1. Vitamin C And Scurvy Vitamin C and scurvy. When capillaries lose the glue that holds them together, symptomsof scurvy appear. An affected person becomes weak and has joint pain. http://www.people.virginia.edu/~rjh9u/vitac.html

Vitamin C and Scurvy Vitamin C (ascorbic acid), a reducing agent, is necessary to maintain the enzyme prolyl hydroxylase in an active form, most likely by keeping its iron atom in a reduced state. The precursor molecule to the protein collagen, procollagen, contains an unusual amino acid sequence in that every third amino acid is a glycine and contains a high frequency of two amino acids not found in any other proteins - hydroxyproline and hydroxylysine. These latter two amino acids are converted from proline and lysine, respectively, after the procollagen molecule has been synthesized. The hydroxylation of proline and lysine in procollagen is carried out by the enzyme prolyl hydroxylase using vitamin C as a cofactor. A vitamin C deficiency results in an underhydroxylation of proline and lysine in collagen which results in a lower melting temperature of the resulting collagen fibers which causes a breakdown of the protein collagen needed for connective tissue, bones and dentin, the major portion of teeth. Collagen is a cementing material that binds cells together, and is an essential connective tissue protein in the body. Whenever the body is wounded, collagen glues the separated tissues together to form a scar. A lack of collagen causes the walls of the body's blood capillaries to break down and hemorrhaging occurs in cells throughout the body. When capillaries lose the "glue" that holds them together, symptoms of scurvy appear.

2. A Simple Experiment On Scurvy A Simple Experiment on scurvy. scurvy was described as early as 1500 BC in theEbers papyrus and other descriptions appeared in Greek and Roman writings. http://www.people.virginia.edu/~rjh9u/scurvy1.html

A Simple Experiment on Scurvy I n 1747 as the HMS Salisbury sailed from England to the Plymouth Colony, the ship's physician, James Lind, performed a simple experiment to determine what might be effective as a cure for scurvy. Scurvy was described as early as 1500 BC in the Ebers papyrus and other descriptions appeared in Greek and Roman writings. It struck the crew of Magellan's around the world journey in 1519-22 and a British report in 1600 indicated that in the previous 20 years some 10,000 mariners had been destroyed by the disease. O n May 20, 1747, Lind divided his 12 ill men into six groups of two each. All 12 shared a common diet for breakfast, lunch and dinner but each group received a different supplement as follows: quart of apple juice daily 25 drops of elixir vitriol (sulfuric acid and aromatics) two spoonfuls of vinegar three times a day concoction of herbs and spices half-pint of sea water daily two oranges and one lemon daily T he two men who ate the oranges and lemon recovered immediately. One was fit for duty in six days and the other was also well in six days and was appointed as nurse to all the others. The two men who drank apple cider improved but were not well enough to work. None of the others showed any improvement. M r. Lind concluded that

3. EMedicine - Scurvy : Article By Kumaravel Rajakumar, MD scurvy scurvy is the clinical state arising from dietary deficiency of vitamin C (ascorbic acid). Historically, scurvy is an ancient disease. The Egyptians recorded the symptoms as early as 1550 http://www.emedicine.com/ped/topic2073.htm

(advertisement) Home Specialties CME PDA ... Patient Education Articles Images CME Patient Education Advanced Search Link to this site Back to: eMedicine Specialties Pediatrics Nutrition Scurvy Last Updated: June 20, 2003 Rate this Article Email to a Colleague Synonyms and related keywords: vitamin C deficiency, infantile scurvy, Barlow disease, Barlow's disease, Cheadle disease, Cheadle's disease, osteopathia hemorrhagica infantum, scurvy rickets AUTHOR INFORMATION Section 1 of 10 Author Information Introduction Clinical Differentials ... Bibliography Author: Kumaravel Rajakumar, MD , Assistant Professor, Department of Pediatrics, Children's Hospital of Pittsburgh, University of Pittsburgh Kumaravel Rajakumar, MD, is a member of the following medical societies: Ambulatory Pediatric Association , and American Academy of Pediatrics Editor(s): Steven Schwarz, MD , Chairman, Department of Pediatrics, Long Island College Hospital; Professor of Pediatrics, State University of New York Downstate Medical Center; Robert Konop, PharmD

4. Scurvy a CHORUS notecard document about scurvy white line of Frankel. scurvy zone. DDx rickets ( wide growth plate) child abuse (no lucent "scurvy" zone) Charles E. Kahn, Jr http://chorus.rad.mcw.edu/doc/00688.html

CHORUS Collaborative Hypertext of Radiology Musculoskeletal system Feedback Search scurvy vitamin C deficiency rare xray findings: Wimberger ring periosteal reaction (+/- massive periosteal bleed) white line of Frankel scurvy zone DDx: rickets (wide growth plate) child abuse (no lucent "scurvy" zone) Charles E. Kahn, Jr., MD - 2 February 1995 Last updated 26 May 2004 Medical College of Wisconsin

5. The Scurvy Brothers Cover Band - The Music Of Steely Dan Cover band italiana dedicata alla musica degli Steely Dan e Donald Fagen informazioni sui componenti della banda, le collaborazioni, i concerti ed immagini delle esibizioni. http://www.scurvybrothers.it/

SITO UFFICIALE DELLA BAND THE SCURVY BROTHERS Entra nel sito Salta introduzione in Flash info sito Sito realizzato da Riccardo Romagnoli - www.thaliaservices.it ENTRA NEL SITO Benvenuto nel sito degli Scurvy Brothers la prima cover band italiana dedicata alla musica degli Steely Dan e Donald Fagen. Qui puoi trovare tutte le informazioni relative ai concerti su tutto il territorio nazionale e naturalmente una notevole quantità di notizie e links su Walter Becker e Donald Fagen, i fondatori degli Steely Dan. La Band News Storia Steely Dan Contatti ... Collaboratori

6. Scurvy. The Columbia Encyclopedia, Sixth Edition. 2001 vitamin C (ascorbic acid) in the diet. scurvy does not occur in most animals because they can synthesize scurvy was a serious problem in the past, when fresh fruits and http://www.bartleby.com/65/sc/scurvy.html

Select Search All Bartleby.com All Reference Columbia Encyclopedia World History Encyclopedia Cultural Literacy World Factbook Columbia Gazetteer American Heritage Coll. Dictionary Roget's Thesauri Roget's II: Thesaurus Roget's Int'l Thesaurus Quotations Bartlett's Quotations Columbia Quotations Simpson's Quotations Respectfully Quoted English Usage Modern Usage American English Fowler's King's English Strunk's Style Mencken's Language Cambridge History The King James Bible Oxford Shakespeare Gray's Anatomy Farmer's Cookbook Post's Etiquette Bulfinch's Mythology Frazer's Golden Bough All Verse Anthologies Dickinson, E. Eliot, T.S. Frost, R. Hopkins, G.M. Keats, J. Lawrence, D.H. Masters, E.L. Sandburg, C. Sassoon, S. Whitman, W. Wordsworth, W. Yeats, W.B. All Nonfiction Harvard Classics American Essays Einstein's Relativity Grant, U.S. Roosevelt, T. Wells's History Presidential Inaugurals All Fiction Shelf of Fiction Ghost Stories Short Stories Shaw, G.B. Stein, G. Stevenson, R.L. Wells, H.G. Reference Columbia Encyclopedia PREVIOUS NEXT ... BIBLIOGRAPHIC RECORD The Columbia Encyclopedia, Sixth Edition. scurvy deficiency disorder resulting from a lack of vitamin C (ascorbic acid) in the diet. Scurvy does not occur in most animals because they can synthesize their own vitamin C, but humans, other primates, guinea pigs, and a few other species lack an enzyme necessary for such synthesis and must obtain vitamin C through their diet. Vitamin C is widespread in plant tissues, with particularly high concentrations occurring in citrus fruits (oranges, lemons, limes, grapefruits); tomatoes, potatoes, cabbages, and green peppers are also good sources of this vitamin.

7. Health Library.com An article on this disease and its causes, symptoms and treatment. http://www.healthlibrary.com/reading/nature/chap50.htm

Find Out Everything Your Doctor Would Tell You If Only He Had the Time ! HELP initiates a seminar and releases two books on improving the doctor patient relationship Here we will present you with regular Book Reviews of our latest arrivals. Search the entire Healthlibrary.com site. The search is powered by Google. Would you like to read what others have to say. We would love to hear from you... This section presents your favourite consumer health site Type a search expression and hit enter to search the entire Site. The expression is case-insensitive and spaces are preserved.

8. The Danger Of Scurvy scurvy Isn't Cool! All About scurvy. What is scurvy? scurvy, also called vitamin C deficiency, is of the most serious diseases affecting teenagers today. http://www.monzy.com/scurvy

Scurvy Isn't Cool! All About Scurvy What is scurvy? Scurvy, also called vitamin C deficiency, is of the most serious diseases affecting teenagers today. It is caused by a dietary lack of vitamin C (ascorbic acid), a nutrient found in many fresh fruits and vegetables, particularly the citrus fruits. Ascorbic acid is important in the formation of collagen (an element of normal tissues), and any deficiency interferes with normal tissue synthesis. How can I tell if I have scurvy? Scurvy is characterized by swollen and bleeding gums with loosened teeth, soreness and stiffness of the joints and lower extremities, bleeding under the skin and in deep tissues, slow wound healing, and anemia. If you experience any of these symptoms, you should consult a physician immediately you may be suffering from scurvy. Here are pictures of some of the scurvy "warning signs". Gingival Hemorrhage Corkscrew Hair Periungual Hemorrhage So what's so special about this ascorbic acid stuff anyway? When collagen is made, the proline amino acids are changed to hydroxyproline, by a process called post-translational modification. An enzyme called prolyl hydroxylase catalyses this change. This enzyme requires an Fe

9. Journeys Of Discovery: Scurvy WOODALL, JOHN. The Surgeon's Mate, or Military Domestique Surgery , 1639. FERRARI, GIOVANNI BATTISTA. Hesperides sive de malorum aureorum cultura et usu libri quatuor , 1646. MOELLENBROCK, ANDREAS VALENTINUS. Journeys of Discovery. Journeys. scurvy. Herbals. Vesalius URL http//www.mc.Vanderbilt.Edu/biolib/hc/ journeys/scurvy.html. Last Modified Thursday, 16 October 1997 http://www.mc.vanderbilt.edu/biolib/hc/journeys/scurvy.html

Journeys of Discovery Journeys Scurvy Herbals ... Vesalius WOODALL, JOHN. FERRARI, GIOVANNI BATTISTA. Hesperides sive de malorum aureorum cultura et usu libri quatuor... , 1646 MOELLENBROCK, ANDREAS VALENTINUS. Cochlearia curiosa: or the curiosities of scurvygrass..., 1676 LIND, JAMES. A Treatise of the Scurvy, 1753 Report of the Committee appointed by the Lords Commissioners of the Admiralty To Enquire into the Causes of the Outbreak of Scurvy in the recent Arctic Expedition..., 1877 VUMC Home About VUMC Health Care Services ... Search URL: http://www.mc.Vanderbilt.Edu/biolib/hc/journeys/scurvy.html Last Modified: Thursday, 16 October 1997 Contact: Mary.Teloh@mcmail.Vanderbilt.edu webmaster@www.mc.vanderbilt.edu

10. Scurvy Background. scurvy is Vitamin C deficiency. It occupies an interesting place in the history of the world off the devastating effects of scurvy did the sailors begin to transport http://www.thedoctorsdoctor.com/diseases/scurvy.htm

Background Scurvy is Vitamin C deficiency. It occupies an interesting place in the history of the world when English sailors became progressively ill after long voyages at sea. It was only with the observation that the consumption of fruit helped to ward off the devastating effects of scurvy did the sailors begin to transport limes with them. Hence, the term Limeys came to refer to English sailors. Scurvy results because humans cannot synthesize vitamin C (ascorbic acid) in our bodies. We lack the enzyme L-gluconolactone which converts L-gluconogammalactone to L-ascorbic acid (vitamin C). Curiously, guinea pigs are the only other mammal lacking this enzyme. Vitamin C is essential for collagen synthesis. Any deficiency will affect any organ or structure that requires collagen. Patients may present with hyperkeratotic papules centered in follicles. Hair may grow in a corkscrew-like pattern and may be associated with hemorrhage, often with minor trauma. In chronic disease, ecchymoses, usually over pressure points such as the shins, may occur. The mouth may show gingival hypertrophy. Hemorrhage may occur in any mucosal surface including conjunctiva, subungua, and skin. In addition, hemorrhage in the skeletal muscle, intra-articular sites, and subperiosteal region of the epiphyses of the long bones may occur. SYNONYMS Vitamin C deficiency INCIDENCE Rare, usually in poverty stricken areas

11. The Scurvy Few Motorcycle Club The only charter motorcycle club in the nation, the product of a mutual and shared love of motorcycling. http://www.scurvyfewmc.org

12. WebMD Health - 404 Error A brief explanation of this disorder, the symptoms and the treatment. http://my.webmd.com/content/dmk/dmk_article_1459354

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13. EMedicine - Scurvy : Article By Lynne Goebel, MD scurvy scurvy was first described in 1541 by a Dutch physician named Echthiusworking in Cologne, Germany. scurvy. Last Updated November 26, 2003, http://www.emedicine.com/med/topic2086.htm

(advertisement) Home Specialties CME PDA ... Patient Education Articles Images CME Patient Education Advanced Search Link to this site Back to: eMedicine Specialties Medicine, Ob/Gyn, Psychiatry, and Surgery Endocrinology Scurvy Last Updated: November 26, 2003 Rate this Article Email to a Colleague Synonyms and related keywords: vitamin C deficiency, ascorbic acid deficiency, the rot, scorbutus, limeys AUTHOR INFORMATION Section 1 of 10 Author Information Introduction Clinical Differentials ... Bibliography Author: Lynne Goebel, MD , Director of Transitional Year Residency Program, Associate Professor, Department of Internal Medicine, Marshall University School of Medicine Coauthor(s): Henry Driscoll, MD , Professor, Department of Medicine, Section of Endocrinology, Marshall University School of Medicine Lynne Goebel, MD, is a member of the following medical societies: American College of Physicians , and American College of Physicians-American Society of Internal Medicine Editor(s): Stanley Wallach, MD

14. Scurvy Dogs scurvy Dogs Spraying teeth like Chiclets. Pirates arethe new monkeys. Email Cap n Boyd or Admiral Yount. http://www.scurvy-dogs.com/

E-mail Cap'n Boyd or Admiral Yount

15. Nutrient Deficiency Diseases Information about diseases caused by lack of nutrients, including kwashiorkor, scurvy, cretinism, goiter and rickets. http://www.geocities.com/cheeaungroup2001/

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16. BBC - History - Captain Cook And The Scourge Of Scurvy scurvy was the scourge of the Royal Navy for decades, and Captain Cook is widelycredited with conquering it. Captain Cook and the Scourge of scurvy. http://www.bbc.co.uk/history/discovery/exploration/captaincook_scurvy_01.shtml

@import url('/includes/tbenh.css') ; Home TV Radio Talk ... A-Z Index THURSDAY 3rd June 2004 Text only BBC Homepage History Topics ... Help Like this page? Send it to a friend! Captain Cook and the Scourge of Scurvy By Jonathan Lamb Scurvy was the scourge of the Royal Navy for decades, and Captain Cook is widely credited with conquering it. But how much of his reputation is deserved, and how much is due to luck? Jonathan Lamb investigates. Page 1 of 6 1. The emergence of scurvy 2. Prevention 3. Scurvy takes its toll 4. Cook's men suffer ... Print entire article The emergence of scurvy Scurvy did not emerge as a problem for maritime explorers until vessels started penetrating the Indian and the Pacific Oceans. Vasco da Gama lost two thirds of his crew to the disease while making his way to India in 1499. In 1520 Magellan lost more than 80 per cent while crossing the Pacific. Two voyages made by Pedro de Quiros early in the 17th century resulted in huge mortality from a sickness Sir Richard Hawkins called, after his venture into the South Seas, 'the plague of the Sea, and the Spoyle of Mariners'. '... Magellan lost more than 80 per cent of his crew while crossing the Pacific.'

17. CNN.com - Scurvy Likely Cause Of Afghanistan Outbreak - March 8, 2002 CNN http://cnn.com/2002/WORLD/asiapcf/central/03/08/afghanistan.outbreak/index.html

MAIN PAGE WORLD U.S. WEATHER ... ABOUT US/HELP CNN TV what's on show transcripts CNN Headline News CNN International EDITIONS CNN.com Asia CNN.com Europe CNNenEspanol.com CNNArabic.com ... set your edition Languages Spanish Portuguese German Italian Korean Arabic Japanese Time, Inc. Time.com People Fortune EW InStyle Business 2.0 Scurvy likely cause of Afghanistan outbreak KABUL, Afghanistan (CNN) Officials with the World Health Organization said Friday that they believed a vitamin C deficiency is at the root of an outbreak of disease in a remote, central Afghan province. A spokeswoman for the U.N.-affiliated group said doctors were still not completely clear about the outbreak, but now believe it to be scurvy with a secondary infection. Spokeswoman Loretta Hieber-Girardet in Kabul said WHO is ready to send doctors with supplies of the vitamin to the area, but the region is difficult to access without helicopters, which are in short supply. The lack of access to the region has also hindered identification of the disease. Forty people in Ghowr province have died from the disease, and aid workers have seen symptoms in at least 80 people in a dozen villages. Two staff members of the Action Against Hunger humanitarian group also have shown signs of the disease and are under observation. The group said it wants to evacuate its staff from the area.

18. Sev Files: X-Files Cartoon Satire An online cartoon by John Cook taking off the XFiles. Features scurvy and Mouldy investigating the disappearance of the body of Jesus of Nazareth. http://cartoons.sev.com.au/index.php?catid=63

19. Trummerfeld Scurvy Zone Trummerfeld scurvy zone. lucent band in metaphysis beneath whiteline of Frankel seen in scurvy. Charles E. Kahn, Jr., MD http://chorus.rad.mcw.edu/doc/00689.html

CHORUS Collaborative Hypertext of Radiology Musculoskeletal system Feedback Search Trummerfeld scurvy zone lucent band in metaphysis beneath white line of Frankel seen in scurvy Charles E. Kahn, Jr., MD - 2 February 1995 Last updated 26 May 2004 Medical College of Wisconsin

20. EMedicine - Scurvy : Article By Janet J Wong, MD scurvy scurvy is a condition that has been described for at least 500 years. In 1753, Sir James Lind demonstrated that the condition could be prevented in British sailors by adding citrus fruits http://www.emedicine.com/derm/topic521.htm

(advertisement) Home Specialties CME PDA ... Patient Education Articles Images CME Patient Education Advanced Search Link to this site Back to: eMedicine Specialties Dermatology Metabolic Diseases Scurvy Last Updated: November 25, 2002 Rate this Article Email to a Colleague Synonyms and related keywords: infantile scurvy, Barlow disease, Barlow’s disease, vitamin C deficiency, ascorbic acid, widower scurvy, chronic malnutrition AUTHOR INFORMATION Section 1 of 9 Author Information Introduction Clinical Differentials ... Bibliography Author: Janet J Wong, MD , Staff Physician, Department of Dermatology, University of Illinois at Chicago College of Medicine Coauthor(s): Anne Laumann, MBChB, MRCP(UK) , Assistant Professor, Department of Medicine, Section of Dermatology, University of Chicago Janet J Wong, MD, is a member of the following medical societies: American Academy of Dermatology Editor(s): Kathryn Schwarzenberger, MD , Associate Professor, Departments of Dermatology and Medicine, Medical University of South Carolina; Michael J Wells, MD

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