101. Peripheral Neuropathies and taxol produce doserelated peripheral neuropathies, usually manifested as dysesthesiain the distal feet and later (as the neuropathy progresses) in the http://www.stat.washington.edu/TALARIA/LS2.3.5.html

2.3.5 Peripheral Neuropathies Table 5 Peripheral nerves can be compressed or infiltrated by tumor or constricted by fibrosis, which in rare instances is a complication of radiation treatment. They may also be damaged by neurotoxic chemotherapy or by cutaneous incisions and the retraction of tissues during surgery ( Table 5 Myeloma may cause a progressive painful neuropathy in about 15 percent of patients. In these patients, neuropathy precedes the onset of other symptoms in as many as 8 of 10 (Davis and Drackman, 1972) . This sensorimotor neuropathy is characterized by distal paraesthesia, sensory loss, weakness, and muscle wasting, and it may occasionally ascend in distribution in a manner similar to Guillain-Barre syndrome. Vincristine, cisplatin, and taxol produce dose-related peripheral neuropathies, usually manifested as dysesthesia in the distal feet and later (as the neuropathy progresses) in the hands; rarely, continuous burning pain is a clinical problem. Vincristine neuropathy may also give rise to cranial neuralgias, including jaw claudication. The treatment of chemotherapy-related neuropathy involves decreasing or stopping the offending agent (when possible) and the use of analgesics. In the absence of recurrent tumor, persistent pain following surgery may result from intraoperative injury to cutaneous or deeper nerves. Postsurgical pain syndromes are characterized by either persistent pain after the surgical procedure or recurrent pain after the initial surgical pain has resolved. The clinical characteristics relate to the location and extent of nerve injury

102. Inherited Peripheral Neuropathies Furthermore mutations in these genes are also responsible for other inherited peripheralneuropathies hereditary neuropathy with liability to pressure palsies http://molgen-www.uia.ac.be/CMTMutations/CMT.cfm

Inherited Peripheral Neuropathies C harcot-Marie-Tooth disease (CMT) is the most common inherited disorder of the peripheral nervous system. Soon after the original description by J.M. Charcot, P. Marie and H.H. Tooth in 1886, it became apparent that this syndrome is clinically and genetically heterogeneous. Several subtypes of inherited peripheral neuropathies were delineated and classified as hereditary motor and sensory neuropathies (HMSN), hereditary motor neuropathies (HMN) and hereditary sensory (and autonomic) neuropathies (HSAN). All these types are further subdivided in several subtypes. The classification provides a valuable framework for both diagnostic and research purposes. In this classification, HMSN type I and HMSN type II correspond to CMT type 1 (CMT1, OMIM entries ) and CMT type 2 (CMT2, OMIM entries ) respectively, while Dejerine-Sottas syndrome (DSS,OMIM entry ) is included in HMSN type III. M olecular genetic studies have been very successful in the field of the inherited peripheral neuropathies. Up to date, about 30 loci and 14 genes have been identified. The peripheral myelin protein 22 gene ) on chromosome 17p11.2, the

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