1. Information Center For Sickle Cell And Thalassemic Disorders Enter. Kenneth R. Bridges, MD. Welcomesickle cell diseaseThalassemia InformationInformation Center OverviewLinks. StudyWeb http://sickle.bwh.harvard.edu/

Kenneth R. Bridges, M.D. [Welcome] [Sickle Cell Disease] [Thalassemia Information] Kenneth R. Bridges, M.D. [Welcome] [Sickle Cell Disease] [Thalassemia Information] ... [Links]

2. Sickle Cell Disease Association Of America Page Updated March 14, 2004. sickle cell disease Association of America, Inc. 200 Corporate Pointe, Suite 495 Culver City California http://www.sicklecelldisease.org/

Home Bookmark This Site (IE Only) CALL FOR ABSTRACTS SCDAA 32nd Annual Convention September 29 - October 2, 2004 Atlanta, Georgia January 20, 2004 Press Release - Please Note! SCDAA relocates National Headquarters National Store temporarily suspending services.

3. Sickle Cell Information Center Home Page It is the mission of our organizations to provide world class compassionate care, education, counseling, and research for patients with sickle cell disease. http://www.emory.edu/PEDS/SICKLE/

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4. Sickle Cell Disease Brief History of sickle cell disease. Hemoglobin Basics. Hemoglobin Synthesis. How Does Sickle Cause Disease? Sickle Syndrome Definitons. How Do People Get sickle cell disease? Why is sickle cell disease so Variable? Malaria and The Red Cell http://sickle.bwh.harvard.edu/menu_sickle.html

Overview Brief History of Sickle Cell Disease Hemoglobin Basics Hemoglobin Synthesis How Does Sickle Cause Disease? ... Sickle Cell Trait Management Considerations Development of a Comprehensive Care Program for Patients with Sickle Cell Disease Management Overview Outpatient Management Issues Newborn Screening ... Bone Marrow Transplantation Children's Hospital Oakland Cord Blood Program Transition of Patients with Sickle Cell Disease from Pediatric to Adult Care Research Red Cell Hydration and Sickle Cell Disease

5. Ask NOAH About: Sickle Cell Disease * Ask NOAH About sickle cell disease Screening/Prevention. Types of sickle cell disease. Hydroxyurea. Pain Management http://www.noah-health.org/english/illness/genetic_diseases/sickle.html

Ask NOAH About: Sickle Cell Disease What is Sickle Cell Disease? Care and Treatment Basic Descriptions Sickle Cell Trait Causes/Genetics Screening/Prevention ... Management of Acute Chest Syndrome Special Groups Information Resources Especially For Children Especially For Teens For Families For Women ... Ongoing Research/Clinical Trials Go to the Ask NOAH About Genetic Diseases What Is Sickle Cell Disease? Basic Descriptions Facts About Sickle Cell Anemia - National Heart Lung and Blook Institute ( PDF File of 6 Pages) (also in Spanish Facts About Sickle Cell Anemia - JAMA Patient Page ... Sickle Cell Anemia - Methodist Health Care System, Houston TX (also in Spanish Sickle Cell Disease - March of Dimes (NOAH Provider) (also in Spanish Sickle Cell Disease and Sickle Cell Trait - Texas Department of Health General Information on Sickle Cell Anaemia - Sickle Cell Society What is Sickle Cell Anemia? - Georgia NIH Comprehensive Sickle Cell Center Sickle Cell Trait Hemoglobin C Trait - Wisconsin State Laboratory of Hygiene PDF File of 2 Pages) Sickle Cell Trait - Georgia Comprehensive Sickle Cell Site Sickle Cell Trait - American Sickle Cell Anemia Association Sickle Cell Trait - Virtual Children's Hospital Sickle Cell Trait - Wisconsin State Laboratory of Hygiene ... PDF File of 2 Pages) So Your Baby Has the Sickle Cell Trait - Texas Department of Health (Also in Spanish Causes/Genetics How Do People Get Sickle Cell Disease? - Harvard Medical School

6. Sickle Cell Disease / Family Village Who to Contact. Where to Go to Chat with Others. Learn More About It. Web Sites. Search Google for "Sickle Cell" Who to Contact. sickle cell disease Association of America. 200 Corporate Pointe, Suite 495. Culver City California 902308727 ( Network works to find a cure for sickle cell disease and to help families and individuals lead http://www.familyvillage.wisc.edu/lib_scd.htm

Sickle Cell Disease Who to Contact Where to Go to Chat with Others Learn More About It Web Sites ... Search Google for "Sickle Cell" Who to Contact Sickle Cell Disease Association of America 200 Corporate Pointe, Suite 495 Culver City California 90230-8727 (310) 216-6363 Office (310) 215-3722 Fax (800) 421-8453 General Public E-Mail: scdaa@sicklecelldisease.org Website: http://sicklecelldisease.org/ Sickle Cell Disease Association of America, Inc. is helping to promote finding a universal cure for sickle cell disease, and helping to improve the quality of life for individuals and families where sickle cell disease related conditions exist. Sickle Cell Parent and Family Network P.O. Box 19854 Cincinnati, Ohio 45219 513-398-9620 (fax) E-mail: muhjahmarshall@sprintmail.com Web: http://www.cintishares.com/sickle_cell_parent.htm Sickle Cell Parent and Family Network works to find a cure for sickle cell disease and to help families and individuals lead full lives until a cure is found. Our activities center on communication, education, advocacy, support and emergency assistance. The members of the network collaborate with medical, educational, community and religious institutions to meet the many needs of individuals with sickle cell disease and other chronic conditions and disabilities. Through learning programs designed by and for impacted families, our members are empowered to make wise decisions in meeting their life challenges. The American Sickle Cell Anemia Association

7. Home Personal fight against this disease. Poems, articles, links and photos. http://www.fightscd.com

This site requires flash player to view some images and videos. If you do not have flash player 5 or higher I recommend you download the latest flash player now. Download Flash Player My name is Patricia Imah Imadomwanyi. Welcome to Fight SCD , a website dedicated to the fight against sickle cell disease. This disease does not belong to one race or culture, and has no respect for money or gender. Sickle cell disease was discovered over 80 years ago, but has not been given the attention it deserves. We must unite the world to fight this horrible epidemic, and save our children's dreams. To learn more about sickle cell disease, go to the sickle cell page and the articles page. The sickle cell page includes videos and text explaining this disease. The articles page contains editorials and articles written about sickle cell disease. As many of you know, sickle cell disease takes a great toll on the sufferers and their loved ones. I have expressed some of my emotions through poems that you can access on the

8. SICKLE CELL DISEASE sickle cell disease. WHAT IS sickle cell disease? sickle cell disease is a hereditary blood disorder say that the sickle cell shape is caused by the sickle hemoglobin within http://www.mckinley.uiuc.edu/health-info/dis-cond/misc/sicklecd.html

Sickle Cell Disease WHAT IS SICKLE CELL DISEASE? Sickle Cell Disease is a hereditary blood disorder that affects the oxygen-carrying component of blood, the red blood cell. In other words, it is manifested by diseased red blood cells that have a sickle shape. Red blood cells have proteins called hemoglobin. Hemoglobin transports oxygen from your lungs to every part of your body. When a normal red blood cell (with normal hemoglobin) releases its oxygen, it maintains its discoid shape. However, when a diseased red blood cell containing sickle hemoglobin releases its oxygen, the appearance of the cell can change from discoid to sickle-shaped. This is to say that the sickle cell shape is caused by the sickle hemoglobin within a particular red blood cell. Possible health problems may include fatigue, breathlessness, rapid heartbeat, delayed growth, susceptibility to infections, skin ulcers, and vision problems. NORMAL HEMOGLOBIN vs. SICKLE HEMOGLOBIN While sickle hemoglobin and normal hemoglobin carry the same amount of oxygen, two major differences exist between the two kinds of cells. First, they differ in the way they flow through the blood vessels. Normal hemoglobin is found in disc-shaped red blood cells that are soft (like a bag of jelly), which enables them to easily flow through small blood vessels. Diseased red blood cells, which are sickle-shaped and are hard (like pieces of wood), often get stuck in small blood vessels and stop the flow of blood. The second difference between the two types of cells is their longevity. Sickle cells do not live as long as normal cells. Normal, healthy cells can survive for about 120 days, while the more fragile sickle cells can survive for about 60 days or less. Unfortunately, the body cannot make new red blood cells as fast as it loses sickle blood cells. As a result, a sickle cell patient has fewer red blood cells and less hemoglobin than normal red blood cells. This decreased hemoglobin (called anemia), in turn, results in less oxygen being available for use by the cells of the body.

9. Sickle Cell Disease Association Of America Statewide nonprofit organization providing sickle cell patients and their families with a variety of support programs and services. http://www.sicklecellct.org/

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10. MedlinePlus: Sickle Cell Anemia Outlook Improving for Kids with sickle cell disease ( 04/13/2004, Reuters Health Major Risk for Death in Adults with sickle cell disease ( 02/25/2004, National Institutes of Health http://www.nlm.nih.gov/medlineplus/sicklecellanemia.html

@import url(http://www.nlm.nih.gov/medlineplus/images/advanced.css); Skip navigation Other health topics: A B C D ... List of All Topics Sickle Cell Anemia Contents of this page: From the NIH General/Overviews Prevention/Screening Research ... Teenagers Search MEDLINE for recent research articles on Sickle Cell Anemia You may also be interested in these MedlinePlus related pages: Blood/Lymphatic System Genetics/Birth Defects From the National Institutes of Health Sickle Cell Anemia (National Heart, Lung, and Blood Institute) - Links to PDF File Also available in: Spanish General/Overviews Genetic Disease Profile: Sickle Cell Anemia (Dept. of Energy, Human Genome Project) Sickle Cell Anemia (Mayo Foundation for Medical Education and Research) Sickle Cell Anemia (Nemours Foundation) Clinical Trials ClinicalTrials.gov: Anemia, Sickle Cell (National Institutes of Health) Active Clinical Trials at the Joint Center for Sickle Cell and Thalassemic Disorders (Brigham and Women's Hospital, Harvard Medical School, Massachusetts General Hospital) Disease Management Pain Assessment and Pain Management in Sickle Cell Disease (Georgia Comprehensive Sickle Cell Center at Grady Health System) Prevention/Screening Genetic Counseling (Nemours Foundation) Newborn Screening Tests (March of Dimes Birth Defects Foundation) Also available in: Spanish Sickle Cell Test (American Association for Clinical Chemistry) Research Exploring Important Medicinal Uses for Watermelon Rinds (Dept. of Agriculture)

11. Sickle Cell Disease Practical Tips For Preventing A Sickle Cell Crisis Advice from FamilyDoctor.org. http://familydoctor.org/550.xml

Advanced Search familydoctor.org Home Conditions A to Z Preventing a Sickle Cell Crisis What is sickle cell disease? What is a sickle cell crisis? What causes a sickle cell crisis? What medicines can I use at home to control my pain? ... What else can I do to control the pain? Sickle Cell Disease: Practical Tips for Preventing a Sickle Cell Crisis Printer-friendly version Email this article What is sickle cell disease? Sickle cell disease is a hereditary problem that causes a type of faulty hemoglobin in red blood cells. Hemoglobin carries oxygen in the blood. Normal red blood cells are disc-shaped and very flexible. In sickle cell disease, some red blood cells can change shape so that they look like sickles or crescent moons. Because of their shape, they don't move well through the smallest blood vessels. This can stop or slow blood flow to parts of the body, causing less oxygen to reach these areas. Return to top What is a sickle cell crisis? A sickle cell crisis is pain that can begin suddenly and last several hours to several days. It happens when sickled red blood cells block small blood vessels that carry blood to your bones. You might have pain in your back, knees, legs, arms, chest or stomach. The pain can be throbbing, sharp, dull or stabbing. How often and how bad the pain gets varies a lot from person to person and from crisis to crisis. You might be able to treat your pain crisis at home with medicines that you take by mouth. If these medicines don't control your pain, or if you can't keep fluids down, you might need to be treated in the emergency department. If your pain still isn't controlled or you have other problems, you might need to be treated in the hospital.

12. Sickle Cell Disease Association Of America Education, advocacy and other initiatives which promote awareness and support for sickle cell programs and patients. http://sicklecelldisease.org/

Home Bookmark This Site (IE Only) CALL FOR ABSTRACTS SCDAA 32nd Annual Convention September 29 - October 2, 2004 Atlanta, Georgia January 20, 2004 Press Release - Please Note! SCDAA relocates National Headquarters National Store temporarily suspending services.

13. SCDAA - What Is SCD? About SCD What is SCD? What is sickle cell disease? sickle cell disease is an inherited blood disorder that affects red blood cells. http://www.sicklecelldisease.org/what_is.htm

What is SCD? What is Sickle Cell Disease? Sickle cell disease is an inherited blood disorder that affects red blood cells. People with sickle cell disease have red blood cells that contain mostly hemoglobin* S, an abnormal type of hemoglobin. Sometimes these red blood cells become sickle-shaped (crescent shaped) and have difficulty passing through small blood vessels. Normal red blood cell Sickle-shaped red blood cell When sickle-shaped cells block small blood vessels, less blood can reach that part of the body. Tissue that does not receive a normal blood flow eventually becomes damaged. This is what causes the complications of sickle cell disease. There is currently no universal cure for sickle cell disease. Hemoglobin Normal red blood cells are soft and round and can squeeze through tiny blood tubes (vessels). Normally, red blood cells live for about 120 days before new ones replace them.

14. SickleCellKids.org Animated site with information, games, letters from celebrities and a quiz show to keep kids with sickle cell disease healthy. http://www.sicklecellkids.org/

This site requires Flash 5 If you don't have Flash 5 , you can download it for free by clicking on the link to the right. Contact Lenses Surfing Panama Surf and Surfing in Panama and Central America.

15. Patient Information If you inherit two sickle cell genes you have sickle cell disease. Is Sickle Cell only in African Americans? Are there different types of sickle cell disease? http://www.emory.edu/PEDS/SICKLE/sicklept.htm

Sickle Cell Anemia Sickle Cell anemia is a group of inherited red blood cell disorders. Normal red blood cells are round like doughnuts, and they move through small blood tubes in the body to deliver oxygen. Sickle red blood cells become hard, sticky and shaped like sickles used to cut wheat. When these hard and pointed red cells go through the small blood tube, they clog the flow and break apart. This can cause pain, damage and a low blood count, or anemia. What makes the red cell sickle? There is a substance in the red cell called hemoglobin that carries oxygen inside the cell. One little change in this substance causes the hemoglobin to form long rods in the red cell when it gives away oxygen. These rigid rods change the red cell into a sickle shape instead of the round shape. How do you get sickle cell anemia or trait? You inherit the abnormal hemoglobin from your parents, who may be carriers with sickle cell trait or parents with sickle cell disease. You can not catch it. You are born with the sickle cell hemoglobin and it is present for life. If you inherit only one sickle gene, you have sickle cell trait. If you inherit two sickle cell genes you have sickle cell disease. Is Sickle Cell only in African Americans?

16. ICAGEN Discovers and develops pharmaceutical products to treat medical conditions such as atrial fibrillation, urinary incontinence, central nervous system disorders, and sickle cell disease. http://www.icagen.com/

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17. The Sickle Cell Disease Association Of Illinois (SCDAI) Seeks to enhance the quality of life for people with sickle cell disease and their families. Includes information on healthcare programs and services, events calendar, and contacts. http://www.sicklecelldisease-il.org/

SCDAI What is Sickle Cell? Support Services You Can Help ... Site Map Mission Statement The Sickle Cell Disease Association of Illinois (SCDAI) primary mission is to enhance the quality of life for people with sickle cell disease and their families. To effectively achieve this goal, SCDAI acts as an advocate for improved health care and services for sickle cell patients by educating and informing the community through outreach programs. OBJECTIVES To fund research for the prevention, treatment, and cure of the disease. To encourage the legislature to enact public policies that benefit sickle cell patients and their families. PROGRAMS Provides counseling, referral services, and direct emergency grants to patients in need of food, clothing, shelter, prostheses or other necessities. Sponsors a summer camp for children with sickle cell disease (ages 7-13) where campers are provided with positive values of their own self-worth. Assists deserving sickle cell students with scholarships to achieve their higher education goals. Sponsors a Christmas party with food, games, and gifts for children with sickle cell disease, their siblings and other family members.

18. Medical References: Sickle Cell Disease sickle cell disease is an inherited disease of red blood cells which can cause pain, damage to vital organs, risk of serious infections and can lead to early http://www.marchofdimes.com/professionals/681_1221.asp

View All Chapters Find Your Local Chapter June 2, 2004 Select one Folic Acid Pregnancy Prenatal Screening Infections/Diseases Loss Concerns Newborn Information Birth Defects Polio Genetics Research Funding Perinatal Statistics Medical References Continuing Education ... Prematurity Quick Reference and Fact Sheets Sickle Cell Disease What Is Sickle Cell Disease? It is an inherited disease of red blood cells which can cause attacks of pain, damage to vital organs, risk of serious infections and can lead to early death. Sickle cell disease affects the main protein inside the red blood cells called hemoglobin. The disease occurs when a person inherits one sickle cell gene from each parent or a combination of one sickle cell gene plus one of several other abnormal hemoglobin genes. Hemoglobin in the red blood cells carries oxygen from the lungs and takes it to every part of the body. The main hemoglobin in the red blood cells of people with sickle cell disease is not normal. Red blood cells containing mainly normal hemoglobin are round and flexible. In people with sickle cell disease, the abnormal hemoglobin forces the cells to lose their normally round and flexible shape, becoming distorted and rigid. Under a microscope, these abnormal cells may look like the C-shaped farm tool called a sickle. Sickle cells tend to become trapped and to be destroyed in small blood vessels (veins and arteries), the spleen, the liver and other organs. This results in a shortage of red blood cells, or anemia. Anemia can cause an affected child to be pale, short of breath, easily tired and have slowed growth and physical development. Certain conditions, such as infections or enlargement of the spleen, may worsen the anemia by speeding up destruction of red blood cells. Infections also can reduce red blood cell production, leading to worsening of anemia.

19. Pediatric Hematology/Oncology Clinic At The U-M Cancer Center Affiliated with Mott Children's Hospital, the UMCC Pediatric Cancer Clinic at the University of Michigan treats pediatric cancers, as well as sickle cell disease, chronic neutropenias and chronic granulomatous disease. http://www.cancer.med.umich.edu/clinic/pedclinic.htm

U-M Health System U-M Medical School U-M Gateway Pediatric Hematology / Oncology Clinics and Treatment Areas Amenities Clinical Programs Special News... U-M Chair of Department of Pediatrics recognized as role model for young people Find out more. Pediatric Hematology / Oncology Clinic About the Clinic Appointments Physicians and Staff Pediatric Cancer Treatment Information ... Support Groups See Also: SHARE ing Ped Hem/Onc Newsletter Fertility Counseling and Gamete Cryopreservation Program (FCGCP) Cancer AnswerLine 800-865-1125 U-M Comprehensive Cancer Center 1500 E. Medical Center Drive CCGC 6-303 Ann Arbor, MI 48109-0944 privacy statement

20. Medical References: Sickle Cell Disease sickle cell disease What Is sickle cell disease? sickle cell disease affects the main protein inside the red blood cells called hemoglobin. http://www.marchofdimes.com/printableArticles/681_1221.asp

View All Chapters Find Your Local Chapter June 2, 2004 Select one Folic Acid Pregnancy Prenatal Screening Infections/Diseases Loss Concerns Newborn Information Birth Defects Polio Genetics Research Funding Perinatal Statistics Medical References Continuing Education ... Prematurity Quick Reference and Fact Sheets Sickle Cell Disease What Is Sickle Cell Disease? It is an inherited disease of red blood cells which can cause attacks of pain, damage to vital organs, risk of serious infections and can lead to early death. Sickle cell disease affects the main protein inside the red blood cells called hemoglobin. The disease occurs when a person inherits one sickle cell gene from each parent or a combination of one sickle cell gene plus one of several other abnormal hemoglobin genes. Hemoglobin in the red blood cells carries oxygen from the lungs and takes it to every part of the body. The main hemoglobin in the red blood cells of people with sickle cell disease is not normal. Red blood cells containing mainly normal hemoglobin are round and flexible. In people with sickle cell disease, the abnormal hemoglobin forces the cells to lose their normally round and flexible shape, becoming distorted and rigid. Under a microscope, these abnormal cells may look like the C-shaped farm tool called a sickle. Sickle cells tend to become trapped and to be destroyed in small blood vessels (veins and arteries), the spleen, the liver and other organs. This results in a shortage of red blood cells, or anemia. Anemia can cause an affected child to be pale, short of breath, easily tired and have slowed growth and physical development. Certain conditions, such as infections or enlargement of the spleen, may worsen the anemia by speeding up destruction of red blood cells. Infections also can reduce red blood cell production, leading to worsening of anemia.

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