21. LookSmart - Directory - Blood Platelet Disorders Blood platelet disorders Contains resources on treatment optionsand drug therapies, educational material, and general advice. http://search.looksmart.com/p/browse/us1/us317837/us317920/us53948/us72007/us274

@import url(/css/us/style.css); @import url(/css/us/searchResult1.css); Home IN the directory this category YOU ARE HERE Home Personal Health Blood Disorders Blood Platelet Disorders - Contains resources on treatment options and drug therapies, educational material, and general advice. Directory Listings About allRefer Health - Acquired Platelet Function Defect Information Know the prognosis, symptoms, complications, prevention, and treatment of disorders caused by abnormalities in platelet count or function, thus affecting blood clotting. allRefer Health - Primary Thrombocythemia Essential thrombocythemia is characterized by overproduction of the platelet cells. Know its symptoms, causes, risks, prevention, diagnosis, complications, and treatment. Franklin Institute Online, The - Blood Platelets Educates about the functions and anatomy of blood platelets, mentions when they come into action, and explains the term "scab." Gale Encyclopedia of Medicine - Platelet Count Article looks at the diagnostic test that determines the number of platelets in a person's blood. Gale Encyclopedia of Medicine - Platelet Function Disorders Discusses causes, symptoms, diagnosis and treatment of these disorders that interfere with the proper process of blood clot formation.

22. CCHS Clinical Digital Library Clinical Resources by Topic Hematology. platelet disorders ClinicalResources. See also platelet disorders Patient/Family Resources. http://cchs-dl.slis.ua.edu/clinical/hematology/bleedingdisorders/plateletdisorde

Clinical Resources by Topic: Hematology Platelet Disorders Clinical Resources See also: Platelet Disorders Patient/Family Resources General Hematology Clinical Resources Platelet Disorders Clinical Resources by Sub-Topic: Acquired Platelet Dysfunction Myeloproliferative Disorders Thrombocytopenia von Willebrand Disease For additional Platelet Disorders Sub-Topics, go to General Hematology Clinical Resources Health Sciences Library College of Community Health Sciences The University of Alabama Service provided by the Clinical Digital Libraries Project of the UA and UNT Schools of Library and Information Studies Powered by UA Digital Libraries Navigation Lab technology

23. CCHS Clinical Digital Library Patient/Family Resources by Topic Hematology. platelet disorders Patient/FamilyResources. See also platelet disorders Clinical Resources. http://cchs-dl.slis.ua.edu/patientinfo/hematology/bleedingdisorders/plateletdiso

Patient/Family Resources by Topic: Hematology Platelet Disorders Patient/Family Resources See also: Platelet Disorders Clinical Resources General Hematology Patient/Family Resources Platelet Disorders Patient/Family Resources by Sub-Topic: Acquired Platelet Dysfunction Myeloproliferative Disorders Thrombocytopenia von Willebrand Disease ... College of Community Health Sciences The University of Alabama Service provided by the Clinical Digital Libraries Project of the UA and UNT Schools of Library and Information Studies Powered by UA Digital Libraries Navigation Lab technology

24. Blood Platelet Disorders Google, WWW Medical.WebEnds.com. Blood platelet disorders. Disorderscaused by abnormalities in platelet count or function. Google links. http://medical.webends.com/kw/Blood Platelet Disorders

Medical.WebEnds.com - Medical Terminology Dictionary A B C D ... Z WWW Medical.WebEnds.com Blood Platelet Disorders Thrombocytopathy; Blood Platelet Disorder; Disorder, Blood Platelet; Disorders, Blood Platelet; Platelet Disorder, Blood; Platelet Disorders, Blood; Thrombocytopathies Disorders caused by abnormalities in platelet count or function. Google links Processing time was 0.10209703445435 seconds.

25. Dr. Rose's Peripheral Brain--PLATELET DISORDERS platelet disorders. Causes of Thrombocytopenia. Idiopathic ThrombocytopenicPurpura. Thrombotic Thrombocytopenic Purpura. Platelet lifetime avg. http://faculty.washington.edu/momus/PB/platelet.htm

PLATELET DISORDERS Causes of Thrombocytopenia Idiopathic Thrombocytopenic Purpura Thrombotic Thrombocytopenic Purpura Platelet lifetime avg. 7d Normal platelet count = 150-400k/uL Common wisdom has it that initial bleeding due to platelet disorders is usually from mucous membranes rather than bruising of the skin or hemarthrosis

26. Guidelines For The Management Of Platelet Disorders Guidelines Guidelines for the Management of platelet disorders, 50150 ´ 10 9 /L.Bleeding is unexpected, implies qualitative platelet disorder. 10-50 ´ 10 9 /L. http://peir.path.uab.edu/coag/article_223.shtml

Front Page Announcements Contact Us Clinical Conditions ... Test Order Form Search All Categories Front Page Announcements Contact Us Clinical Conditions Guidelines Links Patient Information Test Menu Test Order Form Guidelines Guidelines for the Management of Platelet Disorders Email this article Printer friendly page Platelet count Thrombocytopenia: the most common cause of bleeding ... Platelet concentrate therapy Platelet Count Ranges and Thrombocytopenia /L /L Bleeding is unexpected, implies qualitative platelet disorder /L Bleeding may follow trauma, surgery, or dental extraction /L Spontaneous bleeding may require therapy [top] Thrombocytopenia: the most common cause of bleeding Marrow hypoplasia: chemotherapy, drug sequelae, ethanol Platelet consumption: acute and chronic immune thrombocytopenic purpura, drug-induced immune thrombocytopenia, neonatal alloimmune thrombocytopenia, post-transfusion purpura, thrombotic thrombocytopenic purpura, hemolytic-uremic syndrome, DIC, HIT, and type 2B vWD [top] /L Reactive thrombocytosis: hemorrhage, surgery, iron deficiency anemia, inflammation Myeloproliferative disorders: essential thrombocythemia, chronic myelocytic leukemia

27. Guidelines For The Management Of Platelet Disorders Guidelines Guidelines for the Management of platelet disorders. 50150 ´ 10 9 /L.Bleeding is unexpected, implies qualitative platelet disorder. 10-50 ´ 10 9 /L. http://peir.path.uab.edu/coag/printer_223.shtml

From UAB Coagulation Service (http://coag.path.uab.edu) Guidelines Guidelines for the Management of Platelet Disorders Platelet count Thrombocytopenia: the most common cause of bleeding Thrombocytosis Platelet diameter and morphology ... Platelet concentrate therapy Platelet Count Ranges and Thrombocytopenia /L /L Bleeding is unexpected, implies qualitative platelet disorder /L Bleeding may follow trauma, surgery, or dental extraction /L Spontaneous bleeding may require therapy [top] Thrombocytopenia: the most common cause of bleeding Marrow hypoplasia: chemotherapy, drug sequelae, ethanol Platelet consumption: acute and chronic immune thrombocytopenic purpura, drug-induced immune thrombocytopenia, neonatal alloimmune thrombocytopenia, post-transfusion purpura, thrombotic thrombocytopenic purpura, hemolytic-uremic syndrome, DIC, HIT, and type 2B vWD [top] /L Reactive thrombocytosis: hemorrhage, surgery, iron deficiency anemia, inflammation Myeloproliferative disorders: essential thrombocythemia, chronic myelocytic leukemia [top] Platelet Diameter and Morphology m m diameter Average normal diameter m m diameter Large physiologic platelets may indicate increased turnover with shortened marrow release time m m diameter Giant platelets imply myeloproliferative disorder, myelodysplastic syndrome, May-Hegglin anomaly

28. Platelet Disorders - General Practice Notebook platelet disorders. The formation of the component of normal haemostasis.platelet disorders that may interfere with this mechanism are http://www.gpnotebook.co.uk/cache/-1389035490.htm

platelet disorders The formation of the initial platelet plug is an important component of normal haemostasis. Platelet disorders that may interfere with this mechanism are: too few platelets - thrombocytopaenia abnormal platelet function - thrombocytopathy Thrombocytopaenia accounts for the majority of cases. Click here for more information...

29. Platelet Disorders - General Practice Notebook platelet disorders. Medical search. The formation normal haemostasis. Plateletdisorders may lead to a bleeding disorder, the causes include http://www.gpnotebook.co.uk/medwebpage.cfm?ID=-1389035490

30. Disease Directory : Blood Disorders : Platelet Blood platelet disorders Blood platelet disorders. SUBCATEGORIES. Blood PlateletDisorders - Google, WWW Medical.WebEnds.com. Blood platelet disorders. http://www.diseasedirectory.net/Blood_Disorders/Platelet/default.aspx

Wednesday, June 02, 2004 Blood Disorders Anemia Blood Coagulation Eosinophilia ... Blood Disorders : Platelet Acquired Bleeding Disorders - An article by Thomas G. DeLoughery, Associate Professor of Medicine. Platelet transfusion therapy and dysfunctional platelets are discussed. Adult Chronic Immune Thrombocytopenic Purpura - A guide for patients. A description of this disease followed by an in depth look. Blood Platelet Disorders - Blood Platelet Disorders. SUBCATEGORIES. Up Blood Platelet Books Thrombocytopenia. Search Now: In Association with Amazon.com. info@medlina.com New York City. Blood Platelet Disorders - Google, WWW Medical.WebEnds.com. Blood Platelet Disorders. Thrombocytopathy function. Search for 'Blood Platelet Disorders' at Market.Webends.com.com books. DISEASE: Platelet Disorders - immunology. Summarises autoimmune platelet disorders. - http://www.angelfire.com/ut/johnsnotes/ Science: Biology: Immunology: People. eMedicine - Platelet Disorders : Article Excerpt by: Perumal ... - Platelet Disorders - The hemostatic system consists of platelets, coagulation factors, and the endothelial cells lining the blood vessels. Glanzmann Thrombasthenia - Supporting those affected by GT and reseachers. Message board, contacts and related information on the condition.

31. Disease Directory : Platelet Disorders First PreviousNext Last Index Home Text. Slide 11 of 30. Date Added 2...... Directory Listing. Title platelet disorders http://www.diseasedirectory.net/detailed/23864.aspx

Wednesday, June 02, 2004 Blood Disorders Anemia Blood Coagulation Eosinophilia ... Platelet : Platelet Disorders Directory Listing Title: Platelet Disorders Description: First Previous Next Last Index Home Text. Slide 11 of 30. Date Added: 2/16/2004 9:03:01 AM URL: http://www.vet.purdue.edu/vpb/clinpath/vpb555/hemostasis/sld011.htm

32. Platelet Disorders platelet disorders. platelet disorders, Paraproteinaemia, Renal failure, Inheritedplatelet dysfunction, See under Bleeding inherited bleeding disorders. http://www.rcpa.edu.au/pathman/platelet.htm

This site has been updated. Please go to www.rcpamanual.edu.au This page will be permanently removed on 30th September 2004. Please update your links. Platelet disorders Platelet disorders Quantitative See Thrombocytopenia and Thrombocytosis Qualitative Acquired platelet dysfunction Aspirin, other NSAID See under Bleeding - acquired bleeding disorders. Myeloproliferative disorders esp Essential Thrombocythaemia Myelofibrosis Paraproteinaemia Renal failure Inherited platelet dysfunction See under Bleeding - inherited bleeding disorders.

33. ► Acquired Platelet Function Defect Alternative Names Acquired qualitative platelet disorders; Acquired disordersof platelet function. Any platelet disorder affects blood clotting. http://www.umm.edu/ency/article/000546.htm

Disease Nutrition Surgery Symptoms Injury ... Encyclopedia (English) Toggle English Spanish Acquired platelet function defect Overview Symptoms Treatment Prevention Definition: Non-hereditary diseases or associated conditions that cause the platelets (the blood cells essential for coagulation) to not function properly. Alternative Names: Acquired qualitative platelet disorders; Acquired disorders of platelet function Causes, incidence, and risk factors: Platelets are blood cells that are essential for blood clotting. Platelet disorders can include inappropriate number of platelets (too many or too few), or normal number but inappropriate functioning of the platelets. Any platelet disorder affects blood clotting. Disorders of platelet function can be caused by congenital diseases or acquired conditions. Acquired platelet function disorders are disorders of inappropriate platelet function, and that develop as a result of another disease or condition (acquired). In many cases, the platelet count may be normal or even elevated, but evidence of a bleeding disorder will be present. Myeloproliferative disorders such as primary thrombocytopenia polycythemia vera chronic myelogenous leukemia , and myelofibrosis can produce abnormalities in platelet function. Other causes include

34. Bmj.com Liesner And Machin 314 (7083): 809 Clinical review. ABC of clinical haematology platelet disorders. RJ Liesner,SJ Machin. Treatment of platelet disorders Congenital disorders. http://bmj.bmjjournals.com/cgi/content/full/314/7083/809

Home Help Search/Archive Feedback ... Respond to this article PubMed citation Related articles in PubMed Download to Citation Manager Search Medline for articles by: Liesner, R J Machin, S J Alert me when: New articles cite this article BMJ Clinical review ABC of clinical haematology: Platelet disorders R J Liesner S J Machin Introduction Top Introduction Normal haemostasis Congenital abnormalities Acquired abnormalities History and examination of... Investigations Management Platelets are produced predominantly by bone marrow megakaryocytes as a result of budding of the cytoplasmic membrane. Megakaryocytes are derived from the haemopoietic stem cell, which is stimulated to differentiate to mature megakaryocytes under the influence of various cytokines, including thrombopoietin. The life span of a platelet is 7-10 days, and the normal count for all ages is 150-450x10 /l Once released from the bone marrow, young platelets are trapped in the spleen for 36 hours before entering the circulation, where they have a primary haemostatic role. View larger version [in this window] [in a new window] Amegakaryocytic thrombocytopenia with absent radii (TAR syndrome).

35. Inherited Platelet Disorders ! Inherited platelet disorders. This site is under construction! This page refers toinherited platelet disorders! Inherited disorders of the platelet membrane. http://www.akh-wien.ac.at/biomed-research/htx/inherit.htm

Inherited platelet disorders This site is under construction! If you are specialist in this field and you feel, we have made mistakes or you would like to contribute with your knowledge, please contact us via e-mail Introduction Platelets play a major role in haemostasis, and defects in platelet function may lead to bleeding. These defects may be inherited or acquired - the latter are far more common. Defective platelet function may present clinically with a variety of symptoms indicative of primary haemostatic failure, such as bruises, ecchymoses, epistaxis, gastrointestinal haemorrhage or menorrhagia. Platelet defects usually give rise to a fairly mild bleeding disorder, and patients may present with exzessive bleeding only after surgery. This page refers to inherited platelet disorders! Inherited disorders of the platelet membrane Glanzmann Thrombasthenia Thrombasthenia was first described by Glanzmann in 1918. It is an autosomal recessive defect of GPIIb/IIIa, a member of the Integrine family of cell surface receptors. Although most patients with this defect have no detectable platelet fibrinogen and absent clot retraction, platelets of some patients contain fibrinogen and can support clot retraction. These criteria were used to classify thrombasthenic patients as type I and II, respectively. Platelets of patients with type I have undetectable intact platelet GPIIb/IIIa complex, whereas in type II disease measureable amounts of functional GPIIb/IIIa can be detected. Clinical symptoms occur only in patients homozygous for thrombasthenia. The heterozygous condition appears to be asymptomatic, even though these subjects have only a half-normal concentration of GPIIb/IIIa

36. Platelet Disorders You can download this Powerpoint presentationby clicking here. Back to Bibliography. http://www.biocytex.fr/biblio/com/disorder/pltdisord.htm

You can download this Powerpoint presentation by clicking here. Back to Bibliography

37. MedlinePlus Medical Encyclopedia: Acquired Platelet Function Defect Acquired qualitative platelet disorders; Acquired disorders of platelet functionDefinition Return to top. Any platelet disorder affects blood clotting. http://www.nlm.nih.gov/medlineplus/ency/article/000546.htm

@import url(http://www.nlm.nih.gov/medlineplus/images/advanced.css); Skip navigation Medical Encyclopedia Other encyclopedia topics: A-Ag Ah-Ap Aq-Az B-Bk ... Z Acquired platelet function defect Contents of this page: Illustrations Alternative names Definition Causes, incidence, and risk factors ... Prevention Illustrations Blood clot formation Blood clots Alternative names Return to top Acquired qualitative platelet disorders; Acquired disorders of platelet function Definition Return to top Acquired platelet function defects are non-hereditary diseases or associated conditions that cause the platelets (the blood cells essential for coagulation) to not function properly. Causes, incidence, and risk factors Return to top Platelets are blood cells that are essential for blood clotting. Platelet disorders can include inappropriate number of platelets (too many or too few), or normal number but inappropriate functioning of the platelets. Any platelet disorder affects blood clotting. Disorders of platelet function can be caused by congenital diseases or acquired conditions. Acquired platelet function disorders are disorders of inappropriate platelet function, and that develop as a result of another disease or condition (acquired). In many cases, the platelet count may be normal or even elevated, but evidence of a bleeding disorder will be present.

38. Www.nlm.nih.gov/cgi/mesh/2K/MB_cgi?term=Blood+Platelet+Disorders platelet disordersAn informative article titled platelet disorders in our Pregnancy Complicationssection on FirstWords.com! platelet disorders. platelet disorders SUMMARY. http://www.nlm.nih.gov/cgi/mesh/2K/MB_cgi?term=Blood Platelet Disorders

39. Neonatal Platelet Disorders Home. •, Common Diagnoses, •, Procedures. Common Diagnoses. Neonatalplatelet disorders. Information coming soon. Back. The Parent Book. http://www.hmc.psu.edu/nicu/services/plateletdisorders.htm

40. Thrombopoietin, Modes Of Action And Role In Platelet Disorders Thrombopoietin modes of action, role in platelet disorders new drug. AlbertEG.Kr. Role of Tpo in platelet disorders. Disorders with thrombocytopenia. http://www.slz.nl/hora/literatu/pages/1998/tpo.htm

Albert E.G.Kr. von dem Borne , Leendert Porcelijn , Claudia Folman , Sonja van den Oudenrijn , Gabor E Linthorst , C. Ellen van der Schoot , Masja de Haas 1 Department of Hematology, Division of Internal Medicine, Academic Medical Center, 2. Department of Hematology, Division of Medical Oncology, Anthonie van Leeuwenhoek Hospital/The Netherlands Cancer Institute, and 3. Department of Experimental Immunohematology, Central Laboratory of the Netherlands Red Cross Blood Transfusion Center Correspondence: Albert E.G.Kr. von dem Borne, Department of Hematology, Division of Internal Medicine, Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam; E-mail borne@amc.uva.nl Table of Contents Introduction Structural Information Thrombopoietin Tpo receptor (Tpo-R) ... Reference List Introduction Thrombopoietin (Tpo) is a haematopoietic growth factor that stimulates the development of megakaryocyte precursors, megakaryocytes and platelets. The existence of such a factor was already suggested in 1958 (Kelemen et al , 1958) and demonstrated in the early sixties by studies in rats (Odell et al , 1961). However, attempts to obtain thrombopoietin were unsuccessful in the years thereafter.

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