41. EMedicine - Osteogenesis Imperfecta : Article By Mandar A Pattekar, MD, MS osteogenesis imperfecta osteogenesis imperfecta (OI) is a condition resulting from abnormality in the type I collagen, which most commonly manifests as http://www.emedicine.com/ped/topic1674.htm

(advertisement) Home Specialties CME PDA ... Patient Education Articles Images CME Patient Education Advanced Search Link to this site Back to: eMedicine Specialties Pediatrics Genetics And Metabolic Disease Osteogenesis Imperfecta Last Updated: December 12, 2003 Rate this Article Email to a Colleague Synonyms and related keywords: OI, fragile bone disease, brittle bones, brittle bone disease, broken bones, bone fragility, osteogenesis imperfecta congenita, osteogenesis imperfecta tarda AUTHOR INFORMATION Section 1 of 11 Author Information Introduction Clinical Differentials ... Bibliography Author: Mandar A Pattekar, MD, MS , Staff Physician, Department of Radiology, William Beaumont Hospital Coauthor(s): Alexander Cacciarelli, MD, FACR , Director, Department of Radiology, Division of Pediatric Radiology, William Beaumont Hospital Mandar A Pattekar, MD, MS, is a member of the following medical societies: American College of Radiology American Roentgen Ray Society , and Radiological Society of North America Editor(s): Erawati Bawle, MD, FAAP, FACMG

42. NORD - National Organization For Rare Disorders, Inc. osteogenesis imperfecta. View Cart/Checkout. Copyright 1984, 1985, 1986, 1987, 1988, 1990, 1992, 1996, 1997, 1999, 2001, 2003 Synonyms of osteogenesis imperfecta http://www.rarediseases.org/search/rdbdetail_abstract.html?disname=Osteogenesis

43. Osteogenesis Imperfecta The page osteogenesis imperfecta The Links to Nutrition. that was formerly at this URL has moved to www.ctds.info/oi.html. The http://www.mindspring.com/~sandysimmons/oi.html

The page: Osteogenesis Imperfecta: The Links to Nutrition that was formerly at this URL has moved to: www.ctds.info/oi.html The doctor of the future will give no medication, but will interest his patients in the care of the human frame, diet and in the cause and prevention of disease. Thomas A Edison Please click on the link to go to the new URL. If you have bookmarked this site, please remember to update your bookmarks with the new URL. If you have linked to this page in the past from your web site, please update your link to point to the new page. By linking to my new page, it will help the search engines find my site under its new URL, and your site will avoid having a broken link when this forwarding page is removed in the near future. Thanks!

44. Osteogenesis Imperfecta osteogenesis imperfecta. Definition osteogenesis imperfecta is a congenital (present from birth) condition of abnormal fragility of the bones. http://www.healthscout.com/ency/article/001573.htm

Advertisement Search HealthScout Web MEDLINE Special Offers TV Specials Top Features Schizophrenia Hair Loss Liver Disease Allergies ... Impotence Resources Healthscout News 3D Interactive Human Atlas Health Videos Health Encyclopedia ... Drug Library Channels Home Today Women Men ... Drug Checker Advertisement Disease Injury Nutrition Poison ... Prevention Osteogenesis imperfecta Definition: Osteogenesis imperfecta is a congenital (present from birth) condition of abnormal fragility of the bones. Alternative Names: Brittle bone disease Causes, incidence, and risk factors: This bone disorder is usually present at birth as an inherited disease. Osteogenesis imperfecta (OI) is classified into four major types (and further subtypes). All four types of OI are caused by defects in the amount or structure of Type 1 collagen, an important part of the bone matrix. The collagen problem usually results from a dominant genetic defect. This defect may be acquired by several different mechanisms: The defect may be inherited in an autosomal dominant pattern from an affected parent. This means that an affected parent, who carries a single gene for the disorder, has a 50% chance of having children with the disorder. Any child who inherits this gene will be affected. The defect may be acquired by a spontaneous mutation occurring in the individual egg or sperm that formed the child. In this case, neither parent carries a gene for the disorder or is affected by it. The parents, in this case, are no more at risk than the general population for having another child with the disorder.

45. Osteogenesis Imperfecta - Information / Diagnosis / Treatment / Prevention home musculoskeletal disorders congenital anomalies osteogenesis imperfecta osteogenesis imperfecta. Information • Diagnosis http://www.healthcyclopedia.com/musculoskeletal-disorders/congenital-anomalies/o

Home Health cyclopedia All Topics by Category The Good Health Search Engine Health Conditions A-Z Gurus ... congenital anomalies > osteogenesis imperfecta Osteogenesis Imperfecta Information / Diagnosis / Treatment / Prevention External links (marked with an arrow ) open in a new window. This site is a web directory and does not offer medical advice. We cannot take responsibility for information found on listed sites. This Page Subtopics Related Topics Medical Definition Message Boards ... Web Directory: Subtopics: Osteogenesis Imperfecta > Personal Pages Related Topics: Musculoskeletal Disorders/Congenital Anomalies/Dwarfism Musculoskeletal Disorders/Osteoporosis Rare Disorders Medical Definition: University of Newcastle-upon-Tyne Medical Dictionary: "osteogenesis imperfecta" Message Boards: Google Groups: alt.support.osteogenesis.imperfecta Health News: Search millions of published articles for news on Osteogenesis Imperfecta Modern Medicine Aging The Ardell Wellness Report HealthFacts Medical Post Medical Update Men's Health and the National Women's Health Report Note: Subscription required to access the full text of articles.

46. UAB Health System | Osteogenesis Imperfecta osteogenesis imperfecta. What is osteogenesis imperfecta? OI can affect males and females of all races. What causes osteogenesis imperfecta? http://www.health.uab.edu/show.asp?durki=15001

47. Osteogenesis Imperfecta MAIN SEARCH INDEX. osteogenesis imperfecta. ligaments. In osteogenesis imperfecta, the collagen produced is abnormal and disorganized. This http://www.ehendrick.org/healthy/000996.htm

MAIN SEARCH INDEX Osteogenesis imperfecta Definition Description Causes and symptoms Diagnosis ... Resources Definition Osteogenesis imperfecta (OI) is a group of genetic diseases of collagen in which the bones are formed improperly, making them fragile and prone to breaking. Description Collagen is a fibrous protein material. It serves as the structural foundation of skin, bone, cartilage, and ligaments. In osteogenesis imperfecta, the collagen produced is abnormal and disorganized. This results in a number of abnormalities throughout the body, the most notable being fragile, easily broken bones. There are four forms of OI, Types I through IV. Of these, Type II is the most severe, and is usually fatal within a short time after birth. Types I, III, and IV have some overlapping and some distinctive symptoms, particularly weak bones. Evidence suggests that OI results from abnormalities in the collagen gene COL1A1 or COL1A2, and possibly abnormalities in other genes. In OI Type I, II, and III, the gene map locus is 17q21.31-q22, 7q22.1, and in OI Type IV, the gene map locus is 17q21.31-q22. In OI, the genetic abnormality causes one of two things to occur. It may direct cells to make an altered collagen protein and the presence of this altered collagen causes OI Type II, III, or IV. Alternately, the dominant altered gene may fail to direct cells to make any collagen protein. Although some collagen is produced by instructions from the normal gene, an overall decrease in the total amount of collagen produced results in OI Type I.

48. Osteogenesis Imperfecta - Brittle Bone Disease Information about osteogenesis imperfecta, a disease that affects collagen and leads to brittle bone disease. osteogenesis imperfecta. http://orthopedics.about.com/bloi.htm

zJs=10 zJs=11 zJs=12 zJs=13 zc(5,'jsc',zJs,9999999,'') About Orthopedics Home Essentials ... A-Z Index of Orthopedic Conditions zau(256,152,145,'gob','http://z.about.com/5/ad/go.htm?gs='+gs,''); Broken Bones Sports Injuries Arthritis Pediatric Orthopedics ... Help zau(256,138,125,'el','http://z.about.com/0/ip/417/0.htm','');w(xb+xb); Stay Current Subscribe to the About Orthopedics newsletter. zau(256,152,100,'hs','http://z.about.com/5/ad/hs.htm?zIhsid=00',''); Search Orthopedics Email to a friend Print this page Stay Current Subscribe to the About Orthopedics newsletter. More About Pediatric Orthopedics Children's Orthopedics Childhood Spine Conditions Fracture Information Broken Bones Most Popular Tendonitis Bursitis Cortisone Injection - Steriod Shot Knee Pain - Injuries and Conditions Causing Knee Pain What's Hot Synovitis - Inflammation of Synovium - Joint Lining Mortons Neuroma Aneurysmal Bone Cyst - ABC Total Knee Replacement in Young Patients ... MRI - How MRI Works Osteogenesis Imperfecta From Jonathan Cluett, M.D. Your Guide to Orthopedics Sign up for my Newsletter Type I: Type II: Type III: Type IV: RATE THIS ARTICLE Would you recommend this article?

49. Osteogenesis Imperfecta Known in laymen s terms as brittle bone disease, osteogenesis imperfecta (OI) is characterized by abnormal fragility of the bones. http://www.stjude.org/disease-summaries/0,2557,449_2166_2945,00.html

@import url(/StJude/CDA/Common/CSS/default.css); @import url(/StJude/CDA/Common/CSS/default_lists.css); @import url(/StJude/CDA/Common/CSS/default_content_types.css); @import url(/StJude/Common/CSS/St_Jude_Clinical_Science); St. Jude Children's Research Hospital Finding Cures. Saving Children. About St. Jude News Donate Now Contact Us ... Ways to Help Rare Diseases Home Clinical Science Home Disease Information Rare Diseases Related Topics St. Jude researchers prove mesenchymal cell transplantation may benefit children with Osteogenesis Imperfecta St. Jude researchers prove mesenchymal cell infusions enhance effects of bone marrow transplant for children with brittle bone disease Disease Information Rare Diseases : Osteogenesis Imperfecta Alternative Names: Brittle bone disease Definition Known in laymen's terms as "brittle bone disease," osteogenesis imperfecta (OI) is characterized by abnormal fragility of the bones. Common features of the disease are bones that break easily, deformities and short stature. Incidence Osteogenesis imperfecta occurs in one in every 20,000 people.

50. Roche Lexikon Medizin (4. Aufl.) - Osteogenesis Imperfecta osteogenesis imperfecta. Einteilung der osteogenesis imperfecta (modif. nach SILLENCE) 308. http://www.gesundheit.de/roche/ro27500/r28303.html

Osteogenesis imperfecta Osteopsathyrosis engl.: osteogenesis imperfecta O. i. congenita Typ Vrolik*, O. i. letalis, O. i. Typ II O. i. tarda, O. i. Typ I, Typ III, Typ IV L OBSTEIN * Krankheit O. i. Typ I O. i. Typ III O. i. Typ IV Einteilung der Osteogenesis imperfecta (modif. nach S ILLENCE Typ I blaue Skleren diskreter Minderwuchs Typ II = perinatale letale Form enger Thorax weicher Kopf, minimal verkalkt schiefergraublaue Skleren Hernien Typ III = progressiv deformierende Form extremer Kleinwuchs Dentinogenesis imperfecta Typ IV Kleinwuchs Dentinogenesis imperfecta Verwandte Themen Blegvad*-Haxthausen* Syndrom Dysplasia, Dysplasie Fragilitas van der Hoeve* Syndrom ... Vrolik* Krankheit

51. Osteogenesis Imperfecta Program, Alfred I. DuPont Institut osteogenesis imperfecta PROGRAM. INTRODUCTION The osteogenesis imperfecta CURRENT ADVANCEMENTS IN osteogenesis imperfecta. Diagnosis of Osteogenesis http://gait.aidi.udel.edu/res695/homepage/pd_ortho/clinics/ost_imp/ostimp.htm

OSTEOGENESIS IMPERFECTA PROGRAM INTRODUCTION: The Osteogenesis Imperfecta Program at the Alfred I. duPont Institute is organized as a subdivision of the Department of Orthopaedics . The program specializes in the management of this rare condition marked by brittle bones which are especially at risk for fracture. The Osteogenesis Imperfecta clinic team includes the family, orthopaedist physical therapist, nurse and adaptive aquatic staff. The mission of the Osteogenesis Imperfecta program is to provide the highest quality multi-disicplinary care by maximizing the function of the child and providing education to family. Treatment plans are designed to correct the existing deformities, and to avoid future deformities by combining state of the art fracture care with prophylactic management of brittle bones using internal supports and external orthotic devices. CURRENT ADVANCEMENTS IN OSTEOGENESIS IMPERFECTA Diagnosis of Osteogenesis Imperfecta using Dual-Energy X-ray Absorptiometry (DEXA) CONTACT INFORMATION: To discuss a specific case or to arrange a referral, contact the Director of the

52. Clinical Trial: Growth Hormone Therapy In Osteogenesis Imperfecta Growth Hormone Therapy in osteogenesis imperfecta. This study is currently recruiting patients. Dwarfism osteogenesis imperfecta, Drug Humatrope, Phase II. http://www.clinicaltrials.gov/ct/gui/show/NCT00001305?order=15

53. ASSOCIAÇÃO BRASILEIRA DE OSTEOGENESIS IMPERFECTA Translate this page Contatos Agradecimentos CréditosCréditos Links InstitucionaisLinks. Sobre osteogenesis imperfecta (clique na cruzinha). O que éO http://www.aboi.org.br/

Sobre a A.B.O.I. (clique na cruzinha) Quem somos Nossa O que fazemos Onde estamos C.R.O.I. C. Lista Oimperfecta AB OI CRISTALEIRA AB OI ABOI na Imprensa Download Ano passado Lojinha da AB OI Contatos Agradecimentos Links Sobre Osteogenesis Imperfecta (clique na cruzinha) Sintomas Hereditariedade Fraturas Cirurgias Dor Tratamentos Fisioterapia Postura Em casa Na Escola No Hospital Equipamento Boas Direitos Artigos Pesquisas Links Sobre as pessoas que formam a ABOI (clique na cruzinha) Associados Pessoas e O.I. Encontro Fotografias Agenda Social Lazer Viajando Cristal e Ruizinho "Quebra-Quebra" Links AB OI. AB OI

54. Osteogenesis Imperfecta - Genetics Home Reference osteogenesis imperfecta. What is osteogenesis imperfecta? osteogenesis imperfecta than average. How common is osteogenesis imperfecta? http://ghr.nlm.nih.gov/condition=osteogenesisimperfecta

A service of the U.S. National Library of Medicine Home Search Conditions Genes ... Help Osteogenesis imperfecta Related Gene(s) Quick links to this topic NIH Publications National Institutes of Health MedlinePlus Health Information Educational resources Information pages Patient support For patients and families Gene Tests DNA test labs ClinicalTrials.gov Research studies PubMed Recent literature OMIM Genetic disorder catalog Osteogenesis imperfecta What is osteogenesis imperfecta? Osteogenesis imperfecta is a group of inherited disorders that mainly affect the bones. The term "osteogenesis imperfecta" means imperfect bone formation. The condition causes bones to be fragile and easily broken and is also responsible for other health problems. Genetic factors cause the following types of osteogenesis imperfecta. osteogenesis imperfecta, type I osteogenesis imperfecta, type II osteogenesis imperfecta, type III osteogenesis imperfecta, type IV Researchers have proposed three more types of osteogenesis imperfecta (type V, type VI, and type VII), but the genetic causes have not yet been identified. The signs and symptoms of this condition vary widely. Type I osteogenesis imperfecta is the mildest form of the disorder, while type II is the most severe. All forms of osteogenesis imperfecta include fragile bones and frequent bone fractures. Some types are associated with brittle teeth, hearing loss, a blue or grey tint to the part of the eye that is usually white (the sclera), curvature of the spine (scoliosis), and loose joints. People with osteogenesis imperfecta are often shorter than average.

55. Osteogenesis Imperfecta osteogenesis imperfecta. osteogenesis imperfecta (OI) is a systemic condition that involves all tissues and organs with a significant collagen matrix. http://imc.gsm.com/integrated/msk/mspath/enneking/sect02/oi.html

About Table of Contents Diseases of Growth Help Osteogenesis imperfecta Definition Natural History Radiographic Features Gross Features ... References Definition Osteogenesis imperfecta (OI) is a systemic condition that involves all tissues and organs with a significant collagen matrix. The most severe expression is present at birth, occurs as an autosomal dominant trait, and is called osteogenesis imperfecta congenita . A less-severe expression becomes manifest during adolescence, occurs as a recessive trait , and is termed osteogenesis imperfecta tarda The principal defect is the imperfect formation of collagen leading to marked reduction in the amount of bone formed and, hence, in the size and thickness of the skeleton. Natural History The principal features of OI congenita are deformed, thin, brittle bones that fracture repeatedly. In addition, abnormally-thin sclerae give the eyes a distinct bluish tint, and short, stunted dentition and short stature with severe bowing deformities are evident. The short stature is due, in part, to defective enchondral ossification and, in part, to the bowing deformities. [Photo] This is a deformed, stillborn infant with OI congenita.

56. Osteogenesis Imperfecta (OI) osteogenesis imperfecta (OI), OI A BRIEF EXPLINATION / KENNEDY KRIEGER OI is a genetic disorder that makes bones break VERY easily . http://hometown.aol.com/quakerparrotb/myhomepage/

Main Other Disabilities htmlAdWH('7002568', '234', '60'); OSTEOGENESIS IMPERFECTA (OI) OI A BRIEF EXPLINATION  / KENNEDY KRIEGER OI is a genetic disorder that makes bones break VERY easily . Their are four types Type one is the most common and mildest ,Type one bones are prone to fractures Type two is the most severe form frequently fatal after birth; a few have lived into adolesence. Type 3 bones fracture easily small stature and severe bone deformities. Type 4 bone's fracture easily shorter then normal stature . KENNEDY KRIEGER HOSPITAL Kennedy Krieger Hospital is a remarkable childrens hospital .Their OI team includes excellent OI specialist( Dr .Shapiro,MD.) A Nutritionist,An Audiologist,A Physical Therapist and much more .They try to find the best treatment for the Individual.They explain everything in a way you can understand it. They schedule test to help make clear of exactly what your disease is ,and what gene is missing or disformed ,Dr.Shapiro is not an Orthopedic he is an OI specialist MY STORY / NUTRTION MY STORY NUTRITION http://expage.com/oi4

57. Osteogenesis Imperfecta - Brittle Bone Society osteogenesis imperfecta (OI) is the medical name for brittle bones. `Brittle Bones What is osteogenesis imperfecta? osteogenesis imperfecta http://www.brittlebone.org/html/overview.htm

What is Osteogenesis Imperfecta? Osteogenesis Imperfecta (OI) is the medical name for brittle bones. `Brittle Bones' refers to a range of conditions resulting from abnormalities in the protein structure of the bones. This causes the bones to break more easily than normal. What is it like to have brittle bones? Some children with OI are born with fractures, others have their first injury soon after birth, yet others when they try to walk for the first time. This is obviously a difficult time for the family and a large part of the society's work is to provide the guidance, support and information that they need. In a few cases children with brittle bones are, initially thought to have been injured by their parents. This accusation does great damage to the families and the Society can provide advice and support. Does it vary in severity?

58. Osteogenesis Imperfecta osteogenesis imperfecta. If your question is not answered here, please contact one of our information specialists. http://www.arthritis.org/conditions/DiseaseCenter/osteogenesis_imperfecta.asp

Welcome! Log In Create Profile advanced search Español ... 51 Ways to Be Good to Your Joints Osteogenesis Imperfecta If your question is not answered here, please contact one of our information specialists. What Is It? What Causes It? Treatment Options Resources and Suggestions What Is It? Osteogenesis Imperfecta (os-tee-oh-GEN-e-sis im-purr-FEC-ta) is a group of inherited disorders in which the bones of the body break easily. It results from a defect in the chemical make-up of collagen, which is a protein that acts like glue to hold tissues together and gives strength to bones. It affects children as well as adults. Early diagnosis can help reduce symptoms and prevent complications. What Causes It? Is an inherited disorder than can be passed from parent to child. It is possible that neither parent carries the gene, but a child will still develop the disease. Treatment Options Casts and splints Muscle-strengthening exercises Pain medication Rehabilitative therapy Safety precautions Surgery Resources and Suggestions Visit Your Arthritis Store to request the free Exercise and Your Arthritis brochure.

59. Uhrad.com - Pediatric Imaging Teaching Files uhrad.com Pediatric Imaging Teaching Files. Case Forty Two - osteogenesis imperfecta. Click on Images for Enlarged View Diagnosisosteogenesis imperfecta. http://www.uhrad.com/pedsarc/peds042.htm

uhrad.com - Pediatric Imaging Teaching Files Case Forty Two - Osteogenesis Imperfecta. Click on Images for Enlarged View Clinical History: Signs often include fragile bones, thin skin, blue sclera, poor dentition and hypermobility of the joints. Radiologic Findings: Osteopenia with multiple fractures accompanied by deformities. Diagnosis: Osteogenesis Imperfecta. Discussion: References: 1. Juhl J, Crummy A, Paul and Juhl's Essentials of Radiologic Imaging, 5th ed, Lippincott 1987. 2.Taveras J, Ferrucci J, Radiology, Diagnosis-Imaging-Intervention, Lippincott. Return to Pediatric Imaging Page Submitted by: Richard Patterson, M.D. Sheila C. Berlin, M.D. Carlos Sivit, M.D. Rainbow Babies and Children's Hospital

60. Uhrad.com - Pediatric Imaging Teaching Files uhrad.com Pediatric Imaging Teaching Files. Case Sixteen - osteogenesis imperfecta. Findings Diagnosisosteogenesis imperfecta. http://www.uhrad.com/pedsarc/peds016.htm

uhrad.com - Pediatric Imaging Teaching Files Case Sixteen - Osteogenesis Imperfecta Findings: A. Initial radiograph from this three-week-old child demonstrates the findings of diffuse osteoporosis, and healing oblique fractures of the femoral diaphyses. Bowing deformities of the markedly foreshortened femora, tibiae, and fibulae can be observed. B. Subsequent examination obtained seven months later describes advanced healing of the previously demonstrated femoral fractures. Gradually increasing lower extremity weight bearing by the patient has resulted in progressive bowing deformity of the osteoporotic long bones. C. Examination of the right lower extremity obtained six days after "B" demonstrates a new oblique fracture of the right femoral diaphysis. Diagnosis: Osteogenesis Imperfecta Discussion: OSTEOGENESIS IMPERFECTA is a relatively common heterogeneous disorder characterized and sub-classified by age of onset and clinical course, and by the presence/absence of: 1)dentinogenesis imperfecta; 2) blue sclerae; and 3) hearing impairment. Sub-classifications (Types I-IV) are also defined, in part, by inheritance pattern and salient radiographic features. The principal biochemical defects related to osteogenesis imperfecta (OI) result in the impairment of early stages in the synthesis of connective tissue fibers, as well as faulty cross- linking of the resultant fibers into adult Type I collagen.

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