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         Portal-systemic Encephalopathy:     more detail
  1. Chronic portal-systemic encephalopathy: An experimental study with special reference to brain serotonin (Bulletin No. 66 from the Department of Surgery, Lund University) by Finn Bengtsson, 1987

21. Karger Publishers
portalsystemic encephalopathy (PSE) results from portal-systemic shunting ofvenous blood that arises either spontaneously or due to surgical portacaval
http://content.karger.com/ProdukteDB/produkte.asp?Aktion=ShowFulltext&ProduktNr=

22. NEJM -- Sign In
Dietary management of portalsystemic encephalopathy. In Conn HO,Bircher J, eds. Hepatic encephalopathy syndromes and therapies.
http://content.nejm.org/cgi/content/full/337/26/1921-a

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23. Portal-Systemic Encephalopathy By Sanjay Sandhir, MD, Frederick L
portalsystemic encephalopathy by Sanjay Sandhir, MD, Frederick L. Weber, Jr,MD,. Figure 3 Algorithm for the treatment of portal-systemic encephalopathy.
http://www.medicus.hotmail.ru/gastro/hepar.html
Portal-Systemic Encephalopathy by Sanjay Sandhir, MD Frederick L. Weber, Jr, MD Current Practice of Medicine Key Points Introduction Portal-systemic encephalopathy (PSE) is a common disorder characterized by a mental disturbance that accompanies the portal-systemic shunting of blood. PSE usually occurs in patients with chronic liver disease and portal hypertension whose portal systemic shunts are either spontaneous or are created surgically, but the transjugular intrahepatic portal-systemic shunt (TIPS) procedure accounts for an increasing number of portal-systemic shunts. PSE can be distinguished from other types of hepatic encephalopathy, most importantly from the encephalopathy that accompanies acute liver failure, which is termed fulminant hepatic failure PSE is a complex neuropsychiatric syndrome with a wide range of signs and symptoms. Many clinical situations are grouped under the broad term hepatic encephalopathy , including PSE; inherited urea cycle enzyme deficiencies; fulminant hepatic failure due to viruses, alcohol, or toxins; and Reyes syndrome. PSE may present with different patterns, including acute, acute recurrent, chronic, or subclinical PSE. Each of these types is potentially reversible, except for certain motor abnormalities when associated with structural alterations in the brain or spinal cord [ Pathogenesis PSE is a metabolic encephalopathy that is thought to be precipitated when the brain is exposed to toxic metabolites of gut origin caused by poor hepatic clearance and portal-systemic shunts. Most interest has focused on nitrogenous metabolites, ammonia in particular, because of the dramatic effect of dietary protein in precipitating hepatic encephalopathy. Blood is usually elevated in patients with PSE [

24. Printed From Www.health.uab.edu On 6/2/2004 8:25:10 PM
Liver encephalopathy is also called portalsystemic encephalopathy,hepatic encephalopathy, or hepatic coma. Symptoms may include
http://www.health.uab.edu/show.asp?durki=60832&print=yes

25. Specialty Laboratories ::: We Help Doctors Help Patients
10 The most common type of HE is portalsystemic encephalopathy (PSE),which occurs almost exclusively in patients with cirrhosis.
http://www.specialtylabs.com/books/display.asp?id=200

26. Hepatitis Central, References, Subclinical Hepatic Encephalopathy Impairs Daily
1. Butterworth RF. Pathogenesis and treatment of portalsystemic encephalopathyan update. 3. Gitlin N. Subclinical portal-systemic encephalopathy.
http://www.hepatitis-central.com/hcv/symptoms/encephalopathy/references.html
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27. CV: Vemuganti
RM and Butterworth RF (1995) Selective alterations of extracellular brain amino acidsin relation to function in portalsystemic encephalopathy Results of an
http://www.neurosurg.wisc.edu/cvvem.htm
University of Wisconsin
Department of Neurological Surgery
CURRICULUM VITAE
Raghavendra Rao L. Vemuganti
Assistant Scientist
Dept. of Neurological Surgery
University of Wisconsin-Madison
F4/309 Clinical Science Center
600 Highland Avenue
Madison, WI 53792, USA
Education
1982 B.Sc., Zoology, Botony and Chemistry, Andhra University, India
1984 M.Sc., Life Sciences (Animal Sciences), University of Hyderabad, India 1986 M.Phil., Life Sciences (Neurochemistry), University of Hyderabad, India 1991 Ph.D. Life Sciences (Neurochemistry), University of Hyderabad, India Fellowships 1984-1985 M.Phil. Fellowship, University of Hyderabad, India 1989-1991 Senior Research Fellowship award, Indian Council of Medical Research, India 1992-1993 Post-doctoral Fellowship Medical Research Council of Canada funded project 1993-1994 Post-doctoral Fellowship award, Jasper Foundation, University of Montreal 1993-1996 Medical Research Council of Canada, Direct Post-doctoral Fellowship Awards 1989 Best poster award, Indian Academy of Neuroscience Annual Meeting, Calcutta, India

28. Arq. Neuro-Psiquiatr.  Vol.57 no.2A; Abstract: S0004-282X1999000200024
Hyperintense basal ganglia on T1 weighted MR images case report in Manson sSchistosomiasis with portalsystemic encephalopathy. Arq.
http://www.scielo.br/scielo.php?script=sci_abstract&pid=S0004-282X1999000200024&

29. Arquivos De Neuro-Psiquiatria -
portal-systemic encephalopathy.
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X1999000200024&l

30. Cirrhosis
FETOR HEPATICUS. A particularly foul dead mouse smell found on the breath.Frequently precedes coma. portalsystemic encephalopathy (PSE).
http://janis7hepc.com/cirrhosis3.htm
Home Cirrhosis Back to Index Dermatologic aspects of liver disease Liver disease Dermatologic associations Cirrhosis Spider angiomas and other telangiectasia, palmar erythema, dilated abdominal wall veins, Terry s nails (white nail bed), Muehrcke s nails (transverse white bands), sparse axillary and pubic hair, gynecomastia, pruritus, jaundice Primary biliary cirrhosis Hyperpigmentation, xanthomas eruptive, plane, and tuberous; severe pruritus Hemochromatosis Bronze color Wilson s disease Kayser-Fleischer ring, blue lunulae Viral hepatitis: A Urticaria, vasculitis B Polyarteritis nodosa, small-vessel vasculitis C Livedo reticularis (Figure 28), essential mixed cryoglobulinemia, porphyria cutanea tarda (Figure 29), linchen planus (?) Gastrointestinal disorders with prominent cutaneous features may be inherited or acquired. Liver disease commonly is associated with cutaneous abnormalities (Table above). Recently it has become evident that hepatitis C viral infection is associated with porphyria cutanea tarda, cryoglobulinemia, and possibly lichen planus. Recognition of this disease in various multisystem disorders with protean manifestations can lead to a change in the therapeutic approach. Because initial infection with hepatitis C is often asymptomatic and there may be a long latency period to the development of an associated condition, we predict that more patients with these cutaneous diseases will be seen in the future.

31. Common Characteristics Of Liver Disease - Lucile Packard Children's Hospital
blood. Liver encephalopathy is also called portalsystemic encephalopathy,hepatic encephalopathy, or hepatic coma. Symptoms may
http://www.lpch.org/DiseaseHealthInfo/HealthLibrary/digest/livdisea.html
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Common Characteristics of Liver Disease
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When diagnosing liver disease, the physician looks at the patient's symptoms and conducts a physical examination. In addition, the physician may request a liver biopsy, liver enzyme tests, an ultrasound, or a CT scan (computed tomography scan). Some common liver disease symptoms include the following, each of which are described briefly below:
  • jaundice cholestasis liver enlargement portal hypertension ascites liver encephalopathy liver failure
What is jaundice? Jaundice is a yellow discoloration of the skin and whites of the eyes due to an abnormally high level of bilirubin (bile pigment) in the bloodstream, which is then excreted through the kidneys. High levels of bilirubin may be attributed to inflammation or other abnormalities of the liver cells, or blockage of the bile ducts. Sometimes jaundice is caused by the breakdown of a large number of red blood cells, which can occur in newborns. Jaundice is usually the first sign, and sometimes the only sign, of liver disease. What is cholestasis?

32. Saint Margaret Mercy Healthcare Centers
liver. Liver encephalopathy is also called portalsystemic encephalopathy,hepatic encephalopathy, or hepatic coma. Symptoms may
http://www.smmhc.com/healthcontent/adult/liver/common.htm
@import url(../../../c/special.css); Hospital Info Physician Directory Clinics Specialty Programs ... For Doctors Only Common Characteristics of Liver Disease What are some common liver disease symptoms? When diagnosing liver disease, the physician looks at the patient's symptoms and conducts a physical examination. In addition, the physician may request a liver biopsy, liver function tests, an ultrasound, a computed tomography (CT) scan, and/or a magnetic resonance imaging (MRI) scan. Some common liver disease symptoms include the following, each of which are described briefly below:
  • jaundice
  • cholestasis
  • liver enlargement
  • portal hypertension
  • esophageal varices
  • ascites
  • liver encephalopathy
  • liver failure
What is jaundice? Jaundice is a yellow discoloration of the skin and whites of the eyes due to abnormally high levels of bilirubin (bile pigment) in the bloodstream. Urine is usually dark because of the bilirubin excreted through the kidneys. High levels of bilirubin may be attributed to inflammation, or other abnormalities of the liver cells, or blockage of the bile ducts. Sometimes, jaundice is caused by the breakdown of a large number of red blood cells, which can occur in newborns. Jaundice is usually the first sign, and sometimes the only sign, of liver disease.

33. Blackwell Synergy - Cookie Absent
reported a case of intrahepatic portal veinhepatic vein shunt with portal-systemicencephalopathy. 5 Ohnishi et al. A case of portal-systemic encephalopathy.
http://www.blackwell-synergy.com/links/doi/10.1046/j.1440-1746.2001.02508.x/full
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34. Blackwell Synergy - Cookie Absent
7, Chu NS, Yang SS. portalsystemic encephalopathy alterations in somatosensoryand brainstem auditory evoked potentials. J. Neurol. Sci. 1988; 84 41-50.
http://www.blackwell-synergy.com/links/doi/10.1111/j.1440-1746.2003.03281.x/enha
 Home An Error Occurred Setting Your User Cookie A cookie is a small amount of information that a web site copies onto your hard drive. Synergy uses cookies to improve performance by remembering that you are logged in when you go from page to page. If the cookie cannot be set correctly, then Synergy cannot determine whether you are logged in and a new session will be created for each page you visit. This slows the system down. Therefore, you must accept the Synergy cookie to use the system. What Gets Stored in a Cookie? Synergy only stores a session ID in the cookie, no other information is captured. In general, only the information that you provide, or the choices you make while visiting a web site, can be stored in a cookie. For example, the site cannot determine your email name unless you choose to type it. Allowing a web site to create a cookie does not give that or any other site access to the rest of your computer, and only the site that created the cookie can read it. Please read our for more information about data collected on this site.

35. Sodbrennen-Welt - Über Die Gesundheit Von Magen Und Speiseröhre
Dig Dis Sci. 1980 Dec; 25(12) 9248. Treatment of chronic portal-systemicencephalopathy with lactose in lactase-deficient patients.
http://www.sodbrennen-welt.de/science/1980/1980_7004808.htm

36. A To Z Encyclopedia Topic: Liver Failure
liver. Liver encephalopathy is also called portalsystemic encephalopathy,hepatic encephalopathy, or hepatic coma. Symptoms of
http://web1.tch.harvard.edu/cfapps/A2ZtopicDisplay.cfm?Topic=Liver Failure

37. Re: Protonix !!!
lactulose for Adjunct in the prevention and treatment of portalsystemic encephalopathy(PSE); treatment of chronic constipation. Regarding Interactions;.
http://www.rxlist.com/rxboard/general.pl?read=776

38. Dictionary Definition Of PORTAL-SYSTEMIC ENCEPHALOPATHY
ILM Klinisk Farmakologi Bergqvist, PBF, Hjort, S., Apelqvist, G. Bengtsson, F. Potassium-evoked neuronalrelease of serotonin in experimental chronic portal-systemic encephalopathy.
http://www.dictionarybarn.com/PORTALSYSTEMIC-ENCEPHALOPATHY.php
Dictionary definition of PORTAL-SYSTEMIC ENCEPHALOPATHY
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An encephalopathy associated with cirrhosis of the liver, attributed to the passage of toxic nitrogenous substances from the portal to the systemic circulation; cerebral manifestations may include coma.
Synonym: hepatic encephalopathy.
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39. Clinical Care Options For Hepatitis - Login
intervals with laboratory tests to identify major complications (ascites, gastrointestinalbleeding, portalsystemic encephalopathy, hepatocellular carcinoma
http://www.clinicaloptions.com/hep/jw/abstract/Benvegnu-Gut-2004-05.asp

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40. Layton F. Rikkers, MD, ]on Thompson, MD, Merril T. Dayton, MD
portalsystemic encephalopathy. portal-systemic encephalopathy isa psychoneuro­logic syndrome secondary to hepatocellular dysfunc
http://surgery.uchicago.edu/ed/HTMLs/General/30Liver.htm
Liver Layton F. Rikkers, M.D., ]on Thompson, M.D., Merril T. Dayton, M.D., Hollis W. Merrick III M.D., and Richard Gusberg, M.D. ASSUMPTIONS The student understands the anatomy of the liver. The student understands the anatomy of portal circula­tion. The student understands the pathology of liver cysts and neoplasms. Describe the treatment modalities available for Portal Hypertension Anatomy and Physiology of the Hepatic Circulation The liver has a dual blood supply, receiving blood from both the hepatic artery and the portal vein. The portal vein is formed behind the pancreas by the con­fluence of the superior mesenteric and splenic veins. It is the most posterior structure in the hepatoduodenal ligament (Fig. 24.1). The portal vein bifurcates into right and left branches just before entering the substance of the liver. The left gastric or coronary vein, which drains the lesser curvature of the stomach, enters the portal vein near its origin. The coronary vein is normally a minor branch of the portal vein but becomes a major collateral when portal venous pressure is elevated. The splenic vein lies behind the pancreas for most of its length and is usually joined by the inferior mesenteric vein just prior to entering the portal vein. Many of the hormones secreted into the portal ve­nous circulation have a role in the regulation of hepatic metabolism. In addition, some hormones, particularly insulin, have trophic effects on the liver and contribute to maintenance of normal liver size, function, and ca­pacity for regeneration.

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