21. Genetic Disorders, Russell Silver Syndrome » Submit your URL to iSeekHealth.com. iSeekHealth Website Submission Forms Take advantage of iSeekhealth s low cost, onetime website http://www.iseekhealth.com/index.php?method=show_submit_site&directory_id=1617

22. Russell-Silver Syndorme russell silver syndrome. (2002). Introduction. Introductions. Birth weights and heights of parents and siblings. RussellSilver Syndrome. Genetics. http://www.genesoc.com/counseling/Outlines/Russell-Silversyndrome.htm

Resources for Genetic Counselors site updated May 10, 2004 outlines links search Russell Silver Syndrome Introduction Introductions What do you understand about why you are coming to genetics? What specific questions would you like to have answered today? Outline what will happen in session: Take medical and family history Doctor will perform physical exam Discussion and answer further questions Obtain Medical History Thorough pregnancy history History of maternal hypertension Teratogenic exposures Intrauterine infections Obtain Family History Birth weights and heights of parents and siblings Russell-Silver Syndrome Genetics Etiology is widely variable 10% of patients have maternal UPD of chromosome 7 autosomal dominant and autosomal recessive forms have also been seen some evidence for AD gene located on long arm of chromosome 17 Clinical Features Growth and Feeding IUGR with weight less than 3SD below mean for gestational age Birth length also diminished Normal head circumference Usually feed normally Normal growth velocity Remain small into adulthood Most do not have growth hormone deficiency Development and Behavior Normal IQ Early gross motor delay Mild hypotonia Many patients have learning disabilities Craniofacial Dental anomalies common including microdontia Micrognathia is common Can cause secondary cleft palate Musculoskeletal Limb length asymmetry

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World Wide Search Engine and Portal to the Best Sites on the Internet Over 15million sites and over 550,000 categories Top Health Conditions and Diseases Genetic Disorders : Russell Silver Syndrome (2) See Also: Health: Conditions and Diseases: Rare Disorders The CaF Directory - A definition of Silver Russell syndrome, its inheritance patterns, and pre-natal diagnosing. Also lists a support group in the United Kingdom. NORD: Russell Silver Syndrome - Offers a general discussion, the synonyms and further resources. Back to ooBdoo Suggest a Site Feedback Link to ooBdoo ... Guarantee your site is listed This page also has modified,additions and deletions of information obtained from the Open Directory Project Help build the largest human-edited directory on the web. Submit a Site Open Directory Project Become an Editor

24. Healthwise Health Information, Topic russell silver syndrome (RSS), Back to previous page. RussellSilver Syndrome, X-linked (Partington Syndrome). General Discussion. http://www.suttercoast.org/health/healthinfo/index.cfm?section=healthinfo&page=a

25. ScienceDaily -- Browse Topics: Health/Conditions_and_Diseases/Genetic_Disorders/ Click Here. Top Health Conditions and Diseases Genetic Disorders russell silver syndrome (2 links). News about russell silver syndrome http://www.sciencedaily.com/directory/Health/Conditions_and_Diseases/Genetic_Dis

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27. Russell Silver Syndrome russell silver syndrome Directory Guide to russell silver syndrome sites on the internet. russell silver syndrome. http://www.directory.net/Health/Conditions_and_Diseases/Genetic_Disorders/Russel

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28. Russell Silver Syndrome From Linkspider UK Health Directory russell silver syndrome by Linkspider UK, russell silver syndrome links and russell silver syndrome topics from our Health directory. http://linkspider.co.uk/Health/ConditionsandDiseases/GeneticDisorders/RussellSil

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35. Russel-Silver Syndrome russellsilver syndrome ,(RSS) silver-russell syndrome, silver syndrome, russell syndrome. Division Consultant Cathy Walbridge russell-silver syndrome. http://www.magicfoundation.org/rss.html

Division Consultant Cathy Walbridge MAGIC Home To Print This Page The MAGIC Foundation for Children's Growth Chicago, Illinois Established in 1989 Russell-Silver Syndrome In 1953 and 1954, respectively, Dr. H. K. Silver and Dr. A. Russell independently described a special group of IUGR (Intrauterine Growth Retardation) children with short stature along with a small triangular face, low-set ears, incurved fifth fingers, and other characteristics. Their independent and varied findings were eventually determined to be a variation of the same syndrome. (A syndrome is a group of physical signs and symptoms which make up a specific disease or disorder.) As a result, the syndrome received its name. Russell-Silver Syndrome (RSS) is also known as Silver-Russell Syndrome, Silver Syndrome, and Russell Syndrome. One of the interesting and at the same time unsettling aspects of this syndrome is the very wide variation of its characteristics. Some individuals with RSS have many of the documented traits, while others have very few. Mental retardation is not characteristic of this disorder. Almost, without exception, every RSS individual has:

36. MAGIC FOUNDATION These two groups of patients are now considered to have had variations of the same disorder that we now call russellsilver syndrome RSS in the US and silver http://www.magicfoundation.org/divisions/rss.htm

INTRODUCTION PDF Brochure Links Child's Site with RSS coltongeorge.com INTRODUCTION In 1953 and 1954, Drs. Silver and Russell independently described groups of small-for-gestational-age [SGA] children whose pregnancies had been complicated by intrauterine growth retardation [IUGR]. Their common findings were short stature without catch-up growth, normal head size for age, a distinctive triangular face, low-set ears and incurving fifth fingers. These two groups of patients are now considered to have had variations of the same disorder that we now call Russell-Silver Syndrome [RSS] in the U.S. and Silver-Russell Syndrome [SRS] in Europe. One interesting and important aspect of the Russell-Silver syndrome is its variation in phenotype. In this context, a phenotype is all the physical characteristics and abnormalities found in an individual patient that are attributed specifically to RSS. Some individuals with RSS have many traits, thus a severe phenotype, while others have very few traits, thus a mild phenotype. When first described, RSS was NOT thought to be a genetic disorder because it recurred within families rarely, and when it did recur, its pattern of transmission failed to follow a consistent genetic mode of inheritance. More recent understandings of genetic mechanisms have led scientists to conclude that RSS is genetic, but its genetics are not simple. Scientists now believe that the RSS phenotype is associated with more than one genotype.

37. MedlinePlus Medical Encyclopedia: Russell-Silver Syndrome russellsilver syndrome. Children with russell-silver syndrome are born small and generally achieve less than 5 feet at adult height. http://www.nlm.nih.gov/medlineplus/ency/article/001209.htm

@import url(http://www.nlm.nih.gov/medlineplus/images/advanced.css); Skip navigation Medical Encyclopedia Other encyclopedia topics: A-Ag Ah-Ap Aq-Az B-Bk ... Z Russell-Silver syndrome Contents of this page: Alternative names Definition Causes, incidence, and risk factors Symptoms ... Calling your health care provider Alternative names Silver-Russell syndrome; Silver syndrome Definition Return to top Rusell-Silver syndrome is a congenital disease (present at birth) characterized by short stature and, frequently, asymmetry in the size of the two halves or other parts of the body. Causes, incidence, and risk factors Return to top Genetic problems are thought to cause this syndrome, although the specific gene(s) remain to be discovered. The pattern of inheritance has not been determined, but in most cases it seems to occur without any family history of the condition. Children with Russell-Silver syndrome are born small and generally achieve less than 5 feet at adult height. Side-to-side asymmetry is fairly common. For example, a left body part may be larger than the right counterpart. This asymmetry may occur anywhere including the face. Other characteristics include excessive sweating , a small triangular face that makes the skull look large by comparison, inward curving 5th fingers, and colored spots on the skin called cafe-au-lait spots Symptoms Return to top slow growth before birth short stature throughout childhood and at final height cafe-au-lait (coffee with milk) colored spots severe feeding problems in childhood (reflux disease, food aversion, failure to thrive)

38. SILVER-RUSSELL SYNDROME : Contact A Family - For Families With Disabled Children A definition of silver russell syndrome, its inheritance patterns, and prenatal diagnosing. Also lists a support group in the United Kingdom. http://www.cafamily.org.uk/Direct/s30.html

printer friendly SILVER-RUSSELL SYNDROME home more about us in your area conditions information ... how you can help search this site Did you find this page helpful? yes no Silver-Russell syndrome: Asymmetry Dwarfism; Russell-Silver syndrome; Silver's syndrome Intra-uterine growth retardation without dysmorphic features is also covered by the group. Inheritance patterns This is not yet fully determined. It has been suggested that while most cases are sporadic, some cases may be X-linked or autosomal dominant. However there is a congenital association between siblings which may result from placental insufficiency. Such placental problems may be hereditary. Prenatal diagnosis There is no biochemical diagnosis but serial ultrasound assessments starting from early pregnancy will confirm intra-uterine growth retardation Medical text last updated October 2001 by Dr R Stanhope, Consultant Paediatric Endocrinologist, Great Ormond Street Hospital, London, UK. Further Online Resources Medical texts in The Contact a Family Directory are designed to give a short, clear description of specific conditions and rare disorders. More extensive information on this condition can be found on a range of reliable, validated web sites and links to them are included in the

39. Major Aspects Of Growth In Children (MAGIC) An organization providing support and education regarding growth disorders in children and related adult disorders. Includes Growth Hormone Deficiency, Barth syndrome, Congenital Adrenal Hyperplasia, Precocious Puberty, russellsilver syndrome, Turner syndrome, Thyroid Disorders Septo Optic Dysplasia, McCune-Albright syndrome, and Rare Disorder/Hypophosphatasia. http://www.magicfoundation.org/

40. Medical Encyclopedia: Russell-Silver Syndrome (Print Version) Medical Encyclopedia russellsilver syndrome. Children with russell-silver syndrome are born small and generally achieve less than 5 feet at adult height. http://www.nlm.nih.gov/medlineplus/print/ency/article/001209.htm

To print this page, use the print option from your browser. To close this window, click on the "x" in the upper right hand corner of the window. Medical Encyclopedia: Russell-Silver syndrome URL of this page: http://www.nlm.nih.gov/medlineplus/ency/article/001209.htm Alternative names Silver-Russell syndrome; Silver syndrome Definition Rusell-Silver syndrome is a congenital disease (present at birth) characterized by short stature and, frequently, asymmetry in the size of the two halves or other parts of the body. Causes, incidence, and risk factors Genetic problems are thought to cause this syndrome, although the specific gene(s) remain to be discovered. The pattern of inheritance has not been determined, but in most cases it seems to occur without any family history of the condition. Children with Russell-Silver syndrome are born small and generally achieve less than 5 feet at adult height. Side-to-side asymmetry is fairly common. For example, a left body part may be larger than the right counterpart. This asymmetry may occur anywhere including the face. Other characteristics include excessive sweating, a small triangular face that makes the skull look large by comparison, inward curving 5th fingers, and colored spots on the skin called cafe-au-lait spots.

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