1. The Childhood Eye Cancer Trust - Home Page Website of The retinoblastoma Society Fighting eye cancer in Children. Gives information about retinoblastoma. Childhood Eye Cancer Trust link to home page. http://www.rbsociety.org.uk/

The Childhood Eye Cancer Trust (CHECT) is a UK wide charity for families and individuals affected by retinoblastoma. We offer support and information, fund research and raise public awareness of this rare cancer. Retinoblastoma is a cancer of the eye that develops in children, typically under five years old. The survival rate for children affected is increasingly good. However many children will have an eye removed as part of their treatment and some both eyes. The work of The Childhood Eye Cancer Trust follows its three aims: 1. Support Support through diagnosis and treatment Information Contact with other families Annual family day ... Ongoing support as needed 2. Funding Research We fund research projects which will directly benefit those affected by retinoblastoma. 3. Raising Awareness With health professionals and the general public Contact us var treeName = "menu"; new menu (treeName, TREE1_NODES, TREE1_FORMAT);

2. About The Eye Cancer Retinoblastoma: Retinoblastoma Basics retinoblastoma is the most common intraocular cancer of childhood and effects children can be cured of retinoblastoma by early detection and treatment of......The New York Eye Cancer Center is one of the premier centers in the country for the treatment of retinoblastoma and other pediatric eye tumors. It is located in New York City. retinoblastoma. http://www.eyecancer.com/conditions/Retinal Tumors/retino.html

The Editor Dr. Finger Patient Information: Conditions The Eye Glossary FAQs ... Links Treatments: Radiation Enucleation Drug Therapy Innovations ... Home Retinoblastoma Description: Retinoblastoma was the first cancer to be directly associated with a genetic abnormality (Deletions or mutation of the q14 band of chromosome 13). Retinoblastoma can occur sporadically (without a family history) or it can be inherited (with a family history). If a genetic mutation is found there is a 45-50% chance that the parents will have another child with retinoblastoma. If there is no family history and no mutation is found, the risk of having a second child with retinoblastoma is 2-5%. The average age of children with retinoblastoma is 18 months. More than 75% of children with retinoblastoma are first noted to have a (which the doctors call leukocoria Treatment: Retinoblastoma treatment typically requires the cooperation of an ophthalmic oncologist, pediatric oncologist, and radiation therapist. Over the last 30 years, treatment has evolved from simple

3. Untitled Document http://www.retinoblastoma.com/

4. Retinoblastoma.Net Home A New Children’s Audio Book Featuring AwardWinning Cast Members From Days of Our Lives Raises Funds To Help Fight retinoblastoma Find out more about Emma http://www.retinoblastoma.net/

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5. Welcome To Retinoblastoma.com If you would like to download a printerfriendly Adobe Acrobat PDF version of the Parent s Guide to Understanding retinoblastoma, please click HERE (PDF file http://www.retinoblastoma.com/guide.htm

If you would like to download a printer-friendly Adobe Acrobat PDF version of the Parent's Guide to Understanding Retinoblastoma, please click HERE (PDF file size: 400K) If you would like to receive the booklet version of the Parent's Guide to Understanding Retinoblastoma by post, please send us an e-mail message to info@retinoblastoma.com specifying the language version you prefer.

6. Retinoblastoma Navigation. About this book. Diseases of the Eye. Best disease. Glaucoma. Gyrate atrophy of the choroid and retina. retinoblastoma. Gene sequence. Genome view. see gene locations. LocusLink. collection of generelated information. The literature Diseases of the Eye. retinoblastoma. retinoblastoma occurs in early childhood and affects about http://www.ncbi.nlm.nih.gov/disease/Retinoblast.html

This Genes and Disease page has been moved to: Please update your bookmarks. If you are not automatically transported to the new page after 15 seconds, click on this link Genome View on chromosome 13 Databases PubMed the literature LocusLink collection of gene-related information OMIM catalog of human genes and disorders Information The National Eye Institute, NIH research and patient information RETINOBLASTOMA occurs in early childhood and affects about 1 child in 20,000. The tumor develops from the immature retina - the part of the eye responsible for detecting light and color. There are both hereditary and non-hereditary forms of retinoblastoma. IN the hereditary form, multiple tumors are found in both eyes, while in the non-hereditary form only one eye is effected and by only one tumor. In the hereditary form, a gene called Rb is lost from chromosome 13. Since the absence of Rb seemed to be linked to retinoblastoma, it has been suggested that the role of Rb in normal cells is to suppress tumor formation. Rb is found in all cells of the body, where under normal conditions it acts as a brake on the cell division cycle by preventing certain regulatory proteins from triggering DNA replication. If Rb is missing, a cell can replicate itself over and over in an uncontrolled manner, resulting in tumor formation. Untreated, retinoblastoma is almost uniformly fatal, but with early diagnosis and modern methods of treatment the survival rate is over 90%. Since the Rb gene is found in all cell types, studying the molecular mechanism of tumor suppression by Rb will give insight into the progression of many types of cancer, not just retinoblastoma.

7. GeneReviews: Retinoblastoma Describes the genetic connection in regard to this condition. http://www.geneclinics.org/profiles/retinoblastoma/

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8. Retinoblastoma Canadian resource which is treatment oriented. http://www.retinoblastoma.ca

The goal of this website is to inform parents and professionals of the resources available for Retinoblastoma with specific focus on Canadian resources. Our Mission Our mission is to expand awareness of retinoblastoma Profile Retinoblastoma (RB) is the most common eye cancer in children and it can be inherited. Although the most common eye cancer in children, retinoblastoma is quite rare and occurs in approximately 1 in every 20,0000 births. The goal with retinoblastoma is early detection to maximize the visual outcome and the quality of life of the affected child. Fortunately, the survival rate for affected children i s In order to achieve our goal of early detection, we believe it is important to educate the public and other health professionals on the signs that might manifest themselves with a child that has retinoblastoma. We encourage people to share this information with others as many of the signs are very subtle and may not be picked up even by a health professional, due to the rarity of this disease. EARLY DETECTION IS THE KEY!!!!

9. Retinoblastoma Recurrent Orbital retinoblastoma after Enucleation This is a case presentation of a 3 year old boy who presented with orbital recurrence of retinoblastoma after enucleation and limited radiation therapy. http://www.lowvision.org/retinoblastoma.htm

Retinoblastoma Recurrent Orbital Retinoblastoma after Enucleation This is a case presentation of a 3 year old boy who presented with orbital recurrence of retinoblastoma after enucleation and limited radiation therapy. Following the case presentation, a review of therapeutic modalities for retinoblastoma will be discussed, with particular focus on enucleation and the management of recurrence of tumor in the globe. A Parent's Guide to Understanding Retinoblastoma Patient Statement: Retinoblastoma - Updated 04/98 What is Retinoblastoma? An Inspirational, Spiritual Book About Childhood Cancer (Retinoblastoma) Perfect Vision, A Mother's Experience With Childhood Cancer, is an inspirational book that deals with a tragic experience. Coming to grips with the grief. Retinoblastoma Basics Retinoblastoma Retinoblastoma Foundation Genetics of Retinoblastoma ... The National Retinoblastoma Research and Support Foundation

10. Retinoblastoma / Family Village Library Who to Contact. Where to Go to Chat with Others. Learn More About It. Web Sites. Search Google for "retinoblastoma" Who to Contact. retinoblastoma International. 4650 Sunset Boulevard MS 88. Los Angeles, CA 90027. Phone 323669-2299 RI has a mission to wipe out retinoblastoma world-wide through education and research http://www.familyvillage.wisc.edu/lib_reti.htm

Retinoblastoma Who to Contact Where to Go to Chat with Others Learn More About It Web Sites ... Search Google for "Retinoblastoma" Who to Contact Retinoblastoma International 4650 Sunset Boulevard MS #88 Los Angeles, CA 90027 Phone: 323-669-2299 Fax: 323-660-8541 E-mail: info@retinoblastoma.net Web: http://www.retinoblastoma.net/ RI has a mission to wipe out retinoblastoma world-wide through education and research. To accomplish this mission we: Provide information about retinoblastoma to parents, family and friends Offer on-line continuing medical education and hands-on training in the management of retinoblastoma to health care professionals Promote early detection of retinoblastoma among parents and professionals Raise funds to support research on safer, more effective treatment that one day will be available to any child anywhere with retinoblastoma. Where to Go to Chat with Others Retinoblastoma Online Support Group Retinoblastoma Survivors Support Group KidsEyeCancerFriends Retinoblastoma Learn More About It About Retinoblastoma A Parent's Guide to Understanding Retinoblastoma What is Retinoblastoma?

11. Mike's Life With Retinoblastoma One parent's account and knowledge of this form of eye tumor. http://www.mrmegabyte.net/rb

On this page What is it? Tony Tony Adults ... Please visit our sponsor's web page and learn all about 3D Baby Ultrasounds! (Mike's Business) Home Retinoblastoma Support

12. Retinoblastoma retinoblastoma. National retinoblastoma Research and Support Foundation http://www.kumc.edu/gec/support/retinobl.html

Retinoblastoma National Retinoblastoma Research and Support Foundation (NRRSF) 900 N.W. 17th Street, Room 257 PO Box 016880 Miami, FL 33101-6880 Phone: (800) 226-2734 National Retinoblastoma Parents Group 603 Fourth Range Rd Pembroke, NH 03275 Phone: (603) 224-4085 Institute for Families of Blind Children P.O.Box 54700, Mailstop 111 Los Angeles, Ca. 90054-0700 Phone: (213) 669-4649 Contact: Nancy Chernus-Mansfield National Cancer Institute Office of Cancer Communications Center Drive, MSC 2580 Bethesda, MD 20892-2580 Cancer Information Service: 1-800-4-CANCER (1-800-422-6237) or TTY: 1-800-332-8615 R-BLASTOMA electronic mailing list for retinoblastoma patients and their parents. To subscribe, email: LISTSERV@listserv.acor.org In the body of message, write only: SUBscribe R-BLASTOMA Yourfirstname Yourlastname A web interface to subscribe also exists at: or contact G Frydman gfrydman@acor.org , Association of Cancer Online Resources, Inc. http://www.acor.org Retinoblastoma resources A Parent's Guide to Understanding Retinoblastoma What is Retinoblastoma? Genetics of Retinoblastoma Genetic Testing Diagnosis of Retinoblastoma Signs and Symptoms of Retinoblastoma Classification of Retinoblastoma Treatment of Retinoblastoma Long Term Consequences of Retinoblastoma Retinoblastoma Foundation Also See: National organizations information on genetic conditions or birth defects Retinoblastoma National Cancer Institute information sheet CancerNet or Retinoblastoma information Other Cancer resources University of Kansas web site

13. Canadian Retinoblastoma Society Promotes the interests of patients and their families. http://www.rbsociety.ca

14. Index a retinoblastoma. q. retinoblastoma is the most common primary ocular tumour in childhood. It is also a favourite topic of the examiners http://www.mrcophth.com/pathology/retinoblastoma/retinoblastoma.html

a Retinoblastoma q Retinoblastoma is the most common primary ocular tumour in childhood. It is also a favourite topic of the examiners as they can test the candidates' knowledge of genetics. If you were given a gross pathology of the eye, comment on the following: the size of the tumour the location of the tumour (endophytic or exophytic; single or multiple; any vitreal seedings) any spread outside the globe (especially of the optic nerve. In optic nerve involvement, there may be abnormal optic nerve enlargement or tumour surrounding the nerve. Extraocular spread is of great prognostic value.) An endophytic retinoblastoma. The tumour grows into the vitreal cavity. (In exophytic type, the tumour grows into the subretinal space). Optic nerve (O) invaded by retinoblastoma (R). Under the microscope, retinoblastoma contains deep blue cells with little cytoplasm. As the tumour cells usually outgrow their blood supplies, necrosis and haemorrhage are common within the tumour. In the slide, you will be expected to comment on: differentiation of the tumour (although this is of little prognostic value) any presence of tumour in the optic nerve.

15. Indiacancer.org - Retinoblastoma Highlights important information often overlooked about retinoblastoma and its treatment. http://www.indiacancer.org/coca/r/retino.html

Retinoblastoma What is the Retina? What is Retinoblastoma? How is Retinoblastoma detected? What are staging and grading? ... What is the importance of follow up? What is the Retina? The retina is a lining of nervous tissue located at the back of the two eyes. It is a photosensitive layer, that is, it is responsible for sensing light and forming images. The Eye (Cut Section) What is Retinoblastoma? This is a cancer of the retina. Although it can occur at any age, it generally occurs before 5 years of age. It maybe unilateral , that is, only on one side, or bilateral , that is, in both eyes. Usually, the tumor is confined to the eye socket without spreading to the adjacent tissues. Retinoblastoma has a tendency to be hereditary , i.e., it can run in families, but this is not always the case. If hereditary, it usually occurs at an younger age and tends to be bilateral. Because it is hereditary, the

16. Retinoblastoma Concise description of factors, survival rates, and treatment strategies for retinoblastoma. http://www.stjude.org/disease-summaries/0,2557,449_2167_3003,00.html

@import url(/StJude/CDA/Common/CSS/default.css); @import url(/StJude/CDA/Common/CSS/default_lists.css); @import url(/StJude/CDA/Common/CSS/default_content_types.css); @import url(/StJude/Common/CSS/St_Jude_Clinical_Science); St. Jude Children's Research Hospital Finding Cures. Saving Children. About St. Jude News Donate Now Contact Us ... Ways to Help Solid Tumors Home Clinical Science Home Disease Information Solid Tumors Related Topics Patient of the Month - July 2003 Video: Eye cancer now 95% curable. Retinoblastoma warning signs Disease Information Solid Tumor : Retinoblastoma Alternative Names: None Definition Incidence An estimated 250-300 children a year will develop retinoblastoma in the United States. Retinoblastoma represents about 3 percent of all childhood malignancies. Influencing Factors Children born with bilateral retinoblastoma may pass the retinoblastoma trait to their children (hereditary). Retinoblastoma serves as the model for understanding the heredity and genetics of childhood cancer. Clinical Features and Symptoms Children with a suspicion of having retinoblastoma need to be examined under anesthesia, with the pupils dilated, and have very careful evaluation of the size and number of tumors.

17. AIGR Associazione italiana genitori di bambini affetti da retinoblastoma. Presentazione dell'associazione e contatti utili, informazioni sulla legislazione in materia, news dal mondo della scienza, Faq, archivio news; accesso per non vedenti. http://www.aigr.it/

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18. Retinoblastoma.Net Home retinoblastoma? Parents, Family, Friends. What We. Are Doing. Contribute Volunteer. Where. Funds Go. About. Us. A New Childrens Audio Book Featuring. AwardWinning Cast Members From "Days of Our http://www.eyecareforkids.com/

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19. RETINOBLASTOMA: HOME Provides information and support for families coping with the diagnosis and treatment of retinoblastoma. http://www.eyecancermd.org/retinoblastoma/

HOME ADULT EYE TUMORS Anatomy of the Eye Eye Tumors ... Contact Us RETINOBLASTOMA Anatomy of the Eye Diagnosis Examination Under Anesthesia Treatment ... PRINT VERSION (PDF) Change font size: Small Large document.selectStream.stream.value = fontSelection; Cancer is always a frightening diagnosis, and when it affects children, the situation is overwhelming. Eye cancer in children, though rare, is the third leading cancer of childhood. Retinoblastoma, a cancer of the retinal eye tissue, is the most common eye cancer in children. It affects approximately one in eighteen thousand live births without regard to race or gender. This number, in fact, probably underestimates the number of cases because children remain at risk for retinoblastoma during the first five years of life. Retinoblastoma can be a particularly distressing form of cancer as it is potentially fatal and can result in vision loss of one or both eyes. Fortunately, almost all children in North America can be successfully treated for retinoblastoma. Not only are children no longer dying of this disease, in most cases, with early diagnosis and treatment, children with retinoblastoma do not have to have an eye removed and will keep normal vision. When they first learn of their child's diagnosis, many families want to gather as much information as possible. Because it is such a rare disease, there is very little information about retinoblastoma available to families. This website is designed to give you more information about retinoblastoma. It will discuss diagnosis, treatment options, follow-up, and the genetic aspects of retinoblastoma. It will also include common issues faced by parents that have been faced with a diagnosis of retinoblastoma in their child. Our aim is to help families better understand and effectively cope with retinoblastoma.

20. Retinoblastoma Covers causes and symptoms, diagnosis, treatment, alternative treatment, prognosis, prevention, and resources for retinoblastoma. http://www.ehendrick.org/healthy/001189.htm

MAIN SEARCH INDEX Retinoblastoma Definition Description Causes and symptoms Diagnosis ... Resources Definition Retinoblastoma is a malignant tumor of the retina that occurs predominantly in young children. Description The eye has three layers, the sclera, the choroid, and the retina. The sclera is the outer protective white coating of the eye. The choroid is the middle layer and contains blood vessels that nourish the eye. The front portion of the choroid is colored and is called the iris. The opening in the iris is called the pupil. The pupil is responsible for allowing light into the eye and usually appears black. When the pupil is exposed to bright light it contracts (closes), and when it is exposed to low light conditions it dilates (opens) so that the appropriate amount of light enters the eye. Light that enters through the pupil hits the lens of the eye. The lens then focuses the light onto the retina, the innermost of the three layers. The job of the retina is to transform the light into information that can be transmitted to the optic nerve, which will transmit this information to the brain. It is through this process that people are able to see the world around them. Occasionally a tumor, called a retinoblastoma, will develop in the retina of the eye. Usually this tumor forms in young children but it can occasionally occur in adults. Most people with retinoblastoma develop only one tumor (unifocal) in only one eye (unilateral). Some, however, develop multiple tumors (multifocal) in one or both eyes. When retinoblastoma occurs independently in both eyes, it is then called bilateral retinoblastoma.

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