21. PiXiE Supporting Sufferers Of Pseudoxanthoma Elasticum Supporting sufferers of pseudoxanthoma elasticum. The pseudoxanthoma elasticum Support Group is a registered charity No 1055465. http://www.pxe.org.uk/pages/aboutpixie.htm

pxeeurope@aol.com Supporting sufferers of Pseudoxanthoma Elasticum The Pseudoxanthoma Elasticum (PXE) Support Group (PiXiE) is a non-profit making charitable trust, founded in 1984 by Elspeth Lax and run entirely by unpaid volunteers. The PXE support group aims to: help, encourage and assist those with PXE and their family members heighten the awareness of PXE amongst the medical community, support services and the general public link members with each other for mutual support and exchange of ideas provide information on the various aspects of PXE provide copies of our newsletter, "Pixie", containing medical articles and letters from members hold meetings to which all members, their families and friends are invited. You can join PiXiE by returning a Membership Application form. If you would like further information on PXE and the support group or would like to make a donation towards running costs, please contact: Elspeth Lax, 15 Mead Close, Marlow, Bucks, SL7 1HR, UK

22. EMedicine - Pseudoxanthoma Elasticum : Article By L Frank Glass, MD pseudoxanthoma elasticum pseudoxanthoma elasticum (PXE) is an inherited connective tissue disorder characterized by progressive calcification and http://www.emedicine.com/DERM/topic359.htm

(advertisement) Home Specialties Resource Centers CME ... Patient Education Articles Images CME Patient Education Advanced Search Consumer Health Link to this site Back to: eMedicine Specialties Dermatology Diseases Of The Dermis Pseudoxanthoma Elasticum Last Updated: July 24, 2003 Rate this Article Email to a Colleague Synonyms and related keywords: PXE, connective tissue disorder, calcification and fragmentation of elastic fibers AUTHOR INFORMATION Section 1 of 10 Author Information Introduction Clinical Differentials ... Bibliography Author: L Frank Glass, MD , Chief of Dermatopathology, Associate Professor, Departments of Internal Medicine and Pathology, University of South Florida College of Medicine Coauthor(s): Daniel F Smith, MD , Staff Physician, Department of Internal Medicine, Division of Dermatology and Cutaneous Surgery, University of South Florida School of Medicine; Anu Gupta, MD , Staff Physician, Department of Internal Medicine, Division of Dermatology and Cutaneous Surgery, University of South Florida School of Medicine L Frank Glass, MD, is a member of the following medical societies:

23. OMIM - PSEUDOXANTHOMA ELASTICUM, AUTOSOMAL RECESSIVE; PXE http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=264800

24. Entrez PubMed No abstract, pseudoxanthoma elasticum. Postgrad Med J. 2004 May;80(943)297. Abstract, Cutis laxalike pseudoxanthoma elasticum with ossification. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?GeneratedBy=Dermatlas&cmd=search&d

25. Pseudoxanthoma Elasticum - Information / Diagnosis / Treatment / Prevention home genetic disorders pseudoxanthoma elasticum pseudoxanthoma elasticum. Web Directory ? MyLifePath An in depth look at pseudoxanthoma elasticum. http://www.healthcyclopedia.com/genetic-disorders/pseudoxanthoma-elasticum.html

Home Health cyclopedia All Topics by Category The Good Health Search Engine Health Conditions A-Z Gurus ... genetic disorders > pseudoxanthoma elasticum Pseudoxanthoma Elasticum Information / Diagnosis / Treatment / Prevention External links (marked with an arrow ) open in a new window. This site is a web directory and does not offer medical advice. We cannot take responsibility for information found on listed sites. This Page Related Topics Medical Definition Health News Web Directory: Related Topics: Cardiovascular Disorders/Vascular Disorders Musculoskeletal Disorders/Connective Tissue Rare Disorders Medical Definition: University of Newcastle-upon-Tyne Medical Dictionary: "pseudoxanthoma elasticum" Health News: Search millions of published articles for news on Pseudoxanthoma Elasticum Modern Medicine Aging The Ardell Wellness Report HealthFacts Medical Post Medical Update Men's Health and the National Women's Health Report Note: Subscription required to access the full text of articles. Web Directory: NORD: Pseudoxanthoma Elasticum Offers a general discussion and resources for PXE. PXE International The comprehensive source for pseudoxanthoma elasticum research and world wide activities.

26. Eye Conditions > Pseudoxanthoma Elasticum -- EyeMDLink.com Last Updated 9/25/2001. pseudoxanthoma elasticum. The eye is often affected by the development of angioid streaks, which are splits http://www.eyemdlink.com/Condition.asp?ConditionID=368

27. Pseudoxanthoma Elasticum pseudoxanthoma elasticum /Angioid Streaks. National Association for pseudoxanthoma elasticum (NAPE). pseudoxanthoma elasticum (PXE http://www.lowvision.org/pseudoxanthoma_elasticum.htm

Pseudoxanthoma Elasticum /Angioid Streaks National Association for Pseudoxanthoma Elasticum (NAPE) Pseudoxanthoma elasticum (PXE)

28. Pseudoxanthoma Elasticum MAIN SEARCH INDEX. pseudoxanthoma elasticum. pseudoxanthoma elasticum An Update. Dermatology 199 (1999) 37. Ringpfeil, F., et al. http://www.ehendrick.org/healthy/001133.htm

MAIN SEARCH INDEX Pseudoxanthoma elasticum Definition Description Causes and symptoms Diagnosis ... Resources Definition Pseudoxanthoma elascticum (PXE) is an inherited connective tissue disorder in which the elastic fibers present in the skin, eyes, and cardiovascular system gradually become calcified and inelastic. Description The course of PXE varies greatly between individuals. Typically it is first noticed during adolescence as yellow-orange bumps on the side of the neck. Similar bumps may appear at other places where the skin bends a lot, like the backs of the knees and the insides of the elbows. The skin in these areas tends to get thick, leathery, inelastic, and acquire extra folds. These skin problems have no serious consequences, and for some people, the disease progresses no further. Bruch's membrane, a layer of elastic fibers in front of the retina, becomes calcified in some people with PXE. Calcification causes cracks in Bruch's membrane, which can be seen through an ophthalmoscope as red, brown, or gray streaks called angioid streaks. The cracks can eventually (e.g., in 10-20 years) cause bleeding, and the usual resultant scarring leads to central vision deterioration. However, peripheral vision is unaffected. Arterial walls and heart valves contain elastic fibers that can become calcified. This leads to a greater susceptibility to the conditions that are associated with hardening of the arteries in the normal

29. THE MERCK MANUALSECOND HOME EDITION, Pseudoxanthoma Elasticum In pseudoxanthoma elasticum. pseudoxanthoma elasticum is a disorder of connective tissue that causes abnormalities in the skin, eyes, and blood vessels. http://www.merck.com/mrkshared/mmanual_home2/sec23/ch279/ch279d.jsp

30. Disease Directory : Genetic Disorders : Pseudoxanthoma Elasticum Diseases Genetic Disorders pseudoxanthoma elasticum. Angioid Streaks Yannuzzi, MD. co. What is pseudoxanthoma elasticum (PXE)? http://www.diseasedirectory.net/Genetic_Disorders/Pseudoxanthoma_Elasticum/defau

Wednesday, June 02, 2004 Genetic Disorders Aarskog Syndrome Aase Syndrome Ablepharon-Macrostomia Syndrome ... Genetic Disorders : Pseudoxanthoma Elasticum Angioid Streaks and Pseudoxanthoma Elasticum CVNET Archive 97: CVNet - Int'l Meeting on Pseudoxanthoma ... - CVNet - Int'l Meeting on Pseudoxanthoma Elasticum. ***** International Centennial Meeting on Pseudoxanthoma Elasticum. November 6 and 7, 1997. Disk drusen and angioid streaks in pseudoxanthoma elasticum. - Disk drusen and angioid streaks in pseudoxanthoma elasticum. Pseudoxanthoma elasticum is associated with marked cardiovascular and gastrointestinal morbidity. Familial pseudoxanthoma elasticum - Photo essay. Familial pseudoxanthoma elasticum. Lindsey Kingdom. Keywords: Pseudoxanthoma elasticum , angioid streak , human genetics . GeneReviews: Pseudoxanthoma Elasticum - Your browser does not support HTML frames so you must view Pseudoxanthoma Elasticum in a slightly less readable form. Please follow this link to do so. Genesis Health System - Detailed Disease Info - Pseudoxanthoma ... - Pseudoxanthoma elasticum. Definition. ORGANIZATIONS. National Association for Pseudoxanthoma Elasticum. 1420 Ogden St., Denver, CO 80218-1910. (303) 832-5055. IM Quiz: Pseudoxanthoma Elasticum - Pseudoxanthoma Elasticum. This patient is exhibiting the findings consistent with the diagnosis of pseudoxanthoma elasticum. The

31. Disease Directory : Pseudoxanthoma Elasticum Diseases Genetic Disorders pseudoxanthoma elasticum pseudoxanthoma elasticum. Directory Listing. National Association for pseudoxanthoma elasticum (NAPE). http://www.diseasedirectory.net/detailed/25919.aspx

Wednesday, June 02, 2004 Genetic Disorders Aarskog Syndrome Aase Syndrome Ablepharon-Macrostomia Syndrome ... Pseudoxanthoma Elasticum : Pseudoxanthoma Elasticum Directory Listing Title: Pseudoxanthoma Elasticum Description: Pseudoxanthoma Elasticum /Angioid Streaks. National Association for Pseudoxanthoma Elasticum (NAPE). Pseudoxanthoma elasticum (PXE Date Added: 2/17/2004 10:03:09 AM URL: http://www.lowvision.org/pseudoxanthoma_elasticum.htm

32. DermIS / Main Menu / DOIA / Alphabetically / Diagnosenames Containing 'pseudoxan DermIS / main menu / DOIA / alphabetically / diagnosenames containing pseudoxanthoma elasticum , deutsch español portugues français. http://www.dermis.net/doia/abrowser.asp?zugr=d&lang=e&beginswith=pseudoxanthoma

33. Pseudoxanthoma Elasticum pseudoxanthoma elasticum National Association for pseudoxanthoma elasticum National network. Founded 1988. Support, education, research http://my.webmd.com/hw/health_guide_atoz/shc29pse.asp

var guid_source = ""; var guid_source_id = ""; //unused var encodedurl = ""; WebMD Today Home WebMD News Center Member Services WebMD University My WebMD Find a Physician Medical Info Check Symptoms Medical Library Quizzes, Calculators Clinical Trials ... Women, Men, Lifestyle Who We Are About WebMD Site Map You are in Medical Library Choose a Topic Our Content Sources Ask A Question Clinical Trials Health Guide A-Z Health Topics Symptoms Medical Tests Medications ... PXE International, Inc. Pseudoxanthoma Elasticum National Association for Pseudoxanthoma Elasticum National network. Founded 1988. Support, education, research and advocacy for persons with (PXE), and their families, interested others, and professionals. Newsletter, information and referrals, phone support. Donations appreciated and tax deductible. WRITE: NAPE 8764 Manchester Rd. #200 St. Louis, MO 63144-2724 CALL: 303-355-3866 FAX: 303-355-3859 E-MAIL: derckd@ttuhsc.edu pxenape@estreet.com WEBSITE: http://www.pxenape.org VERIFIED: 7/1/2003 PXE International, Inc. International. 50 affiliated groups. Founded 1995. Support for persons affected by pseudoxanthoma elasticum (PXE), their families and friends. Peer support for physicians. Offers support groups, phone and mail contacts, literature, and quarterly newsletter. Offers assistance in starting similar group.

34. Pseudoxanthoma Elasticum (PXE) pseudoxanthoma elasticum (PXE) Important It is possible that the main title of the report pseudoxanthoma elasticum (PXE) is not the name you expected. http://my.webmd.com/hw/health_guide_atoz/nord253.asp

var guid_source = ""; var guid_source_id = ""; //unused var encodedurl = ""; WebMD Today Home WebMD News Center Member Services WebMD University My WebMD Find a Physician Medical Info Check Symptoms Medical Library Quizzes, Calculators Clinical Trials ... Women, Men, Lifestyle Who We Are About WebMD Site Map You are in Medical Library Choose a Topic Our Content Sources Ask A Question Clinical Trials Health Guide A-Z Health Topics Symptoms Medical Tests Medications ... For a Complete Report Pseudoxanthoma Elasticum (PXE) Important It is possible that the main title of the report Pseudoxanthoma Elasticum (PXE) is not the name you expected. Please check the synonyms listing to find the alternate name(s) and disorder subdivision(s) covered by this report. Synonyms Elastosis Dystrophica Syndrome (obsolete) Gronblad-Strandberg Syndrome Systemic Elastorrhexis (obsolete) Disorder Subdivisions PXE, Recessive Type PXE, Dominant Type General Discussion Pseudoxanthoma elasticum, PXE, is an inherited disorder that affects selected connective tissue in some parts of the body. Elastic tissue in the body becomes mineralized; that is, calcium and other minerals are deposited in the tissue. This can result in changes in the skin, eyes, cardiovascular system, and gastrointestinal system. Clinicians first recognized PXE more than 100 years ago. Researchers have made a number of significant advances in the past few years. Resources National Association for Pseudoxanthoma Elasticum (NAPE) 8764 Manchester Road Suite 200

35. Pseudoxanthoma Elasticum Articles, Support Groups, And Resources pseudoxanthoma elasticum articles, support groups, and resources for patients from Med Help International (www.medhelp.org). pseudoxanthoma elasticum. http://www.medhelp.org/HealthTopics/Pseudoxanthoma_Elasticum.html

[Health Topics A-Z] A B C D ... Z Pseudoxanthoma Elasticum Support Groups: National Association for Pseudoxanthoma Elasticum [Med Help Home] [Library Search] [Medical Forums] ... [Patient Network] Revised: 6/2/2004

36. Pseudoxanthoma Elasticum pseudoxanthoma elasticum. Definition ORGANIZATIONS. National Association for pseudoxanthoma elasticum. 1420 Ogden St., Denver, CO 802181910. (303) 832-5055. http://www.chclibrary.org/micromed/00062470.html

Main Search Index Definition Description Causes ... Resources Pseudoxanthoma elasticum Definition Pseudoxanthoma elascticum (PXE) is an inherited connective tissue disorder in which the elastic fibers present in the skin, eyes, and cardiovascular system gradually become calcified and inelastic. Description The course of PXE varies greatly between individuals. Typically it is first noticed during adolescence as yellow-orange bumps on the side of the neck. Similar bumps may appear at other places where the skin bends a lot, like the backs of the knees and the insides of the elbows. The skin in these areas tends to get thick, leathery, inelastic, and acquire extra folds. These skin problems have no serious consequences, and for some people, the disease progresses no further. Bruch's membrane, a layer of elastic fibers in front of the retina, becomes calcified in some people with PXE. Calcification causes cracks in Bruch's membrane, which can be seen through an ophthalmoscope as red, brown, or gray streaks called angioid streaks. The cracks can eventually (e.g., in 10-20 years) cause bleeding, and the usual resultant scarring leads to central vision deterioration. However, peripheral vision is unaffected. Arterial walls and heart valves contain elastic fibers that can become calcified. This leads to a greater susceptibility to the conditions that are associated with hardening of the arteries in the normal aging populationhigh blood pressure

37. DermIS / Main Menu / DOIA / Pseudoxanthoma Elasticum / Images pseudoxanthoma elasticum . http://dermis.multimedica.de/doia/diagnose.asp?zugr=d&lang=e&diagnr=757390&topic

38. DermIS / Hauptmenü / DOIA / Pseudoxanthoma Elasticum / Bilder pseudoxanthoma elasticum . http://dermis.multimedica.de/doia/diagnose.asp?zugr=d&lang=d&diagnr=757390&topic

39. Angioid Streaks And Pseudoxanthoma Elasticum Angioid Streaks and pseudoxanthoma elasticum By K. Bailey Freund, MD Lawrence A. Yannuzzi, MD. co. What is pseudoxanthoma elasticum (PXE)? http://www.vrmny.com/angioid_streaks_and_pxe.htm

Angioid Streaks and Pseudoxanthoma Elasticum By K. Bailey Freund, MD Lawrence A. Yannuzzi, MD co What are angioid streaks? Angioid streaks are a retinal finding which can lead to visual loss. Dr. Robert W. Doyne, a British ophthalmologist, first described them in 1889. They are irregular, jagged, curvilinear lines that radiate from the region of the optic nerve into the more peripheral retinal tissue, particularly the central area known as the macula (see above). Often reddish-brown in color, their appearance mimics that of retinal blood vessels, hence, the name "angioid." Angioid streaks represent defects or cracks in a tissue layers beneath the retina known as Bruch's membrane (see above). The retinal pigment epithelium (RPE) and choroid are secondarily effected. Through these cracks, new blood vessels known as choroidal neovascularization (CNV) may proliferate. CNV originates from the small superficial vessels of choroid, known as the choriocapillaris. As CNV progresses, the abnormal vessels may leak fluid and bleed. Eventually this process causes damage to the overlying retina. Decreased and/or distorted vision will often occur. In up to 50% of cases of angioid streaks the cause is unknown or "idiopathic." A number of systemic diseases have been linked to angoid streaks. These include pseudoxanthoma elasticum (PXE), Ehlers-Danlos disease, Paget’s disease of the bone, and sickle cell disease. Of these, PXE is by far the most common.

40. Pseudoxanthoma Elasticum pseudoxanthoma elasticum,. Print this article, Vascular calcifications of pseudoxanthoma elasticum occur most frequently in the femoral arteries. http://www.amershamhealth.com/medcyclopaedia/medical/Volume III 1/PSEUDOXANTHOMA

Amershamhealth.com Search for: Type a word or a phrase. All forms of the word are searchable. Browse entry words starting with: A B C D ... Other characters Pseudoxanthoma elasticum, an inherited disorder of unknown pathogenesis involving the skin, eyes and cardiovascular system; it is characterized by a defect in elastic fibres and has protean clinical manifestations. The dermal lesions relate to progressive mineralization of the elastin component of individual fibers. The calcified elastin is accompanied by abnormally thickened collagen fibers and a marked increase in ground substance, resembling the collagen changes in Ehlers Danlos syndrome and osteogenesis imperfecta . The skin is thickened, redundant, deeply grooved and hyperextensible, with yellow papules between the thickened folds that give the skin a peau d'orange (orange peel) appearance. In the eyes, angioid streaks representing fissuring and scarring of the membrane beneath the retina are seen. Chorioretinitis may also be present in some patients. Other abnormalities are narrowing and occlusion of the large muscular arteries of the extremities, viscera and central nervous system. Vascular calcifications of pseudoxanthoma elasticum occur most frequently in the femoral arteries. On radiographs, the skull frequently demonstrates premature calcification of the falx, tentorium, choroid plexus and petroclinoid ligaments, with thickening of the calvaria and base of the skull. Calcification may be seen

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