21. Medical Encyclopedia: Olivopontocerebellar Atrophy (Print Version) Medical Encyclopedia olivopontocerebellar atrophy. The cause of sporadic olivopontocerebellar atrophy is not known, but the disease is progressive. Symptoms. http://www.nlm.nih.gov/medlineplus/print/ency/article/000758.htm

To print this page, use the print option from your browser. To close this window, click on the "x" in the upper right hand corner of the window. Medical Encyclopedia: Olivopontocerebellar atrophy URL of this page: http://www.nlm.nih.gov/medlineplus/ency/article/000758.htm Alternative names OPCA; Olivopontocerebellar degeneration Definition Olivopontocerebellar atrophy is a neurodegenerative illness that causes certain brain areas (which may include the olivary nucleus, the pons, and the cerebellum) to shrink. Causes, incidence, and risk factors This condition can be inherited but it most commonly affects people without a known family history (sporadic form). Sporadic cases tend to affect people in their 50s while familial cases usually start earlier. The cause of sporadic olivopontocerebellar atrophy is not known, but the disease is progressive. Symptoms Many symptoms are associated with olivopontocerebellar atrophy but the predominant feature is progressive ataxia (clumsiness) and difficulties with balance. There may be slurring of speech and difficulty walking. Other symptoms may include: tremor abnormal movements abnormal eye movements sexual dysfunction bowel or bladder problems stiffness or rigidity spasticity neuropathy difficulty swallowing Signs and tests A thorough medical and neurological examination as well as a good history of symptoms and family history are necessary to make the diagnosis. There are no specific tests for this condition.

22. Olivopontocerebellar Atrophy (OPCA) A description of olivopontocerebellar atrophy (OPCA) including symptoms, treatment and research. What is. olivopontocerebellar atrophy (OPCA)? http://shy-drager-syndrome.org/olivopontocerebellar-atrophy.html

What is Olivopontocerebellar Atrophy (OPCA)? Olivopontocerebellar atrophy (OPCA) refers to a group of ataxias characterized by progressive neurological degeneration affecting the cerebellum, the pons and the inferior olives. OPCA may be classified based on clinical, genetic, or neuropathological findings; thus, there are many classifications of the disorder. Among the different classifications there is wide variation in severity and age of onset. What are the symptoms? The symptoms of OPCA differ from person to person. Most patients experience difficulty with balance and coordination of the legs and arms (ataxia) and slurred speech (dysarthria). Other symptoms may include muscle spasms or weakness and stiffness of the muscles; numbness or tingling of the hands or feet; tremor (shaking) of the hand or arm; reduction or slowness of movements; loss of thinking and/or memory skills; difficulty controlling the bladder or bowels; and feeling faint when standing up. Some patients also have fatigue and/or trouble with sleep. Generally symptoms of OPCA begin in mid-adult life and progress slowly over the course of many years. Is there any treatment?

23. Olivopontocerebellar Atrophy, Hereditary Hereditary olivopontocerebellar atrophy (OPCA) is a rare group of disorders characterized by progressive balance problems (disequilibrium), progressive http://www.bchealthguide.org/kbase/nord/nord495.htm

document.write(''); var hwPrint=1; var hwDocHWID="nord495"; var hwDocTitle="Olivopontocerebellar Atrophy, Hereditary"; var hwRank="1"; var hwSectionHWID="nord495"; var hwSectionTitle=""; var hwSource="cn6.0"; var hwProdCfgSerNo="wsh_html_031_s"; var hwDocType="NORD"; National Organization for Rare Disorders, Inc. Olivopontocerebellar Atrophy, Hereditary Important It is possible that the main title of the report is not the name you expected. Please check the synonyms listing to find the alternate name(s) and disorder subdivision(s) covered by this report. Synonyms Hereditary OPCA Disorder Subdivisions OPCA, Menzel type Spinocerebellar Ataxia 1 OPCA, Holguin type Spinocerebellar Ataxia 2 SCA, Cuban type Spinocerebellar Ataxia 7 OPCA with retinal degeneration OPCA, Fickler-Winkler type OPCA, Schut-Haymaker type OPCA with dementia and extrapyramidal signs Related Disorders List Information on the following diseases can be found in the Related Disorders section of this report: Friedreich's Ataxia Marie's Ataxia Ataxia Telangiectasia Charcot-Marie-Tooth Disease General Discussion Hereditary olivopontocerebellar atrophy (OPCA) is a rare group of disorders characterized by progressive balance problems (disequilibrium), progressive impairment of the ability to coordinate voluntary movements (cerebellar ataxia), and difficulty speaking or slurred speech (dysarthria). There are at least five distinct forms of hereditary OPCA. All forms of hereditary OPCA, except one, are inherited as autosomal dominant traits.

24. Disease Directory : Neurological Disorders : Brain Diseases : Olivopontocerebell AllRefer Health olivopontocerebellar atrophy Symptoms Signs - Olivopontocerebellar olivopontocerebellar atrophy. Conditions http://www.diseasedirectory.net/Neurological_Disorders/Brain_Diseases/Olivoponto

Wednesday, June 02, 2004 Neurological Disorders Brain Diseases Akinetic Mutism Bardet-Biedl Syndrome ... Brain Diseases : Olivopontocerebellar Atrophy Conditions and Diseases - Olivopontocerebellar Atrophy Top Links - Olivopontocerebellar Atrophy Web Site Links. Opca Awareness - A site devoted to Olivopontocerebellar Atrophy. It has links, personal Corticobasal Ganglionic Degeneration (CBGD) - Article by Timothy C. Hain, MD from Northwestern University Medical School. eMedicine - Olivopontocerebellar Atrophy : Article Excerpt by ... - Olivopontocerebellar Atrophy - In 1900, Dejerine and Thomas first introduced the term olivopontocerebellar atrophy (OPCA). Since Geometry.Net - Health_Conditions: Olivopontocerebellar Atrophy - Olivopontocerebellar Atrophy: more detail. MEDLINEplus Medical Encyclopedia: Olivopontocerebellar Atrophy olivopontocerebellar atrophy. Geometry.Net - Health_Conditions: Olivopontocerebellar Atrophy Health Conditions and Diseases Neurological Disorders Brain ... - Top Web Sites: NINDS: Olivopontocerebellar Atrophy - Information sheet compiled by National Institute of Neurological Disorders and Stroke. Health Library - Olivopontocerebellar Atrophy, Hereditary

25. Olivopontocerebellar Atrophy,Atrophy Olivopontocerebellar,OPCA,Spinocerebellar A olivopontocerebellar atrophy,Atrophy Olivopontocerebellar,OPCA,Spinocerebellar Atrophy Type I,Spinocerebellar Ataxia Type IV (SCAIV),Spinocerebellar Ataxia http://www.icomm.ca/geneinfo/opca.htm

For Information on Workshops and Seminars for Special Needs Children click here The GAPS INDEX to Information on the Internet about Genetic Disorders and Birth Defects Genetic Information and Patient Services, Inc. (GAPS) HOME DISORDERS GLOSSARY Olivopontocerebellar Atrophy also known as: Atrophy, Olivopontocerebellar OPCA Spinocerebellar Atrophy Type I Spinocerebellar Ataxia Type IV (SCAIV) Spinocerebellar Ataxia Type V (SCAV) Spinocerebellar Ataxia Type VI (SCAVI) Spinocerebellar Ataxia Type VII (SCAVII) Disorder Subdivisions Olivopontocerebellar Atrophy I Spinocerebellar Ataxia Type I (SCA1) OPCA I Menzel Type OPCA Olivopontocerebellar Atrophy II OPCA II Fickler-Winkler Type Olivopontocerebellar Atrophy III OPCA III Olivopontocerebellar Atrophy with Retinal Degeneration Olivopontocerebellar Atrophy IV OPCA IV Schut-Haymaker Type Olivopontocerebellar Atrophy Olivopontocerebellar Atrophy V OPCA V Olivopontocerebellar Atrophy with Dementia and Extrapyramidal Signs Spinocerebellar Ataxia Type II (SCAII) Spinocerebellar Ataxia Type III (SCAIII) (as defined by the National Organization for Rare Disorders Olivopontocerebellar Atrophy (OPCA) is a group of inherited forms of Ataxia characterized by progressive neurological degeneration affecting the olivopontocerebellar area of the brain.

26. Definitions Of Genetic Disorders-O htm Oligohydramnios Sequence amniot.htm Oligophrenia Microphthalmos norrie.htm Oligophrenic Polydystrophy sanfilipo.htm olivopontocerebellar atrophy opca.htm http://www.icomm.ca/geneinfo/def-o.htm

For Information on Workshops and Seminars for Special Needs Children click here The GAPS INDEX to Information on the Internet about Genetic Disorders and Birth Defects Genetic Information and Patient Services, Inc. (GAPS) HOME DISORDERS GLOSSARY Definitions of Genetic Disorders beginning with the letter O Click on the link next to the disorder to view its definition. OAV Spectrum goldenhar.htm Obstructive Apnea apnea.htm Obstructive Hydrocephalus hydroceph.htm Obstructive Sleep Apnea slpapn.htm OCC Syndrome occs.htm Occlusive Thromboaortopathy taka.htm OCCS occs.htm Occult Intracranial Vascular Malformations vasmalbrain.htm Occult Spinal Dysraphism Sequence tscs.htm Ochoa Syndrome ochoa.htm Ochronosis alkap.htm Ochronotic Arthritis alkap.htm OCR lowe.html OCRL cor.htm Octocephaly octoc.htm Ocular Albinism albinism.htm Ocular Herpes corndyst.htm Ocular Myasthenia Gravis myasgrav.htm Oculo-Auriculo-Vertebral Dysplasia goldenhar.htm

27. Olivopontocerebellar Atrophy - Medical Dictionary Definitions Of Popular Medical MedicineNet Home MedTerms medical dictionary AZ List olivopontocerebellar atrophy. Advanced Search. http://www.medterms.com/script/main/art.asp?articlekey=30933

28. Olivopontocerebellar Atrophy Other characters, olivopontocerebellar atrophy,. Print this article, see olivopontocerebellar degeneration. FS. The Encyclopaedia of Medical Imaging Volume VI1. http://www.amershamhealth.com/medcyclopaedia/Volume VI 1/OLIVOPONTOCEREBELLAR AT

Amershamhealth.com Search for: Type a word or a phrase. All forms of the word are searchable. Browse entry words starting with: A B C D ... Other characters Olivopontocerebellar atrophy, see olivopontocerebellar degeneration FS The Encyclopaedia of Medical Imaging Volume VI:1 Contacts GE Healthcare Making Waves

29. Health Library - olivopontocerebellar atrophy, Hereditary. Synonyms Disorder Subdivisions General Discussion Resources National Organization for Rare Disorders. http://yalenewhavenhealth.org/library/healthguide/IllnessConditions/topic.asp?hw

30. HealthCentral - General Encyclopedia - Olivopontocerebellar Atrophy General Health Encyclopedia, olivopontocerebellar atrophy. http://www.healthcentral.com/mhc/top/000758.cfm

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31. Olivopontocerebellar Atrophy Overview. What Is olivopontocerebellar atrophy? nausea olivopontocerebellar atrophy. olivopontocerebellar atrophy bleeding. diarrhea olivopontocerebellar atrophy. http://www.icongrouponline.com/health/Olivopontocerebellar_Atrophy.html

ICON Health Publications Official Health Sourcebooks The Official Patient's Sourcebook on OLIVOPONTOCEREBELLAR ATROPHY (Atrophy Olivopontocerebellar; Multiple systems atrophy; Olivopontocerebellar degeneration; Spinocerebellar Ataxia Type IV; Spinocerebellar Ataxia Type V; Spinocerebellar Ataxia Type VI; Spinocerebellar Ataxia Type VII; Spinocerebellar Atrophy Type I) Revised and Updated for the Internet Age P A P E R B A C K Paperback Book Paperback Book Order by phone: 800-843-2665 (within USA) 1-201-272-3651 (from outside USA) Paperback Book Shipped in 3 to 5 business days E B O O K Electronic File * E-Book version sent via e-mail in 2 business days Electronic File *E-Book version sent via e-mail in 2 business days Pages Price $28.95(USD) ISBN Published Synopsis A comprehensive manual for anyone interested in self-directed research on Olivopontocerebellar Atrophy. Fully referenced with ample Internet listings and glossary. Related Conditions/Synonyms Atrophy Olivopontocerebellar; Multiple systems atrophy; Olivopontocerebellar degeneration; Spinocerebellar Ataxia Type IV; Spinocerebellar Ataxia Type V; Spinocerebellar Ataxia Type VI; Spinocerebellar Ataxia Type VII; Spinocerebellar Atrophy Type I Description Table of Contents Introduction Overview Organization Scope Moving Forward PART I: THE ESSENTIALS Chapter 1. The Essentials on Olivopontocerebellar Atrophy: Guidelines

32. Re: Olivopontocerebellar Atrophy Subject Re olivopontocerebellar atrophy Forum The Neurology and Neurosurgery Forum Topic Area Ataxia Posted by CCF Neurology MDNT on January 11, 1999 at 20 http://www.medhelp.org/forums/neuro/archive/15044.html

Questions in The Neurology Forum are being answered by doctors from The Cleveland Clinic , consistently ranked one of the best hospitals in America. Subject: Re: Olivopontocerebellar atrophy Forum: The Neurology and Neurosurgery Forum Topic Area: Ataxia Posted by CCF Neurology MD:NT on January 11, 1999 at 20:32:38: In Reply to: Olivopontocerebellar atrophy posted by Dave Felten on January 11, 1999 at 00:59:31: : Hello: : Can you tell me what diagnostic test currently are used to diagnose and confirm OPCA? : Thank you very much!! Dear Dave: Cerebellar degenerations (also called spinocerebellar degenerations) can either be sporadic or heredofamilial. Heredofamilial cerebellar degenerations can be either autosomal dominant (various types termed spinocerebellar ataxia = SCA 1 - 7, DRPLA, Machado-Joseph disease, etc) or autosomal recessive (Friedreich's ataxia, and some other rare types). The syndrome of progressive ataxia (imbalance of gait, incoordination of hands, slurred speech), in association with some other characteristic abnormalities (peripheral neuropathy, optic atrophy, retinitis pigmentosa, dementia, corticospinal dysfunction, oculomotor dysfunction, etc) is seen with heredofamilial forms. Ataxia is associated with autonomic dysfunction and/or parkinsonian features in sporadic cases. Either sporadic or autosomal dominant forms of cerebellar degeneration can be associated with atrophy of the cerebellum, pons and inferior olives, either on MRI, or at autopsy. Hence, OPCA (olivopontocerebellar atrophy) is used as a descriptive term for these disorders.

33. Olivopontocerebellar Atrophy Subject olivopontocerebellar atrophy Topic Area Neurology General Forum The Neurology and Neurosurgery Forum Question Posted By Sandy Clarke on Monday http://www.medhelp.org/perl6/neuro/archive/15346.html

Questions in The Neurology Forum are being answered by doctors from The Cleveland Clinic , consistently ranked one of the best hospitals in America. Subject: Olivopontocerebellar Atrophy Topic Area: Neurology - General Forum: The Neurology and Neurosurgery Forum Question Posted By: Sandy Clarke on Monday, August 18, 1997 : : Hello: : : Can you tell me what diagnostic test currently are used to diagnose and confirm OPCA? : : Thank you very much!! : Dear Dave: : Cerebellar degenerations (also called spinocerebellar degenerations) can either be sporadic or heredofamilial. Heredofamilial cerebellar degenerations can be either autosomal dominant (various types termed spinocerebellar ataxia = SCA 1 - 7, DRPLA, Machado-Joseph disease, etc) or autosomal recessive (Friedreich's ataxia, and some other rare types). : The syndrome of progressive ataxia (imbalance of gait, incoordination of hands, slurred speech), in association with some other characteristic abnormalities (peripheral neuropathy, optic atrophy, retinitis pigmentosa, dementia, corticospinal dysfunction, oculomotor dysfunction, etc) is seen with heredofamilial forms. Ataxia is associated with autonomic dysfunction and/or parkinsonian features in sporadic cases. Either sporadic or autosomal dominant forms of cerebellar degeneration can be associated with atrophy of the cerebellum, pons and inferior olives, either on MRI, or at autopsy. Hence, OPCA (olivopontocerebellar atrophy) is used as a descriptive term for these disorders.

34. Neurological Disorders, Brain Diseases, Olivopontocerebellar Atrophy More olivopontocerebellar atrophy Categories » Submit Your Site to the olivopontocerebellar atrophy category. Sponsored olivopontocerebellar atrophy Sites. http://www.iseekhealth.com/olivopontocerebellar_atrophy-1961.php

Home About Us Contact Submit Your Site Search : Home Health Conditions and Diseases Neurological Disorders ... Olivopontocerebellar Atrophy More Olivopontocerebellar Atrophy Categories: Submit Your Site to the Olivopontocerebellar Atrophy category Sponsored Olivopontocerebellar Atrophy Sites Brain Disease. Is It Alzheimer's? Alzheimer's is a disease of the brain. It makes it hard for people to remember, think, and use language. It can also make it difficult to do daily tasks like using the phone and cooking. But early treatment may help. Learn how to spot early symptoms. Fully searchable traditional medicine and alternative medicine books, videos and products for doctors, students and the public. An affiliate of Amazon.com. PCBs May Cause Brain Damage and Memory Problems Because PCBs damage the thyroid gland, scientists believe PCBs may damage the brain and cause memory problems, along with altered thyroid hormone levels. MCW Health Link - An article about olivopontocerebellar atrophy, which involves progressive loss of certain brain structures: the cerebellum, the pons, and the inferior olives. NINDS: Olivopontocerebellar Atrophy - Information sheet compiled by National Institute of Neurological Disorders and Stroke.

35. Neurological Disorders, Brain Diseases, Olivopontocerebellar Atrophy Home Health Conditions and Diseases Neurological Disorders Brain Diseases olivopontocerebellar atrophy. * Site Title · The name of the site. http://www.iseekhealth.com/directory/index.php?method=show_link_exchange&directo

36. Olivopontocerebellar Atrophy, Hereditary olivopontocerebellar atrophy, Hereditary. http://www.meritcare.com/hwdb/showTopic.asp?pd_hwid=nord495

37. Olivopontocerebellar Atrophy The New Health Directory, Directory, Home Health Conditions and Diseases Neurological Disorders Brain Diseases olivopontocerebellar atrophy (4) See Also http://www.thenewhealthfind.com/Health/ConditionsandDiseases/NeurologicalDisorde

Directory Home Health Conditions and Diseases Neurological Disorders ... Brain Diseases : Olivopontocerebellar Atrophy (4) See Also: Health: Conditions and Diseases: Neurological Disorders: Spinal Cord: Spinocerebellar Degenerations Health: Conditions and Diseases: Rare Disorders Opca Awareness - A site devoted to Olivopontocerebellar Atrophy. It has links, personal stories and a discussion board. NINDS: Olivopontocerebellar Atrophy - Information sheet compiled by National Institute of Neurological Disorders and Stroke. MCW Health Link - An article about olivopontocerebellar atrophy, which involves progressive loss of certain brain structures: the cerebellum, the pons, and the inferior olives. NORD - Olivopontocerebellar Atrophy - Offers synonyms, a general discussion and further resources. Help build the largest human-edited directory on the web. Submit a Site Open Directory Project Become an Editor Quick Links plus size nursing uniforms no prescription fioricet spine information about depression ... fat loss supplements The New Health Directory Site Map Privacy Contact Advertise ... Health Directory

38. Lamb olivopontocerebellar atrophy. Mark Lamb. Abstract. olivopontocerebellar atrophy olivopontocerebellar atrophy. olivopontocerebellar atrophy http://www.indstate.edu/thcme/anderson/ML.html

Olivopontocerebellar Atrophy Mark Lamb Abstract Olivopontocerebellar Atrophy(OPCA), is characterized by neuronal degeneration of the cerebellar cortex, the inferior olive, and the pons. The symptoms associated with it are primarily cerebellar ataxia with disturbances in equilibrium and gait. However, broader symptomology is usually seen with OPCA. Current research is focusing on three primary systems thought to be responsible for the etiology of OPCA. They are excitatory amino acid disturbances, oligodendroglial microtubular tangles, and phospholipid metabolism disorders. The only treatment for OPCA is therapy focusing on improving the dysphagia associated with the disorder. Olivopontocerebellar Atrophy Olivopontocerebellar Atrophy (OPCA) is a disease characterized primarily by the degeneration of neurons in the cerebellar cortex, pons, and inferior olive. It is a genetic disease, being either autosomal dominant or autosomal recessive in nature. This disorder, which usually occurs in the middle years of life, presents symptoms of cerebellar ataxia, equilibrium disturbance, nystagmus, dysphasia, dysarthria, and possibly intellectual deficits. According to Merritt, the pathology of OPCA includes loss of Purkinje cells, reduction of the number of neurons in the molecular and granular layers of the cerebellum, degeneration of the folia and white matter of the cerebellum, atrophy of the inferior olives and of the olivo-cerebellar connections, and atrophy of the pontine nuclei, arcuate nuclei, and brachium pontis (15). In addition to this, degeneration of the spinocerebellar tracts, corticospinal tracts, and frontal and temporal lobes has been reported (15).

39. Opca/ds olivopontocerebellar atrophy. Debra Stenacker. olivopontocerebellar atrophy (OPCA) was first described in 1900 by Dejerine and Thomas. http://www.indstate.edu/thcme/anderson/DS.html

OLIVOPONTOCEREBELLAR ATROPHY Debra Stenacker Olivopontocerebellar atrophy (OPCA) was first described in 1900 by Dejerine and Thomas. OPCA is a group of dominant inheritance and sporadic neurological disorders characterized by a chronic, progressive, cerebellar ataxia that begins in middle age. The cerebellum and its connections are the primary sites of the disease in chronic progressive disorders that often occur in familial or hereditary patterns. Postmortem studies indicate an atrophy of the cerebellum, pons, and inferior olives. This neuropathological neuronal cell loss permits classification of OPCA as a non-Alzheimer’s neurodegenerative illness. Gross postmortem inspection of the brains of patients with OPCA shows marked shrinkage of the ventral half of the pons, and disappearance of the olivary eminence on the ventral surface of the medulla. These brains also exhibit an atrophy of the cerebellum with degeneration of the middle cerebellar peduncles, and to a lesser extent, of the inferior peduncles. Thus, the cerebellum suffers mainly through atrophy of its afferent fibers. The neocerebellum and the olive undergo the primary degeneration. The purkinje cells of the cerebellar cortex are affected secondarily. Histological examination shows severe degeneration of Purkinje cells, reduction in the number of cells in the molecular and granular layers of the cerebellar cortex, severe loss of the number of cells in the pontine nuclei and olives, and demyelination of the middle cerebellar peduncle. The cerebellar nuclei are well preserved. The tegmentum of the pons, the corticospinal tracts, and the restiform body are also usually unaffected. In clinical cases involving extrapyramidal symptoms, degenerative changes in the striatum, especially the putamen, and a loss of pigmented cells in the substantia nigra may be seen. Tubular structures and crystalline inclusions may be found with the electron microscopy. More wide spread degeneration of the central nervous system has been reported in dominant autosomal cases, and may involve the spinocerebellar fibers and the posterior columns.

40. Olivopontocerebellar Atrophy- Medcohealth.com olivopontocerebellar atrophy is a neurodegenerative illness that causes certain brain areas (which may include the olivary nucleus, the pons, and the cerebellum http://www.medcohealth.com/medco/consumer/ehealth/ehsarticle.jsp?topicID=HE:Dise

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