1. NINDS Schizencephaly Information Page schizencephaly information sheet compiled by the National Institute of Neurological Disorders and Stroke (NINDS). More about schizencephaly, http://www.ninds.nih.gov/health_and_medical/disorders/schizencephaly.htm

National Institute of Neurological Disorders and Stroke Accessible version Science for the Brain The nation's leading supporter of biomedical research on disorders of the brain and nervous system Browse all disorders Browse all health organizations More about Schizencephaly Studies with patients Research literature Press releases Search NINDS... (help) Contact us My privacy NINDS is part of the National Institutes of Health NINDS Schizencephaly Information Page Reviewed 07-01-2001 Get Web page suited for printing Email this to a friend or colleague Table of Contents (click to jump to sections) What is Schizencephaly? Is there any treatment? What is the prognosis? What research is being done? ... Related NINDS Publications and Information What is Schizencephaly? Schizencephaly is an extremely rare developmental disorder characterized by abnormal slits, or clefts, in the brain's cerebral hemispheres. Schizencephaly is a form of porencephaly in which there is a cyst or cavity in the cerebral hemispheres. Individuals with clefts in both hemispheres (bilateral clefts) are commonly developmentally delayed and have delayed speech and language skills and corticospinal dysfunction. Individuals with smaller, unilateral clefts (clefts in only one hemisphere) are often paralyzed on one side of the body and may have normal intelligence. Patients with schizencephaly may also have varying degrees of microcephaly (abnormally small head), mental retardation, hemiparesis or quadriparesis (partial or complete paralysis), and reduced muscle tone (hypotonicity). Most patients have seizures. Some may have hydrocephalus.

2. WELCOME TO SCHIZ KIDZ BUDDIES! Welcome To SCHIZ KIDZ BUDDIES! This web site is provided for persons with schizencephaly and their parents, families, physicians, therapists and friends. schizencephaly is a rare developmental disorder characterized by abnormal clefts in the Persons with schizencephaly may present with varying degrees of developmental delays http://www.geocities.com/Heartland/Meadows/7384

Welcome To SCHIZ KIDZ BUDDIES! This web site is provided for persons with Schizencephaly and their parents, families, physicians, therapists,and friends. Schizencephaly is a rare developmental disorder characterized by abnormal clefts in the brain's cerebral hemispheres. Persons with Schizencephaly may present with varying degrees of developmental delays, seizures, delayed speech and language skill, vision and eating disorders. Many have normal intelligence. They may also have microcephaly (abnormally small head), mental retardation, hemiparesis or quadriparesis (partial or complete paralysis)and reduced muscle tone (hypotonicity). Some may have hydrocephalus. Schizencephaly occurs when there is a failure of the normal migration of neurons from the germinal matrix zone at 1-5 months of gestation. Some theories suggest that possible causes of this are in-utero stroke,early gestational viral infections,and recent Italian research has linked Schizencephaly with a mutated gene called the Homeobox gene EMX-2. If the gene EMX-2 is missing or defective, nerve cell growth and migration will not occur normally and this will lead to the formation of the 'clefts' associated with Schizencephaly. We are approximately 800+ families who communicate with each other through our daily EMAIL LIST. The Email List is the "heart" of Schiz Kidz Buddies.... we ask questions, air frustrations, share about our families and our children with Schizencephaly and in doing so gain invaluable support from others who "have been there".

3. Schizencephaly schizencephaly is an extremely rare developmental disorder characterized by abnormal slits, or clefts, in the brain’s cerebral hemispheres. schizencephaly. http://healthlink.mcw.edu/article/921961352.html

Search Articles: search tips Please Take the HealthLink Survey Email this article Print this article Find related articles: By topic: Neurology By keywords: Receive Health Link via email! Subscribe now >> Schizencephaly Schizencephaly is an extremely rare developmental disorder characterized by abnormal slits, or clefts, in the brain’s cerebral hemispheres. Schizencephaly is a form of porencephaly in which there is a cyst or cavity in the cerebral hemispheres. Individuals with clefts in both hemispheres (bilateral clefts) are commonly developmentally delayed and have delayed speech and language skills and corticospinal dysfunction. Individuals with smaller, unilateral clefts (clefts in only one hemisphere) are often paralyzed on one side of the body and may have normal intelligence. Patients with schizencephaly may also have varying degrees of microcephaly (abnormally small head), mental retardation, hemiparesis or quadriparesis (partial or complete paralysis), and reduced muscle tone (hypotonicity). Most patients have seizures. Some may have hydrocephalus. Treatment for individuals with schizencephaly generally consists of physical therapy, treatment for seizures, and, in cases that are complicated by hydrocephalus, a shunt (a surgically implanted tube that diverts fluid from one pathway to another).

4. Ae Closed Lipped schizencephaly. Findings A closely apposed, gray matter lined cleft extends to the left lateral ventricle from the left frontal cortex. Septum pellucidum is absent. Differential Diagnosis http://www.med.uc.edu/neurorad/webpage/aza.html

Closed Lipped Schizencephaly Findings: A closely apposed, gray matter lined cleft extends to the left lateral ventricle from the left frontal cortex. Septum pellucidum is absent. Differential Diagnosis: closed lipped schizencephaly, gray matter heterotopia, hamartoma. Discussion: -most commonly migrational anomaly occurring at approximately 6 weeks gestation. -other migrational anomalies: lissencephaly, polymicrogyria, pachygyria -infarct vs. developmental, TORCH -50% have septo-optic dysplasia -80% rule- bilateral, open, symmetric BACK TO UNKNOWNS BACK TO CATEGORIES HOME NEXT CASE

5. Schizencephaly A description of schizencephaly including treatments and prognosis and further reading. http://www.clevelandclinic.org/health/health-info/docs/1300/1338.asp

Schizencephaly What is Schizencephaly? Schizencephaly is an extremely rare developmental disorder characterized by abnormal slits, or clefts, in the brain's cerebral hemispheres. Schizencephaly is a form of porencephaly in which there is a cyst or cavity in the cerebral hemispheres. Individuals with clefts in both hemispheres (bilateral clefts) are commonly developmentally delayed and have delayed speech and language skills and corticospinal dysfunction. Individuals with smaller, unilateral clefts (clefts in only one hemisphere) are often paralyzed on one side of the body and may have normal intelligence. Patients with schizencephaly may also have varying degrees of microcephaly (abnormally small head), mental retardation, hemiparesis or quadriparesis (partial or complete paralysis), and reduced muscle tone (hypotonicity). Most patients have seizures. Some may have hydrocephalus. Is there any treatment? Treatment for individuals with schizencephaly generally consists of physical therapy, treatment for seizures, and, in cases that are complicated by hydrocephalus, a shunt (a surgically implanted tube that diverts fluid from one pathway to another). What is the prognosis?

6. Virtual Hospital: Radiology Resident Case Of The Week: Schizencephaly Radiology Resident Case of the Week April 26, 1996. schizencephaly. Lorenzo Carson, M.D Keywords 1. schizencephaly 2. clefts 3. brain malformations http://www.vh.org/pediatric/provider/radiology/PedRadSecTF/042696

Radiology Resident Case of the Week: April 26, 1996 Schizencephaly Lorenzo Carson, M.D. Peer Review Status: Internally Peer Reviewed Clinical Sx: Patients may present with seizure disorders, mild to moderate developmental delay and mental retardation. Etiology/Pathophysiology: Failure of the normal migration of neurons from the germinal matrix zone at 1-5 months of gestation. A gray matter lined parenchymal cleft develops that extends from the subarachnoid space to the subependyma of the lateral ventricles. Pathology: The cleft may be narrow or closed (type 1) or wide and open (type 2). It is frequently associated with complete or partial absence of the cavum septum pellucidum in approximately 80-90% of cases. The cleft is usually located near the pre- or postcentral gyri. The clefts can be unilateral or bilateral. Polymicrogyria, microcephaly, and gray matter heterotopia have also been noted. Optic nerve hypoplasia has been noted in 33% of cases, with possibility of blindness. Prognosis is poor, with severe intellectual impairment, spastic tetraplegia and blindness. Miscellaneous: Most brain malformation can be produced by a variety of injuries during gestation. This includes infections, X-radiation, certain drugs, metabolic and genetic abnormalities.

7. Schizencephaly Schiz Kidz Buddies support group for children/persons with schizencephaly and their families and caregivers. Includes daily e-mail loop, birthday club for children (they receive stuffed animals, cards, balloons, etc. http://www.kumc.edu/gec/support/schizenc.html

Schizencephaly Schiz Kidz Buddies - support group for children/persons with Schizencephaly and their families and caregivers. Includes daily e-mail loop, birthday club for children (they receive stuffed animals, cards, balloons, etc. on their birthdays and other gifts during the year!). Web URL: http://www.geocities.com/Heartland/Meadows/7384 E-mail (Judi Wright): wrights@televar.com To locate a genetic counselor or clinical geneticist in your area: Professional Genetics Societies Genetic clinics, centers, departments Genetic Societies Clinical Resources ... Search Genetics Education Center Debra Collins, M.S. CGC , Genetic Counselor, dcollins@kumc.edu This site subscribes to the principles of the HONcode (Health on the Net, Code of Conduct for Medical and Health Web Sites) of the Health On the Net Foundation

8. Schizencephaly - Eurorad - Clinical Case 955 - Resident teaching files radiology schizencephaly was referred to the hospital with frequent daily seizures consisting of double vision and a rigid feeling in the left arm and left leg. He has had these separated by shallow sulci. schizencephaly (split brain) may represent either failure of mechanism for causing polymicrogyria and schizencephaly is probably very similar, and it http://www.eurorad.org/case.cfm?uid=955

9. NINDS - News And Events Health. Sorry! There are no press releases for schizencephaly. Use your browser s Back button to return to your previous activity. http://www.ninds.nih.gov/health_and_medical/news.htm?url=/health_and_medical/dis

10. Pediatric Database A definition of schizencephaly, the epidemiology, pathogenesis, clinical features, investigations and management. http://www.icondata.com/health/pedbase/files/SCHIZENC.HTM

11. Index Personal account about a daughter having Opitc Nerve Hypoplasia, SeptoOptic Dysplasia and had either a Congenital stroke or has schizencephaly. http://www.lebaronfamily.com

Joy Elizabeth LeBaron This site is about our beautiful daughter Joy. She truly is a gift from God. A gift that we are thankful for every day. After many test he finally decided to do a CT scan. Through that test he discovered that she was missing a piece of her brain the size of a walnut in the right hemisphere. Not being able to tell all he wanted to from this test he decided to do aMRI. With the MRI he diagnosed her as having had a Congenital Stroke while in-utero at about 30-40 days after conception. Wanting to make sure that Joy got the best of care he decided that it would be best if we took her to Stanford to do more test and to get a second opinion on the MRI. So, at one week old Joy was off to Lucile Packard's Children's Hospital at Stanford During the week that she spent at Stanford she received many of the same test and was evaluated by many doctors. Finally, they couldn't find anything new and she was stable that whole week so they let us take her home. At that time it was our understanding that they agreed with the diagnoses of Congenital Stroke, and we were told that we were bringing home a well baby. Two weeks after we brought her home we went back to Stanford for the results of her genetic testing and received that happy news that they did not find anything. At this point we were pretty happy and relieved that it was all over. Needless to say we were wrong.

12. Schizencephaly a CHORUS notecard document about schizencephaly Disclaimer. Feedback. Search. schizencephaly. very rare. funnelshaped cleft in midportion of cerebral hemispheres http://chorus.rad.mcw.edu/doc/00363.html

CHORUS Collaborative Hypertext of Radiology Nervous system Feedback Search schizencephaly very rare funnel-shaped cleft in midportion of cerebral hemispheres communicates with ventricles may be destructive (porencephaly) or developmental associated with septo-optic dysplasia Charles E. Kahn, Jr., MD - 2 February 1995 Last updated 26 May 2004 Medical College of Wisconsin

13. Www.geocities.com/Heartland/Plains/8950/schizencephaly.html schizencephaly.com . http://www.geocities.com/Heartland/Plains/8950/schizencephaly.html

14. IRSC - Rare Disorders, Schizencephaly The Internet Resources for Special Children (IRSC) Global disABILITY resource is dedicated to communicating information relating to the needs of children with disABILITIES on a global basis http://www.irsc.org:8080/irsc/irscmain.nsf/sub?readform&cat=Rare Disorders&a

15. Schizencephaly.com - News Welcome! Welcome to schizencephaly.com! Just popping in. Joined 2004/5/3. From Brisbabe Australia. Posts 1. Re Welcome to schizencephaly.com! http://www.schizencephaly.com/modules/news/article.php?storyid=1

16. Schizencephaly.com Dedicated to the family, friends, and caregivers of individuals with schizencephaly. FAQs, forum, and resources. http://www.schizencephaly.com

17. Introduction: Schizencephaly - WrongDiagnosis.com Introduction to schizencephaly as a medical condition including symptoms, diagnosis, misdiagnosis, treatment, prevention, and prognosis. http://www.wrongdiagnosis.com/s/schizencephaly/intro.htm

Diseases IMPORTANT! Use of this site is subject to our and Home Symptoms Diseases Risks Search: We show you all these ads in order to provide this free site; give your feedback WrongDiagnosis TM Premium Report: Diabetes Diagnosis and Misdiagnosis Available Now! Condition Lists By Organ By Symptom By Class By Prevalence ... List A-Z Current chapter: Schizencephaly Next sections Basic Summary for Schizencephaly Prevalence and Incidence of Schizencephaly Prognosis of Schizencephaly Symptoms of Schizencephaly ... Treatments for Schizencephaly Next chapters: Niemann-Pick disease Occipital Neuralgia Chronic pain Neuralgia ... Feedback Introduction: Schizencephaly Schizencephaly: Rare congenital brain defect. Schizencephaly: Schizencephaly is an extremely rare developmental disorder characterized by abnormal slits, or clefts, in the brain's cerebral hemispheres. Schizencephaly is a form of porencephaly in which there is a cyst or cavity in the cerebral hemispheres. Contents for Schizencephaly: Basic Summary for Schizencephaly Prevalence and Incidence of Schizencephaly Prognosis of Schizencephaly Symptoms of Schizencephaly ... Statistics about Schizencephaly Footnotes: 1. excerpt from

18. Schizencephaly Click Here to Read our Forum Disclaimer and Statement of Purpose. This Web Forum is not moderated in any sense. Anyone on the Internet can post articles or reply to previously posted articles, and they may do so anonymously. i have a daughter that was diagnosed with bilateral open lip schizencephaly when she was 6 months old still dont know a whole lot about schizencephaly. there is not a http://neuro-www.mgh.harvard.edu/forum_2/GeneralNeurologyF/10.30.993.23PMschizen

This Web Forum is not moderated in any sense. Anyone on the Internet can post articles or reply to previously posted articles, and they may do so anonymously. Therefore, the opinions and statements made in all articles and replies do not represent the official opinions of MGH and MGH Neurology. Neither is MGH or MGH Neurology responsible for the content of any articles or replies. No messages are screened for content. schizencephaly This article submitted by Kimberly on 10/30/99. Email Address: kimorash@hotmail.com Hi, My name is Kimberly, i have a daughter that was diagnosed with bilateral open lip schizencephaly when she was 6 months old. She is now almost 2. and i still dont know a whole lot about schizencephaly. there is not a lot of info online on this subject. if anyone has any info they can pass along.that would be much appreciated. thank you very much Kimberly Next Article Previous Article Return to Neurological Disorder Topic Menu Here is a list of responses that have been posted regarding this article... Schizencephaly Support Group (11/8/99) 4:57 PM lots of info (10/30/99) 3:30 PM If you want to post a completely new article on any topic you like

19. Symptoms Of Schizencephaly - WrongDiagnosis.com Symptoms of schizencephaly including signs, symptoms, incubation period, duration, and correct diagnosis. Symptoms of schizencephaly. http://www.wrongdiagnosis.com/s/schizencephaly/symptoms.htm

Diseases Schizencephaly IMPORTANT! Use of this site is subject to our and Home Symptoms Diseases Risks Search: We show you all these ads in order to provide this free site; give your feedback WrongDiagnosis TM Premium Report: Diabetes Diagnosis and Misdiagnosis Available Now! Condition Lists By Organ By Symptom By Class By Prevalence ... List A-Z Current chapter: Schizencephaly Next sections Treatments for Schizencephaly Statistics about Schizencephaly Next chapters: Niemann-Pick disease Occipital Neuralgia Chronic pain Neuralgia ... Feedback Symptoms of Schizencephaly List of symptoms of Schizencephaly: The list of symptoms mentioned in various sources for Schizencephaly includes: Seizures Developmental delay Delayed speech Delayed language skills Corticospinal dysfunction Hemiparesis Normal intelligence - not all patients are mentally affected Microcephaly Mental retardation Hemiparesis Quadriparesis ... Hydrocephalus Symptoms of Schizencephaly: Individuals with clefts in both hemispheres (bilateral clefts) are commonly developmentally delayed and have delayed speech and language skills and corticospinal dysfunction. Individuals with smaller, unilateral clefts (clefts in only one hemisphere) are often paralyzed on one side of the body and may have normal intelligence. Patients with schizencephaly may also have varying degrees of microcephaly (abnormally small head), mental retardation, hemiparesis or quadriparesis (partial or complete paralysis), and reduced muscle tone (hypotonicity). Most patients have seizures. Some may have hydrocephalus.

20. EMedicine - Schizencephaly : Article By Ken R Close, MD schizencephaly schizencephaly is an uncommon disorder of neuronal migrational characterized by a cerebrospinal fluid–filled cleft, which is lined by gray http://www.emedicine.com/radio/topic622.htm

(advertisement) Home Specialties CME PDA ... Patient Education Articles Images CME Patient Education Advanced Search Link to this site Back to: eMedicine Specialties Radiology Pediatrics Schizencephaly Last Updated: April 7, 2004 Rate this Article Email to a Colleague Synonyms and related keywords: cerebrospinal fluid–filled cleft in the brain, abnormal cleft of the brain, type I schizencephaly, type II schizencephaly, open-lip schizencephaly, closed-lip schizencephaly AUTHOR INFORMATION Section 1 of 11 Author Information Introduction Differentials Cat Scan ... Bibliography Author: Ken R Close, MD Scott and White Memorial Hospital and Clinic Coauthor(s): L Gill Naul, MD Scott and White Memorial Hospital and Clinic Editor(s): Charles M Glasier, MD , Professor, Departments of Radiology and Pediatrics, University of Arkansas for Medical Sciences; Chief, Magnetic Resonance Imaging, Vice-Chief, Pediatric Radiology, Arkansas Children's Hospital; Bernard D Coombs, MBChB, PhD , Consulting Staff, Department of Specialist Rehabilitation Services, Hutt Valley District Health Board, New Zealand; Marta Hernanz-Schulman, MD, FAAP

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