41. CNN.com - Health - Gene Therapy May Offer Hope In Parkinson's Treatment - Octobe CNN http://www.cnn.com/2000/HEALTH/10/26/parkinsons.disease.ap/index.html

health Editions myCNN Video ... Feedback CNN Sites CNN CNN Europe CNNfn CNNSI myCNN CNNfyi AllPolitics Languages Search CNN.com CNNSI.com CNNfn.com The Web HEALTH TOP STORIES New treatments hold out hope for breast cancer patients MORE TOP STORIES Thousands dead in India; quake toll rapidly rising Israelis, Palestinians make final push before Israeli election Davos protesters confront police MORE ... MORE MARKETS 4:30pm ET, 4/16 DJIA NAS SPORTS Jordan says farewell for the third time ... LOCAL EDITIONS: CNN.com Europe change default edition MULTIMEDIA: video video archive audio multimedia showcase ... more services E-MAIL: Subscribe to one of our news e-mail lists Enter your address: DISCUSSION: chat feedback CNN WEB SITES: CNNfyi.com CNN.com Europe AsiaNow Spanish ... Korean Headlines TIME INC. SITES: Go To ... Time.com People Money Fortune EW CNN NETWORKS: CNN anchors transcripts Turner distribution SITE INFO: help contents search ad info ... jobs WEB SERVICES: Gene therapy may offer hope in Parkinson's treatment WASHINGTON (AP) A gene therapy experiment relieved severe symptoms of Parkinson's disease in monkeys and experts say the technique offers promise for treating the 1.2 million Americans who suffer from the disease, experts say. A virus that had been joined with a gene that prompts production of dopamine, a chemical neurotransmitter, was injected into the brains of monkeys who had chemically induced Parkinson's disease.

42. Senior And Older Adult Health Issues: Alzheimer's Disease PD is a degenerative central nervous system (CNS) disorder. A discussion about the disorder, the symptoms and treatments of this disease. http://angelfire.com/oh2/fountainofyouth/parkinsons.html

var cm_role = "live" var cm_host = "angelfire.lycos.com" var cm_taxid = "/memberembedded" Senior and Older Adult Health Issues Seniors and Older Adults Seniors and Older Adults Grandparenting Making Memories Travel ... Age 92 Health Issues Diseases and Conditions Alzheimer's Andropause Arthritis ... Death And Dying Food and Nutrition Milk Moustaches Beef It Up Coffee Water ... Chocolate Products and Services Ibuprofen Cream Glucosamine Chondroitin ArthroPro ... Calcium Spiritual Matters Spirituality Prayer and Meditation Smiles Memories ... Get Away Genealogy Search For Ancestors The Gunter Gate Tulsa Cemetery Inscriptions Oaklawn Cemetery ... James Maxwell, Mayor You are in Health Issues Library . Topics include: Pharmacy I Blood Testing Information I Blood Tests I Natural Supplements I Vitamins I Minerals I Eye Products I Fiber Products I Hormones Parkinson's Disease Parkinson's Disease Parkinson's disease is actually a group of related CNS disorders caused by the destruction of the substantia nigra (pigmented brain cells), which produce dopamine (a neurotransmitter). The deficiency of dopamine results in the loss of muscle tone and voluntary muscle control seen in PD. Recent studies indicate that dopamine deficiencies in other areas of the brain and abnormalities of other neurotransmitters, such as norepinephrine and serotonin, may also contribute to the disease. Signs and Symptoms Although onset of PD can be rapid, it is generally insidious, with symptoms gradually progressing over a number of years until they interfere with daily activities. The four major symptoms of Parkinson's disease are

43. LogicSong Media - Internet Content & Web Development - Cape Cod, Mass. Sponsored by the National Parkinson Foundation. Primarily for care givers to people with this disease. Includes a discussion forum. A detailed look at the early and advanced stages of this disease. http://www.parkinsons-care.com/

44. Parkinson's Disease: Is Victory In Sight? Comprehensive review of the latest research into parkinson's disease with emphasis on prevention and complementary and alternative treatments. http://www.yourhealthbase.com/parkinsons.html

Comprehensive review of the latest research into Parkinson's disease with emphasis on prevention and complementary and alternative treatments Parkinson's Disease: Is Victory in Sight? by Hans R. Larsen, MSc ChE If research into Parkinson's disease continues at its present pace this dreaded disease may well be fully understood and largely preventable early in the 21st Century. Parkinson's disease ( paralysis agitans , shaking palsy) was first described in 1817. L-dopa, the mainstay of current drug therapy was introduced in 1970 and since then hundreds of research papers have been published on the disease. It is now increasingly clear not only what causes Parkinson's, but also how it can be prevented and its relentless progress slowed down. Incidence and Symptoms Idiopathic (of no known cause) Parkinson's disease affects about one percent of the population over the age of 60 years in the United States. It is more common among men than among women and also seems to be more widespread in northern countries. The incidence of the disease increases with age although aging itself is not believed to be a causative factor. Parkinson's disease is rarely inherited and less than one per cent of all cases are thought to have a genetic component. At this time there is no medical cure for the condition, but drugs that alleviate the symptoms and slow the progress of the disease are available(1-5). The main symptom of Parkinson's disease is a pronounced tremor affecting the extremities notably the hands, chin or lips. The tremor is most evident at rest and disappears with movement. Other characteristic symptoms of Parkinson's disease are stiffness or slowness of movement, a shuffling walk, stooped posture, and difficulties in performing simple tasks. Memory impairment and cognitive dysfunction are rarely encountered in early stage Parkinson's disease. Depression is, however, a common feature and about 30 per cent of Parkinson's disease victims eventually develop Alzheimer's disease or other forms of dementia(1-3,6-8).

45. Parkinsons Power Across America A unique national fundraising event sponsored by the Parkinson's disease Foundation. http://www.parkinsonspower.org

A unique national fundraising event sponsored by the Parkinson's Disease Foundation. More Information about the CORPORATE SPONSORS above and about our other ... along the Parkinson's Power Across America Route Enter the Parkinson's Power Across America Website by clicking the button below: To send a personal email of support, or encouragement, to the PPAA Teams: CLICK HERE To ask specific questions about being a sponsor or making donations to PPAA: CLICK HERE Parkinson's Power Across America Overcoming the Obstacles Sponsored by the Parkinson's Disease Foundation (PDF) , 710 West 168th Street, New York, NY 10032-9982 See our Sponsors! Be a Sponsor!

46. MLPF | Mother Lode Parkinson Foundation, Sonora California Charitable organization dedicated to helping fund the care of those sticken with PD. In addition, reach out to educate those in the Sierra foothills about Parkinson's disease. http://www.mlode.com/~mlpf

Home • Donate • Glossary • Learn more • ... News Letter • On December 10, 1998, five couples from the Tuolumne General Hospital Parkinson Support Group (lead by Pat Noonan, coordinator of Tuolumne County Hospital Adult Care Center) got together to discuss the possibility of starting a non-profit foundation. The purpose was to help Parkinson patients with financial help for a surgical treatment and /or medications before they become so debilitated that their life style becomes non- existent. We started slowly because we needed to have counsel from an attorney and a CPA who would give us their time pro-bono. It took several months to find them but we did. We have named our organization, Mother Lode Parkinson Foundation We are grateful to Mick Grimes and Donna Wilson of the Sonora Area Foundation , who have given us excellent guidance. As of this date, we have all the legal documents granting us tax-exempt corporate status. People at all levels are infected with this disease: MICHAEL J. FOX, JANET RENO, POPE JOHN PAUL and BILLY GRAHAM

47. Parkinson Society Ottawa Dedicated to improving quality of life for those who suffer from this disease. The goal is to help people with Parkinson's, their families, friends and care givers in this region of Canada. http://www.parkinsons.ca

Parkinson Society Ottawa is Mailing Address: 1053 Carling Avenue Ottawa, Ontario Contact Us: Tel: (613) 722-9238 Fax: (613) 722-3241 psoc@lri.ca Located At: 110-1095 Carling Ave (Carling at Hamilton) Neither Parkinson Society Ottawa, Parkinson Society Canada nor any of its other regional partners solicits funds through door-to-door canvassing or through telemarketing Free Hosting Provided By Welcome to Parkinson Society Ottawa If you or someone you know is suffering from Parkinson's disease, you have come to the right place because we are dedicated to improving your quality of life. Our goal is to help people with Parkinson's, their families, friends and caregivers in the Ottawa region by: Working with family physicians and neurologists to offer advice, information and services; Providing specialized physiotherapy and Tai Chi classes designed to maintain flexibility and strength; Offering one-on-one counselling and support groups; Recommending helpful books and videos from our extensive library; Promoting and assisting research into the cause, effects, treatment and cure of Parkinson's; Organizing fundraising events, social gatherings and awareness activities; and

48. SPRING-Special Parkinson's Research Interest Group SPRING is the official Special Interest Group for Medical Research, constituted within the Parkinson's disease Society of UK. Our site includes news and background on research. http://spring.parkinsons.org.uk

Supporting research towards a cure for Parkinson's SPRING S pecial P arkinson's R esearch In terest G roup) is the official Special Interest Group for Medical Research, constituted within The Parkinson's Disease Society of the United Kingdom How to use our web site This site is © SPRING For more information and suggestions email

49. Parkinson's Disease - Wikipedia, The Free Encyclopedia Parkinson s disease. From Wikipedia, the free encyclopedia. MPTP is used asthe model for parkinsons as it can induce the disease in 20 year olds. http://en.wikipedia.org/wiki/Parkinson's_disease

Parkinson's disease From Wikipedia, the free encyclopedia. Parkinson's disease is a neurodegenerative disease of the substantia nigra (an area in the basal ganglia ). The disease was first discovered and its symptoms documented in Essay on the Shaking Palsy ) by the British physician Dr. James Parkinson ; the associated biochemical changes in the brain of patients were identified in the The disease is a progressive movement disorder of the extrapyramidal system , which controls and adjusts communication between neurons in the brain and muscles in the human body Table of contents 1 Causes 2 Symptoms 3 Treatment 4 Related diseases ... edit Causes The cause of Parkinson's disease is not known. Geneticists have since found nine different specific genetic defects, each of which causes the disease in one or a few families with extraordinarily high incidences of the disease, but such families are rare. While a strong inheritance pattern occurs in only a very small percentage of cases, an affected individual is three to four times more likely than an unaffected individual to have a close relative with Parkinson's. Having a parent with Parkinson's raises one's lifetime risk of developing the disorder threefold, from the general population's figure of 2% to about 6%. Three of the genes that have been identified are alpha-synuclein Ubiquitin Carboxy terminal Hydrolosae L1 UCH-L1 ) and Parkin A popular theory holds that the disease might result in most cases from the combination of a subtle genetically determined vulnerability to environmental toxins along with mild exposure to those toxins. The toxins most strongly suspected at present are certain pesticides and industrial metals.

50. Senior And Older Adult Health Issues: Alzheimer's Disease Parkinson s disease (PD) is a degenerative central nervous system (CNS) disordercharacterized by uncontrolled body movements, rigidity, tremor http://www.angelfire.com/oh2/fountainofyouth/parkinsons.html

var cm_role = "live" var cm_host = "angelfire.lycos.com" var cm_taxid = "/memberembedded" Senior and Older Adult Health Issues Seniors and Older Adults Seniors and Older Adults Grandparenting Making Memories Travel ... Age 92 Health Issues Diseases and Conditions Alzheimer's Andropause Arthritis ... Death And Dying Food and Nutrition Milk Moustaches Beef It Up Coffee Water ... Chocolate Products and Services Ibuprofen Cream Glucosamine Chondroitin ArthroPro ... Calcium Spiritual Matters Spirituality Prayer and Meditation Smiles Memories ... Get Away Genealogy Search For Ancestors The Gunter Gate Tulsa Cemetery Inscriptions Oaklawn Cemetery ... James Maxwell, Mayor You are in Health Issues Library . Topics include: Pharmacy I Blood Testing Information I Blood Tests I Natural Supplements I Vitamins I Minerals I Eye Products I Fiber Products I Hormones Parkinson's Disease Parkinson's Disease Parkinson's disease is actually a group of related CNS disorders caused by the destruction of the substantia nigra (pigmented brain cells), which produce dopamine (a neurotransmitter). The deficiency of dopamine results in the loss of muscle tone and voluntary muscle control seen in PD. Recent studies indicate that dopamine deficiencies in other areas of the brain and abnormalities of other neurotransmitters, such as norepinephrine and serotonin, may also contribute to the disease. Signs and Symptoms Although onset of PD can be rapid, it is generally insidious, with symptoms gradually progressing over a number of years until they interfere with daily activities. The four major symptoms of Parkinson's disease are

51. Health Matters - Library A-Z - Parkinson's Disease Parkinson s disease is a degenerative neurological condition. Parkinson sdisease. Parkinson s disease is a degenerative neurological condition. http://www.abc.net.au/health/library/parkinsons.htm

Home Health News Features Your Stories ... Regions Parkinson's disease Parkinson's disease is a degenerative neurological condition. The main symptoms are abnormalities of movement, such as tremor and muscular rigidity. News Cloned human cells spell embryonic first Science News Archive 13/02/2004 Stories and Transcripts ABC-wide Parkinson's drug can trigger gambling Science News: Health 12/08/2003 Towards a cure for neurological illness Ockham's Razor 29/06/2003 Parkinson's - the missing clue Science News: Health 17/04/2002 Breakthrough in fight against Parkinson's AM 10/04/2002 Deep brain stimulation The Health Report 03/12/2001 Depression and Parkinson's disease The Science Show 17/11/2001 Val's miracle Australian Story 17/05/2001 Caffeine fix may reduce risk of Parkinson's Science News: Health 16/05/2001 Stem cell research - separating the hype from reality The Health Report 09/04/2001 Professor Susan Greenfield The Science Show 10/06/2000 Parkinson's disease The Health Report 16/08/1999 The three moirai Ockham's Razor 25/05/1997 Fact File Parkinson's disease fact file includes: Background Symptoms Treatment more Links/www Guide Non-ABC sites about Parkinson's disease Parkinson's Australia A national organisation that coordinates lobbying, fundraising and awareness-raising activities for Parkinson's.

52. The Parkinson's Institute Movement Disorders In 1817, James Parkinson, a British physician, reported on severalpatients with a condition now recognized as Parkinson s disease. http://www.parkinsonsinstitute.org/movement_disorders/parkinsons.html

Treatment Center PD Dystonia ET ... Terms Used to Describe Movement Disorders The Clinical Features of Parkinson's Disease? Being Diagnosed with Early Symptoms Prior to the diagnosis of Parkinson's disease, a person may begin to feel a drop in energy or a loss of coordination. Several symptoms such as impaired handwriting, reduced arm swing, a "limp" or tremor may begin to emerge on one side of the body. Other early symptoms may include internal shakiness, difficulty getting out of a chair, a soft voice and/or depression. These symptoms evolve gradually and may even be imperceptible to the patient or family members until a physically or emotionally stressful event occurs, triggering an exacerbation of these symptoms. Disease Progression Progression of Parkinson's disease is highly variable, although progression may be relatively slower in patients whose initial symptoms include tremor. Although the disease is invariably progressive, the good news is that there are now a wide variety of very effective medications for the disease and surgical therapy, including "deep brain stimulation," has been shown to provide benefit in selected patients who have lost effi medications alone. When the disease is fully expressed, the major clinical features include bradykinesia (slow movement), tremor (typically at rest and extinguished with movement), rigidity (a clinical finding of resistance to movement, often associated with a jerky sensation called cogwheeling) and impaired postual reflexes (poor balance).

53. Parkinson's Disease Parkinson s disease. Referrals Dr. Tanya Simuni (TSimuni@nmff.org) at Northwesternin Chicago, IL is a specialist in conditions related to Parkinson s disease. http://www.neuro.nwu.edu/meded/MOVEMENT/parkinsons.html

Parkinson's Disease Timothy C. Hain, MD This material is primarily written for 2nd and 3rd year medical students . Click here to return to the clerkship curriculum Please read our There is good evidence for genetic factors. A twin study using PET reported greatly increased concordance for dopaminergic dysfunction in monozygotic than dizygotic twins (Piccini et al, 1999). Also, several large pedigrees of autosomal dominantly inherited PD have been reported recently (Polmeropoulos et al. Science 1996:274:1197-1199). A mutation in alpha-synuclein is responsible for this pedigree. Alpha-synuclein includes the non-A-beta component of Alzheimers plaques , is preferentially expressed in dopamine neurons, and is abundant in Lewy bodies (a pathologic marker of Parkinsonism and Lewy body dementia ). Another kindred has mutations in the "parkin" gene, which manifests as autosomal recessive juvenile Parkinsons (Mizuno Y, 1998). Slow acetylation may also be a predisposing factor in sporadic PD (Bandmann O et al. Lancet 1997:350:1136-1139). Slow acetylation might lead to an impaired ability to handle neurotoxic substances, linking together the genetic and toxic hypotheses. Incidence and Prevalence Parkinson's is uncommon in patients less than 40 years of age. It is found in about 1% of those greater than 50 and 3% of those aged 95 or greater. Every year about 50,000 new cases are diagnosed in the United States. In autopsy studies, Parkinson's is found even more frequently about 10% of 70 year olds show evidence of subclinical disease. Prevalence varies greatly throughout the world, ranging from 14/100,000 in China to 328/100,000 in Bombay, India. Asians and African blacks have a lower incidence compared to American blacks and, especially, whites (Lang et al, 1998).

54. Parkinson's Disease: An Overview This particular chapter, written by Patrick J. Sweeney, MD, deals with Parkinson sDisease from its discovery to today s popular treatment methods. http://www.clevelandclinicmeded.com/diseasemanagement/neurology/parkinsons/parki

Published May 29, 2002 Revised July 15, 2003 Patrick J. Sweeney, MD Department of Neurology Print Chapter The Cleveland Clinic Foundation James Parkinson (1755-1824), while best remembered for the disease state named after him by Charcot, was a man of many talents and interests. Publishing on chemistry, paleontology and other diverse topics, he was, early in his career, a social activist championing the rights of the disenfranchised and poor. His efforts in this area were enough to result in his arrest and appearance before The Privy Council in London on at least one occasion. In collaboration with his son, who was a surgeon, he also offered the first description, in the English language, of a ruptured appendix. His small but famous publication, "Essay on the Shaking Palsy", appeared in 1817, 7 years before his death in 1824. The clinical description of 6 patients was a remarkable masterpiece testifying to his prodigious powers of observation for most of the 6 were never actually examined by Parkinson himself; rather, they were simply observed walking on the streets of London. Definition Prevalence Pathophysiology Signs and ... References National Guidelines An Algorithm for the Management of Parkinson's Disease DEFINITION Parkinson's disease is a common neurodegenerative disease of the elderly. Typically beginning in the 60s or 70s, it is characterized by the unilateral onset of resting tremor in combination with varying degrees of rigidity and bradykinesia.

55. Parkinson's Disease And Movement Disorders Center, Feinberg School, Northwestern Parkinson s disease and Movement Disorders Center. http://www.parkinsons.northwestern.edu/

Search Northwestern Search Help Feinberg School Feinberg School ... Movement Disorders Center Introduction Movement Disorders Home Common Disorders About Us Patient Care ... Contact Us Parkinson's Disease and Movement Disorders Center Common Movement Disorders Dystonia Essential Tremor and Other Tremor Disorders Gait Disorders Tic Disorders Department of Neurology, Feinberg School of Medicine, Northwestern University A multidisciplinary team dedicated to improving the quality of life for patients with movement disorders, and their families. Our Mission To provide innovative, multidisciplinary care for patients and families affected by Parkinson's disease and other movement disorders; To promote health education, and support for patients, caregivers, family members. healthcare providers, and the community; To conduct pre-clinical and clinical research in order to extend the knowledge and treatment of movement disorders. The Parkinson's Disease and Movement Disorders Center is recognized by the National Parkinson Foundation as one of its worldwide Centers of Excellence Movement Disorders Home About Movement Disorders Patient Care ... Parkinson's Disease and Movement Disorders Center Davee Department of Neurology and Clinical Neurological Sciences Abbott Hall, Suite 1426, 710 North Lake Shore Drive, Chicago, IL 60611-3078

56. Novartis Pharmaceutical- A Through Z - Parkinson S Disease diseases Conditions / A through Z / Parkinson s disease Parkinson sdisease Parkinson s disease is called a motor system disorder. http://www.pharma.us.novartis.com/conditions/az/parkinsons.jsp

57. Drugs For Parkinson's Disease Drugs for Parkinson s disease. there is a comment for consumers onthis article. See also Parkinson s disease a personal experience. http://www.australianprescriber.com/magazines/vol24no4/parkinsons.htm

Drugs for Parkinson's disease there is a comment for consumers on this article V.S.C. Fung, M.A. Hely, Department of Neurology, G. De Moore, Department of Psychiatry and J.G.L. Morris, Department of Neurology, Westmead Hospital, Westmead, New South Wales See list of relevant Patient Support Organisations. See also Parkinson's disease: a personal experience. Index words: amantadine, dopamine, entacapone, levodopa, selegiline. (Aust Prescr 2001;24:92-5) SYNOPSIS Levodopa is the most effective drug available for treating the motor symptoms of idiopathic Parkinson's disease. It is usually combined with a peripheral dopa decarboxylase inhibitor. Early treatment with dopamine agonists can reduce the risk of developing dyskinesia. Dopamine agonists and catechol-O-methyltransferase inhibitors can significantly reduce motor fluctuations. Amantadine reduces the severity of dyskinesia in some patients. No treatment has been proven to delay disease progression. Introduction Motor dysfunction in idiopathic Parkinson's disease is caused predominantly by degeneration of dopamine-producing neurons in the substantia nigra of the midbrain. Symptomatic treatment of idiopathic Parkinson's disease is therefore aimed at restoring dopaminergic stimulation of the striatal neurons which are involved in controlling movement. These striatal neurons are preserved in idiopathic Parkinson's disease, but degenerate in the atypical parkinsonian syndromes, which explains their variable and usually poor response to therapy.

58. University Of Maryland Parkinson's Disease Center Center offers comprehensive and expert diagnostic, medical, surgical, and rehabilitativeservices for patients with Parkinson s disease and Parkinsonism. http://www.umm.edu/parkinsons/

Parkinson's Disease Center Faculty and Staff Facts About Parkinson's Disease Signs and Symptoms ... View Videos Related Resources Within UMM Learning to Live with Parkinson's Disease NeuroSciences Parkinson's Disease and Movement Disorders Center The Maryland Parkinson's Disease and Movement Disorders Center The Maryland Parkinson's Disease and Movement Disorders Center is a division of the Department of Neurology. The Maryland Parkinson's Disease and Movement Disorders Center is a full service Diagnostic Center for Parkinson's disease. PARKINSON'S DISEASE CLASSES New Hope for Parkinson's Disease: Come learn about Deep Brain Stimulation in a small group session arranged in a comfortable setting. Classes are free. The Center offers comprehensive and expert diagnostic, medical, surgical and rehabilitative services for patients with Parkinson's disease and parkinsonism. We are also members of the Parkinson Study Group, a North American Consortium of Research Neurologists who conduct clinical research studies in Parkinson's disease. The Maryland Parkinson's Disease and Movement Disorders Center has developed specific outpatient and inpatient therapy programs for Parkinson's disease.

59. Diagnosis Of Parkinson's Disease Parkinson s disease and Movement Disorders Center. Diagnosing Parkinson sdisease. The brain of people with Parkinson s disease appears normal. http://www.umm.edu/parkinsons/diagnosis.html

Parkinson's Disease Center Faculty and Staff Facts About Parkinson's Disease Signs and Symptoms ... View Videos Related Resources Within UMM Learning to Live with Parkinson's Disease NeuroSciences Parkinson's Disease and Movement Disorders Center Diagnosing Parkinson's Disease How a Diagnosis is Made Parkinson's disease is just one of several neurologic movement disorders that produce similar symptoms. It is important that the physician you are seeing has experience with all of the different disorders that can masquerade as Parkinson's disease. In some of these diseases people quickly become totally disabled; in others, the disease progresses extremely slowly; and in yet others, illness is chronic (always present) and may have more severe symptoms as time goes on. Because the natural history, or progression, of these diseases varies greatly, proper diagnosis is crucial. People need to know which disease they have. The Neurologic Examination When performing a neurologic examination to evaluate a patient with a movement disorder, the doctor takes a medical history and performs a physical examination. The doctor asks the patient and the family members or friends about symptoms and observes the patient, asking him or her to walk around the room, sit down, stand up, turn around, and so on. The neurologic exam is a thorough evaluation of the nervous system. In particular, the neurologist observes aspects of the patient's movement, coordination and balance.

60. Parkinson S And Dopamine The discovery that the lack of the chemical, dopamine, is associated with the debilitatingailment, Parkinson s disease, encouraged researchers to investigate http://web.sfn.org/content/Publications/BrainBriefings/parkinsons.html

Login Directory Merchandise Contact Us ... Abstracts/Annual Meeting Publications Full size image available below Parkinson's and Dopamine The discovery that the lack of the chemical, dopamine, is associated with the debilitating ailment, Parkinson's disease, encouraged researchers to investigate ways to increase levels of the molecules. In addition, researchers have been developing new drugs that act on dopamine receptors. These receptors are like locks on cells where dopamine acts as a key to carry out certain actions. As the research on dopamine and its receptors advances scientists are developing new therapeutic approaches that will help people with Parkinson's disease experience a better quality of life. Your right hand is shaking. Maybe you need to relax and stop holding that pencil so tightly. Perhaps two cups of coffee overdid it. Another possibility? Parkinson's disease (PD). Approximately one million Americans have this neurological disorder and more than 50,000 new patients are diagnosed each year. From minor hand tremors, symptoms increase and within a few years include a lack of facial expressions, slowness of movement, a weak voice, shuffling steps, muscle stiffness and problems with balance. Eventually, a patient may experience severe immobility and intellectual decline. During the 1950s and 1960s scientists discovered that PD is associated with a loss of dopamine in the brain. Now research on this chemical is leading to treatments that reduce symptoms of people with PD.

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