1. Pertussis Lecture topics by Kenneth Todar of the University of Wisconsin Department of Bacteriology. With introduction, pathogenesis, colonization, the toxins, regulation of virulence factors, and vaccine. http://www.bact.wisc.edu/Bact330/lecturebpertussis

Bacteriology at UW-Madison Bacteriology 330 Home Page Bordetella pertussis and Whooping Cough Bordetella pertussis Whooping cough pertussis ) is caused by the bacterium Bordetella pertussis. B. pertussis is a very small Gram-negative aerobic coccobacillus that appears singly or in pairs. Its metabolism is respiratory, never fermentative, and taxonomically, Bordetella is placed among the "Gram-negative Aerobic Rods and Cocci" in Bergey's Manual. Bordetella is not assigned to any family. The bacteria are nutritonally fastidious and are usually cultivated on rich media supplemented with blood. They can be grown in synthetic medium, however, which contains buffer, salts, an amino acid energy source, and growth factors such as nicotinamide, for which there is a strict requirement. Even on blood agar the organism grows slowly and requires 3-6 days to form pinpoint colonies. Bordetella pertussis colonizes the cilia of the mammalian respiratory epithelium (Figure 1). Generally, it is thought that B. pertussis

2. Pertussis Fact Sheet Symptoms, potential complications, how it is spread, who gets it, treatment, and prevention. By the Seattle and King County. http://www.metrokc.gov/health/prevcont/pertuss.htm

Site Directory Public Health Webpage Directory For Care Providers Care Providers Homepage For Educators Health Educators Toolbox About Us Employee Directory Contact Us Public Health 999 3rd Ave, Ste. 1200 Seattle, WA 98104 Phone: 206-296-4600 TTY: 206-296-4931 Click here to email us Subscribe to Free Email Alerts! Click here to learn more Successful Search Tips Home Pertussis Notice: Change in web address The Pertussis fact sheet has moved to www.metrokc.gov/health/prevcont/pertussis.htm You will be sent there within 10 seconds. Please update your bookmarks. click here to email us King County Public Health News ... Search Links to external sites do not constitute endorsements by King County. By visiting this and other King County web pages, you expressly agree to be bound by terms and conditions of the site. The details

3. MedlinePlus Medical Encyclopedia: Pertussis pertussis. to top. pertussis, also known as whooping cough, is caused by infection with the Bordetella pertussis bacteria. The infection http://www.nlm.nih.gov/medlineplus/ency/article/001561.htm

@import url(http://www.nlm.nih.gov/medlineplus/images/advanced.css); Skip navigation Medical Encyclopedia Other encyclopedia topics: A-Ag Ah-Ap Aq-Az B-Bk ... Z Pertussis Contents of this page: Illustrations Alternative names Definition Causes, incidence, and risk factors ... Prevention Illustrations Respiratory system overview Alternative names Return to top Whooping cough Definition Return to top Pertussis is a highly contagious bacterial disease which affects the respiratory system and produces spasms of coughing that usually end in a high-pitched sounding deep inspiration (the "whoop"). Causes, incidence, and risk factors Return to top Pertussis, also known as whooping cough, is caused by infection with the Bordetella pertussis bacteria. The infection is spread through the air by respiratory droplets from an infected person. The incubation period is usually 7 days. Whooping cough can affect people of any age. Prior to the advent of widespread immunization, the disease occurred mostly in infants and young children. Now that the majority of children are immunized before school age, a higher percentage of cases are seen among adolescents and adults. About 38% of recognized cases still occur in infants younger than 6 months of age, however. Early immunization (see childhood immunization schedule) can usually prevent the occurrence of this serious disease, which can sometimes be fatal or lead to permanent disability when it affects babies.

4. Pertussis.com pertussis.com is a tool to help healthcare providers and parents to recognize pertussis (aka whooping cough), a serious childhood disease. http://www.pertussis.com/

var javascript_version = 1.0; NAPNAP is the professional organization that advocates for children (infants through young adults) and provides leadership for Pediatric Nurse Practitioners who deliver primary health care in a variety of settings. The information contained in the pertussis.com web site should not be used as a substitute for the medical care and advice of your healthcare provider. There may be variations in treatment that your healthcare provider may recommend based on individual facts and circumstances. Pertussis.com is an educational project by the National Association of Pediatric Nurse Practitioners (NAPNAP) . Pertussis.com is made possible through an unrestricted educational grant from Aventis Pasteur If you have comments or suggestions about this site, click here.

5. Pertussis (Whooping Cough) pertussis is characterized by severe coughing spells that end in a whooping sound when the person breathes in. http://kidshealth.org/parent/infections/bacterial_viral/whooping_cough.html

KidsHealth Parents Infections Pertussis, also known as whooping cough, is an infection of the respiratory system caused by the bacterium Bordetella pertussis (or B. pertussis ). It's characterized by severe coughing spells that end in a "whooping" sound when the person breathes in. Before a vaccine was available, pertussis killed 5,000 to 10,000 people in the United States each year. Now, the pertussis vaccine has reduced the annual number of deaths to less than 30. Although pertussis can occur at any age, it's most severe in unimmunized children and in infants under 1 year of age (early immunization can usually prevent this serious disease in babies). About 40% of all pertussis infections occur in children less than 1 year old, and only 15% occur in children over 15 years old. Half of all deaths from pertussis occur in infants under age 1, and serious complications are more common in this group. The incidence of pertussis among adolescents and adults has been increasing in the last several years. This is an important fact, because coughing adolescents and adults who may not realize that they have pertussis are currently the major source of infection for infants and children. Signs and Symptoms The first symptoms of pertussis are similar to those of a common cold runny nose sneezing mild cough low-grade fever After about 1 to 2 weeks, the dry, irritating cough evolves into coughing spells. During a coughing spell, which can last for more than a minute, the child may turn red or purple. At the end of a spell, the child may make a characteristic whooping sound when breathing in or may vomit. Between spells, the child usually feels well.

6. The Sanger Institute : Bordetella Project performed in collaboration with Duncan Maskell and Andrew Preston of the Centre for Veterinary Science, Dept. of Clinical Veterinary medicine, The University of Cambridge. Currently involved in sequencing the 3.88 Mb genome of Bordetella pertussis, the causative agent of whooping cough. http://www.sanger.ac.uk/Projects/B_pertussis/

Sanger Home Acedb YourGenome Ensembl ... Databases Bordetella Overview Blast Search Sequence FTP Artemis ... Sitemap Bordetella pertussis B. parapertussis and B. bronchiseptica The Sanger Institute has published the sequences of Bordetella. pertussis strain Tohama I, B. parapertussis strain 12822 and B. bronchiseptica strain RB50, in collaboration with Duncan Maskell and Andrew Preston of the Centre for Veterinary Science, Dept. of Clinical Veterinary medicine The University of Cambridge The genomes of B. pertussis (4,086,189 bp) B. parapertussis (4,773,551 bp) and B. bronchiseptica (5,339,179 bp) are available for download in Artemis format by FTP and can be searched using our BLAST server. Comparison files in ACT format are also available for download. The annotation for the three Bordetella genomes is now accessible through GeneDB . GeneDB allows searching, browsing and download of the full annotation. The sequences and analysis are described in: Parkhill et al (2003) Comparative analysis of the genome sequences of Bordetella pertussis Bordetella parapertussis and Bordetella bronchiseptica Nature Genetics 32-40 (DOI: 10.1038/Ng1227), and have been submitted to EMBL/GenBank with the accession numbers: BX470248 (

7. Pertussis: An Update On Primary Prevention And Outbreak Control / September 15, Lewis, Washington. pertussis is a highly contagious respiratory disease The incidence of pertussis has been rising steadily in recent years http://www.aafp.org/afp/970915ap/pertussis.html

Advanced Search Articles Departments Patient Information ... Special Medical Reports Pertussis: An Update on Primary Prevention and Outbreak Control PAUL T. SCOTT, CPT, MC, USA, JEFFREY B. CLARK, LTC, MC, USA, and WILLIAM F. MISER, LTC, MC USA Madigan Army Medical Center Ft. Lewis, Washington Pertussis, or whooping cough, is a highly contagious respiratory illness caused by Bordetella pertussis . Outbreaks of the disease are now occurring every three to four years in highly immunized populations throughout the United States and are a significant health threat despite widespread vaccination and effective therapy. Unfortunately, pertussis vaccine provides only transient protection. Infected adults and adolescents with mild disease are the reservoir for more severe infection in infants and young children. Family physicians can reduce the morbidity and mortality of pertussis and help to control outbreaks through primary vaccination, early diagnosis, antibiotic therapy and prophylaxis, and case reporting to public health authorities. The Advisory Committee on Immunization Practices has recently changed its recommendations to include use of acellular pertussis preparations in children as part of the primary vaccination series against diphtheria, pertussis and tetanus (DPT). The revised recommendations are included in this review of the epidemiology, clinical characteristics, laboratory diagnosis, therapy and outbreak control strategies for pertussis.

8. Synopsis - Guidelines For The Control Of Pertussis In Australia Synopsis of the communicable diseases intelligence technical report series number 1 endorsed by the Communicable Diseases Network of Australia and New Zealand. http://www.health.gov.au/pubhlth/strateg/communic/tech/pertus.htm

This site uses Javascript for its navigation, if you have javascript turned off please use the buttons on the left hand side of the page. Please select a topic from list... Alcohol Australia's Biosecurity Health Response Bovine Spongiform Encephalopathy (BSE) Breastfeeding National Child Nutrition Program Communicable Diseases National Comorbidity Project Disaster Medicine Environmental Health Falls Prevention for Older People Initiative Folate Food Policy Group Food Regulation Secretariat Health Inequalities Research Collaboration (HIRC) Hepatitis C HIV/AIDS Illicit Drug Diversion Initiative Immunise Australia Program Injury Prevention JETACAR Lifestyle Prescriptions National Drug Strategy National Illicit Drug Strategy (Tough on Drugs) National Health Strategy Papers Obesity Guidelines Physical Activity Pituitary Hormone Initiatives Population Health Social Marketing Promoting Healthy Weight Tobacco SYNOPSIS Guidelines for the control of pertussis in Australia Communicable Diseases Intelligence Technical Report Series No 1 The control of pertussis in Australia report, endorsed by the Communicable Diseases Network of Australia and New Zealand, is the first in the Communicable Diseases Intelligence Technical Report Series.

9. First Acellular Pertussis Vaccine Approved For Infants Article about the Food and Drug Administration's announcement on licensing the first acellular pertussis vaccine for use in infants and children two months of age and older for the primary series of immunizations. Kidsource.com http://www.kidsource.com/kidsource/content/news/infant_vaccine8_1_96.html

First Acellular Pertussis Vaccine Approved For Infants advertisement Source PR NEWSWIRE Forums Health, Safety, Nutrition and Kids Related Articles Promising Data Released On New Infant Vaccine To Prevent Middle-Ear Infections, Meningitis and Pneumonia Kids' Vaccinations Get a Little Easier Information and news releases furnished by the members of PR Newswire, who are responsible for their fact and content. WASHINGTON, July 31, 1996 The Food and Drug Administration today announced it has licensed the first acellular pertussis vaccine for use in infants and children two months of age and older for the primary series of immunizations. The vaccine protects infants against whooping cough while causing fewer side-effects than whole-cell pertussis vaccines now on the market. Currently, U.S. children receive a whole-cell pertussis vaccine in combination with diphtheria-tetanus toxoid, commonly called DTP, at 2, 4 and 6 months of age, with additional doses of either a DTP or DT vaccine with an acellular pertussis component (DTaP) at 12-18 months and before going to school. The vaccine approved today for infants is one of two DTaP vaccines already approved for children to be given as fourth and fifth doses following three DTP doses. This approval should give parents more confidence in the safety of the pertussis vaccine their infants will receive.

10. Pertussis Facts Questions and answers on pertussis by the Association of State and Territorial Directors of Health Promotion and Public Health Education. http://www.astdhpphe.org/infect/per.html

Pertussis Pertussis is spread easily from person to person. People get pertussis by breathing in airborne droplets expelled from the nose or throat of an infected person. Despite an effective vaccine, pertussis continues to cause serious illness and death. Young children are most at risk for pertussis, but the disease is increasing in adolescents and adults. What is pertussis? Pertussis is a very contagious disease of the mucous membranes that line the air passages. It is also called whooping cough. What is the infectious agent that causes pertussis? Pertussis is caused by Bordetella pertussis , a bacterium. Where is pertussis found? Pertussis occurs worldwide. Pertussis bacteria live in the mouth, nose, and throat of an infected person. How do people get pertussis? Pertussis spreads easily from person to person. People get pertussis by breathing in droplets expelled from the nose or throat of an infected person during coughing or sneezing. It is also spread by direct contact with discharges from the nose or throat of an infected person. What are the signs and symptoms of pertussis?

11. Pertussis pertussis. ( Whooping Cough) The Disease. pertussis, more commonly known as whooping cough, is a very contagious disease. pertussis is caused by a germ that lives in the mouth, nose, and throat. It http://www.ecbt.org/pertussi.htm

Pertussis (Whooping Cough) The Disease Pertussis, more commonly known as whooping cough, is a very contagious disease. Pertussis is caused by a germ that lives in the mouth, nose, and throat. It is spread to others through coughing or sneezing. Pertussis causes violent spells of coughing which can make it hard for a child to eat, drink, or even breathe. The disease is hardest on infants under 1 year old, and half of the cases reported in the United States occur in that age group. More than half of these infants must be hospitalized. Doctors report about 3,500 cases of pertussis each year in the United States. Pertussis can have serious complications. About 1 child in 10 with pertussis also gets pneumonia. About 20 in every 1,000 will have convulsions and in 4 out of every 1,000 the brain will be affected (this is called encephalopathy). Pertussis causes about 9 deaths a year. Immunization Pertussis vaccine is usually given together with diphtheria and tetanus vaccines in a shot called DTaP. You can read about DTaP vaccine here.

12. Pertussis pertussispertussis, or whooping cough, is an acute infectious disease caused. by the bacterium Bordetella pertussis. Outbreaks of pertussis were. first described in the 16th century, and the organism http://www.cdc.gov/nip/publications/pink/pert.pdf

13. Pertussis.com For Parents pertussis (Whooping Cough) FAQ What Is pertussis or Whooping Cough? For More Information Further Reading for Parents What Is pertussis or Whooping Cough? http://www.pertussis.com/parents.html

var javascript_version = 1.0; Pertussis (Whooping Cough) FAQ What Is Pertussis or Whooping Cough? Whooping cough (pertussis) is a highly contagious disease marked by severe coughing. It is named after the "whoop" sound children and adults make when they try to breathe in during or after a severe coughing spell. back to top What are the Symptoms? Whooping cough usually starts with cold or flu-like symptoms such as runny nose, sneezing, fever and a mild cough. These symptoms can last up to two weeks and are followed by increasingly severe coughing spells. Fever, if present, is usually mild. During a classic cough episode: signature "whoop" is heard as the patient struggles to breathe coughs usually produce a thick, productive mucus vomiting may occur lips and nails may turn blue due to lack of oxygen patient is left exhausted after the coughing spell Mild pertussis disease is difficult to diagnose because its symptoms mimic those of a cold. Usually a prolonged cough is present, but without the "whoop". Milder symptoms usually affect all age groups, but are increasing among school children.

14. Communicable Disease Control, Epidemiology And Immunization Section Communicable disease information for HIV/AIDS, pertussis, influenza, tuberculosis, typhoid fever, chickenpox, and others. http://www.metrokc.gov/health/prevcont/

Site Directory Public Health Webpage Directory For Care Providers Care Providers Homepage For Educators Health Educators Toolbox About Us Employee Directory Contact Us Public Health 999 3rd Ave, Ste. 1200 Seattle, WA 98104 Phone: 206-296-4600 TTY: 206-296-4931 Click here to email us Subscribe to Free Email Alerts! Click here to learn more Successful Search Tips Home Communicable disease facts Communicable Diseases and Epidemiology 999 3rd Avenue, Suite 900 Seattle, WA 98104-4039 Phone: (206) 296-4774 Hours: Open Monday - Friday, 8:00 AM to 5:00 PM Hot topics Avian Influenza (Bird Flu) An outbreak of avian influenza, more commonly known as bird flu, is affecting bird populations in countries throughout Asia. The outbreak is caused by the H5N1 subtype of influenza A. Human cases also have been reported in Asia. There have been no cases of avian influenza in humans or poultry in the United States. Influenza ("flu") Season, 2003-04 Information on this year's flu season including where to get a flu shot, fact sheets, and updated case histories affecting King County residents. Severe Acute Respiratory Syndrome (SARS) Newsletters and publications Epi-Log Newsletter Produced monthly, the

15. Anti-immunisation Scare: The Inconvenient Facts A review and debunking of an antivaccine proponent, with information on the effects of reducing immunization rates of pertussis and measles and the false link between DTP and SIDS. http://www.skeptics.com.au/journal/anti-immune.htm

Australian Skeptics What's New Quick Tour Press News ... Search 'The Skeptic' Journal Back to: Home Journal Home About ... Web Anti-immunisation scare: The inconvenient facts Dr. Steve Basser (Vol 17, No 1) Introduction Over the last few years immunisation rates in Australia have fallen. As a result there have been outbreaks of the infectious diseases immunisation is designed to combat. Earlier this year there was a significant outbreak of pertussis (whooping cough) with at least three children dying from this preventable disease. There has been a lot of media attention focused on the immunisation issue, and in an attempt at ‘balanced’ reporting the views of individuals and groups who oppose immunisation have been given plenty of coverage. The most well known example of this was the ABC TV Quantum two part series aired on September 26 and October 3, 1996. The Australian Skeptics have been critical of the media in the past when they have unquestioningly given coverage to issues such as alien abductions or astrology. Can we now have our cake and eat it too? Is it reasonable to expect the media to only present the ‘immunisation is good’ message? Are there really two sides to the immunisation ‘debate’? This is the question the sceptical scientist should be asking. Perhaps the answer lies in the distinction between scientific evidence and individual opinion. There will be a number of different opinions, or beliefs, about immunisation but, as the Australian Skeptics have so often observed, believing something to be so does not necessarily make it so.

16. Pertussis (Whooping Cough) Whooping cough is a serious infection of the respiratory system caused by Bordetella pertussis bacteria. People...... misdiagnosed. http://kidshealth.org/parent/infections/lung/whooping_cough.html

KidsHealth Parents Infections Pertussis, also known as whooping cough, is an infection of the respiratory system caused by the bacterium Bordetella pertussis (or B. pertussis ). It's characterized by severe coughing spells that end in a "whooping" sound when the person breathes in. Before a vaccine was available, pertussis killed 5,000 to 10,000 people in the United States each year. Now, the pertussis vaccine has reduced the annual number of deaths to less than 30. Although pertussis can occur at any age, it's most severe in unimmunized children and in infants under 1 year of age (early immunization can usually prevent this serious disease in babies). About 40% of all pertussis infections occur in children less than 1 year old, and only 15% occur in children over 15 years old. Half of all deaths from pertussis occur in infants under age 1, and serious complications are more common in this group. The incidence of pertussis among adolescents and adults has been increasing in the last several years. This is an important fact, because coughing adolescents and adults who may not realize that they have pertussis are currently the major source of infection for infants and children. Signs and Symptoms The first symptoms of pertussis are similar to those of a common cold runny nose sneezing mild cough low-grade fever After about 1 to 2 weeks, the dry, irritating cough evolves into coughing spells. During a coughing spell, which can last for more than a minute, the child may turn red or purple. At the end of a spell, the child may make a characteristic whooping sound when breathing in or may vomit. Between spells, the child usually feels well.

17. Page Moved - Pertussis What is pertussis? pertussis, or whooping cough, is a highly contagious disease involving the respiratory the symptoms of pertussis? pertussis begins as a mild upper respiratory http://www.health.state.ny.us/nysdoh/consumer/pert.htm

location.href="/nysdoh/communicable_diseases/en/pert.htm"; Page moved click here if your browser does not forward you to the new page. http://www.health.state.ny.us/nysdoh/communicable_diseases/en/pert.htm

18. MedlinePlus: Whooping Cough General/Overviews; pertussis (Whooping Cough) (American Medical Association). Pictures/Diagrams; pertussis (Immunization Action Coalition). http://www.nlm.nih.gov/medlineplus/whoopingcough.html

@import url(http://www.nlm.nih.gov/medlineplus/images/advanced.css); Skip navigation Other health topics: A B C D ... List of All Topics Whooping Cough Contents of this page: General/Overviews Pictures/Diagrams Prevention/Screening Research ... Children Search MEDLINE for recent research articles on Whooping Cough You may also be interested in these MedlinePlus related pages: Childhood Immunization Cough Child and Teen Health Infections General/Overviews Pertussis (Whooping Cough) (American Medical Association) Pictures/Diagrams Pertussis (Immunization Action Coalition) Prevention/Screening Diphtheria, Tetanus, and Pertussis Vaccines (Centers for Disease Control and Prevention) - Links to PDF File Also available in: Spanish Improved Pertussis Vaccines: Enhancing Protection (National Institute of Allergy and Infectious Diseases) Preventing Whooping Cough (American Academy of Pediatrics) Research Measles and Pertussis Risk Higher for Children with Personal Exemptions From Immunizations (American Medical Association) Specific Conditions/Aspects Diphtheria, Tetanus, and Pertussis: Health Information for International Travel

19. Pertussis (Whooping Cough) Fact Sheet pertussis (Whooping Cough) Fact Sheet. pertussis is a highly contagious bacterial infection that causes coughing and gagging with little or no fever. http://www.metrokc.gov/health/prevcont/pertussis.htm

Site Directory Public Health Webpage Directory For Care Providers Care Providers Homepage For Educators Health Educators Toolbox About Us Employee Directory Contact Us Public Health 999 3rd Ave, Ste. 1200 Seattle, WA 98104 Phone: 206-296-4600 TTY: 206-296-4931 Click here to email us Subscribe to Free Email Alerts! Click here to learn more Successful Search Tips Home Communicable disease facts Pertussis Communicable Diseases and Epidemiology Pertussis ("Whooping Cough") fact sheet What is pertussis? Potential complications What are the symptoms? How is it spread? ... Prevention What is pertussis? Pertussis is a highly contagious bacterial infection that causes coughing and gagging with little or no fever. An infected person has cough episodes that may end in vomiting or cause a "whoop" sound when the person breathes in. Potential complications Pertussis is most dangerous to infants less than 1 year old who may develop pneumonia, convulsions, and rarely, brain damage or death. Serious complications are less likely in older children and adults.

20. Pertussis (Whooping Cough) Provides general information, signs and symptoms, and treatments. Includes a guide as to when to call a doctor. http://www.kidshealth.org/parent/infections/bacterial_viral/whooping_cough.html

KidsHealth Parents Infections Pertussis, also known as whooping cough, is an infection of the respiratory system caused by the bacterium Bordetella pertussis (or B. pertussis ). It's characterized by severe coughing spells that end in a "whooping" sound when the person breathes in. Before a vaccine was available, pertussis killed 5,000 to 10,000 people in the United States each year. Now, the pertussis vaccine has reduced the annual number of deaths to less than 30. Although pertussis can occur at any age, it's most severe in unimmunized children and in infants under 1 year of age (early immunization can usually prevent this serious disease in babies). About 40% of all pertussis infections occur in children less than 1 year old, and only 15% occur in children over 15 years old. Half of all deaths from pertussis occur in infants under age 1, and serious complications are more common in this group. The incidence of pertussis among adolescents and adults has been increasing in the last several years. This is an important fact, because coughing adolescents and adults who may not realize that they have pertussis are currently the major source of infection for infants and children. Signs and Symptoms The first symptoms of pertussis are similar to those of a common cold runny nose sneezing mild cough low-grade fever After about 1 to 2 weeks, the dry, irritating cough evolves into coughing spells. During a coughing spell, which can last for more than a minute, the child may turn red or purple. At the end of a spell, the child may make a characteristic whooping sound when breathing in or may vomit. Between spells, the child usually feels well.

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