21. Pernicious Anemia And B12 Injections Subscribe now . pernicious anemia and B12 Injections. When I was finally diagnosed with having pernicious anemia (PA), I was 29 years old. http://healthlink.mcw.edu/article/880000064.html

Search Articles: search tips Please Take the HealthLink Survey Email this article Print this article Find related articles: By topic: By keywords: Receive Health Link via email! Subscribe now >> Pernicious Anemia and B12 Injections Q: I became anemic when my daughter was born in 1940. When I was finally diagnosed with having pernicious anemia (PA), I was 29 years old. My daughter also has P.A. It was diagnosed when she was 48. I have been on B12 many years - I am now almost 80. I receive monthly B12 injections, and would like to know if I still need these every month? My doctors don't check on the need as with other medication A: If you were diagnosed with PA at such a young age, chances are you need the B12 replacement now, at the age of 80, more than ever. In a survey of 548 older people, ages 67-96, about 20% had low levels of B12 on blood tests. Only half of those people were actually anemic, so they and their doctors were probably unaware of the B12 deficiency. Adequate B12 is important for other reasons than just prevention of anemia. The nervous system also utilizes B12, so a lack of B12 can result in numbness and tingling of the hands and feet, memory loss, disorientation, depression, and even personality change. Older people may have lower levels of B12 because they do not adequately absorb B12 from their food. Once malabsorption starts, the person will become deficient in one to two years. The best way to replace B12 is through injections. Pills are available but would not be absorbed any better than B12 in food unless given in fairly high doses. The usual dose is 1 mg per month given by injection. Ask your doctor to measure your blood level of B12. Most likely you will continue to require a monthly shot

22. AllRefer Health - Pernicious Anemia (Congenital Pernicious Anemia, Juvenile Pern pernicious anemia (Congenital pernicious anemia, Juvenile pernicious anemia, Macrocytic Achylic Anemia, Vitamin B12 Deficiency (Malabsorption)) information http://health.allrefer.com/health/pernicious-anemia-info.html

AllRefer Channels :: Yellow Pages Reference Health Home ... Contact Us Quick Jump ADD/ADHD Allergies Alzheimer's Disease Arthritis Asthma Back Pain Breast Cancer Cancer Colon Cancer Depression Diabetes Gallbladder Disease Heart Attack Hepatitis High Cholesterol HIV/AIDS Hypertension Lung Cancer Menopause Migraines/Headaches Osteoporosis Pneumonia Prostate Cancer SARS Stroke Urinary Tract Infection 1600+ More Conditions Alternative Medicine Health News Symptoms Guide Special Topics ... Medical Encyclopedia You are here : AllRefer.com Health Pernicious Anemia Pernicious Anemia Definition Prevention Treatment Expectations or Prognosis ... Go To Main Page Alternate Names : Congenital Pernicious Anemia, Juvenile Pernicious Anemia, Macrocytic Achylic Anemia, Vitamin B12 Deficiency (Malabsorption) Definition Anemia is a condition where red blood cells are not providing adequate oxygen to body tissues. There are many types and causes of anemia. (See the general article - anemia .) Pernicious anemia is caused by a lack of intrinsic factor, a substance needed to absorb vitamin B12 from the gastrointestinal tract. Vitamin B12, in turn, is necessary for the formation of red blood cells.

23. HealthCentral - General Encyclopedia - Pernicious Anemia General Health Encyclopedia, pernicious anemia. Congenital pernicious anemia is inherited as an autosomal recessive disorder. Pernicious http://www.healthcentral.com/mhc/top/000569.cfm

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24. Vitamin B12 Deficiency (Pernicious Anemia) Articles, Support Groups, And Resourc Vitamin B12 Deficiency (pernicious anemia) articles, support groups, and resources for patients from Med Help International (www.medhelp.org). http://www.medhelp.org/HealthTopics/Vitamin_B12_Deficiency.html

[Health Topics A-Z] A B C D ... Z Vitamin B12 Deficiency (Pernicious Anemia) Medical Glossary: PERNICIOUS ANEMIA VITAMIN B12 DEFICIENCY Ask The Doctor Forums Guillain Barre or vitamin B12 deficiency and PN? (Neurology and Neurosurgery Forum) pernicious anemia (Neurology and Neurosurgery Forum) Pernicious Anemia and Blood Group A (Gastroenterology and Liver Diseases Forum) pernicious anemia and neuropathy (Neurology and Neurosurgery Forum) ... [Patient Network] Revised: 6/2/2004

25. UAB Health System | Pernicious Anemia pernicious anemia. Dear Doctor Column, November 26, 2001. Question What is the difference in pernicious anemia and B12 deficiency? What causes this condition? http://www.health.uab.edu/show.asp?durki=61520&site=734&return=18687

26. RxMed: Illness Information - ANAPHYLAXIS The symptoms of pernicious anemia develop slowly and gradually and may not be immediately recognized . Family history of pernicious anemia. Genetic factors. http://www.rxmed.com/b.main/b1.illness/b1.1.illnesses/anemia,_pernicious.html

General Illness Information Common Name: ANEMIA, PERNICIOUS Medical Term: None Specified Description: This anemia is caused by lack of vitamin B-12 (cobalamin). It is a megaloblastic anemia . In this type of anemia the bone marrow produces large abnormal blood cells (megaloblasts). It often affects adults between the ages of 50 and 60. The symptoms of pernicious anemia develop slowly and gradually and may not be immediately recognized . This is because the liver stores large amounts of vitamin B12 and so the anemia does not develop for 2 to 4 years after the body stops absorbing vitamin B12. Vitamin B-12 is found in foods of animal origin, such as meat, fish, dairy products and legumes.. Causes: Prevention: See diagnosis and treatment below. Weakness and tiredness Bleeding gums Nausea, appetite loss and weight loss Sore tongue Numbness and tingling in the hands and feet Difficulty maintaining balance Yellowish tinge to eyes and skin Shortness of breath Poor memory Headache Depression Confusion and dementia Risk Factors Improper diet, especially a vegetarian diet lacking vitamin B-12 and without supplements

27. Information About Vitamin B12 Deficiency What is pernicious anemia? pernicious anemia is a rare condition in which the body does not absorb enough vitamin B12 from the digestive tract. http://www.mamashealth.com/blood/peranemia.asp

Mamashealth.com Home Blood Diseases Agnogenic Metaplasia Amyloidosis Diabetes Hematuria ... Von Willebrand's Disease Links Crystal Products Email Mama What is Pernicious Anemia? Pernicious anemia is a rare condition in which the body does not absorb enough vitamin B12 from the digestive tract. It causes inadequate production of red blood cells. Vitamin B12 is needed to make red blood cells. Pernicious anemia is hereditary. It is rarely caused by a diet lacking in vitamin B12. Vitamin B12 is found in meat, eggs, shellfish, fortified cereals and milk. Pernicious anemia is a chronic condition what progresses steadily if not treated. Symptoms? In early stages, there are usually no symptoms. When symptoms do appear, the most common ones are: weakness pale skin lightheadedness sore tongue diarrhea poor appetite weight loss nausea mental confusion yellow skin numbness or coldness in hands and feet What causes Pernicious Anemia? It most common causes is inheriting it from your parents. Other causes include: surgery to the stomach, surgery to the small intestine, abnormal bacterial growth in the small intestine, Crohn's Disease, and celiac disease. Pernicious anemia may also be associated with type 1 diabetes , thyroid disease, and a family history of the pernicious anemia.

28. Pernicious Anemia pernicious anemia. Definition. pernicious anemia is a disease in which the red blood cells are abnormally formed, due to an inability to absorb vitamin B 12 . http://www.ehendrick.org/healthy/001049.htm

MAIN SEARCH INDEX Pernicious anemia Definition Description Causes and symptoms Diagnosis ... Resources Definition Pernicious anemia is a disease in which the red blood cells are abnormally formed, due to an inability to absorb vitamin B . True pernicious anemia refers specifically to a disorder of atrophied parietal cells leading to absent intrinsic factor, resulting in an inability to absorb B Description Vitamin B , or cobalamin, plays an important role in the development of red blood cells. It is found in significant quantities in liver, meats, milk and milk products, and legumes. During the course of the digestion of foods containing B , the B becomes attached to a substance called intrinsic factor. Intrinsic factor is produced by parietal cells which line the stomach. The B -intrinsic factor complex then enters the intestine, where the vitamin is absorbed into the bloodstream. In fact, B can only be absorbed when it is attached to intrinsic factor. In pernicious anemia, the parietal cells stop producing intrinsic factor. The intestine is then completely unable to absorb B . So, the vitamin passes out of the body as waste. Although the body has significant amounts of stored B

29. Pernicious Anemia pernicious anemia,. pernicious anemia occurs most often in persons older than 35 years and is more common in individuals of northern European descent. http://www.britannica.com/nobel/micro/460_52.html

pernicious anemia, slow-developing disease in which the production of red blood cells is impaired as the result of a vitamin B deficiency. An absence of hydrochloric acid in gastric secretions (achlorhydria) is also characteristic of this condition. Pernicious anemia is one of many types of anemia, a disease marked by a reduction in red blood cells or in the oxygen-carrying substance hemoglobin found in those cells. Anemias are distinguished from one another by cause, symptoms, and cell characteristics. In pernicious anemia, vitamin B , which is necessary for red blood cells to mature properly in the bone marrow, is unavailable owing to a lack of intrinsic factor, a substance responsible for the intestinal absorption of the vitamin. In a healthy person, intrinsic factor is produced by the parietal cells of the stomach, the cells that also secrete hydrochloric acid. In the stomach, intrinsic factor forms a complex with vitamin B . This complex remains intact, preventing degradation of the vitamin by intestinal juices, until it reaches the ileum of the small intestine, where the vitamin is released and absorbed into the body. Pernicious anemia results either when intrinsic factor is prevented from binding with vitamin B or when the parietal cells are unable to produce intrinsic factor. This is believed to stem from an autoimmune reaction in which the body produces antibodies against intrinsic factor and against the parietal cells, destroying them.

30. Pernicious Anemia - Information / Diagnosis / Treatment / Prevention home blood disorders anemia pernicious pernicious anemia. Adam.com An Overview Looks at pernicious anemia, its causes, incidence and risk factors. http://www.healthcyclopedia.com/blood-disorders/anemia/pernicious.html

Home Health cyclopedia All Topics by Category The Good Health Search Engine Health Conditions A-Z Gurus ... anemia > pernicious Pernicious Anemia Information / Diagnosis / Treatment / Prevention External links (marked with an arrow ) open in a new window. This site is a web directory and does not offer medical advice. We cannot take responsibility for information found on listed sites. This Page Medical Definition Health Portals Health News Web Directory: Medical Definition: University of Newcastle-upon-Tyne Medical Dictionary: "pernicious" Health Portals: MayoClinic.com Health News: Search millions of published articles for news on Pernicious Anemia Modern Medicine Aging The Ardell Wellness Report HealthFacts Medical Post Medical Update Men's Health and the National Women's Health Report Note: Subscription required to access the full text of articles. Web Directory: Adam.com: An Overview Looks at pernicious anemia, its causes, incidence and risk factors. Anemia Cases A case study of a 50 year old woman complaining of anorexia and shortness of breath for the past few weeks. InteliHealth: Pernicious Anemia Details about this disorder, what it is, the symptoms, diagnosis, prevention, treatment, prognosis and when to call a doctor.

31. Pernicious Anemia pernicious anemia. Definition Vitamin B12, in turn, is necessary for the formation of red blood cells. pernicious anemia is a type of megaloblastic anemia. http://www.healthscout.com/ency/article/000569.htm

Advertisement Search HealthScout Web MEDLINE Special Offers TV Specials Top Features Schizophrenia Hair Loss Liver Disease Allergies ... Impotence Resources Healthscout News 3D Interactive Human Atlas Health Videos Health Encyclopedia ... Drug Library Channels Home Today Women Men ... Drug Checker Advertisement Disease Injury Nutrition Poison ... Prevention Pernicious anemia Definition: Anemia is a condition where red blood cells are not providing adequate oxygen to body tissues. There are many types and causes of anemia. (See the general article - anemia .) Pernicious anemia is caused by a lack of intrinsic factor, a substance needed to absorb vitamin B12 from the gastrointestinal tract. Vitamin B12, in turn, is necessary for the formation of red blood cells. Pernicious anemia is a type of megaloblastic anemia Alternative Names: Macrocytic achylic anemia; Congenital pernicious anemia; Juvenile pernicious anemia; Vitamin B12 deficiency (malabsorption) Causes, incidence, and risk factors: Intrinsic factor is a protein the body uses to absorb vitamin B12. When gastric secretions do not have enough intrinsic factor, vitamin B12 is not adequately absorbed, resulting in pernicious anemia. Because vitamin B12 is needed by nerve cells and blood cells for them to function properly, pernicious anemia causes a wide variety of symptoms, including fatigue, shortness of breath, tingling sensations, difficulty walking, and diarrhea.

32. What Is Pernicious Anemia? pernicious anemia, a potentially fatal nutritional deficiency, is easily treated by regular intramuscular injections of vitamin B12. http://akak.essortment.com/whatispernicio_rtxl.htm

What is pernicious anemia? Pernicious anemia, a potentially fatal nutritional deficiency, is easily treated by regular intramuscular injections of vitamin B-12. Pernicious anemia is a potentially fatal nutritional deficiency cause by the body's inability to absorb vitamin B-12, which is essential to the body's production of red blood cells. Pernicious anemia is caused by the absence of intrinsic factor, a substance secreted by the stomach. Intrinsic factor facilitates the absorption of vitamin B-12. A blood test can confirm a diagnosis of pernicious anemia, by revealing the presence of megaloblasts in the blood. A megaloblast is a large erythroblast, and an erythroblast is the first identifiable stage in the development of a red blood cell. In pernicious anemia, the number of red blood cells decreases, but their size and hemoglobin content increases. bodyOffer(19807) Because the body stores B-12 very efficiently, it takes years for pernicious anemia to develop and for symptoms to begin to show. What are the symptoms of pernicious anemia?

33. Pernicious Anemia - Medical Dictionary Definitions Of Popular Medical Terms MedicineNet Home MedTerms medical dictionary AZ List pernicious anemia. pernicious anemia A blood disorder caused by inadequate vitamin B12 in the blood. http://www.medterms.com/script/main/art.asp?articlekey=4847

34. Anemia, Pernicious - Medical Dictionary Definitions Of Popular Medical Terms pernicious anemia is characterized by the presence in the blood of large, immature, nucleated cells (megaloblasts) that are forerunners of red blood cells. http://www.medterms.com/script/main/art.asp?articlekey=6855

35. Megaloblastic (Pernicious) Anemia - Lucile Packard Children's Hospital pernicious) anemia? Megaloblastic anemia, also called pernicious anemia, is a type of anemia characterized by very large red blood cells. http://www.lpch.org/DiseaseHealthInfo/HealthLibrary/hematology/megalob.html

Bone Marrow Transplantation Hematology Hematopoietic Stem Cell Transplantation Oncology ... Oncology Megaloblastic (Pernicious) Anemia What is megaloblastic (pernicious) anemia? Megaloblastic anemia, also called pernicious anemia, is a type of anemia characterized by very large red blood cells. In addition to the cells being large, the inner contents of each cell are not completely developed. This malformation causes the bone marrow to produce fewer cells, and sometimes the cells die earlier than the 120-day life expectancy. Instead of being round or disc-shaped, the red blood cells can be oval. What causes megaloblastic (pernicious) anemia? There are many causes of megaloblastic anemia, but the most common source in children occurs from a vitamin deficiency of folic acid. Other sources of megaloblastic anemia include the following: digestive diseases Certain diseases of the lower digestive tract can lead to megaloblastic anemia. These include celiac disease, chronic infectious enteritis, and enteroenteric fistulas. malabsorption Inherited congenital folate malabsorption, a genetic problem in which infants cannot absorb folic acid in their intestines, can lead to megaloblastic anemia. This requires early intensive treatment to prevent long term problems such as mental retardation.

36. Pernicious Anemia Health Channels. Family child health. Men s health. Women s health. Seniors health. Addiction. Allergy NEW! Arthritis. Back health. Brain health. Breast cancer. http://www.medbroadcast.com/condition_info_details.asp?disease_id=278

37. Perniciuos Anemia pernicious anemia. (Transcobalamin II deficiency). Pathology. pernicious anemia (PA) is caused by a lack of vitamin B 12 , otherwise known as cobalamin. http://www.diseasedir.org.uk/genetic/gene2202.htm

Pernicious anemia (Transcobalamin II deficiency) Disease type: Disorder of cobalamin (Vitamin B ) transport Chromosomes: Pathology Pernicious anemia (PA) is caused by a lack of vitamin B , otherwise known as cobalamin. Diced liver has been known since 1926 to cure PA. The active agent at this time was unknown, Eventually in 1948, the active agent was isolated, and characterised. The active agent, being vitamin B . Cobalamin is composed of a carbon ring, containing a cobolt atom in its centre. Cobalamin is involved in only two chemical reactions within the body (see figure 22.02.01). One involving the formation of methionine, and the other, the formation of succinate. These two reactions require modified versions of cobalamin, the methyltransferase requires a methylated cobalamin. Whereas the mutase requires an adenylated cobalamin. Defects in these two enzymes result in the symptoms of PA. Aetiology PA can be brought about by several possible defects. Cobalamin is absorbed across the gut by the secretion of a glycoprotein called "Intrinsic Factor" (IF). IF binds to cobalamin, and then facilitates cobnbalamins crossing into the blood stream through the IF receptor. Once in the blood, cobalamin is released by IF, and binds to transcobalamin II (TCII). This allows TCII, and cobalamin to be taken up by liver cells. Cobalamin is then modified by either adenylation, or methylation. Defects can arise in any of these pathways, particularly with IF, IF receptor, and TCII. A genetic defect in any of these will result in PA. A defect in the methylation/adenylation step results in much less severe symptoms.

38. Pernicious Anemia Review! - The Doctors Lounge(TM) pernicious anemia. Hematology. Medical disease review for USMLE, MRCP. A quick summary before the exams. Hematology. pernicious anemia. (Addisonian anemia). http://www.thedoctorslounge.net/clinlounge/diseases/hematology/pernicious.htm

Advanced Search SELECT A SPECIALTY Medical Specialties Cardiology Gynecology Infertility Internal Medicine Nephrology Obstetrics Oncology Pathology Pharmacology Student Home Forum Humor Jobs ... Med Students Your browser does not support inline frames or is currently configured not to display inline frames. Student Articles Medical Tutorials Medical Games Mnemonics ... Disease Database Other Sections Cardiology Fertility Gynecology Internal Medicine ... Pharmacology Professional Medical Oath Medline search Guidelines search Article search ... Abbreviations Favorites Medical Directory Medical Calculators Membership You are here: Back to hematological diseases index Hematology Pernicious anemia (Addisonian anemia) Autoimmune disorder in which antibodies attack the gastric mucosa (causing gastric atrophy) or intrinsic factor. This leads to inadequate absorption of intrinsic factor and hence a decrease in vitamin B12 absorption ( macrocytic anemia Clinical suspicion: macrocytic anemia due to B12 deficiency Diagnosis: Schilling test We subscribe to the HONcode principles.

39. Untitled Document pernicious anemia, A Victory For Science. From Whipple=s study, Minot believed that the cause of pernicious anemia was some missing essential nutrient. http://www.csulb.edu/~acolburn/SCED496/pernicious_anemia.htm

Home ScEd 401 ScEd 550 EDSS 450C ... Contact Pernicious Anemia, A Victory For Science Anemia is a medical condition in which the blood is low in red blood cells or hemoglobin. However, in the later part of the nineteenth century, a new form of anemia was gradually identified as a distinct medical condition, termed pernicious anemia. The victim commonly exhibited an inflamed, glossy tongue, slight jaundice or yellowing of the eyes and skin, and persistent tingling or numbness in the fingers or toes. Microscopic examination of the blood revealed cells with overly large nuclei called megaloblasts (today the hallmark sign of pernicious anemia). The anemia was almost always fatal. The survival after the onset of the disease was usually from one to three years (Hardisty 1982). For over seventy years since its first recognition, pernicious anemia remained an incurable disorder with an outlook of almost certain death. It was not until 1926 when two physicians from Boston, Doctors George R. Minot and William P. Murphy announced insights into the cure of the disease. In 1925, Minot was 40 years old and an assistant professor of medicine at Harvard University. He also had a busy practice in hematology. He recruited Murphy from Peter Bent Brigham Hospital to help him with his busy practice. Minot wanted all of his office associates to have some research experience and to have published at least one paper before starting his practice. So Minot suggested to Murphy to search for some sort of dietary supplement for patients with anemia. Minot had been interested in the dietary habits in pernicious anemia patients since he graduated from Harvard Medical School. He had noticed that the victims disliked the taste of meat and had poor eating habits (Krantz 1974).

40. NEJM -- Pernicious Anemia With Neuropsychiatric Dysfunction In A Patient With Si Original Article from The New England Journal of Medicine pernicious anemia with Neuropsychiatric Dysfunction in a Patient with Sickle Cell Anemia Treated http://content.nejm.org/cgi/content/short/348/22/2204

HOME SEARCH CURRENT ISSUE PAST ISSUES ... HELP Please sign in for full text and personal services Previous Volume 348:2204-2207 May 29, 2003 Number 22 Next Pernicious Anemia with Neuropsychiatric Dysfunction in a Patient with Sickle Cell Anemia Treated with Folate Supplementation Meekoo Dhar, M.D., Rita Bellevue, M.D., and Ralph Carmel, M.D. Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings. Full Text PDF PDA Full Text CME Exam ... Chapters at Harrison's The administration of folic acid can mask the megaloblastic anemia caused by cobalamin deficiency. More critically, this masking, although neither complete nor permanent, can permit neurologic dysfunction to develop and sometimes become irreversible. A few authors have proposed that folate may actually worsen the neurologic dysfunction. Patients with sickle cell disease are often routinely given folate supplementation. The rationale is to prevent the deficiency caused by the increased folate turnover in chronic hemolytic anemia.

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