1. NORD - National Organization For Rare Disorders, Inc. Offers the synonyms, a general discussion and resources. http://www.rarediseases.org/search/rdbdetail_abstract.html?disname=POEMS Syndrom

2. Treatment Of POEMS Syndrome, Mayo Clinic In Rochester, Minn. Treatment of poems syndrome at Mayo Clinic in Rochester. poems syndrome is a very rare type of bone marrow disorder whose cause is unknown. http://www.mayoclinic.org/poems-rst/

Home About Mayo Clinic Contact Us Mayo Clinic Locations: Arizona Florida Minnesota Mayo Clinic ... Medical Services POEMS Syndrome POEMS Syndrome Treatment Symptoms Appointments Clinical Trials ... Medical Services Treatment of POEMS Syndrome at Mayo Clinic in Rochester POEMS syndrome is a very rare type of bone marrow disorder whose cause is unknown. It involves an overgrowth of bone marrow cells called plasma cells, which produce chemicals that damage other parts of the body. It is not inherited, nor is it contagious. Patients sometimes confuse POEMS syndrome with multiple myeloma. The symptoms and potential complications of these diseases are very different. The average expected life span is better in patients with POEMS (who may have osteosclerotic myeloma ) than it is in patients with multiple myeloma. The diagnosis of POEMS syndrome is made by combining the information from a thorough history, physical examination, and blood, urine, X-ray and bone marrow tests. The overgrowth of plasma cells can often be detected by finding an abnormal protein in the blood or urine (a monoclonal protein), by an abnormality on a bone X-ray and/or a bone marrow biopsy. POEMS is a syndrome, which means that several features must be present to make the diagnosis. Because it is so rare, the diagnosis is often missed. Initially, people may have been told that they have a nerve problem without any known cause. Or they may have been told that they have multiple myeloma, a type of bone marrow cancer. Mayo Clinic approach Mayo Clinic uses an integrated approach involving a multispecialty team of physicians in caring for patients with POEMS syndrome. Working together, Mayo clinicians develop a treatment plan based on the patient's individual needs and health issues.

3. EMedicine - POEMS Syndrome : Article By Wingfield Rehmus, MD, MPH endocrinopathy, monoclonal gammopathy, and skin changes (POEMS) syndrome is a rare multisystemic disease that or a growth factor. poems syndrome first was described by Crow in http://www.emedicine.com/derm/topic771.htm

(advertisement) Home Specialties CME PDA ... Patient Education Articles Images CME Patient Education Advanced Search Link to this site Back to: eMedicine Specialties Dermatology Internal Medicine POEMS Syndrome Last Updated: July 10, 2003 Rate this Article Email to a Colleague Synonyms and related keywords: Crow-Fukase syndrome, Takatsuki syndrome, PEP, polyneuropathy endocrinopathy plasma cell dyscrasia, polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, skin changes AUTHOR INFORMATION Section 1 of 9 Author Information Introduction Clinical Differentials ... Bibliography Author: Wingfield Rehmus, MD, MPH , Staff Physician, Department of Dermatology, Stanford University Medical Center Coauthor(s): Alexa Boer Kimball, MD, MPH , Director of Clinical Trials, Assistant Professor, Department of Dermatology, Stanford University School of Medicine Wingfield Rehmus, MD, MPH, is a member of the following medical societies: American Academy of Dermatology Editor(s): Neil Shear, MD , Professor and Chief of Dermatology, Professor of Medicine, Pediatrics and Pharmacology, University of Toronto Medical School; Head of Dermatology, Sunnybrook Women's College Health Sciences Center, Canada;

4. Immune Demyelinating PN fingers. poems syndrome 21. Geography ? High incidence in Japanese males; Partial poems syndromes Not uncommon; Definition Polyneuropathy; http://www.neuro.wustl.edu/neuromuscular/antibody/pnimdem.html

Front Search Index Links ... Patient Info CHRONIC IMMUNE POLYNEUROPATHIES: DEMYELINATING Comparative features: Demyelinating PN Treatment strategies CIDP ... GALOP syndrome GD1a antibody Motor-Sensory neuropathy Multifocal motor neuropathy MAG antibody associated neuropathy Osteosclerotic Myeloma ... Antibody testing Myelinated Axons: Segmental demyelination in Multifocal Motor Neuropathy (MMN) CHRONIC IMMUNE DEMYELINATING NEUROPATHIES COMPARATIVE FEATURES Neuropathy Clinical Features Electrophysiology Antibody M-Protein Treatment CIDP Weakness: Symmetric Onset: 1 to 80 yrs Chronic or Relapsing Motor + Sensory change Slow NCV Conduction Block Distal Latency: Long Slow F-waves Targets Heparan sulfate Class: IgM or IgG Frequency: 20% T-cell immunosuppression Prednisone Cyclosporine A Methotrexate HIG Plasma Exchange Multifocal CIDP Also see: CIDP variants Chronic Weakness: Asymmetric Onset: 15 to 75 yrs Motor + Sensory change Slow NCV Conduction Block Distal Latency: Long Slow F-waves T-cell immunosuppression Prednisone HIG MMN Motor only Asymmetric Onset: 25 to 60 yrs Slowly progressive Motor only Conduction Block Axonal Loss EMG: No paraspinous denervation Targets Co-GM1 or NP-9 Class: IgM Frequency: 80% HIG B-cell immunosuppression Plasma Exchange + Cyclophosphamide Rituxan Anti-MAG Distal; Symmetric

5. Treatment Of POEMS Syndrome At Mayo Clinic Mayo Clinic Medical Services poems syndrome. Treatment of poems syndrome at Mayo Clinic. poems syndrome is a disorder in which an http://www.mayoclinic.org/poems/

Home About Mayo Clinic Contact Us Mayo Clinic Locations: Arizona Florida Minnesota Mayo Clinic ... Medical Services POEMS Syndrome POEMS Syndrome Treatment Appointments Clinical Trials Other Web Resources ... Medical Services Treatment of POEMS Syndrome at Mayo Clinic POEMS syndrome is a disorder in which an overgrowth of bone marrow cells (called plasma cells) produces chemicals that damage other parts of the body. It is very rare and its cause is unknown. The term "POEMS" is an acronym for the most common symptoms of the syndrome: P peripheral neuropathy (numbness, tingling, and weakness of the feet and hands) O organomegaly (large organs, like the liver, lymph nodes and spleen) E endocrinopathy (abnormal hormone levels including sex hormones, thyroid hormones, etc.) M monoclonal plasmaproliferative disorder (a collection of abnormal bone marrow cells) S skin changes (increased skin pigment, increased body hair, thickening of the skin, etc.) Other common symptoms include fatigue and weakness, edema (swelling of the ankles and legs), enlarging breast tissue in both men and women, generalized aches and pains, ascites (fluid collection in the abdomen) and changes in vision. It can affect anyone, but the majority of people with POEMS syndrome are over 50 with a slightly higher percentage of men with this disorder than women. Diagnosis Diagnosis at Mayo Clinic is made by combining the information from a thorough history, physical examination, and blood, urine, X-ray and bone marrow tests. The overgrowth of plasma cells can often be detected by finding an abnormal protein in the blood or urine (a monoclonal protein), by an abnormality on a bone X-ray, and/or a bone marrow biopsy. POEMS is a syndrome, which means that several features must be present to make the diagnosis. Because it is so rare, the diagnosis is often missed. Sometimes it is diagnosed as a nerve problem without any known cause or as multiple myeloma, which is a type of bone marrow cancer.

6. POEMS Syndrome Links to information and resources for poems syndrome, a multisystem disorder. Rare/Orphan Diseases. poems syndrome. Guide picks Mayo Clinic Information About poems syndrome. Excellent, easy http://rarediseases.about.com/cs/poemssyndrome?iam=savvy&terms=mayo clinic r

7. POEMS Syndrome Information Diseases Database poems syndrome Osteosclerotic myeloma, Disease Database Information http://www.diseasesdatabase.com/sieve/item1.asp?glngUserChoice=29226

8. POEMS Syndrome - Information / Diagnosis / Treatment / Prevention home neurological disorders peripheral nervous system poems syndrome poems syndrome. Information • Diagnosis • Treatment • Prevention. http://www.healthcyclopedia.com/neurological-disorders/peripheral-nervous-system

Home Health cyclopedia All Topics by Category The Good Health Search Engine Health Conditions A-Z Gurus ... peripheral nervous system > poems syndrome POEMS Syndrome Information / Diagnosis / Treatment / Prevention External links (marked with an arrow ) open in a new window. This site is a web directory and does not offer medical advice. We cannot take responsibility for information found on listed sites. This Page Related Topics Medical Definition Health News Web Directory: Related Topics: Blood Disorders Rare Disorders Medical Definition: University of Newcastle-upon-Tyne Medical Dictionary: "poems syndrome" Health News: Search millions of published articles for news on POEMS Syndrome Modern Medicine Aging The Ardell Wellness Report HealthFacts Medical Post Medical Update Men's Health and the National Women's Health Report Note: Subscription required to access the full text of articles. Web Directory: Mayo Clinic Rochester Information about POEMS syndrome, what it is, symptoms, diagnosis, treatment and who gets it. NORD: POEMS Syndrome Offers the synonyms, a general discussion and resources. Notes: Healthcyclopedia presents health information in the form of websites and articles that encompass conventional medicine and alternative treatments Under no circumstances can it recommend or endorse a specific drug or therapy or treatment.

9. NeuroGate.com Search results for "poems syndrome" NO MATCHES FOUNDPlease select a different keyword or category OR. Search AltaVista for 'poems syndrome' Global Search - Add Url http://www.neurogate.com/neuro/result.php3?search=POEMS Syndrome&select=and

10. Poems Syndrome poems syndrome,. Print this article, a combination DR/RB. The Encyclopaedia of Medical Imaging Volume III1. poems syndrome, Fig. 1. AP http://www.amershamhealth.com/medcyclopaedia/medical/Volume III 1/POEMS SYNDROME

Amershamhealth.com Search for: Type a word or a phrase. All forms of the word are searchable. Browse entry words starting with: A B C D ... Other characters Poems syndrome, a combination of plasma cell dyscrasia , chronic progressive polyneuropathy, and endocrine abnormalities such as diabetes mellitus . This syndrome is of unknown cause and takes its name from the typical features: polyneuropathy, organomegaly, endocrinopathy, M proteins and skin changes. Numerous other characteristics can be noted. However, patients do not have an increased prevalence of amyloidosis and rarely reveal Bence Jones proteinuria. Bone proliferation occurs at entheses (sites of tendon and ligament attachment to bone). Particularly characteristic are irregular bony excrescences on the posterior elements of the spine and about the sacroiliac and costovertebral joints ( Fig.1 DR/RB The Encyclopaedia of Medical Imaging Volume III:1 Poems syndrome, Fig. 1 AP radiograph of the pelvis in a patient with POEMS syndrome demonstrates numerous sclerotic foci in the pelvis and femora owing to plasma cell myeloma. Contacts GE Healthcare Making Waves

11. Entrez PubMed Click here to read poems syndrome definitions and longterm outcome. Dispenzieri We identified 99 patients with poems syndrome. Minimal http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1

12. EMedicine - POEMS Syndrome : Article Excerpt By: Wingfield Rehmus, MD, MPH endocrinopathy, monoclonal gammopathy, and skin changes (POEMS) syndrome is a rare multisystemic disease that or a growth factor. poems syndrome first was described by Crow in http://www.emedicine.com/derm/byname/poems-syndrome.htm

(advertisement) Excerpt from POEMS Syndrome Synonyms, Key Words, and Related Terms: Crow-Fukase syndrome, Takatsuki syndrome, PEP, polyneuropathy endocrinopathy plasma cell dyscrasia, polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, skin changes Please click here to view the full topic text: POEMS Syndrome Background: Polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes (POEMS) syndrome is a rare multisystemic disease that occurs in the setting of a plasma cell dyscrasia. The pathophysiologic link between the constellation of symptoms and the underlying disease is not well understood, but the link may be related to changes in the levels of a cytokine or a growth factor. POEMS syndrome first was described by Crow in 1956 and then by Fukase in 1968. The syndrome was termed Crow-Fukase syndrome (by which it is known in Japan) by Nakanishi in a study of 102 cases in Japan. In 1980, the acronym POEMS was coined by Bardwick et al based on the 5 main features of the disease, namely, polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes. No specific case definition for POEMS exists; however, most authors agree that patients with POEMS syndrome should have 3 or more of the 5 features. The pathophysiology of the disease is not known; however, elevated levels of cytokines and growth factors have been implicated. The polyneuropathy associated with POEMS syndrome is a bilateral symmetric disturbance. It involves both motor and sensory nerves, begins distally, and has a progressive proximal spread. Associated cranial or autonomic nerves are not involved. Both demyelination and axonal degeneration are noted.

13. Entrez PubMed The spectrum of poems syndrome. Miralles GD, O Fallon JR, Talley NJ. Five patients fulfilled all the criteria for the poems syndrome. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Retrieve&list_uids=1

14. POEMS Syndrome - Eurorad - Clinical Case 1972 - Senior teaching files,radiology,poems syndrome,The patient presented with diffuse erythrodermia, hepatosplenomegaly, adenopathy and peripheral neuropathy. http://www.eurorad.org/case.cfm?uid=1972

15. POEMS Syndrome Information Diseases Database 2 synonyms or equivalents were found. poems syndrome aka/or Osteosclerotic myeloma Medical information linkspoems syndrome specific sites. http://www.diseasesdatabase.com/ddb29226.htm

Diseases Database Index Sponsors Contact ... Previous Page POEMS syndrome Information Search 2 synonyms or equivalents were found. POEMS syndrome aka/or Osteosclerotic myeloma may cause or feature (Follow link for list) may be associated with (Follow link for list) belong(s) to the category of (Follow link for list) POEMS syndrome: Definition(s) via UMLS Code translations and terms via UMLS POEMS syndrome: specific sites Send POEMS syndrome to medical search engines (JavaScript enabled browsers only) If your browser has no JavaScript you can still use these: Search using Internet medical databases Search using Internet search engines (non-specialist) We subscribe to the HONcode principles of the Health On the Net Foundation i-medicine.info - the evidence based medicine, informatics and audit portal Valid XHTML 1.0 Served 2004-06-03 02:15:10 Metadata Updated 2004-05-22

16. POEMS Syndrome poems syndrome Important It is possible that the main title of the report poems syndrome is not the name you expected. Please check http://my.webmd.com/hw/health_guide_atoz/nord789.asp

var guid_source = ""; var guid_source_id = ""; //unused var encodedurl = ""; WebMD Today Home WebMD News Center Member Services WebMD University My WebMD Find a Physician Medical Info Check Symptoms Medical Library Quizzes, Calculators Clinical Trials ... Women, Men, Lifestyle Who We Are About WebMD Site Map You are in Medical Library Choose a Topic Our Content Sources Ask A Question Clinical Trials Health Guide A-Z Health Topics Symptoms Medical Tests Medications ... For a Complete Report POEMS Syndrome Important It is possible that the main title of the report POEMS Syndrome is not the name you expected. Please check the synonyms listing to find the alternate name(s) and disorder subdivision(s) covered by this report. Synonyms Crow-Fukase Syndrome PEP Syndrome Polyneuropathy-organomegaly-endocrinopathy-M protein-skin lesions Shimpo syndrome Takatsuki syndrome Polyneuropathy-organomegaly-endocrinopathy-M protein-skin lesions Disorder Subdivisions None General Discussion POEMS syndrome is an extremely rare multisystem disorder. POEMS is an acronym that stands for (P)olyneuropathy, disease affecting many nerves; (O)rganomegaly, abnormal enlargement of an organ; (E)ndocrinoapthy, disease affecting certain hormone-producing glands that help to regulate the rate of growth, sexual development, and certain metabolic functions (endocrine system); (M)onoclonal gammopathy or M proteins; and (S)kin defects. Common symptoms include progressive weakness of the nerves in the arms and legs, an abnormally enlarged liver and/or spleen (hepatosplenomegaly), abnormally darkening of the skin (hyperpigmentation) and excessive hair growth (hypertrichosis). Endocrine abnormalities such as failure of the ovaries and testes (gonads) to function properly (primary gonadal failure) and diabetes mellitus type I may be present. Specific endocrine abnormalities associated with POEMS syndrome vary from case to case.

17. POEMS Syndrome poems syndrome is an extremely rare multisystem disorder. POEMS produ. National Organization for Rare Disorders, Inc. poems syndrome. http://www.bchealthguide.org/kbase/nord/nord789.htm

document.write(''); var hwPrint=1; var hwDocHWID="nord789"; var hwDocTitle="POEMS Syndrome"; var hwRank="1"; var hwSectionHWID="nord789"; var hwSectionTitle=""; var hwSource="cn6.0"; var hwProdCfgSerNo="wsh_html_031_s"; var hwDocType="NORD"; National Organization for Rare Disorders, Inc. POEMS Syndrome Important It is possible that the main title of the report is not the name you expected. Please check the synonyms listing to find the alternate name(s) and disorder subdivision(s) covered by this report. Synonyms Crow-Fukase Syndrome PEP Syndrome Polyneuropathy-organomegaly-endocrinopathy-M protein-skin lesions Shimpo syndrome Takatsuki syndrome Polyneuropathy-organomegaly-endocrinopathy-M protein-skin lesions Disorder Subdivisions None Related Disorders List Information on the following diseases can be found in the Related Disorders section of this report: Scleroderma Chronic inflammatory demyelinating polyneuropathy (CIDP) Osteosclerotic myeloma General Discussion POEMS syndrome is an extremely rare multisystem disorder. POEMS is an acronym that stands for (P)olyneuropathy, disease affecting many nerves; (O)rganomegaly, abnormal enlargement of an organ; (E)ndocrinoapthy, disease affecting certain hormone-producing glands that help to regulate the rate of growth, sexual development, and certain metabolic functions (endocrine system); (M)onoclonal gammopathy or M proteins; and (S)kin defects. Common symptoms include progressive weakness of the nerves in the arms and legs, an abnormally enlarged liver and/or spleen (hepatosplenomegaly), abnormally darkening of the skin (hyperpigmentation) and excessive hair growth (hypertrichosis). Endocrine abnormalities such as failure of the ovaries and testes (gonads) to function properly (primary gonadal failure) and diabetes mellitus type I may be present. Specific endocrine abnormalities associated with POEMS syndrome vary from case to case.

18. ORPHANET - Maladies Rares - Médicaments Orphelins Translate this page Glossaire, Version pour Impression, MALADIE poems syndrome, Synonyme(s) Crow-Fukase, syndrome de, Aucun descriptif disponible, Signes cliniques(23), http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=FR&Expert=2905

19. ORPHANET® POEMS Syndrome Translate this page ORPHANET. Accès à la base de données Orphanet. poems syndrome. Accès direct aux détails Signes de la maladie CONDUCTION NERVEUSE http://www.orpha.net/static/FR/poemssyndrome.html

20. POEMS, Syndrome : Sites Et Documents Francophones syndrome . Arborescence(s) du thesaurus MeSH contenant le mot-clé POEMS, syndrome poems syndrome http://www.chu-rouen.fr/ssf/pathol/poemssyndrome.html

POEMS, syndrome Menu général CISMeF Synonyme(s) CISMeF Crow-Fukase, syndrome ; Polyneuropathie Organomégalie Endocrinopathie protéine Monoclonale, anomalies cutanées ; syndrome de Takatsuki . Synonyme(s) MeSH Syndrome Crow-Fukase ; Takatsuki, syndrome Arborescence(s) POEMS, syndrome POEMS syndrome hémopathies et maladies lymphatiques maladies et malformations congénitales, héréditaires et néonatales maladies immunologiques système nerveux, maladies Position du mot-clé dans l' (les) arborescence(s) : Vous pouvez consulter toutes les ressources ou seulement les principales ou utiliser l' outil de recherche les recommandations les documents concernant l' enseignement les documents destinés aux patients Ou consulter ci-dessous une sélection des principales ressources : structure recherche POEMS syndrome [Site éditeur Orphanet base de données sur les maladies rares et les médicaments orphelins. Direction Générale de la Santé / INSERM ; signes de la maladie, sites internet, dysmorphologie, projet de recherche en cours ; pays : France ; langue : français ; format : html ; accès : gratuit ; non parrainé ; daté de : 2003 ; visité le : 11/09/2003]. mots clés : maladies rares POEMS, syndrome

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