41. World Parkinson Disease Association (WPDA) 2003, Jan Feb Mar Apr May. Steroid therapy of neuroleptic malignant syndrome(NMS) in PD. Steroid therapy of neuroleptic malignant syndrome (NMS) in PD. http://www.wpda.org/news.html?n=606

42. American Psychiatric Publishing, Inc. - Neuroleptic Malignant Syndrome And Relat neuroleptic malignant syndrome and Related Conditions, Second Edition Stephan C.Mann, MD, Stanley N. Caroff, MD, Paul E. Keck, Jr., MD, and Arthur Lazarus, MD http://www.appi.org/book.cfm?id=62011

43. American Psychiatric Publishing, Inc. - Catatonia He also serves as Director of the neuroleptic malignant syndrome Information Serviceand is a member of the Board of Directors of the Malignant Hyperthermia http://www.appi.org/book.cfm?id=62085

44. Myoglobinuria; Rhabdomyolysis myoglobinuria. neuroleptic malignant syndrome (NMS). Drugs Butyrophenones;Lithium; Phenothiazines; Pimozide; Promethazine; Thioxanthines; http://www.neuro.wustl.edu/neuromuscular/msys/myoglob.html

Front Search Index Links ... Patient Info MYOGLOBINURIA - RHABDOMYOLYSIS Myoglobinuria Malignant hyperthermia General features Pathophysiology Specific causes Myoglobinuria: Acquired causes Drugs Hypokalemia Idiopathic recurrent Infections ... Other: Occasional myoglobinuria Polymyositis: Anti-MAS syndrome Serotonin syndrome Snake venoms Thyroid: Hyper or Hypo Toxins Trauma Myoglobinuria: Familial causes ... Malignant hyperthermia (MHS) loci : Ryanodine Receptor; 19q13 : Na channel (SCNA4); 17q11 : Ca channel (CACNL2A); 7q21 : Ca channel (CACNA1S); 1q32 Mitochondrial Myoadenylate deaminase deficiency Sickle cell anemia Other familial causes MYOGLOBINURIA: General features Myoglobinuria: General pathology Necrosis, especially acute, of muscle fibers (rhabdomyolysis) Release of muscle components into circulation Mechanisms of muscle injury Rise in free intracellular calcium: Due to Damage to muscle sarcolemma Failure of energy supply within muscle cell Destroys myofibrillar, cytoskeletal, and membrane proteins Lysosomal digestion of muscle fiber contents ensues Typical clinical features Muscle Discomfort: Pain; Tenderness

45. Neuroleptic Malignant Syndrome neuroleptic malignant syndrome. Early identification of and treatment forindividuals with neuroleptic malignant syndrome improves outcome. http://www.sciencedaily.com/encyclopedia/neuroleptic_malignant_syndrome

Match: sort by: relevance date Free Services Subscribe by email RSS newsfeeds PDA-friendly format loc="/images/" A A A Find Jobs In: Healthcare Engineering Accounting College Contract / Freelance Customer Service Diversity Engineering Executive Healthcare Hospitality Human Resources Information Tech International Manufacturing Nonprofit Retail All Jobs by Job Type All Jobs by Industry Relocating? Visit: Moving Resources Moving Companies Mortgage Information Mortgage Calculator Real Estate Lookup Front Page Today's Digest Week in Review Email Updates ... Outdoor Living Encyclopedia Main Page See live article Neuroleptic malignant syndrome Neuroleptic malignant syndrome is a life-threatening, neurological disorder most often caused by an adverse reaction to neuroleptic (antipsychotic) drugs. Symptoms include high fever sweating , unstable blood pressure From the public domain resource at " class="external">http://www.ninds.nih.gov/health_and_medical/disorders/neuroleptic_syndrome.htm Note: The original source of this article can be found on the main Wikipedia Web site. This article is licensed under the GNU Free Documentation License , which means that you can copy and modify it as long as the entire work (including additions) remains under this license.

46. ScienceDaily -- Browse Topics: Health/Conditions_and_Diseases/Neurological_Disor See Also Health Conditions and Diseases Rare Disorders. News about NeurolepticMalignant Syndrome More news about neuroleptic malignant syndrome . http://www.sciencedaily.com/directory/Health/Conditions_and_Diseases/Neurologica

Match: sort by: relevance date Free Services Subscribe by email RSS newsfeeds PDA-friendly format loc="/images/" A A A Find Jobs In: Healthcare Engineering Accounting College Contract / Freelance Customer Service Diversity Engineering Executive Healthcare Hospitality Human Resources Information Tech International Manufacturing Nonprofit Retail All Jobs by Job Type All Jobs by Industry Relocating? Visit: Moving Resources Moving Companies Mortgage Information Mortgage Calculator Real Estate Lookup Front Page Today's Digest Week in Review Email Updates ... Basal Ganglia Neuroleptic Malignant Syndrome (6 links) See Also: Health: Conditions and Diseases: Rare Disorders News about Neuroleptic Malignant Syndrome UNC Scientists Block Cellular Enzyme Activity Involved In Cancer Progression (June 2, 2004) full story New Cardiac Arrhythmia Syndrome Identified (June 1, 2004) full story Silence Of The Genes: Researchers Provide Unique View Of Inherited Disorders And Cancer (June 1, 2004) full story Researchers Identify New Target Of Protein Involved In Cancerous Cell Growth (May 31, 2004) full story Shortened Chromosomes Linked To Early Stages Of Cancer Development (May 28, 2004)

47. Neuroleptic Malignant Syndrome - Encyclopedia Article About Neuroleptic Malignan Neurological malignant syndrome encyclopedia article about neuroleptic malignant syndrome is a life-threatening, neurological disorder Neurologicaldisorders are a group of disorders that involve the central nervous http://encyclopedia.thefreedictionary.com/Neuroleptic malignant syndrome

Dictionaries: General Computing Medical Legal Encyclopedia Neuroleptic malignant syndrome Word: Word Starts with Ends with Definition Neuroleptic malignant syndrome is a life-threatening, neurological disorder Neurological disorders are a group of disorders that involve the central nervous system (brain, brainstem and cerebellum), the peripheral nervous system (including cranial nerves), and the autonomic nervous system (parts of which are located in both central and peripheral nervous system). Major branches are headache, stupor and coma, dementia, seizure, sleep disorders, trauma, infections, neoplasms, neuroophthalmology, movement disorders, demyelinating diseases, spinal cord disorders, and disorders of peripheral nerves, muscle and neuromuscular junctions. Click the link for more information. most often caused by an adverse reaction to neuroleptic The term antipsychotic is applied to a group of drugs used to treat psychosis. Common conditions with which antipsychotics might be used include schizophrenia, mania and delusional disorder, although antipsychotics might be used to counter psychosis associated with a wide range of other diagnoses. Antispychotics also have some effects as mood stabilizers, leading to their occasional use in treating mood disorder (particularly bipolar disorder) even when no signs of psychosis are present. Click the link for more information.

48. Neuroleptic Malignant Syndrome neuroleptic malignant syndrome is a potentially fatal reaction to any ofa group of antipsychotic drugs or major tranquilizers (neuroleptics). http://www.bchealthguide.org/kbase/nord/nord763.htm

document.write(''); var hwPrint=1; var hwDocHWID="nord763"; var hwDocTitle="Neuroleptic Malignant Syndrome"; var hwRank="1"; var hwSectionHWID="nord763"; var hwSectionTitle=""; var hwSource="cn6.0"; var hwProdCfgSerNo="wsh_html_031_s"; var hwDocType="NORD"; National Organization for Rare Disorders, Inc. Neuroleptic Malignant Syndrome Important It is possible that the main title of the report is not the name you expected. Please check the synonyms listing to find the alternate name(s) and disorder subdivision(s) covered by this report. Synonyms None Disorder Subdivisions None Related Disorders List Information on the following diseases can be found in the Related Disorders section of this report: Heat Stroke Tardive Dyskinesia Malignant Hyperthermia Anaphylaxis General Discussion Neuroleptic Malignant Syndrome is a potentially fatal reaction to any of a group of antipsychotic drugs or major tranquilizers (neuroleptics). These drugs are commonly prescribed for the treatment of schizophrenia and other neurological, mental, or emotional disorders. Phenothiazines are one type of neuroleptic and may occasionally be prescribed as a treatment for nausea and vomiting. Several of the most commonly prescribed neuroleptics include thioridazine, haloperidol, chlorpromazine, fluphenazine and perphenazine. Major tranquilizers or neuroleptics have a strong effect on thought disturbances associated with paranoid thinking, delusions, anxiety, and agitation. Neuroleptic Malignant Syndrome occurs when a person taking these drugs reacts with a high fever and other heart, respiratory, and muscle symptoms.

49. Malignant Hyperthermia Database.) neuroleptic malignant syndrome is a potentially fatal reaction to anyof a group of antipsychotic drugs or major tranquilizers (neuroleptics). http://www.bchealthguide.org/kbase/nord/nord8.htm

document.write(''); var hwPrint=1; var hwDocHWID="nord8"; var hwDocTitle="Malignant Hyperthermia"; var hwRank="1"; var hwSectionHWID="nord8"; var hwSectionTitle=""; var hwSource="cn6.0"; var hwProdCfgSerNo="wsh_html_031_s"; var hwDocType="NORD"; National Organization for Rare Disorders, Inc. Malignant Hyperthermia Important It is possible that the main title of the report is not the name you expected. Please check the synonyms listing to find the alternate name(s) and disorder subdivision(s) covered by this report. Synonyms Fulminating Hyperpyrexia Hyperthermia of Anesthesia Malignant Fever Malignant Hyperpyrexia MH Pharmacogenic Myopathy Disorder Subdivisions None Related Disorders List Information on the following diseases can be found in the Related Disorders section of this report: Neuroleptic Malignant Syndrome Noonan Syndrome King Syndrome General Discussion Malignant Hyperthermia (MH) is an inherited disorder in which affected individuals do not react appropriately to certain general anesthetia drugs such as halothane, cyclopropane, and the muscle relaxant succinylcholine. This disorder is charactericized by the development of a sudden and rapid high fever, muscle rigidity, and an irregular heartbeat (cardiac arrhythmia), after the administration of general anesthesia or certain muscle relaxants. Malignant Hyperthermia is inherited as an autosomal dominant trait. Once a person is diagnosed with Malignant Hyperthermia, their relatives should be tested to determine if they also have the disorder.

50. Atypical Neuroleptic Malignant Syndrome Associated With Olanzapine neuroleptic malignant syndrome (NMS) is a potentially lifethreatening adverseeffect of antipsychotic agents, which has been associated with Olanzapine http://www.namiscc.org/Research/2002/NMS.htm

NAMI SCC Website Source: Medscape Atypical Neuroleptic Malignant Syndrome Associated With Olanzapine Roy R. Reeves, D.O., Ph.D., Raphael A. Torres, M.D., Vincent Liberto, M.D., Roy H. Hart, M.D. Abstract Neuroleptic malignant syndrome (NMS) is a potentially life-threatening adverse effect of antipsychotic agents. It generally is characterized by fever, altered mental status, rigidity, and autonomic dysfunction. A 53-year-old man developed NMS without rigidity while taking olanzapine. Such atypical cases may support either a spectrum concept of NMS or the theory that NMS secondary to atypical antipsychotics differs from that caused by conventional neuroleptics. More flexible diagnostic criteria than currently mandated by the the Diagnostic and Statistical Manual of Mental Disorders, Fourth Revision, may be warranted. Introduction Neuroleptic malignant syndrome (NMS) is an uncommon side effect of antipsychotic drugs, usually characterized by fever, altered mental status, rigidity, and autonomic dysfunction. The pathophysiology of NMS is not fully understood. Reduction in dopaminergic activity secondary to neuroleptic-induced dopamine blockade is considered the chief mechanism. This syndrome was first described in 1960 during clinical trials with haloperidol. Since that time, NMS has been associated with virtually all dopamine-blocking agents. Because many atypical antipsychotic agents have weaker dopamine blockade and lower rates of extrapyramidal side effects than conventional antipsychotic agents, it has been suggested that atypical antipsychotic agents are less likely to cause NMS. However, this remains unproven, and cases of NMS associated with clozapine, risperidone, olanzapine, and quetiapine have been reported...

51. Facts You Should Know About NMS Facts You Should Know About NMS neuroleptic malignant syndrome (NMS).What is NMS? NMS is characterized by development of muscle http://www.dpw.state.pa.us/omr/omrNewmns.asp

Search OMR DPW Links DPW Home DPW Services Apply for Services ... Search DPW OMR Services The Community Mental Retardation System HCSIS MR Terminology ... Medicaid Waivers Quality Management PUNS OMR Budget Highlights Health Care HCQUs Health Risk Assessment Medical Alerts ... Contact OMR Facts You Should Know About NMS NEUROLEPTIC MALIGNANT SYNDROME (NMS) What is NMS? NMS is characterized by development of muscle rigidity and fever after taking an antipsychotic medication. There can also be changes in mental alertness, difficulty with drooling or swallowing, problems with blood pressure and sweating. What causes NMS? It is a rare but serious side effect of a drug from a category called neuroleptics or antipsychotics. These are typically used to treat psychotic disorders like schizophrenia. When does NMS occur? Typically, symptoms appear in the first 2 weeks after starting a neuroleptic or increasing the dosage of a neuroleptic. It may develop over hours or a few days. It also may occur at any time while on the medicine. Who is most likely to develop NMS?

52. Neuroleptic Malignant Syndrome (NMS) http://pharma-help.com/nms

Neuroleptic Malignant Syndrome (NMS) Neuroleptic Malignant Syndrome (NMS) Information Neuroleptic Malignant Syndrome (NMS) is an uncommon but potentially fatal complication of antipsychotic and neuroleptic drug treatment. Its defining features include elevated body temperature, muscle rigidity, changes in mental state and abnormal vital signs. Although NMS is uncommon, the widespread use of antipsychotic drugs suggests that the absolute number of cases is not insignificant. Because it occurs infrequently, individual practitioners may have limited experience in diagnosing and treating NMS. What drugs are associated with Neuroleptic Malignant Syndrome (NMS)? Neuroleptic Malignant Syndrome (NMS) has been associated mostly with neuroleptic or antipsychotic drugs. These drugs have been essential in improving the lives of people with severe mental illness and are safely tolerated by the majority of patients. Newer drugs in this class may have even fewer side effects. However, NMS is not seen only in psychiatric patients. Other similar drugs used in medicine in the treatment of gastrointestinal complaints, sedation, or neurologic disorders have also been associated with NMS on rare occasions. What are the Symptoms of Neuroleptic Malignant Syndrome (NMS)?

53. CJP - November 2002 Letters to the Editor. A Case of neuroleptic malignant syndrome WithClozapine and Risperidone. Dear Editor Neuroleptic malignant http://www.cpa-apc.org/Publications/Archives/CJP/2002/November/lettersMalignant.

The Canadian Journal of Psychiatry November 2002 La revue canadienne de psychiatrie ... Tarifs publicitaires (PDF) Guest Editorial Psychiatric Epidemiology: Vibrant Art and Penetrating Science Elliot M Goldner (PDF) In Review The National Survey of Mental Health and Well-Being in Australia: Impact on Policy Scott Henderson (PDF) Child Psychiatric Epidemiology and Canadian Public Policy-Making: The State of the Science and the Art of the Possible Charlotte Waddell, David R Offord, Cody A Shepherd, Josephine M Hua, Kimberley McEwan (PDF) Review Papers Prevalence and Incidence Studies of Schizophrenic Disorders: A Systematic Review of the Literature Elliot M Goldner, Lorena Hsu, Paul Waraich, Julian M Somers (PDF) Original Research Sleep Quality in Chronic Pain Patients Kemal Sayar, Meltem Arikan, Tulin Yontem (PDF) Psychiatric Disorders and Use of Mental Health Services by Ontario Women Sarah Frise, Allan Steingart, Margaret Sloan, Michelle Cotterchio, Nancy Kreiger (PDF) Counsellors in Primary Care: Benefits and Lessons Learned Nick Kates, Anne-Marie Crustolo, Sheryl Farrar, Lambrina Nikolaou (PDF) Neuropsychological Performance in DSM-IV ADHD Subtypes: An Exploratory Study With Untreated Adolescents Marcelo Schmitz, Luciana Cadore, Marcelo Paczko, Letícia Kipper, Márcia Chaves, Luis A Rohde, Clarissa Moura, Márcia Knijnik

54. CJP - October 2002 Quetiapine and neuroleptic malignant syndrome. 1. Hasan S, Buckley P. Novel antipsychoticsand the neuroleptic malignant syndrome a review and critique. http://www.cpa-apc.org/Publications/Archives/CJP/2002/october/lettersQuetiapine.

The Canadian Journal of Psychiatry La revue canadienne de psychiatrie October 2002 octobre ... Tarifs publicitaires (PDF) Editorial Geriatric Psychiatry: Complex Challenges, Promising Treatments Kenneth I Shulman (PDF) In Review Cognitive Pharmacotherapy of Alzheimer’s Disease and Other Dementias Nathan Herrmann (PDF) Brief Screening Tests for Dementia Wendy J Lorentz, James M Scanlan, Soo Borson (PDF) Effective Use of Electroconvulsive Therapy in Late-Life Depression Alastair J Flint, Nadine Gagnon (PDF) Review Papers Are Leptin and Cytokines Involved in Body Weight Gain During Treatment With Antipsychotic Drugs? Trino Baptista, Serge Beaulieu (PDF) Original Research Strategies of Collaboration Between General Practitioners and Psychiatrists: A Survey of Practitioners’ Opinions and Characteristics Ricardo J M Lucena, Alain Lesage, Robert Élie, Yves Lamontagne, Marc Corbière (PDF) A Test of the Phase Model of Psychotherapy Change Anthony S Joyce, John Ogrodniczuk, William E Piper, Mary McCallum (PDF) Brief Communication Lamotrigine Use in Geriatric Patients With Bipolar Depression Matthew Robillard, David K Conn

55. Neuroleptic Malignant Syndrome In Mexico neuroleptic malignant syndrome in Mexico. A Montoya, M Ocampo, A TorresRuiz. KeyWords Frequency; Incidence; neuroleptic malignant syndrome; NMS; Neuroleptics. http://www.pulsus.com/clin-pha/10_03/mont_ed.htm

forgot your password? DRUG SAFETY Autumn 2003 Volume 10, Number 3 : Neuroleptic malignant syndrome in Mexico A Montoya, M Ocampo, A Torres-Ruiz BACKGROUND: Neuroleptic Malignant Syndrome (NMS) is an uncommon but potentially fatal complication of antipsychotic and neuroleptic drug treatment. OBJECTIVES: This study estimated the frequency, clinical presentation, and outcome of NMS in a referral center for neurological, neurosurgical and psychiatric disorders in Mexico. METHODS: The authors conducted a thorough search of psychiatry, neurology, neurosurgery and intensive care unit records for cases of NMS during the 10-year period between 1990 and 1999. They examined the clinical features, course and treatment of the NMS episodes, and performed a follow-up survey for residual symptoms and clinical outcome. The mean time to follow-up assessment was 36 months. RESULTS: A total of eight of 4831 neuroleptic-treated patients had an episode of NMS (incidence 0.165%). Seven of the eight patients were treated with haloperidol. Other neuroleptics agents associated with NMS were depot pipotiazine palmitate and levomepromazine maleate. One patient received lithium concomitantly. No fatal outcome was found. Only one patient developed persistent clinical sequelae, consisting of extrapyramidal and cerebellar symptoms, three years after the NMS episode.

56. National Parkinson Foundation, Inc. neuroleptic malignant syndrome (NMS). by Abe Lieberman MD Neurolepticmalignant syndrome (NMS) is an unusual reaction to neuroleptic http://www.parkinson.org/nmsyndrome.htm

Neuroleptic malignant syndrome (NMS) by Abe Lieberman MD Neuroleptic malignant syndrome (NMS) is an unusual reaction to neuroleptic drugs (drugs used as major tranquillizers) and to abrupt withdrawal of levodopa. The NMS is characterized by high fever, ., unresponsiveness, rigidity, and autonomic nervous system dysfunction. Laboratory abnormalities include elevated serum creatine phosphokinase (a muscle enzyme) and myoglobinuria (breakdown products of muscle in the urine). The symptoms of NMS may develop from a few days to a few weeks following neuroleptic drug use or a few days after stopping levodopa. The symptoms are progressive. NMS occurs in 1% of patients who receive neuroleptic drugs and is attributed by some to a dopamine receptor blockade in the basal ganglia and hypothalamus, and by others to a disturbance of calcium uptake in skeletal muscle. The morality rate associated with NMS, when not recognized and treated is at least 20%. Treatment consists of the withdrawal of the neuroleptic drug (if this is the cause of the NMS syndrome), or the reinstitution of levodopa (if this is the cause of the NMS syndrome), supportive care, and the use of a dopamine agonist or sodium dantrolene. The NMS will not be recognized if it is not considered when a high fever, rigidity, and autonomic nervous system dysfunction (rapid heart rate, high blood pressure, rapid respirations) occur while using neuroleptic drugs or after stopping levodopa. When these symptoms occur the first thought is to look for infections or metabolic disturbances and not consider the symptoms as arising from the use of neuroleptic drugs or after stopping levodopa. NMS may result from dopamine receptor blockade in the basal ganglia and hypothalamus. This blockade can then result in inhibition of calcium uptake in skeletal muscle, which can then result in rigidity. The rigidity may be so severe as to result in immobility, which may lead to high fever, shortness of breathing, decreased oxygen saturation and death.

57. National Parkinson Foundation, Inc. neuroleptic malignant syndromelike, or-dopaminergic malignant syndrome-dueto levodopa therapy withdrawal. Clinical features in 11 patients. http://www.parkinson.org/neuroleptic_dopaminergic.htm

Neuroleptic malignant syndrome-like, or-dopaminergic malignant syndrome-due to levodopa therapy withdrawal. Clinical features in 11 patients. Marcos Serrano-Duenas Parkinsonism and Related Disorders volume 9 (2003) 175 Abstract A clinical picture named neuroleptic malignant-like syndrome has been described in patients with Parkinson's disease (PD) who suddenly stop their L-dopa treatment. The sudden withdrawal of the drug is deemed to lead to an acute deficiency stage in a patient who has an iatrogenic increase of dopaminergic transmission. We present a series of 11 patients with PD with an average age of 72.09 years, a mean disease duration of 9.45 years who developed this problem after a 92.72 h latency period. If patients with PD develop severe rigidity, stupor and hyperthermia, L-dopa withdrawal should be suspected and the dopaminergic drug restarted as soon as possible. 1. Introduction A clinical picture similar to that of the neuroleptic malignant syndrome (NMS) has been described in patients with Parkinson's disease (PD) who suddenly stop their L-Dopa treatment, which has been called a neuroleptic malignant-like syndrome. A series of 11 patients with PD recorded over a 9 year period that developed this serious complication is presented. In all of the patients, the reason for the withdrawal of L-dopa was that they took the option of 'alternate treatment' (AT) for their disease without consultation. All patients were personally evaluated by the author.

58. Neuroleptic Malignant Syndrome (a Case Report). Patkar AA, Shah LP J Postgrad Me Year 1991 Volume 37 Issue 3 Page 16870. Neuroleptic malignantsyndrome (a case report). neuroleptic malignant syndrome (a case report). http://www.jpgmonline.com/article.asp?issn=0022-3859;year=1991;volume=37;issue=3

59. Neuroleptic Malignant Syndrome (a Case Report).,Patkar AA, Shah LP: J Postgrad M neuroleptic malignant syndrome (a case report). Patkar AA, Shah LP Departmentof Psychiatry, KEM Hospital, Parel, Bombay, Maharashtra. http://www.jpgmonline.com/article.asp?issn=0022-3859;year=1991;volume=37;issue=3

60. Neuroleptic Malignant Syndrome In An Adolescent neuroleptic malignant syndrome (NMS) is best defined as a form of druginducedhyperthermia. Classic neuroleptic malignant syndrome (NMS) was diagnosed. http://www.medscape.com/viewarticle/449736

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