41. Retinoblastoma Provides a review using NCI materials of the prognosis, classification and treatment of the tumor. Aimed at the professional level. http://www.meb.uni-bonn.de/cancer.gov/CDR0000062846.html#REF_1

Treatment statement for Health professionals Retinoblastoma Get this document via a secure connection General Information Cellular Classification Stage Information ... More Information General Information This cancer treatment information summary provides an overview of the prognosis, diagnosis, classification, and treatment of retinoblastoma. The National Cancer Institute provides the PDQ pediatric cancer treatment information summaries as a public service to increase the availability of evidence-based cancer information to health professionals, patients, and the public. These summaries are updated regularly according to the latest published research findings by an Editorial Board of pediatric oncology specialists. Cancer in children and adolescents is rare. Children and adolescents with cancer should be referred to medical centers that have a multidisciplinary team of cancer specialists with experience treating the cancers that occur during childhood and adolescence. This multidisciplinary team approach incorporates the skills of the primary care physician, an ophthalmologist with extensive experience in the treatment of children with retinoblastoma, pediatric surgical subspecialists, radiation oncologists, pediatric medical oncologists/hematologists, rehabilitation specialists, pediatric nurse specialists, social workers, and others in order to ensure that children receive treatment, supportive care, and rehabilitation that will achieve optimal survival and quality of life. Refer to the PDQ

42. Retinoblastoma Treatment statement for Health professionals. retinoblastoma. Get this document via a secure connection. Intraocular retinoblastoma. http://www.meb.uni-bonn.de/cancer.gov/CDR0000062846.html

Treatment statement for Health professionals Retinoblastoma Get this document via a secure connection General Information Cellular Classification Stage Information ... More Information General Information This cancer treatment information summary provides an overview of the prognosis, diagnosis, classification, and treatment of retinoblastoma. The National Cancer Institute provides the PDQ pediatric cancer treatment information summaries as a public service to increase the availability of evidence-based cancer information to health professionals, patients, and the public. These summaries are updated regularly according to the latest published research findings by an Editorial Board of pediatric oncology specialists. Cancer in children and adolescents is rare. Children and adolescents with cancer should be referred to medical centers that have a multidisciplinary team of cancer specialists with experience treating the cancers that occur during childhood and adolescence. This multidisciplinary team approach incorporates the skills of the primary care physician, an ophthalmologist with extensive experience in the treatment of children with retinoblastoma, pediatric surgical subspecialists, radiation oncologists, pediatric medical oncologists/hematologists, rehabilitation specialists, pediatric nurse specialists, social workers, and others in order to ensure that children receive treatment, supportive care, and rehabilitation that will achieve optimal survival and quality of life. Refer to the PDQ

43. Retinoblastoma Description. What is retinoblastoma? retinoblastoma......Treatment statement for Patients. retinoblastoma. Get this document via a secure connection. http://www.meb.uni-bonn.de/cancer.gov/CDR0000062683.html

Treatment statement for Patients Retinoblastoma Get this document via a secure connection Description Stage Explanation Treatment Option Overview ... About PDQ Description What is retinoblastoma? Retinoblastoma is a malignant (cancerous) tumor of the retina. The retina is the thin nerve tissue that lines the back of the eye that senses light and forms images. Although retinoblastoma may occur at any age, it most often occurs in younger children, usually before the age of 5 years. The tumor may be in one eye only or in both eyes. Retinoblastoma is usually confined to the eye and does not spread to nearby tissue or other parts of the body. Your child’s prognosis (chance of recovery and retaining sight) and choice of treatment depend on the extent of the disease within and beyond the eye. Retinoblastoma may be hereditary (inherited) or nonhereditary. The hereditary form may be in one or both eyes, and generally affects younger children. Most retinoblastoma occurring in only one eye is not hereditary and is more often found in older children. When the disease occurs in both eyes, it is always hereditary. Because of the hereditary factor, patients and their brothers and sisters should have periodic examinations, including genetic counseling, to determine their risk for developing the disease. A child who has hereditary retinoblastoma may also be at risk of developing a tumor in the brain while they are being treated for the eye tumor. This is called trilateral retinoblastoma, and patients should be periodically monitored by the doctor for the possible development of this rare condition during and after treatment. If your child has retinoblastoma, particularly the hereditary type, there is also an increased chance that he or she may develop other types of cancer in later years. Parents may therefore decide to continue taking their child for medical check-ups even after the cancer has been treated.

44. CancerBACUP : Retinoblastoma Quick fact sheet about retinoblastoma. http://www.cancerbacup.org.uk/info/child-retinoblastoma.htm

@import "/stylesheet-site.css"; Search Retinoblastoma This section gives information about retinoblastoma in children. It is helpful to read it alongside CancerBACUP's general information children's cancers, which contains more information about cancers in children, their diagnosis and treatment and the support services available. There are about 40 new cases of retinoblastoma diagnosed each year in the UK. What is retinoblastoma? What causes retinoblastoma? What are the signs and symptoms? How it is diagnosed ... Follow-up Diagram of the eye (d) back to top What is retinoblastoma? Retinoblastoma is a tumour that occurs in the light sensitive lining of the eye known as the retina. It can occur in two forms, an inherited form where there are often tumours in both eyes and a non-inherited form where there is usually only a tumour in one eye. back to top What causes retinoblastoma? In the inherited tumours (which are about two cases in every five), it is caused by a genetic abnormality. This means that an abnormal gene, passed from a parent to the child, allows the tumour to develop. Patients with this gene, known as the Rb gene, also have a slightly increased risk of developing other tumours outside the eye. Genetic counselling and support is available for all families with a diagnosis of retinoblastoma. The cause of the non-inherited tumours is unknown. back to top What are the signs and symptoms?

45. People Living With Cancer - Cancer Type - Cancer Page Describes risk factors, symptoms, diagnosis, staging, and treatment of retinoblastoma. http://www.peoplelivingwithcancer.org/plwc/MainConstructor/1,1744,_04-0067-00_12

Home About Us Contact Us Message Boards Cancer Type: Select a Cancer Type Bladder Bone Brain Breast Carcinoid Tumors Cervical Childhood Central Nervous System Astrocytoma Brain Stem Glioma Medulloblastoma Ewing's Sarcoma Leukemia, Acute Lymphoblastic (ALL) Leukemia, Acute Myeloid (AML) Lymphoma, Hodgkin Lymphoma, Non-Hodgkin Neuroblastoma Osteosarcoma Retinoblastoma Rhabdomyosarcoma Wilms Tumor Colorectal Esophageal Eye Nasopharyngeal Salivary Gland Kidney Leukemia, Acute Lymphocytic (ALL) Leukemia, Acute Myeloid (AML) Leukemia, Chronic Lymphocytic (CLL) Leukemia, Chronic Myeloid (CML) Liver Lung Lymphoma, Hodgkin Lymphoma, Non-Hodgkin Melanoma Multiple Myeloma Ovarian Pancreatic Prostate Sarcoma Skin Stomach Testicular Thyroid Unknown Primary Uterine Vaginal Or use Advanced Search Sign up for PLWC Updates You are here: Home Cancer Type Cancer Page Retinoblastoma People Living With Cancer provides oncologist-approved cancer information, including PLWC Guides to understanding 50 different types of cancer. In this section, you will also find information on clinical trials, support services, cancer news, and other resources such as ASCO abstracts, patient care guides, and expert chat transcripts. ASCO believes that all treatment decisions should be made between patients and their doctors. PLWC GUIDE TO RETINOBLASTOMA Print All Articles Introduction Medical Illustrations Risk Factors Symptoms ... Treatment ASCO PATIENT RESOURCES Find an Oncologist ASCO Patient Guide: Preventing and Treating Nausea and Vomiting Caused by Cancer Treatment Cancer Advances: News from the 2003 ASCO Annual Meeting Cancer Advances: News from the ... Chat Transcript: Childhood Cancers, September 5, 2003

46. Retinoblastoma retinoblastoma Menu. About retinoblastoma Organisations / Support Groups Resources About retinoblastoma. retinoblastoma is a rare tumour of http://www.cancerindex.org/ccw/guide2r.htm

Home Site Map Cancer Types Treatments ... About Retinoblastoma Menu Cancer-Types Retinoblastoma Retinoblastoma Menu About Retinoblastoma Organisations / Support Groups Resources for Parents and the Public Home Pages of Children and Families Resources for Health Professionals Search Elsewhere for Resources About Retinoblastoma Retinoblastoma is a rare tumour of the eye which develops in the cells of the retina, most patients are under 5 years old. Sometimes only one eye is affected (unilateral-retinoblastoma ), but in about two fifths of patients both eyes have the disease (bilateral-retinoblastoma ). Some cases are known to be hereditary. This page contains links to information specifically related to Retinoblastoma, other relevant resources are availible via the Main Menu of Children's Cancer Web. Retinoblastoma Menu Site Menu Suggest a site Organisations / Support Groups (3 links) National Retinoblastoma Research and Support Foundation (USA) A support group established by parents and friends of children treated at Bascom Palmer Eye Institute. The NRRSF aims to establish a national network to provide support to parents with children affected by retinoblastoma. R-BLASTOMA - Email list (ACOR) Retinoblastoma Information and Support Retinoblastoma Society, The

47. Retinoblastoma 1 Summary of known facts about the retinoblastoma 1 gene and protein. http://www.hprd.org/genes/180200?selectedtab=SUMMARY

48. National Cancer Institute - Retinoblastoma (PDQ®): Tratamiento Translate this page versiones. Fecha de actualización 08/28/2002, profesionales. retinoblastoma. return to top. Descripci³n. ¿Qu© es un retinoblastoma? Un http://www.cancer.gov/espanol/pdq/tratamiento/retinoblastoma/Patient

var bSearchBoxBool=false; window.onload+="MM_preloadImages('/images/nav_home_over.gif','/images/nav_cancer_topics_over.gif','/images/nav_clinical_trials_over.gif','/images/nav_cancer_statistics_over.gif','/images/nav_research_funding_over.gif','/images/nav_news_over.gif','/images/nav_about_over.gif');" Fecha de actualizaci³n: Descripci³n Explicaci³n de las etapas Aspectos generales de las opciones de tratamiento Retinoblastoma intraocular Retinoblastoma extraocular ... F¡cil para Imprimir Quick Links Dictionary Funding Opportunities NCI Publications NCI Calendar NCI Highlights Some Men with Low PSAs Have Prostate Cancer Energy Balance Trans-HHS Cancer Health Disparities Report Past Highlights Descripci³n ¿Qu© es un retinoblastoma? ¿Qu© es un retinoblastoma? Un retinoblastoma es un tumor maligno (canceroso) de la retina, el tejido nervioso delgado que reviste la parte posterior de los ojos y que detecta la luz y forma las im¡genes. A pesar de que el retinoblastoma puede presentarse a cualquier edad, aparece con mayor frecuencia en los ni±os m¡s j³venes, usualmente antes de cumplir los cinco a±os. El tumor puede estar situado en uno o ambos ojos. Este tipo de tumor normalmente se concentra en los ojos y no se extiende a otros tejidos o partes del cuerpo. El pron³stico de su ni±o (sus probabilidades de recobrar y retener la vista) as­ como las opciones de tratamiento depender¡n de hasta qu© punto se haya extendido la enfermedad, tanto en los ojos como fuera de ellos. El retinoblastoma puede ser hereditario (viene de familia) o no hereditario. Los tumores hereditarios se pueden encontrar en uno o ambos ojos, y generalmente se presentan en los ni±os de m¡s corta edad. La mayor­a de los retinoblastomas que ocurren en un s³lo ojo no son hereditarios y son m¡s frecuentes en ni±os mayores. Cuando la enfermedad aparece en ambos ojos siempre es hereditaria. Debido al factor hereditario, tanto los pacientes como sus hermanos y hermanas deber­an someterse a ex¡menes peri³dicos, incluyendo asesoramiento gen©tico, para determinar el riesgo que tienen de desarrollar la enfermedad.

49. National Cancer Institute - Retinoblastoma Treatment Select a tab below to switch between versions. Date Last Modified 04/21/2004, patient. retinoblastoma. return to top. Intraocular retinoblastoma. http://www.cancer.gov/cancerinfo/pdq/treatment/retinoblastoma/healthprofessional

var bSearchBoxBool=false; window.onload+="MM_preloadImages('/images/nav_home_over.gif','/images/nav_cancer_topics_over.gif','/images/nav_clinical_trials_over.gif','/images/nav_cancer_statistics_over.gif','/images/nav_research_funding_over.gif','/images/nav_news_over.gif','/images/nav_about_over.gif');" Date Last Modified: General Information Cellular Classification Stage Information Treatment Option Overview Intraocular Retinoblastoma ... Print-friendly Quick Links Dictionary Funding Opportunities NCI Publications NCI Calendar NCI Highlights Some Men with Low PSAs Have Prostate Cancer Energy Balance Trans-HHS Cancer Health Disparities Report Past Highlights General Information This cancer treatment information summary provides an overview of the prognosis, diagnosis, classification, and treatment of retinoblastoma. The National Cancer Institute provides the PDQ pediatric cancer treatment information summaries as a public service to increase the availability of evidence-based cancer information to health professionals, patients, and the public. These summaries are updated regularly according to the latest published research findings by an Editorial Board of pediatric oncology specialists.

50. THE MERCK MANUAL, Sec. 19, Ch. 266, Neoplasms click here for navigation help. retinoblastoma. retinoblastoma occurs in 1/15,000 to 1/30,000 live births and represents about 2% of childhood malignancies. http://www.merck.com/mrkshared/mmanual/section19/chapter266/266d.jsp

51. THE MERCK MANUALSECOND HOME EDITION, Retinoblastoma In Ch. 283 retinoblastoma. retinoblastoma is a cancer of the retina, the lightsensing area at the back of the eye. retinoblastomas represent http://www.merck.com/mrkshared/mmanual_home2/sec23/ch283/ch283d.jsp

52. Retinoblastoma retinoblastomaSARAH S retinoblastoma HOMEPAGE. This We live in Sydney Australia and Sarah was recently diagnosed with unilateral retinoblastoma. This http://www.moffitt.usf.edu/cancjrnl/v5n4/article2.html

Retinoblastoma Curtis E. Margo, MD, MPH, Lynn E. Harman, MD, and Zuber D. Mulla, MSPH Although treatment outcomes for retinoblastoma have improved, patients with a germline gene mutation carry a high risk for second cancers. Background: Retinoblastoma is the most common intraocular malignancy of infants and children. With early diagnosis and treatment, survival is greater than 90%; however, patients with a germline retinoblastoma mutation have a substantial risk of having a second high-grade malignancy. Methods: The recent developments in the diagnosis and treatment of retinoblastoma are reviewed. Results: Identification of the retinoblastoma germline mutation is now possible with the discovery of the retinoblastoma gene. Patients with the germline mutation have a 51% cumulative risk over 50 years of developing a second malignancy. Several pilot studies using primary chemotherapy for retinoblastoma have shown promising results. Conclusions: Risk assessment and genetic counseling have become more precise with the development of laboratory methods to identify the retinoblastoma gene. The development of primary chemotherapy regimens to reduce the size of retinoblastoma tumors may decrease the need for radiation therapy and thereby reduce the risk of radiation-related malignancies in patients with the germline mutation. Introduction Retinoblastoma is the most common intraocular malignancy of infancy and childhood. Prior to this century, retinoblastoma was a uniformly fatal disease.

53. Retinoblastoma - General Practice Notebook Clinicallyoriented information. http://www.gpnotebook.co.uk:80/simplepage.cfm?ID=1248526346

54. Sena's Eyes, Home Dedicated to retinoblastoma awareness and early detection of treatable eye diseases. http://home.mchsi.com/~senaseyes//wsb/html/view.cgi-home.html-.html

Sena's Eyes Highlights Legislative Updates Quote for the week Retinoblastoma Pamphlet Sena's Rb Blankies ... Write to your legislators! What is Retinoblastoma? Retinoblastoma is a cancer of the eye. One baby is diagnosed with retinoblastoma every day in the United States. Symptoms of Retinoblastoma Poor eye alignment A white "cat's eye" look in photographs or in dark rooms (called "leukocoria" meaning white pupil) "Lazy eye" Vision difficulties Red, irritated eyes Sensitivity to light Watery eyes Nothing unusual Trust yourself. You know more than you think you do. -Dr. Benjamin Spock You are visitor

55. The Retinoblastoma Gene Full size image available below. The retinoblastoma Gene In the late 1980s, scientists isolated the gene, called Rb, that is mutated in retinoblastoma. http://web.sfn.org/content/Publications/BrainBriefings/retinoblastoma.html

Login Directory Merchandise Contact Us ... Abstracts/Annual Meeting Publications Full size image available below The Retinoblastoma Gene Studies of a rare childhood tumor, retinoblastoma, reveal an important class of genes called tumor suppressers that control cell division. The retinoblastoma tumor suppresser gene produces a protein important for nervous system development, aging and replication of some viruses. Studies of this gene and other tumor suppressers are leading to new ideas for preventing or treating retinoblastoma and other diseases. Think of riding a rollercoaster without brakes. The thrilling speed and curves quickly become frightening as the coaster accelerates out of control. Like a rollercoaster, the cells in our bodies normally operate with great precision, safely cycling between rapid cell division and rest. Occasionally, however, a cell's molecular "brakes" fail, allowing run-away cell growth and division. Many of the first insights into the importance of cellular "braking" come from studies of an eye tumor called retinoblastoma that affects about 400 children a year. Learning how cell division goes awry in this disease is leading to: Understanding of many genes that control division of nerve and other cells.

56. Retinoblastoma - General Practice Notebook retinoblastoma. Medical search. retinoblastoma is a rare tumour of the eye affecting about 1 in 25 000 individuals. The majority http://www.gpnotebook.co.uk/simplepage.cfm?ID=1248526346

57. ACS :: What Is Retinoblastoma? Detailed Guide retinoblastoma (An Eye Cancer). What Is retinoblastoma? retinoblastoma starts in the retina, the very back portion of the eye. http://www.cancer.org/docroot/CRI/content/CRI_2_4_1X_What_is_retinoblastoma_37.a

Home Community Get Involved Donate ... Search GetRandomImage("headerImage", "jpg", 121, 77, 30); My Planner Register Sign In Cancer Reference Information ... Treatment Decision Tools Detailed Guide: Retinoblastoma (An Eye Cancer) What Is Retinoblastoma? Differences Between Cancers in Adults and Children Cancers in children younger than 15 account for less than 1% of all cancers that are diagnosed in the United States. Every year, about 9,000 children in this age group are diagnosed with cancer and about 1,500 die of cancer. Cancer is the second leading cause of death in children younger than 15 years of age. The types of cancers that develop in children are different from the types that develop in adults. Although there are exceptions, childhood cancers tend to respond better to chemotherapy because they are growing rapidly. Most forms of chemotherapy specifically affect cells that are dividing rapidly. Children and adolescents with cancer and their families have special needs that can be best met by cancer centers for children and adolescents working closely with the child's primary care physician. Treatment in specialized centers takes advantage of a team of specialists who know the differences between cancers that occur in adults and those that occur in children and adolescents, as well as the unique needs of children and adolescents with cancers. This team usually bincludes pediatric oncologists, surgeons, radiation oncologists, pediatric pathologists, pediatric oncology nurses, and nurse practitioners.

58. EMedicine - Retinoblastoma : Article By Marichelle L Aventura, MD retinoblastoma retinoblastoma is the most common primary ocular malignancy of childhood.The first description of a tumor resembling retinoblastoma was by http://www.emedicine.com/OPH/topic346.htm

(advertisement) Home Specialties Resource Centers CME ... Patient Education Articles Images CME Patient Education Advanced Search Consumer Health Link to this site Back to: eMedicine Specialties Ophthalmology Retina Retinoblastoma Last Updated: February 18, 2002 Rate this Article Email to a Colleague Synonyms and related keywords: intraocular childhood malignancy, tumor, ocular malignancy, RB gene, retinoblastoma gene AUTHOR INFORMATION Section 1 of 11 Author Information Introduction Clinical Differentials ... Bibliography Author: Marichelle L Aventura, MD , Consulting Staff, Department of Ophthalmology, Santo Tomas University Hospital of Manila, Philippine Heart Center Coauthor(s): Manolette R Roque, MD Eye Republic Thomas M Aaberg, Jr, MD , Ophthalmology, Associated Retinal Consultants Marichelle L Aventura, MD, is a member of the following medical societies: American Academy of Ophthalmology , and International Society of Refractive Surgery Editor(s): Gerhard W Cibis, MD

59. Joey Home The Joey Bergsma retinoblastoma Awareness Page Has your pediatrician checked your child? What you need to know You can take a picture of a tumor or cataract. http://www.lovejoey.com/

The Joey Bergsma Retinoblastoma Awareness Page Has your pediatrician checked your child? What you need to know: You can take a picture of a tumor or cataract. The ophthalmoscope needs to be used at every exam in a darkened room. An infant needs an eye dilation exam Click here to learn more about Joey and how your photos may save your child's life Email Me

60. Retinoblastoma Translate this page Terapia. Chirurgica con enucleazione in caso di retinoblastoma unilaterale al IV-V stadio o di retinoblastoma bilaterale ma solo a carico del bulbo oculare più http://web.tiscali.it/ambupedy/retinoblastoma.htm

Su Leucemia linfoblastica acuta Leucemia mieloblastica acuta Leucemia mieloide cronica ... Sarcoma di Ewing [ Retinoblastoma ] Epatoblastoma Definizione Tumore maligno congenito che origina dalla retina di uno o entrambe gli occhi. Epidemiologia 3-4 nuovi casi all'anno ogni 1.000.000 di soggetti di età inferiore a 15 anni. 1 caso ogni 23000 nascite. Forma bilaterale : ereditaria. Forma unilaterale : ereditaria solo nel 20% dei casi. Segni clinici La pupilla presenta un riflesso lucente simile a quello dell'occhio del gatto quando è investito da un fascio di luce ( riflesso amaurotico di gatto ); a questo si associa spesso strabismo e anisocoria (diversità del diametro pupillare). Diagnosi L'oftalmoscopia dimostra la presenza della massa all'interno dell'occhio; può essere eseguita inoltre l'ecografia del globo oculare nonché la TAC e la radiografia del cranio. Terapia Chirurgica con enucleazione in caso di retinoblastoma unilaterale al IV-V stadio o di retinoblastoma bilaterale ma solo a carico del bulbo oculare più estesamente interessato. Radioterapia come unico trattamento in pazienti al I, II e III stadio; come supporto nei pazienti trattati con terapia chirugica negli stadi IV e V.

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