1. Understanding Primary Progressive Aphasia What is primary progressive aphasia? The syndrome Is there any assistancefor people with primary progressive aphasia? People with http://www.aphasia.org/NAAppa.html

Printed Date: Spring 1997 Updated: March 3, 2004 PRIMARY PROGRESSIVE APHASIA is a rare neurological syndrome in which language capabilities become slowly and progressively impaired. This information sheet was prepared by the National Aphasia Association to help explain the condition of Primary Progressive Aphasia to the general public. What is aphasia? Aphasia is an acquired disorder caused by brain damage which affects a person's ability to communicate. The principal signs of aphasia are impairments in the ability to express oneself when speaking, trouble understanding speech, and difficulty with reading and writing. Aphasia is most often the result of stroke or head injury, but can also occur in other neurological disorders, such as brain tumor or Alzheimer's disease. The effects of aphasia differ from person to person, and can sometimes benefit from speech therapy. Strategies to communicate non-verbally (without words) may also be helpful to the person with aphasia. What is primary progressive aphasia?

2. NAA: Newsletter Diagnosing primary progressive aphasia. Alan Mandell, MD Boston University Schoolof Medicine. primary progressive aphasia. Aphasiology 1992; 61 16. Mesulam MM. http://www.aphasia.org/newsletter/Fall2002/DiagnosingPPA.html

National Aphasia Association Newsletter Volume 14, Number 2, Fall 2002 Diagnosing Primary Progressive Aphasia Alan Mandell, MD Boston University School of Medicine Aphasia is the loss or impairment of the use of language due to brain damage. The signs of aphasia are errors in verbal output including word-finding problems, trouble understanding speech, and difficulty in reading and/or writing. Language is a “localized” brain function, meaning that some brain regions are more important for language than others. (In contrast, personality is mostly a non-localized brain function.) Aphasia usually results from damage to the left side of the brain; it is unusual for aphasia to result from right-sided brain damage. The severity of aphasia and prognosis for recovery depend on the volume of tissue damage and its exact location(s), the type of injury, and whether other parts of the brain are also damaged. The onset of aphasia is usually sudden as the cause is most often stroke or traumatic brain injury. Infection can also cause the rapid onset of aphasia. The onset of aphasia is, however, not always sudden. “Primary Progressive Aphasia” (PPA) is one of several labels attached to a language disorder “of insidious onset, gradual progression and prolonged course, in the absence of generalized cognitive impairments (at least for a substantial period of time), due to a degenerative [brain] condition” (Duffy). In layperson's terms, it is a slowly worsening aphasia not due to stroke, trauma, tumor or infection. It is sometimes called "progressive aphasia without dementia." Mesulam, who coined the term "primary progressive aphasia," believes that the aphasia must exist with no significant memory, behavioral, intellectual or visual impairments at least for two years before one can correctly use it diagnostically. (In some cases these other symptoms do appear later on, in which case the diagnosis is amended.)

3. Treatment Of Primary Progressive Aphasia At Mayo Clinic Mayo Clinic Medical Services primary progressive aphasia. Treatment ofprimary progressive aphasia at Mayo Clinic. (Synonyms Semantic http://www.mayoclinic.org/ppa/

Home About Mayo Clinic Contact Us Mayo Clinic Locations: Arizona Florida Minnesota Mayo Clinic ... Medical Services Primary Progressive Aphasia Primary Progressive Aphasia Treatment Appointments Clinical Trials Research ... Medical Services Treatment of Primary Progressive Aphasia at Mayo Clinic (Synonyms: Semantic aphasia, semantic dementia, progressive nonfluent aphasia, chronic progressive aphasia) Primary progressive aphasia (often abbreviated PPA) is a degenerative disorder of the brain in which nerve cells die over time, causing a progressive decline in language skills. Symptoms include poor recall of names of people or objects, difficulties with speech, poor comprehension, etc. Although no cure for primary progressive aphasia yet exists, there are several medications as well as many non-medication approaches that can potentially improve daily functioning and quality of life. One of the keys to effective management is a coordinated approach to the treatment options. Mayo Clinic offers a multidisciplinary approach that involves a comprehensive evaluation of the patient's disease and associated symptoms by physicians who have extensive experience in the diagnosis and treatment of patients with primary progressive aphasia. These specialists include neurologists, speech pathologists, speech therapists, neuropsychologists, neuroradiologists, psychiatrists, sleep medicine clinicians and physical medicine specialists. Treatment programs are tailored to each individual patient and take into account the patient's and family's needs while providing state-of-the-art care and access to new developments and appropriate clinical trials.

4. Treatment Of Primary Progressive Aphasia At Mayo Clinic In Rochester, Minn. Mayo Clinic Rochester Medical Services primary progressive aphasia. Treatmentof primary progressive aphasia at Mayo Clinic in Rochester. http://www.mayoclinic.org/ppa-rst/

Home About Mayo Clinic Contact Us Mayo Clinic Locations: Arizona Florida Minnesota Mayo Clinic ... Medical Services Primary Progressive Aphasia Primary Progressive Aphasia Treatment Appointments Clinical Trials Research ... Medical Services Treatment of Primary Progressive Aphasia at Mayo Clinic in Rochester Primary progressive aphasia (often abbreviated PPA) is a degenerative disorder of the brain in which nerve cells die over time, causing progressive language impairment. Symptoms include poor recall of names of people or objects, difficulties with speech, poor comprehension, etc. Although no cure for primary progressive aphasia yet exists, there are several medications as well as many non-medication approaches that can potentially improve daily functioning and quality of life. One of the keys to effective management is a coordinated approach to the treatment options. Mayo Clinic's Experience with PPA Mayo Clinic offers a multidisciplinary approach that involves a comprehensive evaluation of the patient's disease and associated symptoms by physicians who have extensive experience in the diagnosis and treatment of patients with primary progressive aphasia. These specialists include neurologists, speech pathologists, speech therapists, neuropsychologists, neuroradiologists, psychiatrists, sleep medicine clinicians, and physical medicine specialists. Treatment programs are tailored to each individual patient and take into account the patient's and family's needs while providing state-of-the-art care and access to new developments and appropriate clinical trials.

5. References: Primary Progressive Aphasia & AAC References primary progressive aphasia AAC. Compiled by Margaret A. Rogers, Julia M. King Nancy B. Alarcon. from a chapter to appear (July of 2000) in the following volume 1997). Principled http://aac.unl.edu/reference/PPA_AAC.html

from a chapter to appear (July of 2000) in the following volume: Augmentative Communication for Adults with Neurologic and Neuromuscular Disabilities Edited by: David R. Beukelman, Kathryn Yorkston, and Joe Reichle Paul H. Brookes Publishing Co., Inc. Aphasiology,11(12) Comptes Rendus des Seances de laSociete de Biologie (Paris), 49 Aphasiology Archives of Physical Medicine and Rehabilitation, 77 Annals of Neurology Augmentative communication in the medical setting (pp. 245-338). Tucson, AZ: Communication Skill Builders. Neurology Neurology Neurology Aphasiology Journal of the InternationalNeuropsychological Society Archives of Neurolology Journal of Neurology, Neurosurgery, and Psychiatry Archives of Neurology, Journal ofCommunication Disorders Light, J. C. (1988). Interaction involving individuals using augmentative and alternative communication systems: State of the art and future directions. Augmentative and Alternative Communication, 4, Building communicative competence with individuals who use augmentative and alternative communication. Baltimore: Paul H. Brookes Publishing.

6. CNADC - Primary Progressive Aphasia And Frontal Dementia Featuring a patientand-family guide to PPA and description of the PPA Program of Northwestern University's Cognitive Neurology and Alzheimer's Disease Center. http://www.brain.nwu.edu/ppa/index.html

Search Northwestern Search Help CNADC CNADC CNADC Links About CNADC Memory, Dementia, and AD PPA and Frontal Dementia Cognitive Brain Mapping Group Clinical Services Employment For more information about the PPA Program, please contact: Dr. Nancy Johnson, PPA Program 320 E. Superior, Suite 11-499 Chicago, IL 60611 phone: 312 908-9432 fax: 312-908-8789 email: ppa@northwestern.edu If you would like to schedule an appointment, or talk with someone about billing or related questions, please contact: Neurobehavior and Memory Health Services Clinic 675 N. St. Clair, Galter 20-100 Chicago, IL 60611 phone: 312 695-9627 PPA Program Program Information PPA Newsletter PPA Newsletter Comment Form Handbook Introduction to PPA Diagnosis Treatment For Family and Friends ... Resources Support Find a Clinician Family Correspondence List International PPA Database (for researchers only) Register for Access to Databases Terms and Conditions Search Submit Case Data Research Research Areas and Faculty Literature References Calls for Collaboration Frontal Dementia

7. CNADC - PPA Handbook What is primary progressive aphasia? primary progressive aphasia (PPA) is a form of dementia that can http://www.brain.northwestern.edu/ppa/handbook.html

Search Northwestern Search Help CNADC CNADC PPA Handbook CNADC Links About CNADC Memory, Dementia, and AD PPA and Frontal Dementia Cognitive Brain Mapping Group Clinical Services Employment Program Information PPA Newsletter PPA Handbook Diagnosis ... Research Areas and Faculty PPA Handbook What is Primary Progressive Aphasia? PPA begins very gradually and initially is experienced as difficulty thinking of common words while speaking or writing. PPA progressively worsens to the point where verbal communication by any means is very difficult. The ability to understand what others are saying or what is being read also declines. In the early stages, memory, reasoning and visual perception are not affected by the disease and so individuals with PPA are able to function normally in many routine daily living activities despite the aphasia. However, as the illness progresses, other mental abilities also decline. The time frame within which these changes occur varies greatly between patients. A few cases have been reported in which language deficits were the only symptoms for at least 10 years. On average, impairments are confined exclusively to the area of language for approximately 5 years, but may spread to other areas after 2 years.

8. CNADC - Primary Progressive Aphasia And Frontal Dementia Feinberg School of Medicine. CNADC primary progressive aphasia Frontal Dementia, primary progressive aphasia Frontal Dementia. http://www.brain.northwestern.edu/ppa/

Search Northwestern Search Help CNADC CNADC CNADC Links About CNADC Memory, Dementia, and AD PPA and Frontal Dementia Cognitive Brain Mapping Group Clinical Services Employment For more information about the PPA Program, please contact: Dr. Nancy Johnson, PPA Program 320 E. Superior, Suite 11-499 Chicago, IL 60611 phone: 312 908-9432 fax: 312-908-8789 email: ppa@northwestern.edu If you would like to schedule an appointment, or talk with someone about billing or related questions, please contact: Neurobehavior and Memory Health Services Clinic 675 N. St. Clair, Galter 20-100 Chicago, IL 60611 phone: 312 695-9627 PPA Program Program Information PPA Newsletter PPA Newsletter Comment Form Handbook Introduction to PPA Diagnosis Treatment For Family and Friends ... Resources Support Find a Clinician Family Correspondence List International PPA Database (for researchers only) Register for Access to Databases Terms and Conditions Search Submit Case Data Research Research Areas and Faculty Literature References Calls for Collaboration Frontal Dementia

9. NeuroGate.com Search results for "primary progressive aphasia" NO MATCHES FOUNDPlease select a different keyword or category OR. Search AltaVista for 'primary progressive aphasia' Global Search http://www.neurogate.com/neuro/result.php3?search=Primary Progressive Aphasia&am

10. CNADC - Primary Progressive Aphasia (PPA) Program primary progressive aphasia (PPA) Program. Thank you for your interestin the Northwestern Alzheimer’s Disease Center Primary Progressive http://www.brain.northwestern.edu/ppa/ppa.html

Search Northwestern Search Help CNADC CNADC PPA Program CNADC Links About CNADC Memory, Dementia, and AD PPA and Frontal Dementia Cognitive Brain Mapping Group Clinical Services Employment Program Information PPA Newsletter PPA Handbook Diagnosis ... Research Areas and Faculty Primary Progressive Aphasia (PPA) Program Primary Progressive Aphasia (PPA) is a form of dementia that can occur in individuals under the age of 65, sometimes as early as in the 40’s. "Aphasia" is a deficit in the capacity to use language for communication and it is evident in speaking, undertsanding what others are saying, naming common objects, reading and writing. PPA begins very gradually and is initially experienced as difficulty thinking of common words while speaking or writing. However, there are individual differences and the first symptoms can involve any aspect of language functioning. The NADC PPA Program is a 3-4 day, comprehensive, multidisciplinary approach to evaluation, diagnosis, and treatment of Primary Progressive Aphasia. Over the course of the examination, we may determine that PPA is not the correct diagnosis and will make appropriate recommendations in that event. The PPA Program consists of four main components:

11. Primary Progressive Aphasia primary progressive aphasia. This article submitted by Doug on 6/21/99. She has just been diagnosed with primary progressive aphasia. Her words are mixed up, and she can't http://neuro-www.mgh.harvard.edu/forum_2/HuntingtonsDiseaseF/6.21.991.46AMPrimar

This Web Forum is not moderated in any sense. Anyone on the Internet can post articles or reply to previously posted articles, and they may do so anonymously. Therefore, the opinions and statements made in all articles and replies do not represent the official opinions of MGH and MGH Neurology. Neither is MGH or MGH Neurology responsible for the content of any articles or replies. No messages are screened for content. Primary Progressive Aphasia This article submitted by Doug on 6/21/99. Email Address: DWil13@ix.netcom.com (I had posted this in speech disorders forum a week ago, and had no response) Howdy! Hey, wondered if you folks could help my mother with some information. She has just been diagnosed with Primary Progressive Aphasia. Her words are mixed up, and she can't write like she used to, and this has been going on for about a year now. She was an English/Drama teacher for years, so it is very frustrating for her not to be able to be accurate with her spoken and written English. She just started taking Aricept but hasn't noticed any improvements yet. Also, her mother, my grandmother, had Huntingtons Chorea, and died of the complications of that disease. I can't help but think that there may be some conection between the two. My mother will be 65 in July, my grandmother was 59 when diagnosed with Huntingtons, and 71 when she died. Any advice and or information would be tremendously appreciated. My mother is on Web TV, and once I get more information, I will try to get her to post here herself.

12. Primary Progressive Aphasia - Information / Diagnosis / Treatment / Prevention home neurological disorders dementia primary progressive aphasia PrimaryProgressive Aphasia. Information • Diagnosis • Treatment • Prevention. http://www.healthcyclopedia.com/neurological-disorders/dementia/primary-progress

Home Health cyclopedia All Topics by Category The Good Health Search Engine Health Conditions A-Z Gurus ... dementia > primary progressive aphasia Primary Progressive Aphasia Information / Diagnosis / Treatment / Prevention External links (marked with an arrow ) open in a new window. This site is a web directory and does not offer medical advice. We cannot take responsibility for information found on listed sites. This Page Medical Definition Health News Web Directory: Medical Definition: University of Newcastle-upon-Tyne Medical Dictionary: "aphasia, primary progressive" Health News: Search millions of published articles for news on Primary Progressive Aphasia Modern Medicine Aging The Ardell Wellness Report HealthFacts Medical Post Medical Update Men's Health and the National Women's Health Report Note: Subscription required to access the full text of articles. Web Directory: Understanding Primary Progressive Aphasia An article with a description, assistance available and where to obtain additional information. WebMD Live Chat Transcript: Living with aphasia with Martha Taylor Sarno, MD. Notes: Healthcyclopedia presents health information in the form of websites and articles that encompass conventional medicine and alternative treatments Under no circumstances can it recommend or endorse a specific drug or therapy or treatment.

13. NEJM -- Primary Progressive Aphasia -- A Language-Based Dementia Review Article from The New England Journal of Medicine primary progressive aphasia A LanguageBased Dementia 2004). Left Hemicranial Hypoplasia in 2 Patients With primary progressive aphasia. Arch Neurol 61 265-268 http://www.nejm.org/cgi/content/short/349/16/1535

HOME SEARCH CURRENT ISSUE PAST ISSUES ... HELP Please sign in for full text and personal services Previous Volume 349:1535-1542 October 16, 2003 Number 16 Next M.-Marsel Mesulam, M.D. Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings. Full Text PDF PDA Full Text Add to Personal Archive ... Chapters at Harrison's Dementia is a generic term used to designate chronically progressive brain disease that impairs intellect and behavior to the point where customary activities of daily living become compromised. In some patients, specific abnormalities, such as a vitamin B deficiency, normal pressure hydrocephalus, multiple strokes, paraneoplastic encephalitis, or human immunodeficiency virus infection, are identified as the underlying cause. In others, characteristic sensory or motor abnormalities indicate that the dementia is a component of a more extensive neurologic disease such as Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis, or multiple sclerosis. In the majority of

14. NEJM -- Primary Progressive Aphasia -- A Language-Based Dementia Review Article from The New England Journal of Medicine Primary ProgressiveAphasia A LanguageBased Dementia. Language in primary progressive aphasia. http://content.nejm.org/cgi/content/short/349/16/1535

HOME SEARCH CURRENT ISSUE PAST ISSUES ... HELP Please sign in for full text and personal services Previous Volume 349:1535-1542 October 16, 2003 Number 16 Next M.-Marsel Mesulam, M.D. Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings. Full Text PDF PDA Full Text Add to Personal Archive ... Chapters at Harrison's Dementia is a generic term used to designate chronically progressive brain disease that impairs intellect and behavior to the point where customary activities of daily living become compromised. In some patients, specific abnormalities, such as a vitamin B deficiency, normal pressure hydrocephalus, multiple strokes, paraneoplastic encephalitis, or human immunodeficiency virus infection, are identified as the underlying cause. In others, characteristic sensory or motor abnormalities indicate that the dementia is a component of a more extensive neurologic disease such as Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis, or multiple sclerosis. In the majority of

15. Pick's Disease Support Group - Primary Progressive Aphasia, Pick's Disease Suppo Factsheets (CANDID). primary progressive aphasia Extract from the PPAnewsletter issued by Dr. Nancy Johnson, Northwestern University http://www.pdsg.org.uk/Factsheets/PPAphasia.htm

PDSG Newsletters Latest Archive Information Communication Factsheets General Internet Forum Messages Join YahooGroups Events Meetings Roadshow Contacts Email Directory PDSG Phone Directory Articles Caregivers Home Alone Poetry Factsheets (C.A.N.D.I.D.) Primary Progressive Aphasia Extract from the PPA newsletter issued by Dr. Nancy Johnson, Northwestern University Medical School, The Cognitive Neurology and Alzheimer Center, Chicago. Primary Progressive Aphasia (PPA) is a disorder caused by degenerative diseases of the brain, in which speech and language functions deteriorate gradually over a period of years, while memory and other abilities remain relatively preserved. This form of dementia tends to occur more often in men than in women. SYMPTOMS: Symptoms can begin as early as the 40's, but can appear any time afterwards. Initially, the symptoms of PPA are confined exclusively to the area of language functions. The types of language difficulties that occur differ between patients, but generally involve things such as the following: Increased difficulty thinking of words substituting the wrong word (e.g. "school" for "work")

16. Pick's Disease Support Group - Caregiver Stories, Pick's Disease Support Group - and because its symptoms are so easy to confuse with something else often Alzheimer sdisease in the case of the primary progressive aphasia patients, or http://www.pdsg.org.uk/articles/JDFC-2.htm

PDSG Newsletters Latest Archive Information Communication Booklet Factsheets General ... Internet Forum Messages Join YahooGroups Events Meetings Contacts Email Directory PDSG Phone Directory Articles Caregivers Home Alone Poetry The following article is reproduced by kind permission of the John Douglas French Center for Alzheimer's Disease and appeared in Volume X of their Journal Page 1 Page 3 Page 4 It's only been in the last two years that autopsy findings have confirmed the existence of a degenerative disease called frontotemporal dementia, distinct from Alzheimer's disease. As the name suggests, FTD affects the brain's frontal and temporal lobes (in marked contrast to Alzheimer's, which tends to originate in the back of the brain before spreading forward). In some cases, Pick bodies can be found in the brains of frontotemporal dementia patients, but Pick's is now thought to be only one of several subtypes of a disease that is probably more common than was previously believed, representing as much as 20 percent of all dementias. FTD is considered a pre-senile dementia, typically becoming symptomatic when patients are in their 50s and 60s. Its progression is thought to be slow; in fact, some experts suspect that the process may begin decades before symptoms become apparent.

17. A GUIDE FOR ALZHEIMER'S CARERS -Primary Progressive Aphasia SEEKING A DIAGNOSIS. primary progressive aphasia primary progressive aphasia. primary progressive aphasia (PPA) is a disorder caused by degenerative diseases of the brain http://www.caringforcarers.net/diagnosis/dic3.html

18. AAC-Medicare Resources diseases. primary progressive aphasia. AACMedicare WWW Site. For information Co.Reference List. primary progressive aphasia. WWW Sites http://aac.unl.edu/AACMedicare.html

AAC-Medicare Resources Amyotrophic Lateral Sclerosis Also known as ALS and Lou Gehrig disease AAC-Medicare WWW site For information about Medicare Policy, Procedures, Sample Assessment Reports, and Frequently Asked Questions Books with Chapters Dealing with AAC Interventions for Persons with ALS Augmentative and alternative communication: Management of severe communication disorders in children and adults (Second Edition). Baltimore: Paul H. Brookes Publishing Co. Augmentative and alternative communication for adults with acquired neurologic disorders. Baltimore, MD: Paul H. Brookes Publishing Co. Speaking up and spelling out: Personal essays on augmentative and alternative communication. Baltimore, MD: Paul H. Brookes Publishing Co. Management of speech and swallowing disorders in degenerative disease. Austin, TX: Pro-ed. Reference List AAC for Persons with ALS WWW Sites of Interest PALS American ALS Society Amyotrophic lateral sclerosis Neurological diseases Non-Progressive Aphasia and Apraxia AAC-Medicare WWW site For information about Medicare Policy, Procedures, Sample Assessment Reports, and Frequently Asked Questions

19. Wordbank On The Mental Health Foundation Website Home, You are in Wordbank. A B C D E F G H I J K L M N O P Q R S TU V W X Y Z. primary progressive aphasia (PPA). A form of dementia http://www.mentalhealth.org.uk/wordbank.cfm?wordid=669&wbletter=P

20. Disease Directory : Neurological Disorders : Dementia : Primary Progressive Apha Diseases Neurological Disorders Dementia primary progressive aphasia. DYSPHAGIAprimary progressive aphasia DYSPHAGIA primary progressive aphasia. http://www.diseasedirectory.net/Neurological_Disorders/Dementia/Primary_Progress

Wednesday, June 02, 2004 Neurological Disorders Dementia AIDS Dementia Complex Care Givers ... Dementia : Primary Progressive Aphasia [DYSPHAGIA] Primary Progressive Aphasia - [DYSPHAGIA] Primary Progressive Aphasia. Please pardon the language question but I am seeking info on Primary Progressive Aphasia. [DYSPHAGIA] Primary Progressive Aphasia - [DYSPHAGIA] Primary Progressive Aphasia. A recent article by Westbury, and Bub (1997) Primary Progressive Aphasia: A review of 112 cases. - PRIMARY PROGRESSIVE APHASIA. Analisys of 16 cases. KEY WORDS: primary progressive aphasia, focal cortical degeneration, cerebral perfusion, neuroimaging. Axonal injury within language network in primary progressive ... - Click here to read Axonal injury within language network in primary progressive aphasia. Catani M, Piccirilli M, Cherubini A, Tarducci Conditions and Diseases - Primary Progressive Aphasia Top Links - Primary Progressive Aphasia Web Site Links. Primary Progressive Aphasia - A description of what this is, the symptoms and its course. Geometry.Net - Health_Conditions: Primary Progressive Aphasia

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