81. PiD Kertesz, A (2003) Pick complex An integrative approach to frontotemporal dementia primary progressive aphasia, corticobasal degeneration, and progressive http://www.biols.susx.ac.uk/home/Julian_Thorpe/ad_PiD.htm

Alzheimer's Disease and FTD-Tauopathies: a review with particular reference to Pin1 protein Home About this Site Pin1 protein Alzheimer's Disease ... Our Research Literature: A-K L-Z subject area Search site by subject area ... Feedback Compiled by: Julian Thorpe Pick's Disease (PiD) N.B. This page is in the initial phases of construction, so I suggest you follow the external link below for more on this disease. (external site links in italics See: NINDS Pick's disease Information Page and the 'Institut National de la Sante et de la Recherche Medical' website for more detail on PiD. Type: PiD is a sporadic tauopathy belonging to the frontotemporal dementia (FTD) group of neurodegenerative diseases. Regions affected: neocortex and hippocampus. Tau pathology: Neuronal: Pick bodies of straight and twisted filaments of tau in the neocortex (most numerous in layers 2 and 6) and in the dentate granule neurons of the hippocampus. Glial Other Pathology : frontotemporal lobar and limbic atrophy, spongiosis and gliosis.

82. American Journal Of Alzheimer's Disease And Other Dementias 2002 Abstracts primary progressive aphasia A review of the neurobiology of a common presentationof Pick complex Andrew Kertesz, MD, FRCPC; David G. Munoz, MD, FRCPC January http://www.pnpco.com/pn02024.html

American Journal Alzheimer's Disease and Other Dementias Publications Journal of Cancer Integrative Medicine American Journal of Recreation Therapy Journal of Emergency Management Healing Ministry ... Contact information 2002 Abstracts January/February 2002, Volume 17, Number 1 Editorial The forgotten stepchild Christopher V. Rowland, Jr., MD January/February 2002; page 5 Newsbriefs Memory loss affects nearly one-quarter of people over age 65 Nursing staff shortage is becoming critical HHS Secretary Thompson announces new quality-of-care initiative for nursing homes January/February 2002; pages 6-9 Shannon Rogan, BS; Carol F. Lippa, MD January/February 2002; pages 11-17 Abstract Slowly progressive aphasia with striatal involvement Nages Nagaratnam, FRACP; Gary Cheuk, FRACP; Kujan Nagaratnam, FRACP January/February 2002; pages 18-22 Abstract We have described four patients with slowly progressive aphasia with striatal involvement occurring at different stages in the course of the illness. There were two males and two females, and their ages ranged from 68 to 76 (mean: 72) years. The extrapyramidal signs included tremors, bradykinesia, rigidity, and focal dystonia, and one had weakness resembling stroke. There is a heterogeniety among patients with slowly progressive aphasia and the clinical features correspond to the functional anatomy of the areas involved rather than to the pathology. Key words: aphasia, bradykinesia, dementia, dystonia, extrapyramidal signs, rigidity, striatal involvement, tremors

83. Argye Hillis, MD Her clinical research interests include studies of aphasia and hemispatial neglectin patients with acute stroke; primary progressive aphasia; and the http://www.neuro.jhmi.edu/profiles/hillis.html

17-Nov-2003 Argye Hillis, M.D. Argye Beth Hillis, MD, MA has been on the faculty of the Department of Neurology since 1999. She is an Associate Professor of Neurology, with a joint faculty appointment in Cognitive Science at Johns Hopkins University School of Arts and Sciences. She has clinical responsibilities in both the Division of Cognitive Neurology and Cerebrovascular Disorders. Prior to medical training and neurology residency, Dr. Hillis trained in the fields of speech-language pathology and cognitive neuropsychology. Her clinical practice specializes in stroke, focal dementias, and other cognitive impairments. Her clinical research interests include studies of: aphasia and hemispatial neglect in patients with acute stroke; primary progressive aphasia; and the cognitive effects of neurosurgical interventions, interventional neuroradiology procedures, and cardiac bypass surgery. Dr. Hillis sees patients for consultations on Monday afternoons, 12:00 to 5:00 PM. To make an appointment please call 410-614-2381 between 9:00 AM and 4:00 PM on weekdays. CURRENT ADDRESS The Johns Hopkins Hospital Department of Neurology Meyer 5-185 600 N. Wolfe Street

84. Article, Newsworthy, Feinberg School, Northwestern University Dr. Mesulam described, for example, primary progressive aphasia, an unusual dementiaof unknown cause that is characterized by a relentless loss of language http://lydgate.nums.northwestern.edu/feinbergnews/newsDetail.asp?objectID=207&ty

85. Entrez PubMed Click here to read Cognition and anatomy in three variants of primaryprogressive aphasia. GornoTempini ML, Dronkers NF, Rankin http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1

86. Progressive Primary Aphasia progressive primary aphasia. General outline Language disorder Apeculiar disease starting with progressive impairment of verbal http://perso.wanadoo.fr/alzheimer.lille/PPA.html

Alzheimer Brain dis eases Research ... untington Hallenvorden IBM L ewy BD MSA NPiD c Parkinson D Guadeloupe Parkinson Dementia  in Parkinson Pick ... Semantic  D SSP ToD Alzheimer Brain dis eases Research ... BD DS GSS F TD FTDP-17 ... untington Hallenvorden IBM L ewy BD MSA NPiD c PDG Parkinson Pick PPA Prion ... SP PEP SSP ToD Progressive primary aphasia General outline Language disorder - A peculiar disease starting with progressive impairment of verbal skills developing into fronto-temporal dementia after several years. Synonyms Slowly Progressive Aphasia Symptoms The key feature is impaired verbal fluency, agrammatism, impaired comprehension of word scanning and naming deficit. Despite their communication problems, patients at a mild stage are able to continue usual activities of daily life and even may continue working. Two forms: non-fluent and fluent forms of PPA. After an average of 5 years and more, patients gradually develop clinical symptoms of FTD. Course Gradually progressive language disorder, making communication more and more difficult. After an average of 5 years or more patients gradually develop the clinical symptoms of FTD with relative sparing of memory. Average onset around 60, average survival time 6 - 8 years Caregiver problems Communication Epidemiology About 10% of fronto-temporal degeneration Aetiology Pathologically PPA belongs to the family of fronto-temporal degenerations and frequently abnormal tau is found. Localisation ?

87. Nothing To Say, Something To Sing: Primary Progressive Dynamic Aphasia Nothing to Say, Something to Sing primary progressive Dynamic aphasia. Jason D.Warren 1, 2 , Jane E. Warren 3 , Nick C. Fox 1 and Elizabeth K. Warrington 1. http://www.szp.swets.nl/szp/journals/nc092140.htm

Neurocase 2003, Vol.9, No.2, pp. 140-155 research article Nothing to Say, Something to Sing: Primary Progressive Dynamic Aphasia Jason D. Warren , Jane E. Warren , Nick C. Fox and Elizabeth K. Warrington Institute of Neurology, Dementia Research Group, London, UK University of Newcastle Medical School, Auditory Group, Newcastle-upon-Tyne, UK MRC Clinical Sciences Centre, Cyclotron Unit, Hammersmith Hospital, London, UK

88. Extenza - Nothing To Say, Something To Sing: Primary Progressive Dynamic Aphasia Nothing to Say, Something to Sing primary progressive Dynamic aphasia.Author(s) Jason D. Warren 1 Jane E. Warren 2 Nick C. Fox http://www.extenza-eps.com/extenza/loadHTML?objectIDValue=15068&type=abstract

89. Penn State Faculty Research Expertise Database (FRED) aphasia, PostIctal, aphasia, Post-Traumatic. aphasia, progressive, aphasia,Semantic. aphasia Post-Traumatic aphasias, progressive aphasia. progressive http://fred.hmc.psu.edu/ds/retrieve/fred/meshdescriptor/D001037

90. Blackwell Synergy - Cookie Absent Case Report. An autopsy case of Alzheimer s disease presenting with primaryprogressive aphasia A clinicopathological and immunohistochemical study. http://www.blackwell-synergy.com/links/doi/10.1046/j.1440-1789.2000.00343.x/full

Home An Error Occurred Setting Your User Cookie A cookie is a small amount of information that a web site copies onto your hard drive. Synergy uses cookies to improve performance by remembering that you are logged in when you go from page to page. If the cookie cannot be set correctly, then Synergy cannot determine whether you are logged in and a new session will be created for each page you visit. This slows the system down. Therefore, you must accept the Synergy cookie to use the system. What Gets Stored in a Cookie? Synergy only stores a session ID in the cookie, no other information is captured. In general, only the information that you provide, or the choices you make while visiting a web site, can be stored in a cookie. For example, the site cannot determine your email name unless you choose to type it. Allowing a web site to create a cookie does not give that or any other site access to the rest of your computer, and only the site that created the cookie can read it. Please read our for more information about data collected on this site.

91. Alzheimer's Association Of Orange County http//www.angelsonmyside.com/picks2/picks.html. Websites for primary Progressiveaphasia (PPA) http//www.brain.northwestern.edu. http//www.aphasia.org. http://www.alzoc.org/thedisease/Pickslinks.htm

Statistics FAQ's 10 Warning Signs Research ... http://www.angelsonmyside.com/picks2/picks.html Websites for Primary Progressive Aphasia (PPA): http://www.brain.northwestern.edu http://www.aphasia.org http://www.aphasia.org/NAAppa.html http://aac.unl.edu/reference/PPA_AAC.html ... Religious Services

92. Abstract - Clinical And Pathological Characterisation Of Primary Progressive Aph Abstract Clinical and pathological characterisation of primary progressiveaphasia and other focal atrophies. by A. Kertesz Interest http://www.jswresearch.com/abs/abs1995_13.htm

Abstract - Clinical and pathological characterisation of primary progressive aphasia and other focal atrophies by A. Kertesz To get the complete article please contact office@jswresearch.com

93. Medical Expert aphasia Diagnosis. January 2000 Q. My 79year-old mother was diagnosed with primaryprogressive aphasia three years ago. She has been taking Aricept since then. http://www.medinfosource.com/expert/exp3013100d.html

Select One Contact CME? Order? Register? Place an Ad? Print Pages? Ask a Colleague? More... AIDS/HIV Allergy Alternative Med. Alzheimer's Arthritis Asthma Blood Disorders Cancer Childhood Illness Chronic Fatigue Common Cold Dementia Dermatology Diabetes Ear/Nose/Throat Exercise Gastrointestinal Geriatrics Headache Heart Disease Hepatitis High Cholest. Medications Men's Health Migraine Nervous Syst. Neurology Nutrition Opthamology Orthopedics Osteoporosis Pediatrics Pregnancy Skin Disorders Sleep Disorders Stroke/TIA Women's Health Aphasia Diagnosis January 2000 Q. My 79-year-old mother was diagnosed with primary progressive aphasia three years ago. She has been taking Aricept since then. We have seen great degeneration in her ability to reason, comprehend and find a word that seems to be on the tip of her tongue. Is there any other help for her? How much benefit is Aricept for these symptoms? A. Aphasia is a difficulty with speech, either hearing the spoken word (receptive aphasia) or speaking itself. Aphasia can have many causes, from severe mental retardation, stroke, Alzheimer's disease, or (as in your mother's case) there is sometimes no identifiable cause, and the person is diagnosed with primary progressive aphasia. The difficulty is making a definite diagnosis as to the type of aphasia a person has. Since Alzheimer's disease is a frequent cause of aphasia, and since Aricept is frequently helpful in patients with Alzheimer's disease, many patients with primary progressive aphasia will be given Aricept as a trial. So, in other words, the Aricept is used primarily with the hope that it is going to work, rather than with the knowledge that it is effective in primary progressive aphasia.

94. EMedicine - Frontal And Temporal Lobe Dementia : Article Excerpt By: Howard Kirs reported. This disorder, which is currently termed primary progressiveaphasia (PPA), has gained acceptance as a syndrome. Rarely http://www.emedicine.com/neuro/byname/frontal-and-temporal-lobe-dementia.htm

(advertisement) Excerpt from Frontal and Temporal Lobe Dementia Synonyms, Key Words, and Related Terms: frontotemporal dementia, frontal dementia, nonspecific dementia, Pick's disease, Pick disease, primary progressive aphasia, FTD, PPA Please click here to view the full topic text: Frontal and Temporal Lobe Dementia Background: Cases of elderly patients with progressive language deterioration have been described since Arnold Pick's landmark case report of 1892. This case study, "On the relationship between aphasia and senile atrophy of the brain," still serves as a frame of reference for apparently focal brain syndromes in diffuse or generalized degenerative diseases of the brain. In 1982, Mesulam reported 6 patients with progressive aphasia, gradually worsening over a number of years, who did not develop a more generalized dementia. Since Mesulam's publication, numerous other cases have been reported. This disorder, which is currently termed primary progressive aphasia (PPA), has gained acceptance as a syndrome. Rarely, cases of isolated right frontal or temporal degeneration have been reported. These patients experience failure to recognize family members (prosopagnosia), failure to remember topographic relationships, and similar disorders. In England, cases of frontal lobe dementia have been described with progressive dysfunction of the frontal lobes. In a series of case reports, Neary and Snowden outlined a syndrome with initial symptoms that were suggestive of psychiatric illness. However, the following frontal lobe behavioral abnormalities appeared over time: disinhibition, impulsivity, impersistence, inertia, loss of social awareness, neglect of personal hygiene, mental rigidity, stereotyped behavior, and utilization behavior (ie, tendency to pick up and manipulate any object in the environment). These descriptions included language abnormalities such as reduced speech output, mutism, echolalia, and perseveration. Recently, the condition described in the North American literature as PPA and that described in the European literature as frontal dementia have been combined under the diagnosis frontotemporal dementia (FTD).

95. Riferimenti Bibliografici Sezione intestazione vai alla sezione contenuti vai alla sezionenavigazione. Il portale di neuropsicologia clinica un progetto http://www.neuropsy.it/articoli/dir06/06.html

@import "http://www.neuropsy.it/wai.css"; Sezione intestazione vai alla sezione contenuti vai alla sezione navigazione Il portale di neuropsicologia clinica un progetto hyperlabs.net Sezione navigazione Vai alla sezione contenuti Vai alla sezione intestazione Articolo precedente: Commento finale Paragrafi Neuropsy.it Cos'è Neuropsy.it La Neuropsicologia clinica Contatti Sezioni Formazione Casi clinici Articoli scientifici Test neuropsicologici Patologie Neoplasie Alzheimer Parkinson Trauma cranico ... Depressione Deficit Dislessia Funzioni Intelligenza Gruppo di discussione neuropsy.it , il gruppo di discussione su yahoo Mailing list Vuoi essere informato sulle novità di neuropsy.it? iscriviti alla nostra mailing list iscriviti Forum I forum di Neuropsy.it, per discutere di intelligenza, depressione, dislessia, alzheimer, trauma cranico. Sezione contetuti Vai alla sezione intestazione vai alla sezione navigazione neuropsy.it articoli ... Afasia progressiva con demenza rapidamente progressiva in una donna di 49 anni Riferimenti bibliografici Apparso in: J Neurol Neurosurg Psychiatry 1999 ; 66 : 238- 243 (February): Conferenza su un caso di clinica patologica

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