1. MedlinePlus Medical Encyclopedia: Pernicious Anemia pernicious anemia. Macrocytic achylic anemia; Congenital pernicious anemia; Juvenile pernicious anemia; Vitamin B12 deficiency (malabsorption) http://www.nlm.nih.gov/medlineplus/ency/article/000569.htm

@import url(http://www.nlm.nih.gov/medlineplus/images/advanced.css); Skip navigation Medical Encyclopedia Other encyclopedia topics: A-Ag Ah-Ap Aq-Az B-Bk ... Z Pernicious anemia Contents of this page: Illustrations Alternative names Definition Causes, incidence, and risk factors ... Prevention Illustrations Megaloblastic anemia - view of red blood cells Alternative names Return to top Macrocytic achylic anemia; Congenital pernicious anemia; Juvenile pernicious anemia; Vitamin B12 deficiency (malabsorption) Definition Return to top Pernicious anemia is caused by a lack of intrinsic factor, a substance needed to absorb vitamin B12 from the gastrointestinal tract. Vitamin B12, in turn, is necessary for the formation of red blood cells. Anemia is a condition where red blood cells are not providing adequate oxygen to body tissues. There are many types and causes of anemia. (See the general article - anemia Pernicious anemia is a type of megaloblastic anemia Causes, incidence, and risk factors Return to top Intrinsic factor is a protein the body uses to absorb vitamin B12. When gastric secretions do not have enough intrinsic factor, vitamin B12 is not adequately absorbed, resulting in pernicious anemia and other problems related to low levels of vitamin B12. Because vitamin B12 is needed by nerve cells and blood cells for them to function properly, deficiency can cause a wide variety of symptoms, including fatigue, shortness of breath, tingling sensations, difficulty walking, and diarrhea.

2. Megaloblastic (Pernicious) Anemia -Blood Diseases & Disorders A definition of pernicious anemia, the causes, symptoms, diagnosis and treatment are discussed. http://www.umm.edu/blood/aneper.htm

Donations / Banking Blood Diseases Blood Disorders... Anemias ... Site Map Related Resources Within UMM Hematology Pediatric Oncology Blood Diseases Megaloblastic (Pernicious) Anemia What is megaloblastic (pernicious) anemia? Megaloblastic (pernicious) anemia is a rare disorder in which the body does not absorb enough vitamin B12 from the digestive tract, resulting in an inadequate amount of red blood cells (RBCs) produced. What causes megaloblastic (pernicious) anemia? Megaloblastic (pernicious) anemia is more common in individuals of northern European descent. Megaloblastic (pernicious) anemia results from a lack of intrinsic factor in gastric secretions (a substance needed to absorb vitamin B12 from the gastrointestinal tract). Vitamin B12 deficiency results. The inability to make intrinsic factor may be the result of chronic gastritis, or the result of a gastrectomy (removal of all or part of the stomach). Megaloblastic (pernicious) anemia may also be associated with type 1 diabetes, thyroid disease, and a family history of the disease. What are the symptoms of megaloblastic (pernicious) anemia?

3. Pernicious Anemia Hub A brief definition, followed by links to research articles, overviews, case reports and clinical trials. http://www.projectlinks.org/peranemia

Pernicious anemia hub Pernicious anemia is the most common cause of vitamin B (cyanocobalamin) deficiency. Patients with pernicious anemia are at higher risk of having gastrointestinal neoplasms than is the general population. It is more common in individuals of northern European descent. On this hub page, you'll find reviewed and categorized links about pernicious anemia. Acne Allergy Antibiotics Antioxidants ... Wedding Overviews - Full text articles Megaloblastic (Pernicious) Anemia - by Lucile Packard Children's Hospital. Pernicious anemia by MEDLINEplus Links Between Helicobacter pylori Infection, Cobalamin Deficiency, and Pernicious Anemia - by Alison Stopeck, MD. Megaloblastic (Pernicious) Anemia - by the University of Maryland Medicine. Pernicious Anemia, A Victory For Science - by Alan Colburn, California State University. Pernicious anemia by Yahoo Health Anemia, pernicious by RUSH Pernicious Anemia - by Marcel E Conrad, MD, Professor, Department of Internal Medicine, Cancer Center of Southern Alabama, University of South Alabama. Megaloblastic Anemias - by Thomas G. DeLoughery.

4. EMedicine - Pernicious Anemia : Article By Marcel E Conrad, MD pernicious anemia pernicious anemia is a chronic illness caused by impaired absorption of vitamin B-12 because of a lack of intrinsic factor (IF) in gastric secretions.pernicious anemia occurs http://www.emedicine.com/med/topic1799.htm

(advertisement) Home Specialties CME PDA ... Patient Education Articles Images CME Patient Education Advanced Search Link to this site Back to: eMedicine Specialties Medicine, Ob/Gyn, Psychiatry, and Surgery Hematology Pernicious Anemia Last Updated: June 21, 2002 Rate this Article Email to a Colleague Synonyms and related keywords: vitamin B-12 deficiency, cobalamin deficiency, Cbl deficiency, addisonian anemia, Biermer anemia, Hunter-Addison anemia, Lederer anemia, Biermer-Ehrlich anemia, Addison-Biermer disease, macrocytic achylic anemia, malignant anemia, cobalamine deficiency, adenosylcobalamin, methylcobalamin, intrinsic factor, IF, macrocytic anemia, neurological complications, severe gastric atrophy, achlorhydria, gastrectomy, gastric stapling, bypass procedures for obesity, extensive infiltrative disease of the gastric mucosa, Zollinger-Ellison syndrome, tropical sprue, regional enteritis, ulcerative colitis, ileal lymphoma, Imerslünd-Grasbeck syndrome AUTHOR INFORMATION Section 1 of 11 Author Information Introduction Clinical Differentials ... Bibliography Author: Marcel E Conrad, MD

5. Perncious An indepth overview of pernicious anemia and links to other informative sites. http://www.geocities.com/Athens/Acropolis/6338/pernicious.html

DRACULA'S Campaign Against Pernicious Anemia WELCOME TO ANOTHER WACKY MEDICAL WEBSITE created by Cynthia Donlan. If you have any questions or just need someone to talk to who understands what you are going through don't hesitate to E-mail me! I don't bite. Also check out my homepage by clicking on the link below. Finally,At the Medical Website I developed, I have information on various other Autoimmune diseases such as Systemic Lupus Erythematosus, Sjogren's Syndrome, Myasthenia Gravis, Diabetes and many many more. Just click on the back button below!!! GOOD EVENING! Hello I am Count Dracula. I have been known for a long time to have an affinity for blood so I have gone to medical school to become a Hematologist. As part of my training we were taught about the various types of anemia. Those conditions both sickened and frightened me. What is a vampire to do if they lose their food source? I need healthy blood from healthy people so that I don't become deficient. This WebPage is brought to you by Blood Brothers, a fraternal order of Transylvanian Vampire Physicians. We hope you find this informative! Stay Healthy and try to be O+ about life! WHAT IS PERNICOUS ANEMIA?

6. Pernicious Anemia pernicious anemia. pernicious anemia is caused by an inability to absorb vitamin B12 (cobalamin) that is intrinsic factor, vitamin B12 is not absorbed and pernicious anemia occurs. http://www.animatedmedical.com/Pernanem/pernanem.html

Home Educational Topics Pernicious Anemia Pernicious anemia is caused by an inability to absorb vitamin B12 (cobalamin) that is naturally found in certain foods. These foods are all of animal origin and include meat, milk and dairy products, and eggs. Vitamin B12 is not found in plants. Although bacteria in the large intestine produce vitamin B12, it is not absorbed into the blood stream from this site. Most people need only 2 micrograms of vitamin B12 daily but the average diet provides about 5 to 30 micrograms a day. When it is ingested, vitamin B12 needs to be chemically linked to a substance called intrinsic factor, which is produced in the stomach. In the animation on the right , vitamin B12 is shown in pink and the intrinsic factor is shown in blue. They combine in the stomach and pass into the small intestine where the intrinsic factor helps the vitamin B12 get absorbed into the circulation. Through the circulation, the vitamin is transported to the liver where it is stored, being released back into the circulation as needed. Without intrinsic factor, vitamin B12 is not absorbed and pernicious anemia occurs. Other causes of vitamin B12 deficiency produce the same symptoms as pernicious anemia. Diseases of the small intestine that cause malabsorption may cause vitamin B12 deficiency. Vegans (individuals who consume absolutely no foods of animal origin) are at risk of vitamin B12 deficiency due insufficiency of this vitamin in their diet. But it takes a long time to deplete all the vitamin B12 that is stored in the liver. Even if the absorption of vitamin B12 is suddenly cut off (for example, as in gastrectomy, surgical removal of the stomach), there is enough vitamin B12 stored in the liver to last for one to five years.

7. Vitamin B12 Deficiency / Pernicious Anemia: Patient Information: Arizona Telemed A collaborative project of the Arizona Telemedicine Program, the Arizona Health Sciences Libraryand the Arizona Cancer Center. See GENERAL DISCLAIMER. Vitamin B12 Deficiency pernicious anemia http://www.telemedicine.arizona.edu/patient_info/benign_disorders/disorders/vita

Patient Information Resource: Benign Hematologic (Blood) Disorders A collaborative project of the Arizona Telemedicine Program , the Arizona Health Sciences Library and the Arizona Cancer Center See: Vitamin B Deficiency: Pernicious Anemia Vitamin B deficiency results in anemia, an RBC deficiency limiting the amount of oxygen in the tissues. Vitamin B deficiency is usually caused by pernicious anemia, a condition in which the digestive system is altered and cannot absorb vitamin B systemic lupus erythematosus , myxedema), or drug action. Among the drugs that may inhibit absorption are histamine blockers, such as cimetidine (Tagamet) and ranitidine (Zantac). Multiple symptoms result from malabsorption of vitamin B . Anemia, mentioned above, is associated with weakness, pallor, elevated heart rate, and elevated breathing rate (see Anemia ). In addition, the patient may be especially prone to infection and may bruise or bleed easily (see Neutropenia and Thrombocytopenia ). Other symptoms include sore tongue, numbness, and tingling.

8. NORD - National Organization For Rare Disorders, Inc. General Discussion. pernicious anemia is a rare blood forms of pernicious anemia include Congenital pernicious anemia, Juvenile pernicious anemia, and Adult Onset Pernicious http://www.rarediseases.org/search/rdbdetail_abstract.html?disname=Anemia, Perni

9. Pernicious Anemia Residents' Report. August 17, 1998. Kevin P. O'Reilly. pernicious anemia. Overview ·. pernicious anemia (PA) is the most common cause of vitamin B12 deficiency. http://www.med.unc.edu/medicine/web/perniciousanemia.htm

Residents' Report August 17, 1998 Kevin P. O'Reilly Pernicious Anemia Overview Pernicious anemia (PA) is the most common cause of vitamin B deficiency. B deficiency actually has many causes however PA applies only to the condition associated with chronic atrophic gastritis. PA was first described by Addison in 1849 and associated with the stomach by Austin Flint in 1860. PA was later successfully treated with cooked liver and subsequent theories on the pathogenesis of PA involved the loss of an extrinsic factor from the liver and an intrinsic factor (IF) from the stomach. A recent population survey found that approximately 2% of persons over 60 years of age have undiagnosed PA. The disease was previously thought to occur only in those of Northern European extraction, however subsequent studies have noted PA to occur in Hispanic and African-American patients. Pathology Gross pathology – The stomach has three regions: the fundus and the body, which contain acid secreting parietal cells and pepsinogen secreting zymogen cells, and the antrum which contain gastrin secreting G-cells. Chronic atrophic gastritis is recognized grossly by the loss of gastric mucosal folds and thinning of the gastric mucosa. There are two types based on whether the lesion affects the antrum. Type A (autoimmune) Chronic Gastritis Type B (nonautoimmune) Chronic Gastritis Affects fundus and body, spares antrum

10. Medical Encyclopedia: Pernicious Anemia (Print Version) Medical Encyclopedia pernicious anemia. pernicious anemia is a type of megaloblastic anemia. Causes, incidence, and risk factors. http://www.nlm.nih.gov/medlineplus/print/ency/article/000569.htm

To print this page, use the print option from your browser. To close this window, click on the "x" in the upper right hand corner of the window. Medical Encyclopedia: Pernicious anemia URL of this page: http://www.nlm.nih.gov/medlineplus/ency/article/000569.htm Alternative names Macrocytic achylic anemia; Congenital pernicious anemia; Juvenile pernicious anemia; Vitamin B12 deficiency (malabsorption) Definition Pernicious anemia is caused by a lack of intrinsic factor, a substance needed to absorb vitamin B12 from the gastrointestinal tract. Vitamin B12, in turn, is necessary for the formation of red blood cells. Anemia is a condition where red blood cells are not providing adequate oxygen to body tissues. There are many types and causes of anemia. (See the general article - anemia.) Pernicious anemia is a type of megaloblastic anemia. Causes, incidence, and risk factors Intrinsic factor is a protein the body uses to absorb vitamin B12. When gastric secretions do not have enough intrinsic factor, vitamin B12 is not adequately absorbed, resulting in pernicious anemia and other problems related to low levels of vitamin B12. Because vitamin B12 is needed by nerve cells and blood cells for them to function properly, deficiency can cause a wide variety of symptoms, including fatigue, shortness of breath, tingling sensations, difficulty walking, and diarrhea.

11. Cynspage This page is links to various websites I created on a variety of auto immune conditions from Asthma to Lupus, to pernicious anemia. http://www.geocities.com/queen_nefertitti/Cyndylinks.html

Cynthia's MEDICAL LINKS In Honor of: Dr. Mark Cruciani, MD and In Memory of John Delehanty, M.D. Welcome to Cynthia's Wacky Informative Medical Website. Click on the Links below and away you go! Alcoholism Asthma AutoImmune Hepatitis DIABETES ... Sjogren's Syndrome Please take a few minutes to do my survey on medical treatment. It would greatly help me with my research! Click on the Link below and away you go! MY SURVEY TheCometCursor('ambulance',0);

12. InteliHealth: Pernicious Anemia People with pernicious anemia or people who cannot absorb vitamin B12 from their intestines will need injections of vitamin B12 every one to three months http://www.intelihealth.com/IH/ihtIH/WSIHW000/9339/20862.html

chrome_imgPreload('gifChr_mid_but_home_mo_1','http://img.intelihealth.com/i/C/Chr_mid_but_home-o.gif'); chrome_imgPreload('gifChr_mid_but_comm_mo_2','http://img.intelihealth.com/i/C/Chr_mid_but_comm-o.gif'); chrome_imgPreload('gifChr_mid_but_dental_mo_3','http://img.intelihealth.com/i/C/Chr_mid_but_dental-o.gif'); chrome_imgPreload('gifChr_mid_but_drug_mo_4','http://img.intelihealth.com/i/C/Chr_mid_but_drug-o.gif'); chrome_imgPreload('gifChr_mid_but_askexpert_mo_5','http://img.intelihealth.com/i/C/Chr_mid_but_askexpert-o.gif'); chrome_imgPreload('gifChr_mid_but_medical_mo_6','http://img.intelihealth.com/i/C/Chr_mid_but_medical-o.gif'); chrome_imgPreload('gifChr_mid_but_chats_mo_7','http://img.intelihealth.com/i/C/Chr_mid_but_chats-o.gif'); chrome_imgPreload('gifchr_mid_but_news_mo_8','http://img.intelihealth.com/i/c/chr_mid_but_news-o.gif'); chrome_imgPreload('gifChr_mid_but_privacy_mo_9','http://img.intelihealth.com/i/C/Chr_mid_but_privacy-o.gif'); Advertisement Vitamin B12 Deficiency What Is It? Symptoms Diagnosis Expected Duration ... Additional Info What Is It? Vitamin B12, available only in animal foods (meat and dairy products) or yeast extracts (such as brewer's yeast) is needed to produce an adequate amount of healthy red blood cells in the bone marrow. Vitamin B12 deficiency is defined by low levels of stored B12 in the body that can result in anemia, a lower-than-normal number of red blood cells.

13. InteliHealth: Pernicious Anemia Details about this disorder, what it is, the symptoms, diagnosis, prevention, treatment, prognosis and when to call a doctor. http://www.intelihealth.com/IH/ihtIH/WSCHN000/9339/20862.html

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14. Pernicious Anemia - Cancer: Health And Medical Information About Cancer Detectio An article about pernicious anemia with a full explanation of what it is, some history and treatment. http://www.aboutdigestion.com/script/main/art.asp?articlekey=1966

15. Pernicious Anemia - Cancer: Health And Medical Information About Cancer Detectio pernicious anemia. pernicious anemia is a blood disorder caused by a lack of vitamin B12. Nowadays, pernicious anemia is not so pernicious. http://www.medicinenet.com/Pernicious_Anemia/article.htm

document.write(''); MedicineNet Home Cancer Home > Pernicious Anemia Advanced Search Printer-Friendly Format Add to Favorites Email to a Friend ... Next page Pernicious Anemia Pernicious anemia is a blood disorder caused by a lack of vitamin B12. Patients who have this disorder do not produce a protein (intrinsic factor) in the stomach that allows the body to absorb vitamin B12. Pernicious anemia is characterized by the presence in the blood of large, immature, nucleated cells (megaloblasts) that are forerunners of red blood cells. (Red blood cells, when mature, have no nucleus). Pernicious anemia is therefore one of the types of megaloblastic anemia. Doctors diagnose pernicious anemia when a patient with a low red blood cell count has large red blood cells and white blood cells with large, multi-lobed nuclei. The patient often has antibodies in the blood called intrinsic factor and parietal cell antibodies. A test that measures that lack of absorption of B12 (Schillings test) can be used to support the diagnosis. Nowadays, pernicious anemia is not so pernicious. Pernicious anemia is simply treated with vitamin B12. The vitamin B12 has to be administered by injection because people with pernicious anemia do not have adequate protein intrinsic factor (or an effective form of intrinsic factor) and so cannot absorb vitamin B12 taken by mouth.

16. Pernicious Anemia pernicious anemia is a disease in which the red blood cells are abnormally formed, due to an absorb vitamin B12. True pernicious anemia refers specifically to a disorder of http://www.ehendrick.com/healthy/001049.htm

MAIN SEARCH INDEX Pernicious anemia Definition Description Causes and symptoms Diagnosis ... Resources Definition Pernicious anemia is a disease in which the red blood cells are abnormally formed, due to an inability to absorb vitamin B . True pernicious anemia refers specifically to a disorder of atrophied parietal cells leading to absent intrinsic factor, resulting in an inability to absorb B Description Vitamin B , or cobalamin, plays an important role in the development of red blood cells. It is found in significant quantities in liver, meats, milk and milk products, and legumes. During the course of the digestion of foods containing B , the B becomes attached to a substance called intrinsic factor. Intrinsic factor is produced by parietal cells which line the stomach. The B -intrinsic factor complex then enters the intestine, where the vitamin is absorbed into the bloodstream. In fact, B can only be absorbed when it is attached to intrinsic factor. In pernicious anemia, the parietal cells stop producing intrinsic factor. The intestine is then completely unable to absorb B . So, the vitamin passes out of the body as waste. Although the body has significant amounts of stored B

17. Health And Medical Information: Diseases And Conditions, Medical Dictionary, Pro Advanced Search. Ask The Experts! Question Regardingpernicious anemia and dementia in elderly. Patients with pernicious anemia become B12 deficient and anemic. http://www.medicinenet.com/script/main/Ques.asp?QaKey=21617

18. Pernicious Anemia B12, the condition is described as pernicious anemia. The term pernicious was adopted many years ago when there pernicious anemia can affect all racial groups, but the incidence is http://www.medbroadcast.com/condition_info_details.asp?disease_id=278&dowhat

19. Pernicious Anemia pernicious anemia. Definition. pernicious anemia is a disease in which the red blood cells are abnormally formed, due to an inability to absorb vitamin B 12 . http://www.healthatoz.com/healthatoz/Atoz/ency/pernicious_anemia.html

Encyclopedia Index P Home Encyclopedia Encyclopedia Index P Pernicious anemia Definition Pernicious anemia is a disease in which the red blood cells are abnormally formed, due to an inability to absorb vitamin B . True pernicious anemia refers specifically to a disorder of atrophied parietal cells leading to absent intrinsic factor, resulting in an inability to absorb B Description Vitamin B , or cobalamin, plays an important role in the development of red blood cells. It is found in significant quantities in liver, meats, milk and milk products, and legumes. During the course of the digestion of foods containing B , the B becomes attached to a substance called intrinsic factor. Intrinsic factor is produced by parietal cells which line the stomach. The B -intrinsic factor complex then enters the intestine, where the vitamin is absorbed into the bloodstream. In fact, B can only be absorbed when it is attached to intrinsic factor. In pernicious anemia, the parietal cells stop producing intrinsic factor. The intestine is then completely unable to absorb B . So, the vitamin passes out of the body as waste. Although the body has significant amounts of stored B

20. Pernicious Anemia: An Explanation Feeling tired? One cause of fatigue is pernicious anemia. Luckily it can be easily treated. Subscribe now . pernicious anemia An Explanation. http://healthlink.mcw.edu/article/901225865.html

Search Articles: search tips Please Take the HealthLink Survey Email this article Print this article Find related articles: By topic: By keywords: Receive Health Link via email! Subscribe now >> Pernicious Anemia: An Explanation Q: I have been diagnosed as having pernicious anemia and have been getting a B-12 shot once a month for the past year. However, I don't feel any different; I am always very tired, which is very different for me. Can you explain to me just what it is and what causes it? Is there anything else I can do? A: Pernicious anemia (PA) results from inadequate vitamin B12, which is necessary for making healthy red blood cells. In classic pernicious anemia the person lacks "intrinsic factor," a substance made by the stomach which binds to the B12 in food and enables the B12 to be absorbed. A person can get PA from a hereditary deficiency of intrinsic factor, surgical removal of portions of the stomach, chronic inflammation of the stomach lining (atrophic gastritis), and rarely from lack of B12 in the diet (mainly found in meat and dairy products). After a year of B12 injections, your body stores should be more than adequate, so I suspect there is probably another reason to explain your fatigue other than pernicious anemia. Fatigue can be due to so many things that range from the trivial, such as this very hot, humid weather we've been having this summer, to the serious, such as cancer. If you don't "feel right," it's best to get checked out.

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