21. Polycystic Kidney Disease National Center for Biotechnology Information a division of the National Library of Medicine at the National Institutes of Health gives a description of this disease. http://www.ncbi.nlm.nih.gov/books/bv.fcgi?call=bv.View..ShowSection&rid=gnd.

22. Polycystic Kidney Of The Kidney polycystic kidney of the Kidney From the Virtual Pathology Museum, Department of Pathology, University of Connecticut Health Center polycystic kidney, Kidney. Infantile polycystic kidney . The cysts affect the renal parenchyma diffusely http://radiology.uchc.edu/Code/639.htm

Polycystic kidney, Kidney Infantile Polycystic Kidney • The cysts affect the renal parenchyma diffusely. • Both the cortex and the medulla are affected. • The cysts involving the cortex are not spherical, but tend to be elongate. They actually represent cystically dilated collecting ducts and tubules. Image Contrib. by: UCHC Description by: H. Yamase, M.D. ( 529-8003) More Information

23. Feline Symposium - Polycystic Kidney Disease In Cats polycystic kidney Disease in Cats. Susan Newell, DVM, MS Diplomate polycystic kidney Disease in Cats. Autosomal dominant polycystic kidney disease http://www.netcat.org/symposium/PKD.html

Polycystic Kidney Disease in Cats Susan Newell, DVM, MS Diplomate, American College of Veterinary Radiology College of Veterinary Medicine Polycystic Kidney Disease in Cats Autosomal dominant polycystic kidney disease (PKD) is the most common genetic disease of human beings, and has recently been recognized in cats. This disease is characterized by progressive development of fluid filled cysts within the kidneys, which distort the normal renal architecture and can lead to renal failure in many affected animals. The Persian breed and other breeds of Persian heritage are frequently affected. The simplest and most accurate method of identifying affected cats has been abdominal ultrasound, where the cysts appear as black round structures with acoustic enhancement within the renal cortex and medula. Studies have shown that ultrasound can correctly identify PKD in cats that are only 7 weeks of age. Provided that the cat is 10 months of age or older, over 95% of those cats that are affected with PKD can be accurately identified with ultrasound. Recently, many cat breeders have used ultrasound PKD screening clinics as a means to identify and potentially eliminate this disease from their bloodlines. To date, over 4400 cats in the United States have been evaluated with 37% of these cats diagnosed positive for the disease. This seminar will review the pertinent facts and literature about PKD with particular emphasis on diagnostic techniques used to evaluate PKD.

24. CFA Health Committee - PKD Seminar Update polycystic kidney Disease Seminar. polycystic kidney Disease affects 600,000 Americans and more than 12 million people worldwide. http://www.cfainc.org/health/pkd-seminar.html

Feline Health Asthma Inflammatory Bowel Disease Cat Scratch Disease Feline Immunodeficiency Virus (FIV) ... Hip Dysplasia Autosomal Dominant Polycystic Kidney Disease in Persian Cats Polycystic Kidney Disease Seminar Feline Respiratory Virus Non-obstructive Lower Urinary Tract Disease in the Cat Feline Bladder Stones and Urinary Obstructions Feline Reproduction Feline Reproduction Series Blood Type Incompatibility and Kitten Mortality Feline Care Antifreeze Warning! Chronic Gingivitis in the Cat Early Spay/Neuter in the Cat Feline Dental Pathology and Care ... Vaccination Protocols for Catteries Cats and Plants Easter Lilies Deadly to Cats Lilies Dangerous to Cats Non-Toxic Plants Toxic Plants Related Links Pet Ownership for Immunocompromised People Feline Genome Project - Genetics! for Cats Polycystic Kidney Disease Seminar Update by Betty White Chairman, CFA Health Committee Philadelphia, PA June 1998 The PKD Seminar was held in Philadelphia at the CFA Annual on Saturday at 2 pm and lasted, with questions and answers, until 4 pm. The group attending numbered about 75, a very good turnout considering the variety of options available that afternoon. Pamphlets which were reproductions of the CFA Health Committee website article on PKD were available. Joining me on the panel were Debi Faryna (NIH and one of our genetics advisors to Breeds and Standards), Sue Helmke (Marhei Persians), Hilary Helmrich (President of the Winn Foundation/Abydos Abyssinians and Persians), Dr. Leslie Lyons (NIH and presently involved in the Havana Brown project), and Anna Sadler (CFA Legislative Committee/Brannaway Persians).

25. Glenn Foley Wings Foundation Glenn Foley, a veteran NFL quarterback, and his foundation have created this site to help educate and inspire others to help fight polycystic kidney Disease. http://www.wings4pkd.org/

Click to enter! Click to enter!

26. Polycystic Kidney Disease (PKD) Access Center Home Page of the polycystic kidney Disease (PKD) Access Center Patient support for those with or knowing someone with PKD. Polycystic http://www.nhpress.com/pkd/

Polycystic Kidney Disease (PKD) Access Center Welcome ! This site is dedicated to all those who have or know someone who has (had) Polycystic Kidney Disease. Do you know of information or have any ideas that might improve this site? CLICK HERE! Introduction ... HotList (Links) Library What's New Basics Advanced The Kidney Glossary References Click to go to the NEW NOTE: This page is the beginning of another complete rewrite of previous Polycystic Kidney Disease (PKD) pages. Previous versions of this site were started on 21-Aug-98, 15-Dec-97 and 25-May-95. Interested in promoting faster revisions to this site? Contributions as small as $10 can help! Click Here! Jump to NHP Home Page NHP/ mao / 17-Sep-01 / nhp@nhpress.com New Horizons Press Designed by a member of

27. Our Polycystic Kidney Disease Page A personal site about polycystic kidney disease with chat room for sharing and support. http://www.geocities.com/HotSprings/5291/

Sign My Guestbook View My Guestbook You are the . person to view this page since 1/1/99 This site is a better place to be because of-My Mom! Thanks Mom!!! Last modified 1/1/99 This PKD Ring site is owned by Mary Elizabeth Jones

28. Basics: Polycystic Kidney Disease (PKD) What is PKD? What are the symptoms of PKD? What is the cause of PKD? . What Is PKD? PKD stands for polycystic kidney Disease . http://www.nhpress.com/pkd/basics.html

PKD Access Center The Basics of PKD What is PKD? symptoms cause of PKD? ] What Is PKD? PKD stands for "Polycystic Kidney Disease" The name for this disease comes from the fact that this is a disease involving many ("poly" = many in Greek) " cysts " that grow throughout the kidneys . These cysts are presumed to be what directly or indirectly cause the symptoms that are characteristic of this disease. Though they start out microscopic in size, as the accompanying picture shows, some of these cysts can become quite large. Jump to the PKD Access Center Symptoms Of PKD In the early stages of PKD , many people with the disease show no symptoms. As PKD progresses, symptoms such as the following may gradually start to develop: Hypertension , better known as "high blood pressure". (about 50% of PKD patients) Fatigue, or a general feeling of tiredness. Frequent urination, headaches, or urinary tract infections. Low back or flank pain. On the average, patients start to begin to notice these symptoms somewhere between ages 20 and 40. When the disease does become more advanced , it begins to noticeably affect several internal organs: Kidneys Both kidneys develop numerous and often large cysts . These cysts may get infected or sometimes may rupture. Substantial kidney enlargement is very common Kidney stones become more prevalent than in the general public Kidney function decreases markedly Liver Develops cysts in about 60% of PKD patients Almost never fails because of cysts In a few patients can cause chronic pain due to the size and location of the cysts

29. Polycystic Kidney Disease What is polycystic kidney Disease? polycystic kidney Disease has many symptoms. Individuals with PKD may not experience all of the symptoms. http://www.mamashealth.com/poly.asp

Mamashealth.com Home Category Links About Us Allergies Blood Diseases Cancers ... Read Health Books Links Email Mama What is Polycystic Kidney Disease? Polycystic kidney disease (PKD) is an inherited disease characterized by the growth of numerous cysts filled with fluid in the kidneys. PKD cysts can slowly replace much of the mass of the kidneys, reducing kidney function and leading to kidney failure. PKD can also cause cysts in the liver and problems in other organs, such as the heart and blood vessels in the brain. The cysts may also cause pain or may get infected. There are two types of PKD ( autosomal dominant and autosomal recessive Types? Autosomal dominant PKD is inherited. This kind of PKD accounts for about 90 percent of all PKD cases. The term "Autosomal dominant" means that if one parent has the disease, there is a 50 percent chance that the disease will pass to a child. Autosomal recessive PKD is also inherited. This type of PKD is rare. Parents that do not have the disease can have a child with the disease. How can this happen? Ib both parents carry the recessive gene and pass the recessive gene to their child, the child will have two recessive genes and develop the disease.(inherited). What are the symptoms of PKD?

30. Melanie's PKD Page The personal story of experiences with polycystic kidney disease and resources. http://victorian.fortunecity.com/ferndale/686/pkd.html

web hosting domain names email addresses Melanie's PKD Page This page is all about PKD (Polycystic Kidney Disease). Even though very few people have heard of it, Polycystic Kidney Disease affects 600,000 people in the U.S. alone, and 12.5 million world wide. There are more people with PKD than cystic fibrosis, muscular dystrophy, hemophilia, Downs syndrome and sickle cell anemia combined. Many PKD patients find it useful to have access to the same information as their doctors because many doctors are unfortunately pretty unfamiliar with the disease. I will try to bring you as much information and sources about the disease as possible. If you have any questions about PKD for any reason, or if you know of anyone who has the disease and is looking for more information or for support groups I encourage you to contact any of the sources I have listed here, or to ask me a question . I would also appreciate an email if you have any pertinent information I should add to this page. PKD has been a profound part of my life so far, and will only continue to become more so. Likewise, the information on this page is just the beginning, and will continue to grow as time and research allows. If there is just one person out there that this page might help, I will be grateful for having the opportunity to make a difference. How to help PKD Resources My personal experience with PKD How to help One woman and her dog are traveling across the country by car to raise awareness of PKD and money to help find a cure. You can use the

31. Polycystic Kidney Disease (PKD) Access Center Information about polycystic kidney disease, its symptoms, causes and progression. Research and support group. http://www.nhpress.com/pkd/index.html

Polycystic Kidney Disease (PKD) Access Center Welcome ! This site is dedicated to all those who have or know someone who has (had) Polycystic Kidney Disease. Do you know of information or have any ideas that might improve this site? CLICK HERE! Introduction ... HotList (Links) Library What's New Basics Advanced The Kidney Glossary References Click to go to the NEW NOTE: This page is the beginning of another complete rewrite of previous Polycystic Kidney Disease (PKD) pages. Previous versions of this site were started on 21-Aug-98, 15-Dec-97 and 25-May-95. Interested in promoting faster revisions to this site? Contributions as small as $10 can help! Click Here! Jump to NHP Home Page NHP/ mao / 17-Sep-01 / nhp@nhpress.com New Horizons Press Designed by a member of

32. EID V3 N2: Polycystic Kidney Disease: An Unrecognized Emerging Infectious Diseas polycystic kidney Disease An Unrecognized Emerging Infectious Disease? polycystic kidney disease (PKD) is one of the most common genetic diseases in humans. http://www.cdc.gov/ncidod/eid/vol3no2/miller.htm

Synopses Polycystic Kidney Disease: An Unrecognized Emerging Infectious Disease? Polycystic kidney disease (PKD) is one of the most common genetic diseases in humans. We contend that it may be an emerging infectious disease and/or microbial toxicosis in a vulnerable human subpopulation. Use of a differential activation protocol for the Limulus amebocyte lysate (LAL) assay showed bacterial endotoxin and fungal (1 3)-ß-D-glucans in cyst fluids from human kidneys with PKD. Fatty acid analysis of cyst fluid confirmed the presence of 3-hydroxy fatty acids characteristic of endotoxin. Tissue and cyst fluid from three PKD patients were examined for fungal components. Serologic tests showed Fusarium Aspergillus, and Candida antigens. IgE, but not IgG, reactive with Fusarium and Candida were also detected in cyst fluid. Fungal DNA was detected in kidney tissue and cyst fluid from these three PKD patients, but not in healthy human kidney tissue. We examine the intertwined nature of the actions of endotoxin and fungal components, sphingolipid biology in PKD, the structure of PKD gene products, infections, and integrity of gut function to establish a mechanistic hypothesis for microbial provocation of human cystic disease. Proof of this hypothesis will require identification of the microbes and microbial components involved and multifaceted studies of PKD cell biology. Examining the hypothesis that polycystic kidney disease (PKD) is an emerging infectious disease and/or microbial toxicosis in a vulnerable population of humans must begin with a review of the conceptual tools that relate disease etiology and progression to the identification of microbes, their cellular components, and shed toxins in affected persons (

33. Polycystic Kidney Disease (PCKD) polycystic kidney disease. from EdREN, the website of the Renal Unit of the Royal Infirmary of Edinburgh. What happens in polycystic kidney disease? http://renux.dmed.ed.ac.uk/EdREN/EdRenINFObits/PCKDLong.html

Polycystic kidney disease from EdREN , the website of the Renal Unit of the Royal Infirmary of Edinburgh What happens in polycystic kidney disease? Can anything else cause kidney cysts? What kidney trouble can PCKD cause? What else can PCKD do? ... Where can I get further information? What happens in polycystic kidney disease? Polycystic kidney disease (often shortened to PCKD or PKD ) is the commonest inherited cause of kidney failure. It may be inherited from either your mother or your father. Sometimes they will not know that they carry the disease. Not everyone with PCKD gets trouble from their kidneys. Can anything else cause kidney cysts? It is quite common for healthy people to have one or two cysts, and occasionally people may have several. But when the kidney is filled with many cysts, PCKD is the most likely diagnosis. There are some other rare diseases that very occasionally cause many kidney cysts. Infantile polycystic kidney disease is rare, causes liver damage as well as kidney trouble, and unfortunately often leads to affected children dying when they are young. It is not the same as the disease that occurs in adults. Up to contents What kidney trouble does PCKD cause?

34. Polycystic Kidney Disease polycystic kidney disease. from EdREN, the website of the Renal Unit of the Royal Infirmary of Edinburgh. What is polycystic kidney disease? http://renux.dmed.ed.ac.uk/EdREN/EdRenINFObits/PCKDShort.html

Polycystic kidney disease from EdREN , the website of the Renal Unit of the Royal Infirmary of Edinburgh What is polycystic kidney disease? Polycystic kidney disease, or PCKD , causes the kidneys to be slowly enlarged by many fluid-filled cysts. It is an inherited disease that can be passed on from your father or your mother, although they are sometimes unaware that they carry it. This page provides short information about it - more information is also available. How is it diagnosed? Often high blood pressure or an abnormal urine test leads to further tests. An ultrasound scan can show the cysts developing, although they may be too small to be seen until you are in your twenties or even later, even though you have the disease. Can it cause kidney failure? Kidney function is very slowly damaged by PCKD, and in some people the kidneys are eventually completely destroyed. It is quite a common cause of needing dialysis or a kidney transplant. However in some people the disease is mild, and they may never develop serious kidney failure, or only in old age. Can PCKD cause any other trouble?

35. EMedicine - Polycystic Kidney Disease : Article By Roser Torra, MD, PhD polycystic kidney Disease Autosomal dominant polycystic kidney disease (ADPKD) is one of the most common inherited disorders in humans. http://www.emedicine.com/med/topic1862.htm

(advertisement) Home Specialties CME PDA ... Patient Education Articles Images CME Patient Education Advanced Search Link to this site Back to: eMedicine Specialties Medicine, Ob/Gyn, Psychiatry, and Surgery Nephrology Polycystic Kidney Disease Last Updated: March 18, 2004 Rate this Article Email to a Colleague Synonyms and related keywords: PKD, autosomal dominant polycystic kidney disease, ADPKD, adult polycystic kidney disease, polycystic kidney disease type 1, PKD1, polycystic kidney disease type 2, PKD2, polycystic kidney disease type 3, PKD3, kidney failure, renal failure, dialysis-dependent kidney disease, renal cysts, kidney cysts, end-stage renal disease, ESRD, end-stage kidney disease, ESKD, renal transplantation, renal transplant, kidney transplantation, kidney transplant, hemodialysis, peritoneal dialysis AUTHOR INFORMATION Section 1 of 11 Author Information Introduction Clinical Differentials ... Bibliography Author: Roser Torra, MD, PhD , Consulting Staff, Hereditary Renal Diseases, Department of Nephrology, Fundacio Puigvert, Barcelona, Spain Editor(s): Laura Lyngby Mulloy, DO

36. EMedicine - Polycystic Kidney Disease : Article By Henrique M Lederman, MD, PhD polycystic kidney Disease In the description of these diseases, clear terminology is important. polycystic kidney Disease. Last Updated April 11, 2003, http://www.emedicine.com/ped/topic1846.htm

(advertisement) Home Specialties CME PDA ... Patient Education Articles Images CME Patient Education Advanced Search Link to this site Back to: eMedicine Specialties Pediatrics Nephrology Polycystic Kidney Disease Last Updated: April 11, 2003 Rate this Article Email to a Colleague Synonyms and related keywords: PKD, cystic kidney disease, genetic cystic disease, autosomal dominant polycystic kidney disease, ADPKD, adult polycystic kidney disease, autosomal recessive polycystic kidney disease, ARPKD, infantile polycystic kidney disease, medullary cystic disease, obstructive cystic disease, multicystic dysplasia, cystic dysplasia, cysts associated with systemic disease, tuberous sclerosis, von Hippel-Lindau disease AUTHOR INFORMATION Section 1 of 10 Author Information Introduction Clinical Differentials ... Bibliography Author: Henrique M Lederman, MD, PhD , Consulting Staff, Department of Radiology, The Children's Hospital of Philadelphia; Professor of Radiology, Chief, Division of Diagnostic Imaging in Pediatrics, Federal University of Sao Paulo, Brazil Coauthor(s): Peter J Hurh, BS

37. Discovery Health Polycystic Kidney Disease polycystic kidney disease (PKD) is an inherited condition that results in abnormally formed kidneys. It also causes throughout the body. http://health.discovery.com/diseasesandcond/encyclopedia/1708.html

38. Polycystic Kidney Disease polycystic kidney disease. Definition. polycystic kidney disease (PKD) is one of the most common of all lifethreatening human genetic disorders. http://www.healthatoz.com/healthatoz/Atoz/ency/polycystic_kidney_disease.html

Encyclopedia Index P Home Encyclopedia Encyclopedia Index P Polycystic kidney disease Definition Polycystic kidney disease (PKD) is one of the most common of all life-threatening human genetic disorders. It is an incurable genetic disorder characterized by the formation of fluid-filled cysts in the kidneys of affected individuals. These cysts multiply over time. It was originally believed that the cysts eventually caused kidney failure by crowding out the healthy kidney tissue. It is now thought that the kidney damage seen in PKD is actually the result of the body's immune system. The immune system, in its attempts to rid the kidney of the cysts, instead progressively destroys the formerly healthy kidney tissue. Description A healthy kidney is about the same size as a human fist. PKD cysts, which can be as small as the head of a pin or as large as a grapefruit, can expand the kidneys until each one is bigger than a football and weighs as much as 38lb (17 kg). There are two types of PKD: infantile PKD, which generally shows symptoms prior to birth; and adult onset PKD. Individuals affected with infantile PKD are often stillborn. Among the liveborn individuals affected with infantile PKD, very few of these children survive to the age of two. The adult onset form of PKD is much more common. The time and degree of symptom onset in the adult form of PKD can vary widely, even within a single family with two or more affected individuals. Symptoms of this form of PKD usually start to appear between the ages of 20 and 50. Organ deterioration progresses more slowly in adult onset PKD than it does in the infantile form; but, if left untreated, adult onset PKD also eventually leads to kidney failure.

39. The Feline PKD Home Page; Information About "Autosomal Dominant Polycystic Kidne Information about Autosomal Dominant polycystic kidney Disease, Feline PKD, PKD in cats. Autosomal Dominant polycystic kidney Disease in. http://www.felinepkd.com/

Home Basic Information, flyer Links to more PKD information Ultrasound Testing Form ... News This web site was opened to spread information about Feline PKD Autosomal Dominant Polycystic Kidney Disease in cats The main studies in this disease in cats have so far been done in Persian Cats and crosses between Persians and Domestic Shorthairs. This is the reason why mainly Persian Cats (and Exotic Shorthairs) are mentioned in the various articles/texts. My recommendation is that breeders of other breeds as well respect the presence of this dominantly inherited disease, and consider to have their breeding cats scanned by ultrasound in order to detect possible PKD. Marie Thiers Please, report broken links - thank you! April 4, 1995 - September 18, 2001 Autosomal Dominant Polycystic Kidney Disease in Persians / Exotic Shorthairs PKD / ADPKD What is Polycystic Kidney Disease - PKD? Polycystic Kidney Disease is an inherited kidney disease that has been found in Persian/Exotic cats. Feline Polycystic Kidney Disease (PKD) has been reported sporadically in the literature since 1967, but actual study into this renal disease did not begin until 1990. In1990 an affected female Persian was referred to the Ohio State University teaching hospital with symptoms of renal failure. Offspring of this female were used to start a colony and begin research into this condition.

40. NEJM -- Polycystic Kidney Disease Review Article from The New England Journal of Medicine polycystic kidney Disease. Next Next. polycystic kidney Disease. Patricia D. Wilson, Ph.D. http://content.nejm.org/cgi/content/short/350/2/151

HOME SEARCH CURRENT ISSUE PAST ISSUES ... HELP Please sign in for full text and personal services Previous Volume 350:151-164 January 8, 2004 Number 2 Next Polycystic Kidney Disease Patricia D. Wilson, Ph.D. Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings. Full Text PDF PDA Full Text Supplementary Material ... Chapters at Harrison's Polycystic kidney diseases are a leading cause of end-stage renal failure and a common indication for dialysis or renal transplantation. Recent advances have led to insights into mechanisms underlying the cause and prognosis of these diseases and suggest new directions for treatment. Polycystic kidney disease may arise sporadically as a developmental abnormality or may be acquired in adult life, but most forms are hereditary. Among the acquired forms, simple cysts can develop in kidneys as a consequence of aging; dialysis, drugs, and hormones can cause multicystic disease ; and renal cysts are often secondary manifestations of genetic Full Text of this Article Autosomal Dominant Polycystic Kidney Disease Autosomal Recessive Polycystic Kidney Disease Familial Nephronophthisis Medullary Cystic Kidney Disease Cell Biology Proliferation and Apoptosis Secretion Polarity Signal Transduction Cilia Molecular Biology PKD Genes and Mutations Polycystic Kidney Disease Proteins Polycystin-1 Polycystin-2 Fibrocystin Nephrocystin Functions of Polycystins Developmental Regulation and Programming Prospects for Prognosis and Therapy

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