61. Center For Cancer And Blood Disorders At Children's Medical Center Dallas sickle cell disease The sickle cell disease program in Dallas is centered within Children s Medical Center Dallas. Children s is http://www.childrens.com/ccbd/hematology/sicklecell_index.cfm

Oncology Stem Cell Transplant Hematology Sickle Cell Disease The outpatient facility includes a spacious waiting room, six examination rooms, three treatment rooms, a six-bed infusion area (where chronic red-cell transfusions and erythrocytapheresis procedures occur), a conference room/library, physician workstation, consultation room and rooms for vital sign assessment and phlebotomy. The inpatient hematology-oncology unit has 22 beds, including five rooms specially designed for patients receiving stem cell transplantations. The dedicated nursing staff is knowledgeable about blood disorders and familiar with related clinical research. Frequently asked questions Sickle cell population Staff Home ... Contact Us

62. Sickle Cell Anemia Complications of sickle cell disease may include pain, stroke, increased risk of infection, and leg ulcers. Signs of sickle cell http://www.labtestsonline.org/understanding/conditions/sickle.html

TESTS Test not listed? A/G Ratio ACE ACT ACTH AFB Culture AFP Maternal AFP Tumor Marker Albumin Aldosterone Allergies ALP Alpha-1 Antitrypsin ALT Amylase ANA Antibody Tests Apo A Apo B ApoE Genotyping aPTT AST Autoantibodies Bilirubin Blood Culture Blood Gases Blood Smear BMP BNP Bone Markers BRCA BUN C-peptide CA-125 CA 15-3 CA 19-9 Calcium Cardiac Risk CBC CEA Celiac Disease Tests CF Gene Mutation Chlamydia Chloride Cholesterol CK CK-MB CMP CMV Coagulation Factors Complement Levels Cortisol Creatinine Creatinine Clearance CRP CRP, high-sensitivity Cystatin C D-dimer DHEAS Differential DLDL EGFR Electrolytes Electrophoresis ESR Estrogen Estrogen Receptors Factor V Leiden Fecal Occult Blood Ferritin fFN Fibrinogen Flu Tests Folate Fructosamine FSH Genotypic Resistance GFR GGT Glucose Gonorrhea Gram Stain Growth Hormone H-pylori hCG HDL Hematocrit Hemoglobin Hemoglobin Variants Hepatitis A Hepatitis B Hepatitis C Her-2/neu Herpes HIV Antibody HLA-B27 Home Tests Homocysteine HPV hs-CRP IGF-1

63. Sickle Cell Disease Association Of The Piedmont sickle cell disease Association of the Piedmont 1102 E. Market Street Greensboro, North Carolina 27401 Phone (336)2741507 E-Mail scdap@scdap.org MAILING http://www.scdap.org/

QUICK VIEW - SITE PAGES Click HERE for Job Opportunities Mission Statement Sickle Cell Page HIV/AIDS Page AIDS Research ... Wake Forest Center PLEASE VISIT OUR SPECIAL CORPORATE PARTNER POLO RALPH LAUREN FOR MEN, WOMEN AND CHILDREN'S STYLES > click on logo Sickle Cell Disease Association of the Piedmont 1102 E. Market Street Greensboro, North Carolina 27401 Phone: (336)274-1507 E-Mail: scdap@scdap.org MAILING ADDRESS: Sickle Cell Disease Association of the Piedmont PO Box 20964 Greensboro, North Carolina 27420 Phone: (336)274-1507 SCDAP High Point Office 401 Taylor Avenue High Point, North Carolina 27260 Phone: (336)886-2437 E-Mail: scdap@scdap.org SCDAP Winston-Salem Office 1225 E. fifth St. Winston-Salem, NC 27101 Phone: (336)723-1390 E-Mail: scdap@scdap.org ATTENTION! If you cannot see our introductory page then your computer did not come with Flash 5 Player installed. It takes less than a minute to install and you will need it in the future as you surf the WEB. Click HERE to install it and then come back to our page. OR Click HERE to visit all our other site pages.

64. Sickle Cell Anemia 216.229.8600, Fax 216.229.4500 URL www.ascaa.org/ Email ashc@cybernex.net Support Groups Online video sickle cell disease Association of America, Inc. http://www.kumc.edu/gec/support/sickle_c.html

Sickle Cell Anemia American Sickle Cell Anemia Association P.O. Box 1971, 10300 Carnegie Ave, Cleveland, OH 44106, Phone: 216.229.8600, Fax: 216.229.4500 URL: www.ascaa.org/ E-mail: ashc@cybernex.net Support Groups Online video Sickle Cell Disease Association of America, Inc. (SCDAA), formerly know as the National Association for Sickle Cell Disease (NASCD) 200 Corporate Pointe, Suite 495, Culver City California 90230-8727, Phone: 310.216.6363 or 800.421.8453, Fax: 310.215.3722, E-mail: scdaa@sicklecelldisease.org What is Sickle Cell Disease? Education materials on Alpha Thalassemia, Beta Thalassemia, Hemoglobin C Trait (AC), Sickle Cell Trait (AS), Hemoglobin E Trait (AE) Map of United States with links to state organizations Uriel Owens Chapter SCDAA, PO BOX 171371, 650 Minnesota Ave., 2nd Floor, Kansas City, KS 66117, 913.621.1713, owens@sicklecellkck.org Sickle Cell Disease Association of Piedmont , NC What is Sickle Cell Disease? Sickle Cell Anemia Research Foundation (SCARF), 2625 Third Street, P.O. Box 206, Alexandria, Louisiana 71309, 877.722.7370, e-mail: scarf@sicklecelldisease.org Regional Organizations, Clinics, Groups

65. Berkeley Scientists Develop Mouse Model For Sickle Cell Research This enables the mice to develop all clinical manifestations of the sickle cell disease. Paszty with mouse engineered to model sickle cell disease. http://www.lbl.gov/Science-Articles/Archive/sickle-cell-mouse.html

Berkeley Scientists Develop Mouse Model For Sickle Cell Research By Lynn Yarris, lcyarris@lbl.gov October 30, 1997 BERKELEY, CA Genetically engineered mice that fully mimic all the symptoms of human sickle cell disease have been developed by scientists at the Lawrence Berkeley National Laboratory. With this new mouse model, medical researchers finally have a means of effectively testing experimental treatments for the disease. Research by Drs. Chris Paszty and Edward Rubin of Berkeley Lab's Life Sciences Division has reported the creation of a new strain of mice that carries human hemoglobin genes with no counteracting mouse genes. This enables the mice to develop all clinical manifestations of the sickle cell disease. Paszty with mouse engineered to model sickle cell disease The research has been reported in this week's issue (October 31) of the magazine Science. In addition to Paszty and Rubin, other authors of the Science paper were Catherine Brion, Mary Stevens, and Mohandas Narla of Berkeley Lab, plus Ewa Witkowska of the Children's Hospital Oakland Research Institute and Elizabeth Manci of the University of South Alabama Doctors Hospital. Each year approximately 100,000 babies in the world, mostly of African descent, are born with sickle cell disease, a painful and debilitating condition caused by a mutant hemoglobin gene. Although sickle cell disease has been extensively studied, there is still no effective treatment a failure attributed in part to the lack of an animal model that accurately reproduces the disease's symptoms.

66. The MUSC Pediatric Sickle Cell Center - About Sickle Cell Disease Who is affected by sickle cell disease? In countries. How do you get sickle cell disease? sickle cell disease is an inherited disease. http://www.muschealth.com/pscc/about_dis.htm

What you should know What is sickle cell anemia? Sickle cell anemia is a disease that affects the hemoglobin anemia. What is sickle cell trait? Someone who has one gene for hemoglobin A and one gene for a different type of hemoglobin has a hemoglobin trait. Trait is not a disease. Sickle cell trait rarely causes medical problems. If one parent has sickle cell trait there is a 50 percent (1 in 2) chance with each pregnancy of having a child with sickle cell trait. Who is affected by sickle cell disease? In the United States, most people who are affected by sickle cell disease are African-Americans. About 1 in 375 African-American children has sickle cell disease. Sickle cell disease is also found in people from Turkey, Greece, Italy, the Middle East, East India, and Hispanic countries. How do you get sickle cell disease?

67. Page Title sickle cell disease is an inherited red blood cell disorder. Pain episodes are the most common recurring complication of sickle cell disease. http://www.greensboro.com/sickle/page2.html

What is Sickle Cell Disease? Sickle cell disease is an inherited red blood cell disorder. Normal red blood cells are doughnut shaped and transport oxygen throughout the body. For a person with sickle cell disease, the red blood cells release oxygen too quickly, become hard, sticky, and banana shaped. Oxygen transport through small blood vessels becomes difficult and often impossible. Blockage of blood flow and oxygen circulation can then lead to severe pain, as well as, tissue and organ damage. The sickling process leads to early destruction of red blood cells. Normal red blood cells live 120 days but sickle cells live between 6 to 60 days. The bone marrow, the site of production for all blood cells, cannot produce red blood cells fast enough to compensate for the short-lived red blood cells. This reduced number of red blood cells causes a person to become anemic. Pain episodes are the most common recurring complication of sickle cell disease. The pain episode can range in location and duration. Often it can be treated at home with medication or, depending on the intensity, may require hospital attention. Other complications can include high susceptibility to infections, chronic anemia, fatigue, jaundice, recurring strokes, leg ulcers, painful joints and organ deterioration.

68. ClinicalTrials.gov - Information On Clinical Trials And Human Research Studies: 2. Recruiting, Safety of ICL670 vs. deferoxamine in sickle cell disease patients with iron overload due to blood transfusions Condition sickle cell disease. http://www.clinicaltrials.gov/ct/gui/action/FindCondition?ui=D000755&recruiting=

69. Clinical Trial: Home Based Massage And Relaxation For Sickle Cell Pain care utilization in a sample of African American adolescents age 15 years and older and adults with chronic pain associated with sickle cell disease who have http://www.clinicaltrials.gov/show/NCT00066079

Home Search Browse Resources ... About Home Based Massage and Relaxation for Sickle Cell Pain This study is currently recruiting patients. Sponsored by National Center for Complementary and Alternative Medicine (NCCAM) Purpose The purpose of this study is to compare the effects of in-home, family-administered massage and in-home relaxation training on measures of physical status and health care utilization in a sample of African American adolescents age 15 years and older and adults with chronic pain associated with sickle cell disease who have been randomly assigned to six sessions of either family-administered massage or progressive muscle relaxation training. Condition Treatment or Intervention Phase Sickle Cell Disease Procedure: massage Behavior: relaxation Phase II MedlinePlus related topics: Sickle Cell Anemia Genetics Home Reference related topics: sickle cell anemia Study Type: Interventional Study Design: Treatment, Randomized, Open Label, Active Control, Parallel Assignment, Safety/Efficacy Study Eligibility Ages Eligible for Study: 15 Years - 65 Years, Genders Eligible for Study: Both

70. Babyworld - Your Baby - Special Needs - Sickle Cell Disease sickle cell disease. What is it? Looking after a child with sickle cell disease. Every child with sickle cell disease experiences the illness differently. http://www.babyworld.co.uk/information/baby/special_needs/sickle.asp

// 29, 176, , document.write(""); // 30, 201, , document.write(""); Who is responsible for your child's weight? Vote now! Sickle cell disease What is it? Sickle cell disease is most common among people of West African or Afro-Caribbean origin. What causes it? Sickle cell disease is an inherited genetic condition, which your baby will only be born with if he inherits the gene from both you and his other parent. It can be detected antenatally by amniocentesis or chorionic villus sampling Looking after a child with sickle cell disease Every child with sickle cell disease experiences the illness differently. Some are able to lead an almost normal life, while others have a lot of illness and pain, and need extensive medical treatment. Most will need to take regular medicine. All of them will need lots of love and support to help them through painful episodes, help to avoid the things that can lead to these episodes occurring, and encouragement to lead as normal a life as possible. The Sickle Cell Society site has a lot of information about sickle cell disease and caring for a child who has it.

71. The Sickle Cell Disease Program At St. Louis Children’s Hospital. The sickle cell disease Program at St. Louis Children sickle cell disease Program. Phone 314.454.6228 Email Us Map and Directions. http://www.stlouischildrens.org/articles/kids_parents.asp?ID=247

72. Texas Department Of Health-Sickle Cell Disease Newborn Screening Case Management Program. sickle cell disease. sickle cell disease and Sickle Cell Trait. sickle cell disease A Resource for the Educator. http://www.tdh.state.tx.us/newborn/sickle.htm

Newborn Screening Case Management Program Sickle Cell Disease Information Sickle Cell Disease in Children and Adolescents: Diagnosis, Guidelines for Comprehensive Care, and Protocols for Management of Acute and Chronic Complications© Homozygous Beta Thalassemia Major also known as Cooley's Anemia So Your Baby Has The Sickle Cell Trait Con Que Su Bebé Tiene El Rasgo de Glóbulos Falciformes ... La Anemia Falciforme (Sickle Cell) en Bebés y Niños Pequeños Newsletter The Sickle Cell Rapper - The Children's Sickle Center, San Antonio, Texas Summer 2002 Fall 2001 Spring 2001 Fall 2000 ... Fall, 1998 Publications Newborn Screening Publications Order Form Practitioner's Guide Related Sites The fourth edition of The Management of Sickle Cell Disease developed by physicians, nurses, psychologists, and social workers who specialize in the care of children and adults with sickle cell diseasedescribes the current approach to counseling and also to management of many of the medical complications of sickle cell disease. Sickle Cell Association of Austin - Marc Thomas Chapter The Sickle Cell Information Center Please note: External links to other sites are intended to be informational and do not have the endorsement of the Texas Department of Health. These sites may also not be accessible to persons with disabilities.

73. What Is Sickle Cell Disease? Provides easyto-understand explanations of sickle cell disease and a description of how the body reacts to this inherited disorder. http://www.ahrq.gov/consumer/bodysys/edbody12.htm

What Is Sickle Cell Disease? Sickle cell disease is an inherited disorder of the red blood cells. Red blood cells carry oxygen to all parts of the body by using a protein called hemoglobin. Normal red blood cells contain only normal hemoglobin and are shaped like doughnuts. These cells are very flexible and move easily through small blood vessels. But in sickle cell disease, the red blood cells contain sickle hemoglobin, which causes them to change to a curved shape (sickle shape) after oxygen is released. Sickled cells become stuck and form plugs in small blood vessels. This blockage of blood flow can damage the tissue. Because there are blood vessels in all parts of the body, damage can occur anywhere in the body. The most common types of sickle cell disease are: Sickle cell anemia. Hemoglobin SC disease. Sickle beta-thalassemia. Current as of August 2000 Internet Citation: Understanding Your Body: What Is Sickle Cell Disease? August 2000. Life Sciences Education and Health Literacy. Agency for Healthcare Research and Quality, Rockville, MD. http://www.ahrq.gov/consumer/bodysys/edbody12.htm Return to Understanding Your Body Consumers and Patients AHRQ Home Page Department of Health and Human Services

74. National Human Genome Research Institute - Learning About Sickle Cell Disease Answers to frequently asked questions about sickle cell disease, published by the National Human Genome Research Institute. Learning About sickle cell disease. http://www.genome.gov/10001219

Talking Glossary Frequently Asked Questions about Genetics Clinical Research Online Health Resources ... Specific Genetic Disorders Learning About Sickle Cell Disease Learning About Sickle Cell Disease What do we know about heredity and sickle cell disease? Is there a test for sickle cell disease? NHGRI Clinical Research on Sickle Cell Disease Additional Resources for Sickle Cell Disease Information What do we know about heredity and sickle cell disease? Sickle cell disease is the most common inherited blood disorder in the United States. Approximately 80,000 Americans have the disease. In the United States, sickle cell disease is most prevalent among African Americans. About one in 12 African Americans and about one in 100 Hispanic Americans carry the sickle cell trait, which means they are carriers of the disease. Sickle cell disease is caused by a mutation in the hemoglobin-Beta gene found on chromosome 11. Hemoglobin transports oxygen from the lungs to other parts of the body. Red blood cells with normal hemoglobin (hemoglobin-A) are smooth and round and glide through blood vessels. In people with sickle cell disease, abnormal hemoglobin molecules - hemoglobin S - stick to one another and form long, rod-like structures. These structures cause red blood cells to become stiff, assuming a sickle shape. Their shape causes these red blood cells to pile up, causing blockages and damaging vital organs and tissue.

75. Sickle Cell Anemia of human genes and disorders Information Fact Sheet from the National Heart, Lung and Blood Institute, NIH SCDAA sickle cell disease Association of America. http://www.ncbi.nlm.nih.gov/disease/sickle.html

This Genes and Disease page has been moved to: Please update your bookmarks. If you are not automatically transported to the new page after 15 seconds, click on this link Genome View HBB on chromosome 11 Databases PubMed the literature Key Papers Recent literature LocusLink collection of gene-related information OMIM catalog of human genes and disorders Information Fact Sheet from the National Heart, Lung and Blood Institute, NIH SCDAA Sickle Cell Disease Association of America SICKLE CELL ANEMIA (SCA) is the most common inherited blood disorder in the United States, affecting about 72,000 Americans or 1 in 500 African Americans. SCA is characterized by episodes of pain, chronic hemolytic anemia and severe infections, usually beginning in early childhood. SCA is an autosomal recessive disease caused by a point mutation in the hemoglobin beta gene ( HBB ) found on chromosome 11p15.4. Carrier frequency of HBB varies significantly around the world, with high rates associated with zones of high malaria incidence, since carriers are somewhat protected against malaria. About 8% of the African American population are carriers. A mutation in HBB results in the production of a structurally abnormal hemoglobin (Hb), called HbS. Hb is an oxygen carrying protein that gives red blood cells (RBC) their characteristic color. Under certain conditions, like low oxygen levels or high hemoglobin concentrations, in individuals who are homozygous for HbS, the abnormal HbS clusters together, distorting the RBCs into sickled shapes. These deformed and rigid RBCs become trapped within small blood vessels and block them, producing pain and eventually damaging organs.

76. Gene Therapy Used To Treat Sickle Cell Disease In Mice This Story National Geographic Today. Related Sites Stories. - E-mail this story. Sponsored in part by. Gene Therapy Used to Treat sickle cell disease in Mice http://news.nationalgeographic.com/news/2001/12/1213_TVsickle.html

Sign up for our free e-mail newsletter Also see: Today's Top Stories This Story National Geographic Today E-mail this story Sponsored in part by Gene Therapy Used to Treat Sickle Cell Disease in Mice Bijal P. Trivedi National Geographic Today December 13, 2001 Researchers have successfully used gene therapy to treat sickle cell disease in mice. The researchers, led by Philippe Leboulch,of Harvard MedicalSchool and the Massachusetts Institute of Technology, designed a new gene that can counter the effects of the sickle cell gene. Human Sickle Cell Photograph by R.L. Nagel, Albert Einstein College of Medicine, Bronx, NY. Courtesy of Dr. Philippe Leboulch More News Kids News The Environment Travel National Geographic Channel Special Series Emerging Explorers TravelWatch National Geographic Out There Oceans ... Pulse of the Planet Sickle cell disease, which can be fatal, is caused by a genetic mutation in the hemoglobin gene that causes red blood cells to become crescent or sickle-shaped and sticky. A person with one mutated copy sickle cell gene does not show any symptoms of the disease and does not require treatment. In fact, having one copy of the mutant gene is common in tropical countries where malaria is endemic because it actually protects against malaria; it is fairly common in people of African, Indian, Mediterranean and Middle Eastern descent. About 1 in 13 African Americans carries one sickle cell gene. About 72,000 in the United States have two copies of the sickle cell gene and have the disease.

77. Index WELCOME TO SICKLE CELL ASSOCIATION TEXAS GULF COAST HOME. Touching Those, Touched By sickle cell disease. http://www.sicklecell-texas.org/

WELCOME TO SICKLE CELL ASSOCIATION TEXAS GULF COAST HOME Touching Those, Touched By Sickle Cell Disease

78. Sickle Cell Disease sickle cell disease is an inherited disorder of red blood cells that causes the cells to become sickleshaped and firm, instead of round and flexible. http://www.stjude.org/disease-summaries/0,2557,449_2162_2955,00.html

@import url(/StJude/CDA/Common/CSS/default.css); @import url(/StJude/CDA/Common/CSS/default_lists.css); @import url(/StJude/CDA/Common/CSS/default_content_types.css); @import url(/StJude/Common/CSS/St_Jude_Clinical_Science); St. Jude Children's Research Hospital Finding Cures. Saving Children. About St. Jude News Donate Now Contact Us ... Ways to Help Hematologic Disorders Home Clinical Science Home Disease Information Hematologic Disorders Related Topics The Pediatric Hematology Center of Memphis (PHECOM) Better drugs for babies with sickle cell disease New hope for children with Sickle Cell Disease St. Jude to receive multi-million dollar grant for sickle cell program ... TG1373 Protocol / Clinical Study Disease Information Hematologic Disorders : Sickle Cell Disease Alternative Names: None Definition Sickle cell disease is an inherited disorder of red blood cells that causes the cells to become sickle-shaped and firm, instead of round and flexible. These abnormal blood cells clog blood vessels, causing episodes of severe pain, organ damage and eventually a premature death. Incidence About one in 375 African-Americans is born with a form of sickle cell disease.

79. Virtual Children's Hospital: Pediatrics: Sickle Cell Trait Sickle cell trait is not a disease. It does not turn into sickle cell disease. It is not contagious. What is sickle cell disease? http://www.vh.org/pediatric/patient/pediatrics/faq/sicklecell.html

Pediatrics Sickle Cell Trait Department of Pediatrics Children's Hospital of Iowa Peer Review Status: Internally Peer Reviewed Creation Date: March 1993 Last Revision Date: March 1993 What is hemoglobin? Hemoglobin (Hb) is the special protein within the red blood cells that carries oxygen from the lungs to the rest of the body. Hemoglobin is what makes your blood look red in color. Where does your hemoglobin come from? Your hemoglobin type is inherited through family genes. The color of your hair, the color of your eyes, your body build, and your hemoglobin type are all examples of things about you that are determined by genes. You receive one gene for hemoglobin type from your mother and one from your father. Hemoglobin A or normal adult hemoglobin is the most common type. There are over 500 different types or variations of hemoglobin. What is hemoglobin S? Sickle hemoglobin or hemoglobin S is a hemoglobin type that is most common in the African-American population. However, it does occur in other racial groups including the white population. What is Sickle Cell Trait?

80. HealthDay Printer Friendly Format. Children With sickle cell disease Living Longer Early detection key to boosting survival rate. By Ed Edelson HealthDay Reporter. http://www.healthday.com/view.cfm?id=518116

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