81. Vitamin B12 -- Anemia / Sleep / Mental Quickness This verifies reports from Sweden dating from the 1970s that pernicious anemia, a disease of B12 deficiency, can be controlled with oral B12. http://www.smartbodyz.com/vitamin-B12-text.htm

vitamin B12 anemia / sleep / mental quickness B12 The Vital Vitamin Oral B12 Equivalent to Injections Reprinted by permission from Bill Faloon of The Life Extension Foundation by Terri Mitchell For decades, people have been injecting themselves with vitamin B12 because they thought oral supplements were not adequately absorbed. New research indicates that oral B12 supplements may be as good or better than injections. Those who have low levels of vitamin B12 in the blood have long resorted to injections of this essential B vitamin, an uncomfortable delivery method at best. New evidence suggests that oral B12 works as well as injections, according to a study published in the journal Blood but high doses must be taken. This verifies reports from Sweden dating from the 1970s that pernicious anemia , a disease of B12 deficiency, can be controlled with oral B12. Resolving the debate over oral-versus-injections is very timely, given that vitamin B12 is a homocysteine-lowering factor. Homocysteine has emerged as a strong and independent risk factor for heart disease and stroke, and is also connected to chronic diseases such as

82. Vitamin Syndromes Gastrointestinal malabsorption Deficient intrinsic factor production Postgastrectomy; Antibody vs parietal cells 6 pernicious anemia http://www.neuro.wustl.edu/neuromuscular/nother/vitamin.htm

Front Search Index Links ... Selenium deficiency Vitamins A: Retinoids B1: Thiamine B2: Riboflavin B ... D E Deficiency Intoxication Niacin Pyridoxine Deficiency Intoxication MULTIFACTORIAL Alcoholism Celiac disease Critical illness polyneuropathy Cuban neuropathy ... Strachan's Also see: GI disorders Thiamine (B1) deficiency Thiamine Biochemistry Metabolically active form: Thiamine pyrophosphate Enzyme systems Pyruvate dehydrogenase: Pyruvate Acetyl CoA Transketolase: Pentose monophosphate shunt Sources: Yeast, Pork, Legumes, Cereal grains, Rice Clinical features Extraocular movement paresis Peripheral neuropathy Distribution: Symmetric Pain: Burning feet; Lancinating pain; Calf tenderness Sensory loss Autonomic neuropathy: Orthostatic hypotension Tendon reflexes: Reduced in Legs Cerebellar degeneration Encephalopathy Acute: Wernicke's disease Mental status change: Confusion; Memory loss; Agitation Ataxia: Especially truncal Ocular: Paresis; Nystagmus; Retinal hemorrhages Chronic: Korsakoff's psychosis Memory disorders Dementia Systemic Cardiac failure: Congestive; Tachycardia; Edema

83. Welcome To AJC! pernicious anemia. pernicious anemia results from a lack of intrinsic factor in gastric secretions which, in turn, causes inadequate vitamin B12 absorption. http://www.ajc.com/search/healthfd/shared/health/adam/ency/article/000569.html

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84. NCI: Pernicious Anemia NCI Dictionary from PDQ®. Numbers A B C D E F G H I J K L M N O P Q R S T U V W X Y Z pernicious anemia. (perNISH-us a-NEE-mee-a) http://www.jamesline.com/patientsandpublic/cancertypes/glossary/index.cfm?action

85. Nat'l Academies Discovery Engine Currently using pernicious anemia as the search focus. high intake of folate has been said to delay the diagnosis of pernicious anemia. http://lab.nap.edu/nap-cgi/discov9.cgi?term=pernicious anemia&restric=

86. Nat'l Academies Discovery Engine Currently using pernicious anemia as the search focus. Try this search on the older NAP title search Please comment on the Discovery Engine. http://lab.nap.edu/nap-cgi/discov9.cgi?term=pernicious anemia&restric=NAP

87. Introducing Vita-Man B12 The classic B12 deficiency diseases is called pernicious anemia. Before the cause of pernicious anemia was understood, this disease was always fatal. http://www.vita-men.com/xnoplug/xcardB12/xB12frnt.htm

Preventer of pernicious anemia Water soluble Vita-Man sm B is essential for growth, for the formation of mature red blood cells, and for the normal functioning of the nervous system. The classic B deficiency diseases is called pernicious anemia. If the supply of Vitamin B is inadequate, people develop pernicious anemia because their bodies can't form red blood cells properly. The word "pernicious" means "causing great harm" a good description of this disease. Before the cause of pernicious anemia was understood, this disease was always fatal. Protector of the nervous system The spinal cord, brain, and other parts of the nervous system need Vita-Man B in order to function properly. Without him, serious neurologic symptoms may develop. And with Vita-Man B and Vita-Woman sm Folic Acid , Vita-Man B helps regulate homocysteine. Too much homocysteine in the bloodstream has been associated with an increase in the risk of heart disease. Vita-Man B and his two teammates (Vita-Man B and Vita-Woman Folic Acid) are necessary for the reactions that transform homocysteine into other substances and prevent it from building up to potentially harmful levels.

88. Pernicious Anemia pernicious anemia. Slide 29 of 33. http://meds.queensu.ca/medicine/deptmed/hemonc/macro/slide29.html

Pernicious Anemia Slide 29 of 33

89. Vitamin B12 Deficiency Information From EVitamins Vitamin B12 Deficiency. Also indexed as pernicious anemia. nervous system. The result is pernicious anemia (PA). In the classical http://www.evitamins.com/healthnotes/healthnotes.asp?ContentID=1287007

90. Vitamins & Anemia Its isolation from liver brought to a successful conclusion more than 20 years of investigation aimed at finding the cause of pernicious anemia. http://www.clevelandclinic.org/myeloma/anemiaANDvitamins.htm

Multiple Myeloma Research Center VITAMINS AND IRON IN ANEMIA General Concept The maintenance of normal red cell mass and the synthesis of hemoglobin are normally adjusted to take care of the physiological loss of the blood elements. Anemia results when there is excessive loss or diminished replacement of red cells. Most anemia's are deficiency diseases resulting from inadequate tissue concentrations of iron, vitamin B12, or folic acid. Correction of the deficiency is highly successful provided an accurate diagnosis is made. Erythropoietin is a useful stimulator of bone marrow in certain diseases. Iron Iron is contained in the body in various forms, principally as hemoglobin. Normal blood contains about 15 g of hemoglobin/100 ml, and each gram of hemoglobin contains 3.4 mg of iron. It may be calculated then that the total normal blood volume contains about 2.6 g of iron. In addition to hemoglobin, iron is contained in ferritin, the storage form for iron in the tissues, and in the serum attached to the carrier substance, the globulin transferrin. Minute quantities are also present in the cytochrome enzymes and myoglobin of muscle. Quantitatively, hemoglobin and ferritin contain the bulk of the iron in the body, amounting to a total of about 4 to 5 g. Under normal circumstances red cells are broken down at a steady rate, their lifespan being on the order of 120 days. Most of the iron released from the breakdown of hemoglobin is reutilized. As a consequence, the daily iron requirement in a normal adult is quite low, about 1 mg. Growth, menstruation, and pregnancy increase the iron requirement.

91. The Anemia File: Ground-breaking New Research pernicious anemia—current research on the treatment and prognosis of pernicious anemia, as well as the complications associated with this form of anemia. http://www.lifestages.com/health/anemia.html

The Anemia File SM C E N T E R F O R C U R R E N T R E S E A R C H Approved by Physicians' Home Page Medinex Seal of Approval WellnessWeb: The Patient's Network HONcode Principles of the Health On the Net Foundation Partners of CareData.com W Anemia File . Learn about late-breaking research from recognized experts at blood centers and departments of internal medicine worldwide. Compiled from the National Library of Medicine database at the National Institutes of Health, the Anemia File Anemia File informs you about studies at such renowned institutions as Mount Sinai Medical Center in New York, the Blood and Marrow Transplant Program at the University of Minnesota, and the Mayo Clinic. The Anemia File brings you the inside medical story on: Pernicious Anemia Aplastic Anemia Iron Deficiency Anemia Cobalamine Deficiency Hormone Therapy for Anemia Transplantation Techniques Hemolytic Anemia Diamond-Blackfan Anemia Fanconi Anemia General Studies in Anemia Care Access to Free Full-Text Articles from Postgraduate Medicine, the British Medical Journal, and the New England Journal of Medicine

92. Nutrimed Labs: PERNICIOUS ANEMIA Condition pernicious anemia. SUGGESTED NUTRITION PHYSIOLOGICAL CONSIDERATIONS pernicious anemia is basically a nutritional deficiency disease. http://www.nutrimed.com/ANEMIAP.HTM

Home Online Catalog Newsletters Therapy Index ... Contact Us Condition: PERNICIOUS ANEMIA SUGGESTED NUTRITION: Hemaplex #969 3 - per day - Stimulates hemopoiesis. Potent hematinic. Intrinsic Plus #400 3 to 6 per day - Intrinsic factor for vitamin B-12 and iron absorption. Livatrate #982 3 to 18 per day (divided dose) - Tends to improve liver function, aids in detoxification. Supplies needed iron for red blood cell production, raw liver factors, and enzymes. To order any of these products, click the blue link and use our online shopping cart. All of our products are manufactured in a US FDA approved facility. PATHOLOGICAL CONSIDERATIONS: A chronic, macrocytic anemia characterized by achlorhydria, gastro-intestinal disturbances, and neurologic syndromes. It occurs most often in Caucasians after age 50. The fundamental defect is a permanent deficiency of the intrinsic factor normally present in gastric juice. In addition to atrophy of gastric mucosa and changes in bone marrow common to all megaloblastic anemias, there is often specific neurologisc changes. Subacute combined degeneration of the spinal cord is a common finding. Degeneration may also occur in peripheral nerves, nerve plexuses of the gastro-intestinal tract, and subcortical areas in the motor region of the brain. PHYSIOLOGICAL CONSIDERATIONS: Pernicious anemia is basically a nutritional deficiency disease. Characteristic blood abnormalities can be corrected by use of folic acid. However, if there is an accompanying deficiency of vitamin B-12, an irreversible degeneration of the spinal cord may take place. The intrinsic factor normally produced by stomach mucosa is necessary in order that B-12 may be absorbed and utilized. In pernicious anemia, the stomach has become unable to produce either the intrinsic factor or hydrochloric acid. Vitamin B-6 and vitamin C increase absorption of vitamin B-12. Adequate protein is also needed as vitamin B-12 is almost always associated with animal proteins such as liver, kidney, muscle meats, etc.

93. Pernicious (Anemia) Articles, Support Groups, And Resources pernicious (anemia) articles, support groups, and resources for patients from Med Help International (www.medhelp.org). pernicious (anemia). http://www.medhelp.org/HealthTopics/Pernicious.html

[Health Topics A-Z] A B C D ... Z Pernicious (Anemia) Medical Glossary: ANEMIA ANEMIA OF CHRONIC DISEASE APLASTIC ANEMIA AUTOIMMUNE HEMOLYTIC ANEMIA ... SIDEROBLASTIC ANEMIA Medical Library: CDC's Nutrition and Physical Activity - Anemia and Iron Status Ferrlecit Consumer Information Ask The Doctor Forums AIH and Aplastic Anemia (Hepatitis Forum) Anemia (Gastroenterology and Liver Diseases Forum) Anemia - Stomach or Colon (Gastroenterology and Liver Diseases Forum) anemia and 3 positive hemocults, colonoscopy finds nothing (Gastroenterology and Liver Diseases Forum) ... What Should I do? (Heart Forum) Support Groups: Cooley's Anemia Foundation [Med Help Home] [Library Search] [Medical Forums] ... [Patient Network] Revised: 6/2/2004

94. UAB Health System | Megaloblastic (Pernicious) Anemia Megaloblastic (pernicious) anemia. What is anemia? Always consult your physician for a diagnosis. What is megaloblastic (pernicious) anemia? http://www.health.uab.edu/show.asp?durki=15481

95. Hematology & Blood Disorders - Megaloblastic (Pernicious) Anemia Megaloblastic (pernicious) anemia. What is megaloblastic (pernicious) anemia? Megaloblastic What causes megaloblastic (pernicious) anemia? Megaloblastic http://www.med.utah.edu/healthinfo/adult/Hemat/aneper.htm

What is anemia? Anemia is a common blood disorder, which is caused when there is a drop in hemoglobin or hematocrit in the blood. Hemoglobin is the part of blood that distributes oxygen from the lungs to tissues in the body. Hematocrit is the measurement of the percentage of red blood cells found in a specific volume of blood. Anemia is usually a symptom of a disease rather than a disease itself. Anemia may be a symptom of another disease. The following are the most common symptoms of anemia. However, each individual may experience symptoms differently. Symptoms may include: abnormal paleness or lack of color of the skin increased heart rate (tachycardia) breathlessness, or difficulty catching a breath (dyspnea) lack of energy, or tiring easily (fatigue) dizziness, or vertigo, especially when standing headache irritability irregular menstruation cycles absent or delayed menstruation (amenorrhea) sore or swollen tongue (glossitis) jaundice, or yellowing of skin, eyes, and mouth

96. Megaloblastic (Pernicious) Anemia Detailed information on megaloblastic (pernicious) anemia, including causes, symptoms, diagnosis, and treatment. Megaloblastic (pernicious) anemia. http://www.healthsystem.virginia.edu/uvahealth/peds_hematology/megalob.cfm

@import url(/assets/UVAHealth/ssi/css/greystone_advance.css); Adolescent Medicine Allergy/Asthma/Immunology Blood Disorders Burns Cancer Common Injuries/Poison Tips Craniofacial Anomalies Dermatology Diabetes/Endo/Metabolism Eye Care Genitourinary/Kidney High-Risk Newborn High-Risk Pregnancy Infectious Diseases Medical Genetics Mental Health Nervous System Disorders Normal Newborns Oral Health Orthopaedics Pediatric Surgery Respiratory Disorders Terminal Illness in Children Transplantation FIND A DOCTOR MAKE AN APPOINTMENT CALENDAR OF EVENTS CLINICAL TRIALS Megaloblastic (Pernicious) Anemia What is megaloblastic anemia? Megaloblastic anemia is a type of anemia characterized by very large red blood cells. In addition to the cells being large, the inner contents of each cell are not completely developed. This malformation causes the bone marrow to produce fewer cells, and sometimes the cells die earlier than the 120-day life expectancy. Instead of being round or disc-shaped, the red blood cells can be oval. What causes megaloblastic anemia? There are many causes of megaloblastic anemia, but the most common source in children occurs from a vitamin deficiency of folic acid or vitamin B-12. Other sources of megaloblastic anemia include the following:

97. Health Information Megaloblastic (pernicious) anemia. What is megaloblastic (pernicious) anemia? Megaloblastic What causes megaloblastic (pernicious) anemia? Megaloblastic http://www.baptisthealth.net/greystone/content.jsp?pageid=P00080

98. NewYork-Presbyterian Hospital: Health A To Z: Megaloblastic (Pernicious) Anemia Health information about Megaloblastic (pernicious) anemia from NewYorkPresbyterian. The University Hospitals of Columbia and Cornell. http://wo-pub2.med.cornell.edu/cgi-bin/WebObjects/PublicA.woa/1/wa/viewHContent?

99. Case 3 Case 3. A white woman of 61 yrs has had increasing fatigue for 3 months, and tingling in her feet for 2 weeks. Blood Count (CBC) (M)*. http://meds.queensu.ca/medicine/deptmed/hemonc/anemia/Quiz/case3.htm

Case 3 A white woman of 61 yrs has had increasing fatigue for 3 months, and tingling in her feet for 2 weeks. Blood Count (CBC) (M) *Figures in square brackets indicate normal values WBC x 10 /L Hb g/L MCV fl Platelets x 10 /L Neuts x 10 /L Lymphs x 10 /L Monos x 10 /L Eos x 10 /L Basos x 10 /L Blasts x 10 /L Promyleocytes x 10 /L Myelocytes x10 /L Metamyelocytes x 10 /L Nucleated RBC x 10 /L Film comment oval macrocytes++ hypersegmented neutrophils Clinical Data Weight loss Dietary history Alcohol intake Indigestion ... Family history of jaundice Investigations Reticulocytes LDH Mean red cell survival Serum iron ... Serum protein electrophoresis Quantitative IgG IgA IgM Return to table of contents...

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