood and the role of hemoglobin, See Box Blood.] Sickle-cell disease occurs from genetic abnormalities in hemoglobin: Normal red blood cells contain molecules called hemoglobin A. In a sickle red blood cell, a variant of this molecule exists and is called hemoglobin S (S for sickle). The difference between hemoglobin A (HbA) and hemoglobin S (HbS) lies in only one protein out of about three hundred that are common to both. This protein lies along an amino-acid chain called beta-globin, where even a tiny abnormality has disastrous results. Polymerization and Other Changes in Hemoglobin S Leading to Disease Sickle cells disease is a result of changes in hemoglobin S: The destructive nature of the sickle hemoglobin develops when it loses oxygen. The deoxygenated molecules form rigid rods called polymers that distort the red blood cells into a sickle or crescent shape. This process is called

110. Human Gene Testing - Summary Article by Drs. Stuart Orkin and Gary Felsenfeld describing how basic research led to genetic testing, including how the discoveries of DNA, restriction enzymes, cloning, PCR (polymerase chain reaction) make tests for diseases like sicklecell anemia and breast cancer possible. http://www.beyonddiscovery.org/content/view.article.asp?a=239

111. CNN - Boy Receives First Cord Blood Transplant For Sickle Cell Anemia - December Boy receives first cord blood transplant for sickle cell anemia. Researchers have cured sickle cell before using bone marrow transplants. http://www.cnn.com/HEALTH/9812/14/cord.blood.sickle.cell/

MAIN PAGE WORLD ASIANOW U.S. ... news quiz CNN WEB SITES: TIME INC. SITES: Go To ... Time.com People Money Fortune EW MORE SERVICES: video on demand video archive audio on demand news email services ... pagenet DISCUSSION: message boards chat feedback SITE GUIDES: help contents search FASTER ACCESS: europe japan WEB SERVICES: Boy receives first cord blood transplant for sickle cell anemia Keone is the first sickle cell patient to receive a cord blood transfusion from an unrelated donor. December 14, 1998 Web posted at: 2:09 p.m. EDT (1809 GMT) From Medical Correspondent Rhonda Rowland ATLANTA (CNN) Researchers say children who might have died from inherited immune disorders or leukemia may be cured with umbilical cord blood transplants. Now scientists at Emory University Hospital have done the world's first "unrelated donor" cord blood transplant in a child with sickle cell anemia. Keone Penn of Snellville, Georgia, looks like a typical 12-year-old. But he has a severe cased of sickle cell anemia, an inherited disorder where red blood cells are abnormally shaped. "He had a stroke when he was 5 and he's been getting chronic blood transfusions ever since he had the stroke lots of fevers, infections, seizures," said his mother, Leslie Penn.

112. Welcome To The American Sickle Cell Anemia Association Welcome to The American sickle cell Association web site. Visitors to this site. Copyright © 2000 American sickle cell Association All Rights Reserved. http://www.ascaa.org/

A United Way Agency Categories Who We Are Mission Statement Board of Trustees Executive Director ... Contacts NEW!!! Request for Information NEW!!! View Online Video Related Sites/Links Home Welcome to The American Sickle Cell Association web site. Please visit often to get the latest news and available information. Visitors to this site. Updated 5/26/04 *Information relayed on this site is collective, and has been accumulated over time from various factual sources, medical journals and general knowledgebase's on sickle cell. For specific printed mater, useful for citing text information, please contact us and will forward printed mater to you.

113. Template For Redirect If there is a problem with the automatic redirect, this page now exists at http//www.cdc.gov/genomics/hugenet/reviews/sickle.htm. Please reset your bookmarks. http://www.cdc.gov/genetics/hugenet/reviews/sickle.htm

If there is a problem with the automatic redirect, this page now exists at http://www.cdc.gov/genomics/hugenet/reviews/sickle.htm . Please reset your bookmarks.

114. Seek Wellness May 15, 2004. Congratulations to Don for being named USA Triathlon s Male Grandmaster Duathlete of the Year. Incontinence Center http://wellweb.com/INDEX/QSICKLE.HTM

home wellness pelvic health other conditions ... contact us // syntax: swSlideMenu(id, dir, left, top, width, height) new swSlideMenu('menu1', 'down', 230, 91, 180, 350); new swSlideMenu('menu2', 'down', 295, 91, 180, 350); new swSlideMenu('menu3', 'down', 381, 91, 180, 350); new swSlideMenu('menu4', 'down', 487, 91, 180, 350); June 02, 2004 Congratulations to Don for being named USA Triathlon 's Male Grandmaster Duathlete of the Year. Incontinence Center with Diane Newman, RNC, MSN, CRNP, FAAN Millions of men and women are at risk for incontinence due to age, illness, surgery, and other factors. Diane Newman has over twenty years of experience helping people solve these problems. Visit the Incontinence Center and see what Diane can do for you. learn more Featured link for health professionals: Men's Sexual Problems Center with Dr. Chris Steidle, MD. Many men experience sexual problems at some time in their lives and don't know where to turn for expert advice. Visit Dr. Steidle and learn about typical issues that men face, especially as they age. learn more Women's Sexual Problems Center with Dr. Chris Steidle, MD.

115. Seek Wellness May 24, 2004. Congratulations to Don for being named USA Triathlon s Male Grandmaster Duathlete of the Year. Incontinence Center http://wellweb.com/INDEX/QANOREX.HTM

home wellness pelvic health other conditions ... contact us // syntax: swSlideMenu(id, dir, left, top, width, height) new swSlideMenu('menu1', 'down', 230, 91, 180, 350); new swSlideMenu('menu2', 'down', 295, 91, 180, 350); new swSlideMenu('menu3', 'down', 381, 91, 180, 350); new swSlideMenu('menu4', 'down', 487, 91, 180, 350); June 02, 2004 Congratulations to Don for being named USA Triathlon 's Male Grandmaster Duathlete of the Year. Incontinence Center with Diane Newman, RNC, MSN, CRNP, FAAN Millions of men and women are at risk for incontinence due to age, illness, surgery, and other factors. Diane Newman has over twenty years of experience helping people solve these problems. Visit the Incontinence Center and see what Diane can do for you. learn more Featured link for health professionals: Men's Sexual Problems Center with Dr. Chris Steidle, MD. Many men experience sexual problems at some time in their lives and don't know where to turn for expert advice. Visit Dr. Steidle and learn about typical issues that men face, especially as they age. learn more Women's Sexual Problems Center with Dr. Chris Steidle, MD.

116. Www.aap.org/policy/re1011.html http://www.aap.org/policy/re1011.html

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